KR20170000902A - Composition for growth promotion comprising herb extracts and formulation - Google Patents
Composition for growth promotion comprising herb extracts and formulation Download PDFInfo
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- KR20170000902A KR20170000902A KR1020150089987A KR20150089987A KR20170000902A KR 20170000902 A KR20170000902 A KR 20170000902A KR 1020150089987 A KR1020150089987 A KR 1020150089987A KR 20150089987 A KR20150089987 A KR 20150089987A KR 20170000902 A KR20170000902 A KR 20170000902A
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
Description
The present invention relates to a composition for growth promotion, which contains various herbal medicine extracts and provides chewable tablets so as to be able to be taken by children in the growing period.
Genetic factors, nutritional factors, and stress factors are known to be important factors that inhibit the growth of human body during growth period. The double genetic factors are difficult to cope with congenital, and the nutritional factors are not seriously problematic due to the improvement of the national income and the improvement of the eating habits, and the excessive nutrient intake is a problem. In this respect, the most serious problem that impedes growth is known as growth inhibition due to stress.
Currently, currently used methods for promoting the growth of the human body include a method of directly injecting a growth hormone produced by a microorganism by biotechnology, a method of mixing nutrients such as various kinds of herbal medicines and calcium, A method of ingesting a special growth supplement, a method of using a fixture for a key size, and an exercise prescription are known.
In particular, when injecting growth hormone, adverse effects due to the administration of an artificial growth hormone, a stress due to a treatment period of about one year and a great deal of pain during injection, as well as economic problems due to expensive treatment costs, There are many differences depending on the constitution of the patient to be administered.
Therefore, there is a high interest in health foods and medicines for growth promotion using safer natural materials.
An object of the present invention is to provide a composition for growth promotion, which is chewable so as to be able to be taken by growing children using various herbal medicine extracts which are safer natural materials.
In order to attain the above object, the present invention provides a process for producing a water-soluble polymer, which comprises, by weight based on 100 parts by weight of water, 0.1 to 5 parts by weight of sulfur, 0.1 to 5 parts by weight of acid, 0.1 to 5 parts by weight, 0.1 to 5 parts by weight, 0.1 to 5 parts by weight of dicalcium phosphate, 0.1 to 5 parts by weight of Danggui, 0.1 to 5 parts by weight of peony root, 0.1 to 5 parts by weight of peony root, 0.1 to 5 parts by weight of ginger, 0.1 to 5 parts by weight of dermis, , 0.1 to 5 parts by weight of a sine, 0.1 to 5 parts by weight of a raw material, 0.05 to 3 parts by weight of raw paper, 0.1 to 5 parts by weight of ginger, and 0.1 to 5 parts by weight of a jujube, ≪ / RTI >
The herbal medicine extract according to the present invention has a relatively small adverse effect as a natural material. In particular, it induces differentiation of C212 cells into osteoblasts, thereby providing excellent growth promoting effect and providing chewable tablets for increasing adherence of children in growing age Therefore, it can be usefully used as a growth promoting agent or a health functional food.
FIG. 1 and FIG. 2 are photographs showing the result of induction of differentiation into osteoblast by microscopic observation at a magnification of 40-fold and 100-fold after treatment of herbal medicine extract according to the present invention with C2C12 cells.
FIG. 3 is a graph showing the results of induction of differentiation into osteoblast by absorbance of C2C12 cells after treatment with herbal extracts according to the present invention.
Hereinafter, the present invention will be described in more detail.
The present inventors have made efforts to develop a growth promoting agent using a natural material, which is not a hormone agent such as the former growth hormone. As a result, the present inventors have found out that the growth promoter using natural materials such as Hwanggi, , Ginseng extract, ginger, and jujube extracts, and thus the present invention has been completed.
