JP2001139487A - Medicinal composition of nasal spray or nasal liquid medicine for pyrogenic common cold and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide safe nasal spray or nasal liquid medicine for pyrogenic common cold having high treating effect. SOLUTION: The present invention relates to a medicinal composition of nasal spray or nasal liquid medicine for pyrogenic common cold and method for producing the medicinal composition. The medicinal composition comprises Bupleurum chinese DC., Radix Isatidis Indigotica, Folium Isatidis and vitamin C. The medicine is produced by a method distilling and filtering the ingredients of the medicinal composition. The medicine is absorbed from nasal cavity into a patient body by directly spraying and dropping the medicine into the nasal cavity to provide alleviation effect of defervescence, analgesic and cold symptoms (e.g. headache, nasal congestion, cough, sore throat, sneeze, snivel and unpleasant cold symptoms of whole body). The medicine in the present invention is suitable for treatment of fever caused by various infectious diseases, particularly upper respiratory tract inflammation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pharmaceutical composition of a fever sensation or nasal drop and a method for producing the same, and the pharmaceutical composition comprises Bupleurum chinose D
C. ), Radix Isatidis In
digotica), large green leaves (FoliumIsati)
dis), after boiled and boiled, take out the contained components, filter, add vitamin C to this drug solution to produce a drug, and provide the manufactured drug directly to the patient by spraying or dripping into the nasal cavity. The present invention relates to a pharmaceutical composition of a fever cold nasal or nasal drop and a method for producing the same.

[0002]

2. Description of the Related Art The common cold considers the common cold as a very mild disease, but in fact, the common cold is a very infectious viral infectious disease. Common symptoms that can be distinguished from the common cold include malaise, fever, lacrimation, nasal congestion, headache, throat irritation or pain. The cold virus is small enough to easily pass through the nasal passages, which can only capture relatively large volumes of bacteria, and enter the human body. And the virus multiplies quickly, invades the nose and throat, causes the aforementioned cold symptoms, and if improperly processed, can cause complications such as pneumonia and bronchitis, and can even lead to death . For this reason, it can be said that the common cold is a normal disease that cannot be neglected. In western medicine, colds are treated with drugs such as antibiotics, steroids, and antihistamines to relieve the symptoms of the cold, and to give the patient plenty of water and rest.
In general, western medicine has a rapid response, but the anti-drug properties of antibiotics, the toxicity of steroids that can cause injury to humans, and the injuries of chemicals to human organs are all poorly known to people. Side effects. In addition, the above-mentioned chemical drugs were not ideal in alleviating and preventing fever and cold. In addition, the above-mentioned common cold drugs are generally in the form of capsules, tablets, suppositories, oral liquids, sprays or drops into the nasal cavity. In the treatment and prevention of cold, in Chinese medicine, the main composition is a drug that relieves the symptoms of cold, the so-called “tablet” drug, the main function of which is to promote sweating and has the effect of releasing colds I have. The function of the drug is roughly divided into three. One is sweating, which removes the symptoms of colds that appear on the surface due to sweating and prevents the disease from entering the body. The second is called "open skin", and when a cold has already penetrated deeper into the body surface and the symptoms cannot be released even if sweating, the communication between the body surface and the inner part is considered good, and A portion of the cold is pushed to the body surface and removed. The third is called "wheal", which guides a cold that has penetrated further into the body to the surface of the body, forming mottles and rashes, thereby causing the cold to escape. Cold symptoms are classified into cold and fever in Chinese medicine, and human body is classified into illness and actual illness. Therefore, there are three types of disintegrating drugs: one for removing chills caused by a cold, one for removing heat due to a cold, and one for improving symptoms caused by a cold in response to a weak constitution. Usually, the form of the drug is mainly a powder or hot water (liquid). Although the herbal medicine is excellent in that it is safe to use and has few side effects, it also has the drawback that it takes a long time for the effect of the medicine to appear and is relatively inconvenient in use. As for the antipyretic effect, there are physical cooling methods such as icing, alcohol rubbing, ice water enema, etc., in addition to antipyretic treatment with chemical drugs and Chinese medicine.
These methods have certain clinical effects. However, in a number of clinical cases, the body temperature tended to increase after using the above method. In particular, the physical cooling method using an ice pad or an alcohol rubbing bath is not suitable when the sick person has high fever and feels chills. For this reason,
Can quickly relieve fever, relieve cold symptoms, have no side effects,
The development of an antipyretic cold preparation that can be used by men and women of all ages is a very significant invention.

