JP2001288072A - Bathing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a bathing agent exhibiting sufficient treating effect on atopic dermatitis. SOLUTION: Whole grass of Japanese horseradish including leaf, stalk and rhizome is crushed and the product is used as the bathing agent within the period not to deteriorate the freshness after crushing or in a state suppressing the deterioration of freshness by the freeze storage within the period not to deteriorate the freshness. As an alternative, the rhizome, stalk and leaf of Japanese horseradish are immersed in water or alcohol and the extracted solution is used as the bathing agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a bath preparation, and more particularly to a bath preparation having an excellent effect in treating or preventing atopic dermatitis.

[0002]

2. Description of the Related Art Since ancient times, it has been known that hot springs containing various components are effective for the treatment of various diseases as a spa treatment or spa treatment. Conventionally, bath preparations containing various components have been proposed for the purpose of enjoying the effects of hot springs even in general households, in view of the therapeutic effect of various diseases such as atopic dermatitis. But,
No bathing agent having a sufficient therapeutic effect on atopic dermatitis has yet been proposed.

[0003] Conventionally, external preparations for treating various diseases such as atopic dermatitis have been proposed. However, in general, compared to external preparations, bath preparations have an advantage that a therapeutic effect may be exerted even when the active ingredient is at a considerably lower concentration than external preparations. On the other hand, bath agents have the advantage of being applied to the whole body evenly, and bath agents may be preferred over external agents due to such advantages.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a bath preparation having a sufficient therapeutic effect on atopic dermatitis in view of the above-mentioned conventional circumstances.

[0005]

The present inventors have conducted intensive studies to achieve the above object of the present invention. As a result, (a) wasabi pulverization obtained by pulverizing whole wasabi including leaves, stems and rhizomes When the product is used as a bath agent, a sufficient therapeutic effect for atopic dermatitis can be obtained. (B) Bathing of the above-mentioned ground wasabi, which has deteriorated in freshness due to progress of decay due to progress of decay, etc. That the desired therapeutic effect of atopic dermatitis cannot be obtained even when used as an agent, (c) when the above-mentioned wasabi pulverized material needs to be stored for a long time after pulverization before use as a bath agent Have found that it is necessary to preserve frozen in order to suppress a decrease in freshness, and have completed the present invention based on these findings. Also, the present inventor:
(A) When only a wasabi rhizome is crushed and used as a bath preparation, itching occurs on the skin, and the therapeutic effect of intended atopic dermatitis is reduced. (B) Wasabi stem,
When only the leaves are crushed and used as a bath agent, it has the effect of smoothing the skin, but the therapeutic effect of the intended atopic dermatitis decreases. (C) crushing the whole wasabi It has also been found that the obtained ground wasabi has not only a therapeutic effect on atopic dermatitis but also a preventive effect thereof. In addition, atopic dermatitis here,
It is a disease in which the body's antibodies cause an abnormal reaction to bacteria and fungi from the outside.
Various atopic dermatitis such as Escherichia coli atopy are included.

That is, the present invention provides a crushed product obtained by crushing whole wasabi including leaves, stems and rhizomes in order to achieve the above-mentioned object of the present invention. The present invention provides a bath preparation characterized by comprising, as an active ingredient, an active ingredient in a period in which no freshness is reduced or in a period in which freshness is not reduced after pulverization.

The inventor of the present invention has conducted intensive studies to achieve the above object of the present invention. As a result, wasabi was added as a raw material by adding wasabi rhizomes, stems and, if necessary, leaves. By immersing and extracting the effective ingredient of wasabi raw material, a tasteless, colorless and transparent liquid can be obtained,
This solution was found to have a sufficient therapeutic effect on atopic dermatitis. Furthermore, the above-mentioned wasabi rhizome, stem,
When immersing the leaves, by slicing (slicing) in advance, while fully extracting the active ingredient,
It was found that spiciness and irritation to the skin can be suppressed.

