CN110075197A - A kind of Chinese medicine composition that treating herpangina and its preparation and application - Google Patents
A kind of Chinese medicine composition that treating herpangina and its preparation and application Download PDFInfo
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- CN110075197A CN110075197A CN201910475252.2A CN201910475252A CN110075197A CN 110075197 A CN110075197 A CN 110075197A CN 201910475252 A CN201910475252 A CN 201910475252A CN 110075197 A CN110075197 A CN 110075197A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to pharmaceutical technology fields, and in particular to a kind of to treat anginal Chinese medicine composition of blister disease property and its preparation method and application.The formula of the Chinese medicine composition is as follows: rhizoma atractylodis 70-90 parts by weight, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 parts by weight, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 parts by weight, shell of areca nut 110-125 parts by weight, dried pinellia 70-90 parts by weight, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2 parts by volume and perilla leaf oil 0.2-0.6 parts by volume.The oral preparation of the Chinese medicine composition preparation has good curative effect to treatment herpangina, and total effective rate 58.1% has significant meaning for the clinical treatment of herpangina.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of to treat the anginal Chinese medicine composition of blister disease property and its system
Preparation Method and application.
Background technique
Herpangina (herpangina) is caused by enterovirus with febris acuta and isthmus faucium portion bleb ulcer
The acute infective angina being characterized, using excrement-mouth or respiratory tract as major transmission path, infectiousness is very strong, propagates fastly, spreads
All over the world, in distributing or popular, summer and autumn is high-incidence season, mainly invades 1~7 years old children.Clinic to generate heat, pharyngalgia, pharynx
Isthmus mucous membrane exanthema vesiculosum and superficial ulcer are main performance.For self-limited disease, the general course of disease 4~6 days, severe one can be to 2 weeks.Together
One infant, which can be repeated several times, occurs this disease, is that different shaped virus causes.
Incubation period is 2~4 days.Often sharply generate heat, heat be mostly it is low or in it is isocratic, accidental up to 40 DEG C or more, or even draw
It rises and faints from fear.Hot journey mostly 2~4 days.Older infant can tell that pharyngalgia, pharyngalgia severe one can influence to swallow.Infant then shows
For salivation, food refusal, dysphoria.Sometimes companioned with headache, abdominal pain or myalgia, 5 years old or less children have 1/4 can occur together vomiting.
Classical symptom appears in pharyngeal.Show as congestion of throat, in onset 2 days mucous membrane of mouth occur it is several (it is few then 1~2
A, up to more than 10) small (1~2mm of diameter) canescence bleb, around around with blush.Blush aggravation expands after 2~3 days, blister
Rash ulceration forms yellow ulcer.Such erathema is more common in anterior tonsillar pillar, may be alternatively located at soft palate, uvula, on tonsillotome, but
Gums and cheek mucous membrane are not involved.The course of disease is generally 4~6 days, is occasionally extended down to 2 weeks persons.Part hand-foot-and-mouth disease infant is with herpetic pharynx
Gorge inflammation is onset symptoms, then red rash can occurs at positions such as palm, vola, buttocks.
Herpangina infectiousness is stronger, it should be noted that and isolation treatment there is no specific short to enterovirus infection at present,
Mainly symptomatic treatment.Pay attention to oral hygiene, keeps oral cleaning.It can rinse with salt water, be applied to ulcer with 10% silver nitrate
Place or with throat miracle, Bingpeng San etc. blow broadcast it is pharyngeal to mitigate pharyngalgia symptom.Oral vitamin C and B etc..And Chinese medicine treatment is to this
Disease has certain effect, the therapy that common removing toxic substances relieving sore-throat, dampness elimination are brought down a fever, therefore the present invention is intended to provide a kind of effectively can be used for controlling
Treat the Chinese medicine composition of herpangina.
Summary of the invention
In view of this, one of the objects of the present invention is to provide a kind of Chinese medicine composition for treating herpangina, institute
Herpangina can effectively be treated by stating Chinese medicine composition.