[0003]

SUMMARY OF THE INVENTION The main object of the present invention is to provide an antipyretic herbal medicine which can provide a high antipyretic effect by mixing a Chinese medicine and a Western common cold medicine. As a component, it is used as a nasal propellant to quickly relieve fever and relieve cold symptoms. The drug according to the present invention utilizes the characteristics of human body physiology and organs and is administered to the nasal mucosa to prevent the drug from being destroyed by the gastrointestinal pH value or enzymes and to be absorbed directly from the nasal mucosa. In addition, the liver is not damaged by excessive action due to oral administration of the drug, and the toxicity and side effects of the drug on the liver can be reduced. In addition, the dosage form is particularly convenient for patients or children who cannot be swallowed or who have difficulty in swallowing because they are in the form of sprays or drops.

[0004]

The invention of claim 1 is a pharmaceutical composition of a fever sensation nasal or instilled nasal solution which is sprayed or instilled into a nasal mucosa of a patient and absorbed.
g of Purple hu (Bupleurum chinese D)
C. ), 120-144 g of Radix Is
atidis Indigotica), 120-14
4 g of large green leaves (Folium Isatidis), 1
It is a pharmaceutical composition of a fever sensation nasal or nasal drop, characterized by being composed of 0 to 12 g of vitamin C. The invention of claim 2 is a method for producing a fever sensation or nasal drop, which comprises the following steps a to f, namely: a. 250 to 300 g of purple husk is immersed in 1 volume of water for 2 hours, and 4 volumes of water are further added and boiled in water, and 2 to 2.4 ml of volatile oil is extracted by a distillation method. Filter further and liquid 1
Obtaining from 000 ml to 1200 ml, and further temporarily storing the volatile oil, the filtered chemical solution and the drug residue in containers, respectively; b. 120-144 g of indigo root and 120-144 g of large green leaves were each added with 7 times the amount of water, decocted for 1 hour, and filtered, and the filtrate was temporarily stored in a container; c. After mixing the residue of the medicine remaining after the extraction or filtration in the above steps a and b, add 5 times the amount of water after mixing the residue of the medicine, and incubate for 1 hour, then add 4 times the amount of water. Incubating for 40 minutes in addition and combining the filtrate obtained by further filtration, d. Combine the three filtrates obtained above and 1m
concentrating until 1 liter of the drug solution corresponds to 1 g of crude drug, further allowing to cool, and adding 95% ethanol to make the alcohol content 70%, e. 2 to 2.4 ml of volatile oil and 10 to 12
g. Dissolving vitamin C in a drug solution after dissolving, mixing and filtering, and dispensing the solution. The method comprises the steps of:

[0005]

FIG. 1 is a manufacturing flowchart of the present invention. The pharmaceutical composition of which is 25
0 to 300 g of purple hugo (Bupleurum chine)
se DC. ), 120-144 g of radish (Radi)
x Isatidis Indigotica), 12
0-144 g of large green leaves (Folium Isatidi)
s) and 10-12 g of vitamin C.
The chemical components, pharmacological aspects, functions, and main therapeutic effects of each of the above-mentioned pharmaceutical compositions are described below.

