JP2001302413A - Controller against indoor mites of tarsonemidae - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an effective controller for indoor mites of Tarsonemidae, having low toxicity, excellent safety, a slight offensive odor and no limitation on use mode. SOLUTION: This controller for indoor mites of Tarsonemidae is characterized by comprising one or more kinds of compounds selected from the group consisting of a compound of general formula (I) (R is a 1-5C alkyl group) and glycol salicylate to attain the purpose.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an agent for controlling indoor dust mites.

[0002]

2. Description of the Related Art In recent years, various diseases have been increasing due to changes in living habits such as changes in human habits and living areas, and changes in eating habits and daily necessities. One of the causes is the irregular explosion of indoor dust mites due to changes in the living environment. Indoor dust mites, themselves, cause discomfort and, in addition to mite allergic diseases and atopic diseases, as a cause of childhood asthma or actually cause injuries and diseases in humans, such as tick bites, in sanitary animals (Vector).

In order to control such indoor dust mites, for example, tatami mats, floors, carpets and the like are provided with an aerosol agent,
Direct spraying of liquids such as oils and emulsions, insect-proof paper,
Various treatments using indoor dust mite control agents conventionally formulated in various forms, such as carpets, sheets and housing materials being impregnated with chemicals, or being treated with fumigation agents and fumigants Has been taken. It is also known to control indoor dust mites by directly applying a spray, lotion, cream or the like prepared with a mite control agent to a human or animal body.

[0004] Compounds contained in such indoor dust mite control agents include, for example, organic chlorine compounds such as DDT and γ-BHC, propentanfos, dichlorvos, and the like.
Organic phosphorus compounds such as fenitrothion, carbaryl,
Carbamate compounds such as probosur, resmethrin,
Pyrethroid compounds such as phenothrin and permethrin,
Terpene compounds such as menthol and hinokitiol, phenyl salicylate, benzyl benzoate, and N, N-diethyl-3-toluamide (hereinafter sometimes also referred to as DET) are known.

[0005] However, organochlorine compounds are highly toxic and their use is currently generally prohibited. Further, many organic phosphorus compounds are generally highly toxic, have a problem in stability, and often generate a peculiar odor when decomposed. In addition, carbamate compounds are also similar and generally have high toxicity, and their effects are not always sufficient. On the other hand, pyrethroid compounds generally have low toxicity, but many of them give off a peculiar odor when decomposed.
Terpene compounds have high volatility and often have an unpleasant odor when present in the air at high concentrations. Benzyl benzoate and phenyl salicylate are sometimes toxic and cause problems. Furthermore, since the DET preparation is applied directly on the skin, the form of use is limited.

[0006]

SUMMARY OF THE INVENTION An object of the present invention is to provide an effective indoor dust mite control agent which has low toxicity, excellent stability, low odor, is not limited in use form, and is effective. is there.

[0007]

Means for Solving the Problems The present inventors have made intensive studies and have found that the compound represented by the general formula (I)

[0008]

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(Wherein R represents an alkyl group having 1 to 5 carbon atoms) and one or more compounds selected from the group consisting of glycols and salicylates as active ingredients. By using an indoor dust mite control agent characterized by the following, an effective mite control agent having few defects as described above has been found.

That is, the present invention is as follows. (1) General formula (I)

[0011]

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(Wherein R represents an alkyl group having 1 to 5 carbon atoms) and one or more compounds selected from the group consisting of glycols and salicylates as active ingredients. An indoor dust mite control agent characterized by the following. Preferred embodiments are as follows. (2) The indoor dust mite control agent according to the above (1), which contains the active ingredient in an amount of 0.05% by weight or more. (3) The indoor dust mite control agent according to the above (1) or (2), wherein R in the general formula (I) is an alkyl group having 1 to 3 carbon atoms. (4) The indoor dust mite control agent according to any one of the above (1) to (3), comprising salicylic acid propyl ether and / or glycol salicylate as an active ingredient.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The indoor dust mite control agent of the present invention comprises, as an active ingredient, one or more compounds selected from the group consisting of the compound represented by the general formula (I) and glycol salicylate. Contained as In the general formula (I), R is an alkyl group having 1 to 5 carbon atoms, and examples thereof include a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a pentyl group, and an amyl group.