To achieve the above object, the present invention uses following scheme:
A kind of Chinese medicine composition for treating herpangina, the formula of the Chinese medicine composition are as follows: rhizoma atractylodis 70-90 weight
Measure part, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 parts by weight, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 parts by weight, big abdomen
Skin 110-125 parts by weight, dried pinellia 70-90 parts by weight, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2 parts by volume and
Perilla leaf oil 0.2-0.6 parts by volume.
Preferably, the Traditional Chinese medicine composition formula is as follows: rhizoma atractylodis 80-85 parts by weight, dried orange peel 80-85 parts by weight, Cortex Magnoliae Officinalis 80-
85 parts by weight, root of Dahurain angelica 120-125 parts by weight, Poria cocos 120-125 parts by weight, shell of areca nut 120-125 parts by weight, dried pinellia 80-85
Parts by weight, extract of licorice root 8-12 parts by weight, patchouli oil 0.8-1.2 parts by volume and perilla leaf oil 0.4-0.6 parts by volume.
It is furthermore preferred that the Traditional Chinese medicine composition formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 weight of Cortex Magnoliae Officinalis
Part, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 weight of extract of licorice root
Part, 0.4 parts by volume of 0.8 parts by volume of patchouli oil and perilla leaf oil.
The second object of the present invention is to provide a kind of preparation side of the Chinese medicine composition for the treatment of herpangina
Method.
To achieve the above object, the present invention uses following scheme:
1) it takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；It will be described in formula ratio
Rhizoma atractylodis, the dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；By the big abdomen of the formula ratio
Skin water is decocted and is filtered, and obtains shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to
70-90 DEG C, to sufficiently infiltrating and filtering, obtains Poria cocos temperature immersion liquid；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains the tuber of pinellia
Soak；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, the mixing for obtaining the tuber of pinellia and rhizoma zingiberis is impregnated
Liquid；
2) by the ethanol extract, distillation extract mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and
The mixed soaking solution of rhizoma zingiberis is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the Radix Glycyrrhizae of formula ratio is added
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol by medicinal extract, and addition auxiliary material Tween 80 is wide with the formula ratio
The aqueous medium of palchouli oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value with sodium hydroxide, obtains the Chinese medicine composition.
Further, step 2) adjusts pH value to 5.8-6.2.
The three of the object of the invention are to provide a kind of application of the Chinese medicine composition for the treatment of herpangina.
To achieve the above object, the present invention uses following scheme:
A kind of application of Chinese medicine composition that treating herpangina in preparation treatment herpangina drug.
The Chinese medicine composition of the treatment herpangina can be used for preparing treatment herpangina drug, and obtain
Good efficacy.
The fourth object of the present invention is to provide prepared by a kind of Chinese medicine composition for the treatment of herpangina
Drug.
To achieve the above object, the present invention uses following scheme；
It is a kind of it is described treatment herpangina Chinese medicine composition prepared by drug
Further, the drug of the treatment herpangina can be any pharmaceutically acceptable dosage form, the treatment blister
The anginal drug of rash further includes pharmaceutical acceptable carrier and/or auxiliary agent.
The pharmaceutically acceptable dosage form includes Chinese medicine composition of the invention and optional one or more pharmaceutically may be used
Carrier, diluent or the excipient of receiving and the addition of suitable step in above-mentioned preparation process.Term used in the present invention
" pharmaceutically acceptable " refers to such compound, raw material, composition and/or dosage form, the model that they judge in rational medicine
In enclosing, be suitable for contacting with patient tissue and without excessive toxicity, irritation, allergy or with reasonable interests/Hazard ratio phase
Symmetrical other problems and complication, and effective for given application.