The present invention relates to a process for the production of a starch composition comprising 0.1 to 5 parts by weight of sulfur, 0.1 to 5 parts by weight of acacia, 0.1 to 5 parts by weight of acacia, 0.1 to 5 parts by weight of acacia, 0.1 to 5 parts by weight of licorice, 0.1 to 5 parts by weight of ginger, 0.1 to 5 parts by weight of ginger, 0.1 to 5 parts by weight of ginger, 0.1 to 5 parts by weight of white ginger, 0.1 to 5 parts by weight of ginger, 0.1 to 5 parts by weight of ginger, , 0.1 to 5 parts by weight of wheat germ, 0.05 to 3 parts by weight of raw ginger, 0.1 to 5 parts by weight of ginger, and 0.1 to 5 parts by weight of jujube, and heating and extracting the same.
The scutellum plays a role of enhancing energy and immunity, and the scutell acts to enhance pulmonary function and kidney function. The scutell acts to strengthen the spleen, the scutellum plays a spleen protective role, The licorice plays a role of restoring the function of the liver, and the yangyuk plays a role of heart and splenic function, and the gangwoo plays a role of a blood, and the peony plays a role of promoting liver and spleen function, The dermis plays a role of improving the digestion of the food, the cystic gland plays a role of promoting blood circulation, the Baekduk plays a role of improving the weakness of the noodles, Wherein the raw material plays a role of improving digestion failure, the raw raw material plays a role of promoting a kidney function, Ginger plays a role in promoting pulmonary function, and jujube plays a role of improving heart function and digestion function.
The herbal extract may be extracted at a temperature of 80 to 110 ° C for 2 to 3 hours.
The composition may further comprise at least one member selected from the group consisting of excipients, whitening agents, sweeteners, flavoring agents, acidifiers and glidants.
The excipient may be a suitable form of the composition or may serve to facilitate handling by increasing the amount of the excipient. Ludipress, mannitol, lactose, starch, microcrystalline cellulose and the like may be used. May be contained in an amount of 20 to 40 parts by weight based on 100 parts by weight.
The foaming agent may serve as a shield against bitter taste, and beta-cyclodextrin, gamma-cyclodextrin or the like may be used, and may be contained in an amount of 1 to 10 parts by weight based on 100 parts by weight of the total amount of the composition for promoting growth.
The sweetener may reduce the bitterness of the composition and may serve as a sweet taste. It may contain xylitol, stevia, aspartame, oligosaccharide, fructose, white sugar or the like and may be contained in an amount of 20 to 40 parts by weight based on 100 parts by weight of the total amount of the composition for promoting growth .
The flavoring agent plays a role of enhancing the fragrance of the composition and can be used as a lemon flavor, a blueberry flavor, a corn flavor, a plum flavor, an orange flavor, a pepper flour, a lime flavor, May be contained in an amount of 1 to 10 parts by weight based on 100 parts by weight of the total amount of the accelerating composition.
The acidic agent serves to add the acidity of the composition, and citric acid, malic acid, succinic acid, or the like can be used. The acidic agent may be contained in an amount of 1 to 10 parts by weight based on 100 parts by weight of the total amount of the composition for promoting growth.
The lubricant acts to reduce frictional force in the preparation of the composition, and silicon dioxide, magnesium stearate and the like can be used. The lubricant may be contained in an amount of 1 to 10 parts by weight based on 100 parts by weight of the total amount of the composition for promoting growth.
The composition may be selected from the group consisting of chewable tablets, tablets, pills, capsules, powders, and liquids, and more preferably chewable tablets which are chewable tablets.
The composition may be a pharmaceutical composition or a health functional food.
The pharmaceutical composition according to the present invention preferably contains 30 to 50 parts by weight of the herbal medicine extract per 100 parts by weight of the total. If the herbal medicine extract is contained in a small amount beyond the above range, it is difficult to obtain a desired growth promoting effect, while if it is contained in an excessive amount, the growth promoting effect may be slowed as compared with the dose.
In addition, the pharmaceutical composition according to the present invention may further comprise an appropriate carrier, excipient or diluent conventionally used in the production of the pharmaceutical composition.
Examples of the carrier, excipient or diluent which can be used in the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate or mineral oil.