[0006] 1. Purple hu (Bupleurum chin)
es DC. ) Chemical composition: Purple root contains 0.15% volatile oil. This volatile oil is composed of valeric acid (pentanoic acid), hexanoic acid (hexanoic acid), enanthic acid (heptanoic acid), 2-enanthic acid (2-heptanoic acid), caprylic acid (o
ctanoic acid), 2-caprylic acid (2-o
ctanic acid), nonylic acid (nonanoic acid)
ic acid), 2-nonyl acid (2-nonanoi)
acid), phenol (phenol), o-methoxyphenol (o-methyoxypheno)
l), γ-heptalactone (γ-heptalacto)
ne), γ-octalactone (γ-octalacto)
ne), γ-decalacton
e), fuji oil (eugenol), γ-undecalactone, cresol, ethylphenol (ethylp)
henol), thymol (thymol), mesosia lactone, vanillin acetate, 2
-Methylcyclopentanone (2-methylcyc
lopenenone), limonen
e), myrcene, carvaclone (c)
arvacrone, carveol
1), pulegone, myrtenol, α-terpineol (α-te)
rpineol), linalool
1), geraniol, n-tridecane, (E) -geranylacetone ((E) -geranylacetone),
α-Cubebene, δ-cadinene, humulen
e), caryophyllen
e), longifolene, longkatone, hexadecanoic acid, hexahydrofarnesylacetone (hexahydrofarn)
esyl acetone, saikosaponin (sai)
kosaponin) a, c, d, s ₁ , adonitol, a-spinasterol (α-s)
pinasterol), including polysaccharides. The foliage of purple sesame contains flavones. That is, kaernpferol, kaernpferol-
7-rhamnoside (kaernpferol-7-rh)
amnoside), caerumpferol-3-O-
α-L-arabinopyranoside-7-O-α-L-rhamnopyranoside (KAERNPFEROL-3-O-α
-L-arabinopyranoside-7-O-
α-L-rhamnopyranoside). Pharmacological: Has an analgesic effect. That is, saikosaponin had a clear analgesic effect in both the lightning experiment of the mouse tail and the subcutaneous injection of acetic acid. According to a lightning experiment on the tail of mice, 478 mg / kg of saikosaponin (1/4 LD50) had a remarkably high pain-blocking effect. When saikosaponin a and syrup-like residue were injected intraperitoneally at 50 mg or 100 mg per kg of body weight, the torsional reaction caused by injecting acetic acid into the abdominal cavity of each mouse could be suppressed. The syrupy residue had a clear analgesic effect on the pain caused by the compression. Also, it has been already recognized that saikosaponin relaxes muscle tone and exerts an analgesic effect. Has a cough sedative effect. That is, saikosaponin a
Have a relatively strong cough sedative effect and have been demonstrated by a method of generating cough by mechanical stimulation. ED50 of sedative saikosaponin cough in guinea pig 9.1 mg / kg
And its effect is close to codeine phosphate 7.6 mg / kg. There is a relationship between the cough sedation effect of saikosaponin a and the dosage, and the cough sedation effect of 100-200 mg / kg guinea pig intraperitoneal injection was most apparent. Function and treatment: Shihu relieves fever by digestion, works on the tired liver, smoothes the function of the liver, and brings the body to life.
It also eliminates fever and cold caused by the common cold, eliminates discomfort in the chest, and has a therapeutic effect on sensation of bitterness, thirst, headache, dizziness, menstrual imperfection, collapse symptoms and anal prolapse, ptosis, ptosis.