That is, another bathing agent according to the present invention comprises a solution obtained by immersing wasabi rhizome, stem, and, if necessary, wasabi leaf in water or alcohol and subjecting it to an extraction operation. Features. Further, as a preferred embodiment, the above-mentioned wasabi rhizome, stem and leaf are sliced in advance.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The bath agent according to the present invention is described below.
Each of (1) a product containing a ground wasabi as an active ingredient and (2) a product comprising a solution obtained by extraction from wasabi will be described in detail. First, the bath additive according to the above (1) will be described. As the wasabi used in the bath preparation of the present invention, generally cultivated and commercially available ones can be used as appropriate. In general, wasabi includes so-called wasabi cultivated in swamps, so-called field wasabi cultivated in fields and the like, lily wasabi, shrimp wasabi, wasabi radish and the like. And the like, which can be used as appropriate. At present, the most common green stalk species are cultivated and marketed, and such species can be preferably used.

In the preparation of the bath preparation of the present invention, it is essential to use whole wasabi including leaves, stems and rhizomes in preparing the bath preparation. For the first time, the intended therapeutic effect for atopic dermatitis is obtained. For example, when a crushed product obtained by crushing only the wasabi rhizome is used as a bath agent, or when a crushed product obtained by crushing only wasabi stalk and leaves is used as a bath agent, the intended atopic skin is used in each case. The therapeutic effect of the flame decreases. The above-mentioned whole wasabi can be pulverized by appropriately selecting and using a pulverizer conventionally used for pulverizing plants and the like. Examples of the crusher include a toothed disk crusher, an edge runner, a hammer mill, a cutter mill and the like. Also,
When crushing, if you make it fine like grinding down,
Since the wasabi's cell tissue is broken and strongly irritating mustard oil and the like are undesired to appear, it is preferable to grind it relatively coarsely. Specifically, it is appropriate that the diameter of the pulverized material is about 0.2 to 10 mm.

In the practice of the present invention, it is important that the ground material obtained by crushing the whole wasabi is used as a bath agent after the crushed material has not been reduced in freshness due to the progress of decay. is there. Even if a wasabi crushed material whose freshness has been reduced due to the progress of putrefaction is used as a bath agent, the intended therapeutic effect for atopic dermatitis cannot be obtained.
If it is necessary to store the pulverized material for a long time before use as a bath agent after pulverization, for example, it takes a long time to transport and distribute the ground wasabi from its preparation place to the place where it is actually used as a bath agent. When time is required, or when a large amount of wasabi pulverized material is prepared in a lump and it is divided into several times and gradually used as a bath agent in a fixed amount, and it takes a long time to use up It is important to keep the frozen wasabi in a frozen state in order to prevent the freshness of the wasabi from being reduced. The period during which the wasabi pulverized material is so fresh that the intended therapeutic effect of atopic dermatitis cannot be obtained cannot be completely determined by environmental conditions such as ambient temperature, etc. The desired therapeutic effect for atopic dermatitis can be obtained if it is used as a bathing agent at room temperature within two days, or if it is stored frozen within two days after crushing. Freezing of the wasabi pulverized product can be appropriately performed by using a conventionally known freezing means. In addition, when frozen and stored, the storage period is generally preferably up to about 6 months from the viewpoint of a reduction in the therapeutic effect of atopic dermatitis over time.
In addition, in using the above-mentioned wasabi pulverized product as a bath agent, the amount of use is generally preferably about 20 to 50 g in a normal bathtub (about 200 liters), and the hot water temperature is 39 to 4 g.
About 2 ° C. is preferable. The bath preparation according to the present invention cleanses the body by its bactericidal activity and improves blood circulation, and thus has the property of restoring the original protection of the living body against external germs. Therefore, it is effective not only for the above-mentioned atopic dermatitis, but also for other skin diseases such as rough skin (bulky skin), acne, wiping, and coldness. Furthermore, in terms of beauty, since vitamin C contained in wasabi has a reducing action, it suppresses the production of melanin pigment, which darkens the skin, keeps the skin white and smooth, and has the effect of making it difficult to remove spots and freckles. .

[0012] In the bath preparation of the present invention, together with a pulverized material obtained by pulverizing the whole wasabi of the active ingredient, if necessary,
As an optional ingredient, a general-purpose drug conventionally conventionally added to bath salts can be added as long as the desired therapeutic effect for atopic dermatitis is not impaired. Examples of general-purpose drugs of this optional component include sodium chloride, potassium chloride, ammonium chloride, sodium sulfide, potassium sulfide, sodium nitrate, potassium nitrate, calcium nitrate,
Inorganic salts such as sodium carbonate and sodium phosphate; organic acids such as citric acid, tartaric acid, malonic acid and adipic acid; polyhydric alcohols such as glycerin, 1,3-butanediol and polyethylene glycol; jojoba oil, olive oil, squalane, etc. Oily components, surfactants such as polyoxyethylene alkyl ethers and polyoxyethylene fatty acid esters, herbal extracts such as rosemary, thyme, eucalyptus, linden tree, ginkgo, fragrances, coloring agents and the like. Also,
The bathing agent of the present invention can be used in combination with a conventional bathing agent, if necessary, as long as the desired therapeutic effect for atopic dermatitis is not impaired.