In the present invention, compounds represented by the general formula (I) include methyl salicylate, ethyl ether salicylate, propyl salicylate,
Examples include, but are not limited to, isopropyl ether salicylate, butyl ether salicylate, isobutyl ether salicylate, pentyl ether salicylate, amyl ether salicylate, and the like.

Among them, in the general formula (I), R represents 1 carbon atom.
Compounds that are alkyl groups of (1) to (3) are preferable, and specifically, a methyl group, an ethyl group, a propyl group, an isopropyl group, and the like are preferable. Preferred compounds represented by the general formula (I) of the present invention include salicylic acid methyl ether,
Examples thereof include ethyl salicylate, propyl ether salicylate, and isopropyl salicylate, with propyl ether salicylate being preferred.

As described above, the indoor dust mite control agent of the present invention comprises as an active ingredient one or more compounds selected from the group consisting of the compound represented by the general formula (I) and glycol salicylate. It is not particularly limited as long as it contains, but among them, those containing propyl salicylate and / or glycol salicylate as an active ingredient are particularly preferable.

The compounds represented by the general formula (I) are generally known compounds, and can be easily synthesized by a method such as a Williamson reaction using a copper catalyst.

Glycol salicylate is also a known compound generally widely used as a poultice or a permeation aid for dermatological agents, and can be obtained by obtaining a commercial product. In addition, salicylic acid and ethylene glycol can be easily synthesized by a method using a phosphorus oxychloride catalyst or the like.

The indoor dust mites to be controlled by the indoor dust mite control agent of the present invention include Dermatophagoides farinae, Dermatophagoid mites, Dermatophagoides, Dermatophagoides, Dermatophagoides, Dermatophagoides and Dermatophagoides. . Dermatophagoids include Dermatophagoides mite, Dermatophagoides and the like. As the mites, there may be mentioned Acarina mites, Acarina mites, Robin mite, and the like.
Examples of the custodial mites include the house crab mite, the netitaita crab mite, and the cypress mite. Examples of house dust mites include mite dust mite and mite dust mite. Dermatophagoides, Dermatophagoides farinae,
Dermatophagoides pteronyssinus and the like. Examples of the mites include a stag mite, a mites mites, and the like. As a species of house salad, there is a species of house salad.

When used as an active ingredient of an indoor dust mite control agent, it can be used as it is, but it is usually held in a liquid, solid, gel or gaseous carrier, or another carrier for pharmaceuticals, , Emulsions, powders, granules, gels,
Aerosol, smoke, incense, transpiration, poison,
It is formulated and applied as a sheet agent, a plate agent, a paint, a kneading coating wall agent, a resin plate, an injecting agent, an impregnating agent and a coating agent for building materials.

Examples of the liquid carrier used in the preparation include aliphatic hydrocarbons such as kerosene and kerosene, aromatic hydrocarbons such as benzene, toluene, xylene and methylnaphthalene, and halogenated hydrocarbons such as dichloroethane, trichloroethane and carbon tetrachloride. Hydrogens, methanol, ethanol, isopropanol, 3-methoxy-3-methyl-1
Alcohols such as butanol, ethylene glycol and propylene glycol, ketones such as acetone, methyl ethyl ketone, cyclohexanone and isophorone, ethers such as diethyl ether, dioxane, tetrahydrofuran and cellosolve, esters such as ethyl acetate, and nitriles such as acetonitrile Acid amides such as dimethylformamide, vegetable oils such as dimethyl sulfoxide and refined rice oil, silicone oils such as dimethylpolysiloxane, and water. Examples of the solid carrier include kaolin clay, talc, diatomaceous earth, acid clay, calcite, silicic acid, zinc oxide, titanium oxide, bentonite, flourite, calcium sulfate, calcium carbonate, calcium hydroxide, potassium chloride, corn cob powder , Walnut shell powder, urea, ammonium sulfate, synthetic hydrous silicon oxide, pulp, powdered charcoal, matirus powder, tub powder, glass fiber and other powders, granules (beads) and other solids. Examples of the gel carrier include, for example, carrageenan gel, agar gel, gelatin gel, xanthan gum gel, locust pea gum gel, coumarind gel, gum arabic gel, kelco gel, curdlan gel, glucomannan gel, psyllium gel, soybean polysaccharide gel, and hardened castor Oils. Examples of the gaseous carrier include laughing gas, nitrogen gas, carbon dioxide gas, liquefied petroleum gas, isopentane, dimethyl ether and the like. Other pharmaceutical carriers include sorbitan trioleate, various surfactants such as benzalkonium chloride,
Various resins such as cellulose derivatives, vinyl resins, epoxy resins, and polyurethane resins; film-forming agents such as polyvinyl alcohol; fixing agents, dispersants, and stabilizers such as lignin sulfonate, alginate, gum arabic, and carboxymethyl cellulose. Is mentioned.