[0007] 2. Radix Isatidi
s Indigotica The root of the indigo root is indigotin,
indigo), indirubin (indirubi)
n), β-sitosterol (β-sitostero)
l), various amino acids, sinigli-n (sinigri-n)
-N), indoxyl-β-glucoside (indox)
yl-β-glucoside, tryptanthrine, 1-thiocyano-2
-Hydroxy-3-butene (thiocyano-2-
hydroxy-3-butene), epigoitrin, adenosine (adenos)
ine), palmitic acid (palmic acid)
d), sucrose, and a 12% amino acid protein polysaccharide. Pharmacology: Has antibacterial and viral effects. In the in vitro test, the 100% blanched root boiled liquid had an inhibitory effect on golden staphylococci and epidermidis staphylococci. Infected single cell V using 50% tissue cell infectious dose (TCID50)
According to the anti-virus experiment for indigo root injection against ero-E6, 1: 100 indigo root had virus killing effect.
The indigo root extract has an effect of suppressing virus infection and suppressing growth. As a regulatory effect on immunity,
Itai root polysaccharide 25mg / kg, 50mg / kg, 100
Intraperitoneal injection of mg / kg enhances the late onset metamorphosis of DNCB (dinitrochlorobenzene) in mice, induces the conversion of in vivo lymphocytes and enhances spleen cells.
The activity of K) was clearly enhanced. Intraperitoneal injection of 50 mg / kg lantern polysaccharide significantly promotes the immune function of mice,
It increased normal mouse spleen weight, increased total number of white cells and lymphocytes, and enhanced antibody-forming cell function. Function and therapeutic effect: Antipyretic, detoxifying, removing heat of blood and smoothing throat. It cools the heat and detoxifies it, cools the heat of the blood and removes the spots. It has a therapeutic effect on fever due to high fever, headache, thirst, epidemic parotitis, purulent infection of the body surface, conjunctivitis, bloody bleeding, coma, craniofacial infection, etc.

[0008] 3. Ooba (Folium Isid)
is) Chemical component: indigotin in its leaves
n, indigo), Isatan B (isatan)
B), including indirubin. In addition, iron, titanium, cobalt, zinc, copper and nickel,
Contains inorganic elements such as selenium, chromium, and arsenic. Isatan B
Is dissolved in water and indigo and D-xylo-5-hexulofanosonic acidide (D-xyloj-5-hexulof)
uranosonic acid). Pharmacological: has antipathogenic microbial activity. According to in vitro tests of green leaf decoction, it has a certain inhibitory effect on all of Staphylococcus aureus, Streptococcus cerevisiae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Bacillus bacillus, Colonic bacillus, Epidemic bacillus, White throat bacillus and Diarrhea bacillus Had. Great green leaves also had an inhibitory effect on type B encephalitis virus, epidemic parotitis virus, flu virus and the like. In addition, large green leaves also have a leptospiral bactericidal action. Function and therapeutic effect: It has antipyretic, detoxifying, pathogenic heat removal, and rash treatment. Ooba blue has a therapeutic effect on headache, thirst, high fever, unconsciousness due to a cold, mottle due to invasion of blood due to heat, sore throat, jaundice, dysentery, carbunkel, and fregmone.

4. Vitamin C Chemical composition: The main ingredient is glucose. Pharmacological direction: has an inhibitory effect on filterable viruses. Function and treatment: Prevents flu, enhances resistance and relieves flu symptoms such as fever, cold, fatigue, severe cough, sputum, nasal congestion, headache, joint pain, etc. Influenza infection causes pneumonia, bronchitis, tonsillitis and the like. Influenza is caused by a filterable virus.

The manufacturing process of the present invention includes the following steps. In the first step, 250-300 g of purple husk is immersed in 1 volume of water for 2 hours, and 4 volumes of water is further added and boiled in water, and 2-2.4 ml of volatile oil is extracted by steam distillation. . After further filtration, the drug solution is 1000ml-1200m
1 is obtained. Further, the volatile oil, the filtered chemical solution, and the drug residue are each temporarily stored in a container. In the second step, 120
To 144 g of indigo root and 120 to 144 g of large green leaves, 7 times the amount of water is added, decocted for 1 hour, filtered, and the filtrate is temporarily stored in a container. In the third step, after mixing the residue of the medicine left after extraction or filtration in the first step and the second step, add the remaining amount of the medicine, add 5 times the amount of water after mixing, incubate for 1 hour, and then quadruple Add the amount of water and add 4
Decant for 0 minutes and combine the filtrates obtained by filtration. In a fourth step, the three filtrates obtained above are combined and concentrated until 1 ml of drug solution corresponds to 1 g of crude drug. It is then left to cool and 95% ethanol is added to bring the alcohol content to 70%. In the fifth step, the drug solution after the addition of ethanol is gently placed for 24 hours, filtered, and the ethanol is collected so that 1 ml contains 1 g of crude drug. In the sixth step, another 2 ml to 2.4 ml of volatile oil and 10 to 1
After dissolving 2 g of vitamin C, the solution is added, mixed, filtered, and then dispensed.

