JP2001286550A5 - - Google Patents

Claims (9)

A blood component collection device for separating blood into a plurality of blood components by a centrifuge having a blood storage space therein, and collecting a specific blood component in a bag,
The blood component collection device includes a first line for connecting a blood collection means and an inlet of the centrifuge, a second line connected to an outlet of the centrifuge, and the first A blood component collection circuit comprising a plasma collection bag having a first tube connected in the middle of the line and a second tube connected to the second line, and a platelet collection bag connected to the second line; ,
Using the turbidity sensor attached to the outlet of the centrifuge or the second line, and the signal detected by the turbidity sensor and the signal change pattern calculated from the signal when collecting platelets, Platelet collection process pattern judgment function that determines whether the platelet collection process is a memorized normal pattern or a plurality of exception patterns, and platelets at a time suitable for the pattern determined by the platelet collection process pattern judgment function A blood component collection device comprising a platelet collection step end adjustment function for ending a collection step.   The platelet collection process pattern judgment function uses a signal detected by the turbidity sensor, a signal change pattern calculated from the signal, and a circulation speed at the time of platelet collection during the platelet collection step. The blood component collection device according to claim 1, wherein it is determined whether the stored pattern is a normal pattern or a plurality of exceptional patterns.   The blood component collection device converts the platelet collection condition in the next platelet collection step into the determined exception pattern when the platelet collection process pattern determination function determines that it is one of a plurality of exception patterns. The blood component collection device according to claim 1 or 2, further comprising a platelet collection condition adjustment function for adjusting platelet collection conditions to suitable conditions.   The platelet collection condition adjusting function adjusts the platelet collection condition so that the change pattern of the signal detected by the turbidity sensor at the platelet collection step approaches the stored normal pattern. The blood component collection device described. The blood component collection device is disposed on the centrifuge side from a centrifuge driving device for rotating a rotor of the centrifuge, a connecting portion between the first line and the first tube, and A first liquid feed pump for one line, a second liquid feed pump for the third line, and a plurality of flow path opening / closing means for opening and closing the flow path of the blood component collection circuit When,
A control unit for controlling the centrifuge drive device, the first liquid feeding pump, the second liquid feeding pump, and the plurality of flow path opening and closing means;
The control unit collects blood to which an anticoagulant has been added, separation of the collected blood, and a plasma collection step of collecting the separated plasma into the plasma collection bag, and the plasma collected by the plasma collection step At least one plasma collection / circulation step comprising circulating the plasma in the plasma collection bag to the centrifuge, and after completion of the plasma collection / circulation step, plasma by the first liquid feeding pump A platelet collection step is performed to accelerate the circulation speed and allow platelets to flow out of the centrifuge and collect platelets in the platelet collection bag. After the platelet collection step is completed, blood in the centrifuge is returned. The centrifuge driving device, the first liquid feeding pump, the second liquid feeding pump, and the like so that a platelet collecting operation for performing a blood return step is performed. 5. The apparatus according to claim 1, which controls the plurality of flow path opening / closing means, and has the platelet collection process pattern judgment function and the platelet collection end adjustment function. Blood component collection device.   The platelet collecting device collects blood to which an anticoagulant has been added, separation of the collected blood, and a plasma collecting step of collecting the separated plasma into the plasma collection bag, and the plasma collecting step. At least one plasma collection / circulation step comprising circulating the plasma in the plasma collection bag to the centrifuge, and after completion of the plasma collection / circulation step, by the first liquid feeding pump Accelerate the plasma circulation rate, let the platelets flow out from the centrifuge, and collect the platelets in the platelet collection bag. After the completion of the platelet collection step, the blood in the centrifuge 6. The function according to claim 1, further comprising a function of controlling the platelet collection operation for performing the blood return step to return blood at least twice. Platelet collection apparatus according to.   The platelet collection process pattern judgment function uses a signal detected by the turbidity sensor, a signal change pattern calculated from the signal, and a circulation speed at the time of platelet collection in the platelet collection step. Is a memorized normal pattern or a plurality of exception patterns, further, the plasma collection device, when it is determined that the initial platelet collection process is a normal pattern, An initial platelet collection process data storage unit for storing data related to the initial platelet collection process, and a data comparison function for comparing data in the platelet collection process in the subsequent platelet collection step with the initial platelet collection process data, The adjustment function at the end of the platelet collection step uses the data comparison function to Blood component collection apparatus according to claim 6 has a function to terminate the platelet collection step if the predetermined level or more differences between the sampling process data comparison target platelet collection process data is detected. A blood component collection device for separating blood into a plurality of blood components by a centrifuge having a blood storage space therein, and collecting a specific blood component in a bag,
The blood component collection device includes a first line for connecting a blood collection means and an inlet of the centrifuge, a second line connected to an outlet of the centrifuge, and the first A blood component collection circuit comprising a plasma collection bag having a first tube connected in the middle of the line and a second tube connected to the second line, and a platelet collection bag connected to the second line; ,
A turbidity sensor attached to the outlet or the second line of the centrifuge, a centrifuge drive device for rotating the centrifuge rotor, and a control unit;
The control unit collects blood to which an anticoagulant has been added, separation of the collected blood, and a plasma collection step of collecting the separated plasma into the plasma collection bag, and the plasma collected by the plasma collection step At least one plasma collection / circulation step comprising circulating the plasma in the plasma collection bag to the centrifuge, and after completion of the plasma collection / circulation step, plasma by the first liquid feeding pump A platelet collection step is performed to accelerate the circulation speed and allow platelets to flow out of the centrifuge and collect platelets in the platelet collection bag. After the platelet collection step is completed, blood in the centrifuge is returned. Controlling the platelet collection operation to perform the blood return step to be performed at least twice,
The control unit measures and stores the peak time from the start of the platelet collection step to the detection of the lower limit peak by the turbidity sensor and the storage function of the lower limit peak voltage during the first platelet collection operation, and the second and subsequent times. A comparison function for comparing whether or not the difference between the turbidity sensor voltage and the lower limit peak voltage when the peak time is reached from the start of the platelet collection step during the platelet collection operation is greater than a predetermined value; When it is determined that the difference between the turbidity sensor voltage and the lower limit peak voltage when the peak time is reached from the start of the platelet collection step in the platelet collection operation after the first time, the turbidity for a predetermined second The voltage change rate calculation function for calculating the sensor voltage change rate and the voltage change rate calculation function Blood component collection apparatus characterized by pressure change rate and a platelet collection step terminates upon adjustment function to terminate the platelet collection step is smaller than a predetermined value.   The adjustment function at the end of the platelet collection step of the control unit is performed again when the voltage change rate in the predetermined seconds calculated by the voltage change rate calculation function is larger than the predetermined value. 9. The blood component collection device according to claim 8, wherein the voltage collection rate of 2 is calculated, and the platelet collection step is terminated when the calculated second voltage change rate is smaller than a predetermined value.