The indoor dust mite control agent of the present invention includes known insecticides, insect repellents, fungicides, synergists, repellents,
Additives such as a fungicide, an antioxidant, a flavor, and a coloring agent can be added. Additives that can be added to the indoor dust mite control agent of the present invention are not particularly limited, and specifically, as the insecticide, a pyrethroid compound, an organic phosphorus compound, a carbamate compound, and the like. Examples of the insect repellent include synthetic camphor, citronella oil, paradichlorobenzene, piperonyl butoxide, and the like, and fungicides such as benzalkonium chloride, benzethonium chloride, salac powder, N-chloro-
p-toluenesulfonamide soda; and synergists as octachlorodipropyl ether, N-
(2-ethylhexyl) -1-isopropyl-4-methylbicyclo [2,2,2] oct-5-ene-2,3-
Dicarboximide, isobornyl thiocyanoacetate, N
-(2-ethylhexyl) -bicyclo [2,2,1] hept-5-ene-2,3-dicarboximide and the like, and as repellents DET, dimethylphthalate,
Dibutyl phthalate, 2,3,4,5-bis (η-2-
(Butylene) -tetrahydrofurfural, di-n-propylisocincomeronate and the like, and as a fungicide, 2- (4-thiazolyl) -benzimidazole, N
-(Fluorodichloromethylthio) -phthalimide, etc., and as the antioxidant, erythorbic acid, dl
-Α-tocopherol, dibutylhydroxytoluene,
Examples of the flavoring agent include citronella oil, geranium oil, lemongrass oil, linalyl acetate, and vanillin, and examples of the coloring agent include indigo carmine, tartrazine, nonalactone, and copper chlorophyll.

The indoor dust mite control agent of the present invention can be sprayed, sprayed, applied, smoke, etc. on tatami mats, carpets, floors, flooring, floors, mattresses, sofas, futons, pillows, bedding, living rooms, closets, warehouses and the like. It is used by processing by means of heat evaporation and installation. The indoor dust mite control agent of the present invention formulated in an aerosol can be attached to an automatic spraying device equipped with a timer and used as a regular spraying device.

Further, the amount of the above-mentioned active ingredient contained in the indoor dust mite control agent of the present invention is appropriately determined according to the dosage form, the mite, and the place of application, and is not particularly limited. However, it is contained in the preparation in an amount of 0.05% by weight or more, preferably 0.5% by weight or more. In addition, the active ingredient,
Preferably 30% by weight or less in the indoor dust mite control agent,
More preferably, the content is 20% by weight or less.

The application rate of the above-mentioned active ingredient is not particularly limited. However, it is usually desirable that the application amount is 25 mg or more per square meter of the plane to be processed or 2.5 mg or more per cubic meter of the space to be processed.

[0026]

The present invention will be described in detail with reference to the following examples, but the present invention is not limited to the following examples. Parts shown below represent parts by weight. Example 1 One part of propyl ether salicylate and 50 parts of kerosene were mixed, taken into a pressure vessel, cooled or pressure-filled with 50 parts of a propellant (liquefied petroleum gas, manufactured by Koike Chemical Co., Ltd.), and an injection port was attached to obtain an aerosol. Was.

Example 2 1 part of glycol salicylate and 25 parts of alcohol were mixed, taken in a pressure vessel, cooled or pressure-filled with 275 parts of a propellant (dimethyl ether, manufactured by Koike Chemical Co., Ltd.), and an aerosol was obtained by attaching an injection port. Was.