The nasal or nasal drops prepared as described above have the following experimental results and methods for their antipyretic and toxicological studies. one. Antipyretic effect: Experimental materials: Nasal or nasal drops containing 2 g of crude drug. The clinical dosage is 2 drops (approximately 0.1 ml) for each 10 kg of the infant's body weight, which is completed within 10 minutes, and repeated 10 times. The cumulative dose is about 0.2 g of crude drug per kg of body weight, and the nasal or nasal solution is diluted to the required drug concentration before the experiment. 2. Analgin injection solution, produced by Wuhan Pharmaceutical Company, batch number 9511.04, standard 0.5g
/ 2 ml, 20% solution for clinical infants is dropped and nosed, and 1-2 drops are dropped from each nostril side each time. The maximum dosage for each is about 4
0 mg and the average weight of the infant is calculated as 10 kg, and the dosage per kg of the weight is set at about 4 mg. The analdine injection solution is diluted to the required drug concentration before the experiment. 3. TYLINOL CHI
LDREN'S P.L. S. LIQUID, manufactured by Johnson, USA, batch number SGM199, each bottle 15m
l) A drug containing 80 mg of acetaminophen per 0.8 ml is clinically dosed according to age or body weight, and is dosed at about 0.12 ml at a time per kg of body weight, ie, 12 ml of acetaminophen. give. 4. Physiological saline (produced by Pingdingshan City Pharmaceutical Company, Henan Province, batch number 9512301). 5. 10% fresh beer yeast suspension (The mingling fermenti
(quid for fresh beer). The fresh brewer's yeast suspension was filtered, the residue was repeatedly washed with saline, centrifuged, and the supernatant was removed.
% Carboxymethylcellulose to give a concentration of 10%. 6. Wistar weighing 170-210 g (Wista
r) Rats (Courtesy of Experimental Animal Center, Henan Medical University) Methods and results: Wistar rats that proceed under conditions of room temperature of 20 to 25 ° C. and weigh 170 to 210 g of males were subjected to three anal basal body temperatures before the experiment. Measurement, body temperature wave <= 0.
10% brewer's yeast suspension 10ml / k in rats at 3 ° C
g, and 4 hours after the injection, the body temperature was measured again.
The experiment is carried out on 50 rats whose temperature has risen by at least 0 ° C., and whose body temperature rise is close. The rats are divided equally into five groups: a high dose nasal or drip nasal group, a low dose nasal nasal group, an analgin administration group, a tylinol antipyretic oral administration drop administration group, and a blank control group. . As shown in FIG. 2, the effects of the nasal spray or nasal drops on the body temperature of rats exothermic with brewer's yeast (° C., X ± SD) were examined for each group of 10 rats. Dosing nasal to each of the experimental groups,
Dropping was completed within 10 minutes at 0.14 ml / kg each time.
A single dose was administered every 0 minutes, and 10 consecutive doses were made so that the total dose was 1.4 ml / kg of body weight. Two groups of nasal or nasal drops were given two sets of nasal or nasal drops after dilution, respectively, and the total dosage was 2.4 g / kg crude drug in the high dose group, low Herbal composition was 1.2 g / kg. Analgin was diluted and administered to the analdine administration group, the cumulative volume of analdine was set to 0.08 g / kg, and the tylinol antipyretic oral dose was administered to the group administered the tylinol antipyretic oral solution at a total dosage of 0.14 g / kg. Was administered. A blank control group received the same volume of saline. Body temperature was measured after 0.5, 1, 2, and 4 hours. The experimental results are as shown in FIG. Experimental results show that nasal or nasal drops, Tylinol antipyretic oral drops, and analdine nasal drops had different degrees of antipyretic activity, and were significantly or less pronounced when compared to the blank reference group. The analgesic effect of analdine was relatively weak among the three test drugs, and only 2 hours after administration, a significant antipyretic effect (P <0.02) was observed.
5) appeared. The nasal fluid high dose group and the Tylinol antipyretic oral solution have a relatively strong antipyretic effect, and are very remarkable at 0.5, 1, 2, and 4 hours after administration as compared to the blank reference group. In view of the whole antipyretic process, Tylinol antipyretic oral liquid had a relatively good immediate effect, and the nasal or nasal solution had a relatively long duration of action.