Next, the bath additive according to the above (2) will be described. This bath preparation is mainly composed of a solution obtained by using a wasabi rhizome, a stem, and, if necessary, a wasabi leaf as a raw material, immersing them in water or alcohol, and performing an extraction operation. The type of wasabi is not particularly limited as in the case of the above (1), and is a so-called wasabi cultivated in a swamp, a so-called field wasabi, a lily wasabi, an era wasabi, a wasabi radish, etc. cultivated in a field or the like. Various kinds of wasabi, such as a green stem type, a red stem type, and a white stem type, can be appropriately selected and used. In addition, it is preferable to use a stem of the wasabi up to 15 cm from the tip of the rhizome.

It is preferable that the rhizome, stem, and leaves of the wasabi are sliced in advance before being immersed in water or alcohol. By slicing, the active ingredient in wasabi can be easily extracted, and since it is less likely to be exposed than when irritating components such as mustard oil are grated, a solution with less wasabi odor and gentle on the skin can be obtained. . If the sliced thickness is too thin, the wasabi cell tissue will be destroyed and the stimulating component will appear, which is inappropriate.If it is too thick, it will take a long time to extract the active ingredient.
It is set appropriately in consideration of these. Specifically, 2-1
The thickness is preferably about 0 mm, but is not limited thereto. Also, the slicing method can be appropriately implemented using various conventionally known slicers.

The raw material to which the above-mentioned wasabi rhizome / stalk and, if necessary, the wasabi leaf are added is immersed in water or alcohol. As the water or alcohol, a conventionally known water or alcohol is appropriately selected. Can be used. Specific examples of alcohol include ethanol and the like. Further, a mixture of water and alcohol may be used, and furthermore, commercially available sake and Western liquors can be applied. Further, the amount of the raw material to be immersed can be appropriately set from the viewpoint of extraction efficiency and the like. For example, when a mixture of water and alcohol is used, 1 to 20 liters of the mixture is used.
Suitably, the amount is about 5 kg.

The temperature at the time of extraction depends on the type of extraction solvent,
Although it depends on the shape of the wasabi to be immersed therein, extraction at a high temperature generally breaks the active ingredient of the wasabi and reduces the desired effect. Therefore, it is preferable to perform the extraction at a relatively low temperature. Specifically, a temperature range of −5 to 100 ° C. is appropriate, and a temperature of about 4 ° C. is particularly preferable. Also,
The period for performing the extraction naturally depends on the above-mentioned extraction temperature and the like, but it is appropriate to set it to several days to about one month.

The bathing agent obtained by the above method can be used by dissolving an appropriate amount in hot water of a bathtub at the time of use. The amount dissolved in hot water varies depending on the concentration of wasabi components in the bath salt, but a general bathtub (about 200 liters)
About 20 to 100 cc. The temperature of the hot water is preferably about 39 to 42 ° C.
In addition, the bath agent according to (2) of the present invention cleanses the body by its sterilizing power, like the bath agent according to (1) above,
In addition, since it improves blood circulation, it has the property of restoring the original defense of the living body to external germs. Therefore, it is effective not only for the above-mentioned atopic dermatitis, but also for other skin diseases such as rough skin (bulky skin), acne, wiping, and coldness. Further, it has a great effect in terms of beauty as well as the above (1).

The bath preparation according to (2) of the present invention may be used in combination with other bath preparations and drugs as long as the therapeutic effect for atopic dermatitis is not impaired, as in the case of (1). Can be.

[0019]

The present invention will be described more specifically with reference to the following examples and comparative examples, but the present invention is not limited to the following examples.

(Example 1) The whole of the green stem wasabi, including the leaves, stems and rhizomes, was pulverized with a hammer mill, and the obtained wasabi pulverized product was immediately pulverized (within 1 hour after the pulverization). It frozen and the frozen wasabi pulverized thing was produced. Into about 200 liters of hot water in a bath at a temperature of 40 ° C. containing 50 g of the obtained ground wasabi crushed product, a patient 30 with atopic dermatitis
A bathing test was conducted in which each subject was taken as a subject and each subject was bathed. In this bathing test, bathing was performed once a day for 15 minutes and performed continuously for one week.