Pharmaceutical preparation is suitable for being administered by any suitable approach, for example, by take orally (including oral cavity or sublingual), rectum,
Nose, part (including oral cavity, sublingual or percutaneous), vagina or parenteral (including subcutaneous, intradermal, intramuscular, intra-articular, intrasynovial, chest
Bone is interior, intrathecal, intralesional, intravenous or intradermal injection or infusion) approach.It can be by any known method of art of pharmacy
This kind of preparation is prepared, such as by mixing active constituent with carrier or excipient.It is preferred that oral administration, local administration or injection
Administration.Pharmaceutical preparation suitable for oral administration is provided by independent unit, for example, solution in aqueous or non-aqueous liquid or
Suspension；Capsule or tablet；Powder or granule；Edible foam formulations or foaming preparations etc..
For example, for oral administration in the form of a tablet or capsule, active medicine component can with can pharmaceutically connect
The oral, non-toxic inert carrier (such as ethyl alcohol, glycerol, water etc.) received mixes.By the way that compound powder is broken into suitable fine ruler
It is very little, and mix with the pharmaceutical carrier (such as the edible carbohydrate such as starch or mannitol) equally crushed to prepare powder.Also
Corrigent, preservative, dispersing agent and colorant may be present.By preparing pulverulent mixture as described above, and it is loaded into forming
Gelatin shell in, to prepare capsule.It, can be by glidant and lubricant (such as colloidal silicon dioxide, cunning before filling operation
Mountain flour, magnesium stearate, calcium stearate or solid polyethylene glycol) it is added in pulverulent mixture.It can also be added when taking capsule
The disintegrating agent or solubilizer (such as agar, calcium carbonate or sodium carbonate) of drug utilizability will be improved.
When furthermore needing or is required, suitable adhesive, lubricant, disintegrating agent and colorant can also be mixed mixture
In.Suitable adhesive includes starch, gelatin, natural sugar (such as glucose or beta lactose), corn sweetener, natural and synthesis
Gummy (such as gum arabic, tragacanth or mosanom), carboxymethyl cellulose, polyethylene glycol etc..For these dosage forms
Lubricant includes enuatrol, sodium chloride etc..
Disintegrating agent includes but is not limited to starch, methylcellulose, agar, bentonite, xanthan gum etc..For example, by being made
Lubricant and disintegrating agent is added in pulverulent mixture, granulation or pre- tabletting, tabletted, so that tablet be made.By what is suitably crushed
Compound and diluent as described above or base-material, optionally with adhesive (such as carboxymethyl cellulose, alginates, gelatin or
Polyvinylpyrrolidone), dissolution inhibitor (such as paraffin), absorbsion accelerator (quaternary salt) and/or absorbent (such as bentonite, height
Ridge soil or Dicalcium Phosphate) mixing, to prepare pulverulent mixture.Useful binders (such as syrup, starch slurry, mucialga of arabic gummy or
Cellulosic material or polymeric material solution) wetting after pressurize sieving, pulverulent mixture is pelletized.One alternative of granulation
It is that particle can be made the result is that bad agglomerate will be formed and smashed again by pulverulent mixture by tablet press machine.It can be hard by being added
Resin acid, stearate, talcum powder or mineral oil make particle lubrication to prevent from adhering on the punch die of tablet press machine.Then it will be lubricated
Mixture is tabletted.The compound of the content of present invention can also be mixed with the inert carrier of free-flowing, without by granulation or
Pre- tableting step can be tabletted.It can provide transparent or opaque by shellac seal coat, sugar-coat or polymeric material clothing and wax
Matter polishes the protectiveness coating material of clothing composition.Dyestuff can be added in these coating materials and distinguish different unit doses.
Oral liquid such as solution, syrup and elixir can be prepared with dosage unit form, so that specified rate contains
There is the compound of predetermined amount.Syrup can be prepared by the way that compound to be dissolved in suitably seasoned aqueous solution, and elixir can lead to
It crosses using non-toxic vehicle and prepares.Can also be added preservative, flavoring additive (such as peppermint oil or natural sweetener or saccharin or
Other artificial sweeteners) etc..
