JP2001302527A - Skin care preparation for applicating body part for lean figure - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation for a body part for lean figure by preventing obesity caused by intercellular edema by retention of lymph and obesity caused by intake of fats in a fat cell and especially suitable to a continuous use, not slimming the whole body but controlling obesity of a body part so as to form a figure as an attractive woman. SOLUTION: This skin care preparation for applicating a body part for lean figure is formulated with a refrigerating agent of one or more kinds of 1-methyl glyceryl ether and 1-menthol as an obesity indicator and comprises one or more kind of Melilotus officinalis and Aesculus hippocastanum L. and an active ingredient obtained by activating a milk derived inactivated cytokinin substance.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention provides a skin external preparation for preventing obesity caused by intercellular edema due to lymphatic fluid retention and obesity caused by fat incorporation into fat cells. In particular, it is used as an external preparation for skin to suppress the obesity of a localized site, not to thin the whole body.

[0002]

2. Description of the Related Art As a general skin external preparation for the purpose of slimming, there are external preparations containing astringents for denaturing skin proteins or caffeine. It was difficult to mix up to Some foods and health supplements use a laxative, but have health problems.

[0003]

In the prior art, there are many raw materials having a problem of low slimming effect, or having safety or health problems. There was no effective application site localized slimming method. In addition, since the slimming that a woman truly desires has site specificities such as a waist and a thigh, there is a problem that an ideal proportion cannot be obtained in a diet of an oral administration method.

[0004]

[Means for Solving the Problems] One or more of cooling sensation agent 1-menthyl glyceryl ether or 1-menthol is blended as an obesity indicator, and one or more of Chinese lobster extract or horse chestnut extract and milk-derived An external skin preparation for the purpose of localized slimming of the application site, containing an active ingredient obtained by activating an inactivated cytokine-like substance

[0005] The present invention relates to
lotus officinalis extract (hereinafter abbreviated as Ebirahagi) or horse chestnut (Aesc)
ulus hippocastanum L.), an active ingredient (hereinafter MP) obtained by activating a milk-derived inactivated cytokine-like substance and at least one kind (comprising 0.01 to 80.0% by weight of each) of a seed extract (hereinafter referred to as horse chestnut). ) (0.01 to 10.0 weight percent blended)
A skin external preparation for the purpose of localized slimming, which is applied to any of cosmetics, cosmeceuticals and pharmaceuticals. As an active ingredient obtained by activating a milk-derived inactivated cytokine-like substance, an inactivated cytokine-like substance in whey produced from milk normally used as food was used. Milk is derived from common mammals and does not contain colostrum. Furthermore, by blending one or more of l-menthyl glyceryl ether (hereinafter referred to as menthol) or l-menthol (hereinafter referred to as menthol) as an obesity indicator (each in a proportion of 0.01 to 1.0% by weight), obesity is subjectively observed. Provided is an external preparation for skin for localization and slimming of an application site, the degree of which can be determined. In this embodiment, a more useful external preparation can be obtained by adding various cosmetic ingredients necessary for skin beauty and other components for the purpose of slimming.

[0006] In the era of satiety these days, there are many products advocating diet and slimming in search of a beautiful body shape in beauty. Most of them are forced to run difficult programs or are frustrated because their effects are not clearly understood. Therefore, there is provided a slimming method in which edematous swelling is removed in the first stage of immediate action, and then body fat is reduced in the second stage of delay. According to this slimming method, it is easy to locally identify the slimming area by the obesity indicator, and in the first step, while feeling the effectiveness of immediate effect, proceeding to the second step, there is sustainability Slimming is now possible. As a result, when the slimming effect appears, the obesity indicator becomes difficult to perceive or becomes insensitive, and it is understood that the effect of the present embodiment has appeared.

The effects will be described below with reference to embodiments. Examples and comparative examples are shown in Table 1. Ebirahagi and horse chestnut were blended as the first-step active ingredient, MP was blended as the component showing the delayed efficacy in the second step, and menthol and menthol were used as obesity indicators. As a comparative control example, Comparative Example 1 is a formulation containing no shrimp and horse chestnut as active ingredients, and Comparative Example 2 is a formulation containing MP without a shrimp and horse chestnut, and Negative Comparative Example 3 This is a prescription from which all the active ingredients of shrimp, horse chestnut and MP are removed. The obesity indicators menthyl and menthol were added to all four test substances.