From the second day after the start of the bathing test, subjects 3
Twenty-three (77%) of the 0 subjects recognized that the pruritus was reduced or remarkably reduced, and it was recognized that the skin symptoms gradually improved as the number of baths increased. The results of the bathing test at the stage when the bathing was completed on the last day of the bathing test were as follows: (A) "Slightly effective" when reduction of pruritus and reduction of skin symptoms were slightly recognized, (B) Reduction of pruritus, skin symptoms "Effective" when reduction of pruritus is sufficiently recognized, and "Critical" when (C) reduction of pruritus and skin symptoms are remarkably observed or when pruritus and skin symptoms disappear. Of the 30 subjects, 14 (47%) were determined to be significantly effective, 13 (43%) effective, and 3 (10%) slightly effective.

(Comparative Example 1) As wasabi pulverized products, only wasabi leaves and stems were pulverized, and a bathing test similar to that of Example 1 was performed using a frozen material of the obtained pulverized products. . As a result, at the stage where the bathing was completed on the last day of the bathing test, all 30 subjects were found to have reduced pruritus and reduced skin symptoms, but did not reach the effects of Example 1.

(Comparative Example 2) In Example 1, a wasabi pulverized product was prepared by pulverizing only a wasabi rhizome, and a bathing test similar to that of Example 1 was performed using a frozen product of the obtained pulverized product. When she tried to bathe, 21 (70%) of the 30 subjects had an increased pruritus in the bath on the first day of the test, and all 30 subjects had a pruritus after the bath on the second day after the start of the bathing test. There was no increase in skin symptoms, and no reduction in skin symptoms was observed. Rather, the skin symptoms appeared to have worsened in 20 (67%) subjects, and the bathing test after the third day was stopped. In addition, the amount of the crushed wasabi rhizome alone was reduced by 15% from the above.
When the same bathing test as described above was carried out, all subjects were found to have reduced pruritus and reduced skin symptoms at the stage where bathing was completed on the last day of the bathing test, but did not reach the effects of Example 1. Was.

Comparative Example 3 The procedure of Example 1 was repeated, except that the ground wasabi was left at room temperature for 5 days and then frozen. As a result, at the stage where the bathing was completed on the last day of the bathing test, all of the 30 subjects did not have any reduction in pruritus and no reduction in skin symptoms.

(Example 2) The rhizome, stem (part from the rhizome to 15 cm) and leaves of a green-sown species of wasabi were 3 mm thick.
2 kg was immersed in 20 liters of a mixture of water and ethanol, placed in a refrigerator at 4 ° C. for 6 days, and extracted to obtain a colorless, transparent and odorless solution. 100 cc of this solution is added to about 2
A bath test was carried out using 30 patients with atopic dermatitis as test subjects in the same manner as in Example 1 above. As a result, all the test subjects were found to have reduced pruritus and reduced skin symptoms.

[0026]

As described above, the bath preparation of the present invention has a sufficient therapeutic effect on atopic dermatitis and also has a preventive effect, and is effective for the treatment and prevention of atopic dermatitis.

Claims (7)

[Claims] 1. A crushed product obtained by crushing whole wasabi including leaves, stems and rhizomes, within a period in which freshness does not decrease after crushing, or does not decrease in freshness after crushing. A bath preparation characterized by containing, as an active ingredient, a substance which has been kept frozen for a period to suppress a decrease in freshness. 2. The crushed wasabi as an active ingredient, wherein the lapsed time after crushing is within 2 days or the lapsed time after crushing is stored frozen within 2 days. Bath salts. 3. A bath preparation comprising a solution prepared by immersing wasabi rhizomes and stems in water or alcohol and performing an extraction operation. 4. The bath preparation according to claim 3, wherein the rhizome and stem of wasabi are sliced in advance. 5. The bath preparation according to claim 3, wherein wasabi leaves are used in addition to wasabi rhizomes and stems. 6. The bath preparation according to claim 5, wherein the rhizomes, stems and leaves of wasabi are sliced beforehand. 7. The bath preparation according to claim 3, wherein the extraction temperature is -5 to 100 ° C.