Example 3 0.5 parts of glycol salicylate, 5 parts of synthetic camphor (synthetic camphor, manufactured by Hasegawa Koran Co., Ltd.), and 0.1 parts of citronella oil.
An emulsion was obtained with 5 parts, 1.0 part of sorbitan trioleate, 0.1 part of dimethylpolysiloxane and 92.9 parts of purified water.

Example 4 2 parts of propyl salicylate was diluted with an appropriate amount of alcohol, and triturated with 100 parts of silica powder to obtain a powder.

Example 5 5 parts of propyl salicylate was diluted with an appropriate amount of alcohol, and triturated with 100 parts of talc beads to obtain granules.

Example 6 5 parts of glycol salicylate, 7 parts of di-2-ethylhexyl phthalate, 50 parts of vinyl acetate resin and 38 parts of purified water
The parts were mixed to obtain a paint.

Example 7 0.6 parts of propyl salicylate was dissolved in an appropriate amount of methanol, and 5 parts of powdered charcoal, 2 parts of silica powder, 2 parts of calcium hydroxide, 2 parts of pulp, 1.2 parts of matiras powder and 1.2 parts of tab powder were prepared. After stirring and mixing uniformly with 1.2 parts to evaporate the alcohol, the mixture was sufficiently kneaded with an appropriate amount of water, molded and dried to obtain a fragrance.

Example 8 A solution was obtained by mixing 10 parts of salicylic acid propyl ether with 60 parts of an 80% alcohol solution and 40 parts of 3-methoxy-3-methyl-1-butanol. This liquid preparation was filled in a closed container with a lid, and a filter paper was inserted into the lid as a liquid absorbing core to obtain an evaporative preparation.

Example 9 After the liquid preparation obtained in Example 8 was filled in a closed container with a lid, a stick-shaped filter paper was inserted into the lid as a liquid absorbing core to obtain an evaporative preparation.

Example 10 After the liquid preparation obtained in Example 8 was filled in a closed container with a lid, a rod-shaped acrylic resin was inserted into the lid as a liquid-absorbing core to obtain a vaporized preparation.

Example 11 After the liquid preparation obtained in Example 8 was filled in a closed container with a lid, a bar-shaped pulp was inserted into the lid as a liquid absorbing core to obtain an evaporative preparation.

Example 12 10 parts of salicylic acid propyl ether, 5 parts of a retaining agent (manufactured by Taisei Kogyo, crystal wax), 17 parts of a thermoplastic resin (manufactured by Tokyo Ink, olefin powder), and a plasticizer (manufactured by Nippon Rika, Sansosizer) 12 parts, 13 parts of silicic anhydride, and 33 parts of a thermoplastic resin (manufactured by Du Pont-Mitsui Chemicals, Evaflex) were mixed by heating and molded to obtain a plate agent.

Example 13 10 parts of propyl salicylate was dissolved in an appropriate amount of methanol, triturated with 30 parts of calcium sulfate, and the alcohol was evaporated. Then, 30 parts of calcium carbonate and 30 parts of calcium hydroxide were added, and the mixture was uniformly mixed. After stirring and mixing, an appropriate amount of water was added to obtain a kneaded coating wall material.

Example 14 5 parts of glycol salicylate was dissolved in an appropriate amount of acetone.
After mixing with 80 parts of polyurethane, uniformly stirring and kneading, and evaporating acetone, 15 parts of glass fibers were further mixed and kneaded, and injection and compression molding was performed to obtain a resin plate.

Example 15 1 part of propyl salicylate was dissolved in an appropriate amount of acetone, mixed with 99 parts of an epoxy resin, uniformly stirred and kneaded, and acetone was evaporated to obtain an injection.

EXAMPLE 16 Purified water (80 parts) was added to 2 parts of carrageenan, 0.5 part of locust pea gum and 5 parts of propyl ether salicylate, mixed, heated and melted, and further 0.1 parts of penzalkonium chloride and 0.05 parts of indigo carmine. 5 parts of propylene glycol were added while cooling the stirred solution.
It was transferred to a container and molded by cooling to obtain a gel.