The pharmaceutical composition according to the present invention may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterilized injection solutions according to a conventional method .
The dosage of the pharmaceutical composition of the present invention may vary depending on the route of administration, the severity of the disease, the age, sex, and body weight of the patient, and may be administered once to several times per day.
The pharmaceutical composition may be administered to mammals such as rats, mice, livestock, humans, and the like in a variety of routes. All modes of administration may be expected, for example, by oral, nasal, rectal or intravenous, intramuscular, subcutaneous, intra-uterine or intracerebroventricular injections.
The functional food according to the present invention can be used as a health functional food or a health drink, and is preferably used as a functional beverage, a pill, a tablet, or a soft or hard capsule filled with the above components as a dry powder.
Examples of the foods to which the herbal medicine extract of the present invention can be added include various foods such as candy, chocolate, beverage, gum, tea, vitamin complex, health supplement food and the like, and powder, granule, tablet, pill, capsule or beverage Can be used.
The health drink of the present invention has no particular limitation on the liquid ingredient except that it contains the herb extract as an essential ingredient in the indicated ratio and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary drinks. Examples of natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose, and polysaccharides such as maltose and sucrose. For example, conventional sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. Examples of the flavors include natural flavors such as tau martin, stevia extract, heba dioside A, glycyrrhizin and synthetic flavors such as saccharin and aspartame.
In addition to the above, the composition of the present invention may also be used as a flavoring agent, coloring agent, enhancer, pectic acid and its salt, alginic acid and its salt, organic acid, protective colloid thickening agent, pH of various nutrients, vitamins, minerals, synthetic flavors and natural flavors, Stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like.
Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these examples are illustrative of the present invention, and the contents of the present invention are not limited by these examples.
<Example 1> Preparation of herbal medicine extract
The human herbal extracts used in the present invention are herbicidal herbs such as Hwanggi, Sanshak, Baekyu, Bokryeong, Licorice, Yongcheng, Angelica, Peony, Gugija, Dermis, .
3.75kg of ginseng, 3.75kg of ginseng, 3.75kg of ginseng, 3.75kg of licorice, 3.75kg of licorice, 3.75kg of ginseng, 3.75kg of ginseng, 3.75kg of ginseng, 3.75kg of ginger, 2.8kg of ginseng, 1.87kg of ginseng, 1.87kg of ginsenoside, 1.87kg kg of water, 1.87 kg of wheat germ, 0.93 kg of raw ginger, 3.75 kg of ginger, and 3.75 kg of jujube, and the mixture was heated at 100 ° C. for 3 hours, No. 2, 25 nm), and the filtrate was recovered. The recovered filtrate was concentrated under reduced pressure with rotary evaporator (N-12, EYELA) and then dried with a spray drier (180 ° C., 18,000 rpm, Sogang Engineering) and a vacuum dryer (50 ° C., 600 mmHg, Were used in the following experimental examples.
<Experimental Example 1> Examination for induction of osteoblast differentiation
Whether or not the herbal extract prepared in Example 1 induces the differentiation of C2C12 cells into osteoblasts was investigated as follows.
That is, C2C12 cells were divided into 6 wells at 5 × 10 3 cells / well and cultured in a CO 2 incubator at 37 ° C. for 24 hours. The differentiation inducing substance was a complete medium containing 50 μM ascorbic acid, 10 mM β-glycerophosphate, and 400 nM hydrocortisone, and the herbal extracts were treated by concentration in each well. The medium was changed at 48 hour intervals. After 2 weeks of differentiation, the cells were stained with 40 mM Alizarin Red S. After microscopic observation, 10% cetylpyridinium chloride solution was decolorized and absorbance was measured at 560 nm using a microplate reader.
Fig. 1 and Fig. 2 are photographs taken with a microscope after staining with Alizarin Red S, and they were observed at 40 times and 100 times, respectively. It was found that the cells were stained more heavily and the volume of differentiated cells was increased with increasing concentration.