[0012] 2. Toxicological research on nasal or nasal solutions: Experimental materials: A nasal or dripping nasal solution, a nasal or dripping nasal solution containing 2 g or 4 g of crude drug per ml is prepared. Every ml in the clinic
A nasal or nasal solution containing 2 g of crude drug to a child, weighing 1
Two drops per 0 kg (ie, about 0.1 ml) are completed in less than 10 minutes. Dosing once every 10 minutes, weight 1
Continuous dosing to give a dosage of about 0.2 g per kg. 2. Wistar rats provided by the Laboratory Animal Center of Henan Medical University, weighing 180-220 g, are used for both male and female. Methods and results: Acute toxicity test: Healthy rats (body weight 180-220)
g), randomly divided into three groups, nasal or nasal drops high dose group, low dose group,
Divide into blank control groups. There are 10 males and 10 males in each group. Under the condition of room temperature of 20 to 25 ° C., the nasal or nasal solution high-dose group was administered with the nasal or nasal solution containing 4 g of crude drug per ml, and 1 m to the low-dosage group.
administering a nasal or nasal solution containing 2 g of crude drug per liter;
The blank control group receives saline. 0.1 each time
The administration is completed within 10 minutes, and the administration is performed once every 10 minutes and 10 times continuously. Then, after 8 hours,
Thereafter, the above-described administration process is repeated, and the total daily dose is accumulated.
g / kg, the low dosage group should be equivalent to 4 g / kg. After dosing, the animals are kept at room temperature and continuously observed for 7 days. There were no abnormalities in drinking water, diet, activity, body weight, hairiness, etc. of the rats after dosing. The detailed situation is as shown in Table 1 below. Seven days later, the rats were dissected, and the heart, liver, spleen, lung, kidney, stomach, intestine, brain, nose,
No abnormalities were found in any of the tissue organs such as the throat, trachea, and bronchus. Thus, a dose of 8 g / kg of nasal or nasal solutions to rats was found not to cause an acute toxic reaction. This dosage is about 40 times the clinical dose.

[Table 1] 2. Irritation test of nasal or instilled nasal solution high drug Twenty healthy rats weighing 180-220 g are selected and divided into a nasal or instilled nasal solution administration group and a blank control group. In addition, each group consists of 10 animals, so that the sex becomes half. The experiment proceeds at room temperature 22 ± 2 ° C. At the time of the experiment, a nasal or nasal solution was slowly instilled into the rat nasal cavity,
Dosing once every 10 minutes, every time 0.1 mg / kg body weight.
Give 1 ml and administer 10 consecutive times. Total dose is 1 body weight
The volume was adjusted to 1 ml (containing 2 g of crude drug) per kg.
After dosing, the rats breathe calmly, their breathing frequency and rhythm are normal, and there are no respiratory tract reactions such as cough, asthma symptoms, and suffocation.
The rats were dissected 24 hours after administration, and no pathological alterations such as hyperemia and erythema were found in any of the mucous membranes of the respiratory tract, such as the nose, throat, trachea, and bronchus. This confirmed that the nasal or nasal drops were non-irritating.