[0008]

[Table 1]

First, the relationship between the self-reported obesity degree and the feeling of coldness by the obesity indicator was examined using Negative Comparative Example 3.
Body mass index as a subject: Body mass inde
x (hereinafter referred to as BMI) was applied to various parts of the body by applying five negative controls to various parts of the body to five healthy control groups of 20 to 22, 24 to 26 overweight groups, and 27 to 35 obesity groups. Self-reported the degree of feeling cold. The results are shown in Table 2.

[0010]

[Table 2]

[0011] As a result, in the group of healthy subjects, a part of the subject who is worried about obesity is more likely to feel a cold sensation. Higher, the cold sensitivity of the obese group becomes even higher,
In the part where the obesity was not anxious, such as the forearm, the value was lower than that in the obese area. From this fact, it was found that the sensation of cold caused by menthyl and menthol was useful as an obesity indicator reflecting the degree of obesity.

Next, 21 women aged 18 to 48 years with a BMI of 24 or more classified as overweight or obese were grouped into 7 groups.
And randomly divided into three groups. In the test group, the negative control comparative example 3 and the comparative example 2 were included in the test group, the negative control comparative example 3 and the comparative example 1 were included in the test group, and the negative control comparative example and the comparative example 2 were included in the comparative example 2 test group. It was applied to the left and right thighs. Each test substance was provided in a double-blind manner and applied twice a day in the morning and evening.
It was applied every day for 4 weeks. The measurement was performed on the day of use, 7 days after use, 14 days after use, 21 days after use, and 28 days after use. After the test was completed, the test subjects applied to each thigh were listened to from the test subjects and counted. The measurement method is described below. In the recumbent state, the same measurer attached a spring scale to one end of the tape measure, measured the length around the thigh at a position 20 cm from the upper end of the patella 10 times from the upper end of the patella with the same strength, and determined the average value. The measurement time is between 9:00 and 17:00
The measurement time of each subject was determined, and the measurement was performed at least within 30 minutes from that time. Table 3 shows the results. He also self-reported the cold sensitivity of the obesity indicator.

[0013]

[Table 3]

The results are summarized below. In the example,
One week after the start of the application, a remarkable decrease in the length around the thigh was observed, and further, a gradual decrease was observed until 4 weeks later. The length around the thigh on the side to which the negative comparative example 3 was applied did not show a significant difference from the use start date. The application site of Comparative Example 1 showed a smaller decrease in the circumference of the thigh than the example after one week, but no significant decrease was observed in subsequent follow-up observations. At the application site of Comparative Example 2, the length around the thigh gradually decreased over 3 weeks and 4 weeks after the start of application. In the group of the comparative example 1 and the group of the comparative example 2, the length around the thigh on the side to which the negative comparative example 3 was applied did not show a significant difference from the use start date, as in the example.

According to the results of self-report of coldness of the obesity indicator, 9/14 out of 14 subjects showed a marked decrease in the length around the thigh in the application site in Example and Comparative Example 1.
Examples reported that they had "feel less cool" or "feel cold" compared to the opposite site. The test subject group using Comparative Example 2 did not feel a difference in cold sensation on the left and right.

Comparative Example 1 shows an immediate effect within 1 week of application, Comparative Example 2 is effective 3 to 4 weeks after application, and the synergistic effect thereof is remarkable in Examples. It was confirmed that the site-specific slimming effect was effective. In addition, it was found that the cooling sensation at the time of application was an index for measuring the local obesity degree of the subject himself, and was also useful as an obesity indicator in the sense of confirming the effect after the implementation of the examples.

 ──────────────────────────────────────────────────続 き Continued on the front page (54) [Title of the Invention] One or more of cooling agents l-menthylglyceryl ether or l-menthol are blended as an obesity indicator. An external skin preparation for the purpose of localized slimming of the application site, containing an active ingredient that activates inactivated cytokine-like substances derived from milk and more than one seed

Claims (2)

[Claims] 1. A skin external preparation for the purpose of local slimming of the application site, comprising at least one of a horseshoe extract or a horse chestnut extract and an active ingredient obtained by activating an inactivated cytokine-like substance derived from milk. 2. A skin external preparation for local slimming of an application site, comprising one or more cooling sensation agents l-menthyl glyceryl ether or l-menthol as an obesity indicator.