Example 17 1.5 parts of carrageenan, 0.25 part of potassium chloride, 3-
A mixture of 15 parts of methoxy-3-methyl-1-butanol, 0.1 part of benzethonium chloride and 0.01 part of tartrazine mixed with 67.14 parts of purified water, heated and melted, and then, with stirring, hardened castor oil 6 parts, glycol salicylate 10 After mixing the parts, the mixture was transferred to a container and cooled and molded to obtain a gel agent.

The following Test Examples 1 to 3 were performed to confirm the indoor dust mite control effect of the present invention. Test Example 1 Each solution obtained by dissolving propyl ether salicylate or glycol salicylate in acetone so as to have a concentration of 2.0 mg / mL and 1.0 mg / mL, respectively, was prepared for 10 times.
cm, 5 cm wide filter paper (No.
In 2), 0.5 mL of each was uniformly dropped, and air-dried indoors. After air drying, each filter paper is 5cm long and 5c wide.
m, fold it into two pieces, and place 30 mites inside the folded part.
About the head was inserted, and three sides of the open site were sealed with clips.
Twenty-four hours after the mite was enclosed, the clip was removed and the mortality of the mite inside was observed. In addition, as a control,
A filter paper dried by applying only acetone and air-dried was prepared in the same manner and subjected to the same test. Such a test was carried out for Dermatophagoides farinae, Dermatophagoides farinae, and Red house dust mites. Table 1 shows the test results of Dermatophagoides farinae, Table 2 shows the test results of Dermatophagoides farinae, and Table 3 shows the test results of Dermatophagoides farinae.

[0044]

[Table 1]

[0045]

[Table 2]

[0046]

[Table 3]

Test Example 2 According to Example 1, 1 part of propyl ether salicylate was mixed with 49 parts of kerosene, placed in a pressure vessel, and filled with 50 parts of propellant to prepare an aerosol. The aerosol agent thus adjusted is uniformly sprayed on a filter paper having a length of 50 cm and a width of 50 cm for 3 seconds and air-dried indoors. After air-drying, a piece of filter paper of 10 cm length and 5 cm width was cut off from the filter paper, and the filter paper piece was folded in two in the same manner as in Test Example 1 so as to have a length of 5 cm and a width of 5 cm. Get in,
Seal the three sides of the open site with clips. Twenty-four hours after the mite was enclosed, the clip was removed and the mortality of the mite inside was observed. As a control, only 50 parts of kerosene was placed in a pressure vessel, filled with 50 parts of propellant, coated with an aerosol prepared in the same manner, and air-dried filter paper was cut out to produce a piece of filter paper. Such a test was carried out for Dermatophagoides farinae, Dermatophagoides farinae, and Red house dust mites. Table 4 shows the results.

[0048]

[Table 4]

Test Example 3 As a control, filter paper was treated in the same manner as in Test Example 1 except that a solution prepared by dissolving phenyl salicylate in acetone to a concentration of 1.0 mg / mL was used to compare the odors. Table 5 shows the results.

[0050]

[Table 5]

[0051]

The formula (I)

[0052]

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(Wherein R represents an alkyl group having 1 to 5 carbon atoms) and one or more compounds selected from the group consisting of glycols and salicylates as active ingredients. The indoor dust mite control agent characterized by the above can be obtained.

Continued on front page F-term (reference) 2B121 AA16 CC02 CC04 CC27 CC31 EA01 FA15 4H011 AC04 BA01 BA06 BB06 BC03 BC06 BC08 BC18 BC19 BC22 DA02 DA07 DA10 DA12 DA16 DA17 DA21 DD05 DE03 DE05 DE15 DF04 DH02 DH07

Claims (4)

[Claims] 1. A compound of the general formula (I) (Wherein, R represents an alkyl group having 1 to 5 carbon atoms), and one or more compounds selected from the group consisting of glycols and salicylates as an active ingredient. Indoor dust mites control agent. 2. The indoor dust mite control agent according to claim 1, wherein the active ingredient is contained in an amount of 0.05% by weight or more. 3. The indoor dust mite control agent according to claim 1, wherein R in the general formula (I) is an alkyl group having 1 to 3 carbon atoms. 4. The indoor dust mite control agent according to claim 1, further comprising salicylate propyl ether and / or glycol salicylate as an active ingredient.