[0013]

The nasal or instilled nasal solution of the present invention described above has a good antipyretic effect, and is superior to the well-known antipyretic analdine in both action intensity and action time. Equivalent to action and non-irritating,
No acute toxic reaction was observed even when the rat was instilled with a clinical dose of 40 times (8 kg / kg crude drug) in the nose, which proved that the nasal or nasal solution of the present invention was a safe paraphrase composition. Was. FIG. 3 to FIG. 6 are observation tables of the therapeutic effects of the fever sensation or nasal drop of the present invention. This therapeutic effect observation table shows the results of spraying or instilling different amounts of a drug into the nasal cavity of a patient according to different cold diseases of people of different ages.
After the drug was absorbed into the mucous membrane inside the nasal cavity, it suppressed the disease state in a short time and showed a remarkable therapeutic effect. It should be noted that the above-mentioned purple huhu (Bupleurum chinese)
DC. ) Instead of narrow leaf purple hu
Scorzonerifolia Will) could be used, the components and pharmacology of both were almost the same, and the results after both experiments were almost the same. The pharmacology and ingredients of the above-mentioned Kampo medicines were commissioned to the Shanghai Science and Technology Publishing Company by the Editorial Committee of the State Chinese Pharmaceutical Management Agency in January 1998.
You can refer to “Chinese book book” (published and published by Tsuki).

[Brief description of the drawings]

FIG. 1 is a production flowchart of a pharmaceutical composition of a fever sensation or nasal drops according to the present invention.

FIG. 2 is a diagram showing the effects (° C., X ± SD) on body temperature of mice heated by brewer's yeast with the nasal or dripping nasal solution of the present invention.

FIG. 3 is a treatment effect observation table of the fever sensation nasal drop or nasal drop of the present invention.

FIG. 4 is a therapeutic effect observation table of the fever sensation or nasal drop of the present invention.

FIG. 5 is a therapeutic effect observation table of the fever sensation or nasal drop of the present invention.

FIG. 6 is a therapeutic effect observation table of the fever sensation or nasal drop of the present invention.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Geng Shu-ken, 2nd floor, 41st street, 2nd floor, Nanjing East Road, Zhongshan District, Taipei, Taiwan No.2 F No.F Reference (reference) BA17 BA18 CB22 EA11 GA17 MA02 MA03 MA04 NA06 NA10 ZA05 ZA07 ZA08 ZA14 ZA62 ZA75 ZA81 ZB07 ZB09 ZB32 ZB33 ZB35 4C088 AB12 AB40 AC05 AC11 BA08 BA09 BA11 BA13 BA18 CA02 CA05 CA17 MA08 MA13 Z05A07 Z10A05 Z10 ZB33 ZB35

Claims (2)

[Claims] 1. A pharmaceutical composition of a fever sensation or nasal solution prepared by spraying or dropping into a nasal mucosa of a patient and absorbing the same, comprising 250 to 300 g of Bupleurum chi.
nice DC. ), 120-144 g of indigo root (Ra)
dix Isatidis Indigotica),
120-144 g of large green leaves (Folium Isati
dis), a pharmaceutical composition of a fever cold or nasal drop, characterized by comprising 10 to 12 g of vitamin C. 2. A method for producing a fever sensation or nasal drop, comprising the steps a to f, namely: a. 250 to 300 g of purple husk is immersed in 1 volume of water for 2 hours, and 4 volumes of water are further added and boiled in water, and 2 to 2.4 ml of volatile oil is extracted by a distillation method. Filter further and liquid 1
Obtaining from 000 ml to 1200 ml, and further temporarily storing the volatile oil, the filtered chemical solution and the drug residue in containers, respectively; b. 120-144 g of indigo root and 120-144 g of large green leaves were each added with 7 times the amount of water, decocted for 1 hour, and filtered, and the filtrate was temporarily stored in a container; c. After mixing the residue of the medicine remaining after the extraction or filtration in the above steps a and b, add 5 times the amount of water after mixing the residue of the medicine, and incubate for 1 hour, then add 4 times the amount of water. Incubating for 40 minutes in addition and combining the filtrate obtained by further filtration, d. Combine the three filtrates obtained above and 1m
concentrating until 1 liter of the drug solution corresponds to 1 g of crude drug, further allowing to cool, and adding 95% ethanol to make the alcohol content 70%, e. 2 to 2.4 ml of volatile oil and 10 to 12
A step of adding g of vitamin C to a drug solution after dissolving, mixing and filtering, and dispensing the solution.