FIG. 2 shows the results of measuring the absorbance at 560 nm by decolorizing with 10% cetylpyridinium chloride after staining with Alizarin Red S, and comparing the increased differentiation level compared to the control group by setting the negative control as the baseline. At the concentration of 100 ㎍ / ml, the degree of differentiation was similar to that of the control group, but at the concentration of 200 ㎍ / ml or more, it showed 1.5 times or more differentiation. (Error bars are S.E.M and ** is p < 0.05)
≪ Preparation Example 1 &
After mixing with the dried powder of the herbal extract extract obtained in Example 1 and the following additives, chewable tablets were prepared by the direct tableting method.
≪ Preparation Example 2 &
After mixing with the dried powder of the herbal extract extract obtained in Example 1 and the following additives, chewable tablets were prepared by the direct tableting method.
While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will appreciate that such specific embodiments are merely preferred embodiments and that the scope of the present invention is not limited thereby. something to do. It is therefore intended that the scope of the invention be defined by the claims appended hereto and their equivalents.
Claims (5)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150089987A KR20170000902A (en) | 2015-06-24 | 2015-06-24 | Composition for growth promotion comprising herb extracts and formulation |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020150089987A KR20170000902A (en) | 2015-06-24 | 2015-06-24 | Composition for growth promotion comprising herb extracts and formulation |
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| KR20170000902A true KR20170000902A (en) | 2017-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020150089987A KR20170000902A (en) | 2015-06-24 | 2015-06-24 | Composition for growth promotion comprising herb extracts and formulation |
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| Country | Link |
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| KR (1) | KR20170000902A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102013847B1 (en) * | 2019-04-30 | 2019-08-23 | (주)펜즈 | Composition for promoting growth of height comprising Humulus japonica Sidb. et Zucc. component as an active ingredient and health functional foods comprising the same |
| KR20200085024A (en) * | 2019-01-04 | 2020-07-14 | 주식회사 디네이쳐 | Method of selective extracting natural material |
| KR102517826B1 (en) * | 2022-07-22 | 2023-04-05 | 주식회사 상상바이오 | Manufacturing method of improving composition the health and development of growing children with excellent palatability |
| KR102621399B1 (en) | 2022-11-30 | 2024-01-08 | 주식회사 함소아제약 | Composition of antler and schisandra complex powder for growth promotion and and method for preparing the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030000306A (en) | 2001-06-23 | 2003-01-06 | 한영근 | Food for growth promotion utilizing crude drug |
-
2015
- 2015-06-24 KR KR1020150089987A patent/KR20170000902A/en not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030000306A (en) | 2001-06-23 | 2003-01-06 | 한영근 | Food for growth promotion utilizing crude drug |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200085024A (en) * | 2019-01-04 | 2020-07-14 | 주식회사 디네이쳐 | Method of selective extracting natural material |
| KR102013847B1 (en) * | 2019-04-30 | 2019-08-23 | (주)펜즈 | Composition for promoting growth of height comprising Humulus japonica Sidb. et Zucc. component as an active ingredient and health functional foods comprising the same |
| WO2020222366A1 (en) * | 2019-04-30 | 2020-11-05 | (주)펜즈 | Food composition for promoting height growth and pharmaceutical composition for promoting height growth including humulus japonicus extract or ground humulus japonicus as active ingredient |
| CN115944080A (en) * | 2019-04-30 | 2023-04-11 | 彭斯株式会社 | Use of a composition for the manufacture of a food or a medicament for promoting growth in height |
| US11759489B2 (en) | 2019-04-30 | 2023-09-19 | Pens Co., Ltd. | Food composition for promoting height growth and pharmaceutical composition for promoting height growth including Humulus japonicus extract or ground Humulus japonicus as active ingredient |
| KR102517826B1 (en) * | 2022-07-22 | 2023-04-05 | 주식회사 상상바이오 | Manufacturing method of improving composition the health and development of growing children with excellent palatability |
| KR102621399B1 (en) | 2022-11-30 | 2024-01-08 | 주식회사 함소아제약 | Composition of antler and schisandra complex powder for growth promotion and and method for preparing the same |
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