Pharmaceutical preparation suitable for percutaneous dosing can be used as discrete patch to keep close with recipient's epidermis in a long time
Cut-grafting touching.For example, active constituent can be by passing medicine by electro-ionic osmosis patch, usually reference can be made to Pharmaceutical
Research1986,3(6),318。
Pharmaceutical preparation suitable for local administration can be made into ointment, cream, suspension, lotion, powder, solution, paste
Agent, gelling agent, spray, aerosol, oil formulation or transdermal patch.Suitable for the pharmaceutical preparation of nose administration, (wherein carrier is solid
Body) it include the dust base that partial size is such as 20-500 micron range, by being administered in a manner of snuffing, i.e., by nasal passage from close
It is quickly sucked in the coarse powder agent container of nose.Wherein carrier is liquid, the conjunction for being suitable for nasal mist or nasal drop administration
Suitable preparation includes the aqueous solution agent or oily solutions of active constituent.
Include minuteness particle pulvis or mist agent suitable for the pharmaceutical preparation by inhalation, can be measured with different type
Dosage compresed gas aerosol, nebulizer, insufflator or other matters delivering aerosol spray device in prepare.Suitable for stomach
The pharmaceutical preparation of parenteral administration includes water-based and non-aqueous sterile injection solution and aqueous and non-aqueous sterile suspensions, aqueous
Antioxidant, buffer, bacteriostatic agent can be contained with non-aqueous sterile injection solution agent and make the preparation and receptor's blood waiting
Isotonic solute.Preparation can be provided with unit dose or multi-dose container, for example, sealing peace is triumphant and bottle, and can be reserved for cold
It is lyophilized under the conditions of dry (freeze-drying), only sterile liquid carrier, such as water for injection need to be added before use.Face the injection of used time configuration
Solution can be prepared by sterile powder injection, granule and tablet.
Pharmaceutical preparation can be in unit dosage forms, and each unit dose contains the active constituent of predetermined amount.Dose regimen can be used as growing
Phase or short-term therapy.Mixing with carrier material will be according to disease to be treated, disease to prepare the amount of the active constituent of single formulation
Disease severity, administration time, administration route, the discharge rate of compound used therefor, treatment time and patient age, gender,
Weight and situation and change.Preferred unit dosage forms are the daily dose containing above-mentioned active constituent or divided dose or its appropriate fraction
Unit dosage forms.It can start to treat with the low dose of already clearly below compound optimal dose.Hereafter, it is increased with lesser increment
Dosage until reaching optimum efficiency in this case.In general, the concentration level for most desirably giving compound is usual
Effective result can be provided without regard to causing any harmful or toxic side effect in anti-virus aspect.
Further, the drug of the treatment herpangina is oral preparation.
Further, the oral preparation includes tablet, powder, oral solution, syrup and elixir.
The beneficial effects of the present invention are:
1) the present invention provides a kind of Chinese medicine composition for treating herpangina, the mouths of the Chinese medicine composition preparation
Formulation has good curative effect, total effective rate 58.1%, for facing for herpangina to treatment herpangina
Bed treatment has significant meaning；
2) Chinese materia medica preparation for the treatment of herpangina provided by the present invention is in the same of effectively treatment herpangina
The apparent adverse reaction of Shi Bingwu.
Specific embodiment
Illustrated embodiment is in order to which preferably the present invention will be described, but is not that the contents of the present invention are limited only to institute
For embodiment.So those skilled in the art according to foregoing invention content to embodiment carry out it is nonessential improvement and
Adjustment, still falls within protection scope of the present invention.
A kind of Chinese medicine composition for treating herpangina of embodiment 1
A kind of Chinese medicine composition for treating herpangina, the Traditional Chinese medicine composition formula are as follows: 80 parts by weight of rhizoma atractylodis,
80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 parts by weight of Poria cocos, 120 parts by weight of the shell of areca nut, dried pinellia
80 parts by weight, 0.4 parts by volume of 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and perilla leaf oil.
A kind of Chinese medicine composition for treating herpangina of embodiment 2
A kind of Chinese medicine composition for treating herpangina, the Traditional Chinese medicine composition formula are as follows: 90 parts by weight of rhizoma atractylodis,
90 parts by weight of dried orange peel, 90 parts by weight of Cortex Magnoliae Officinalis, 125 parts by weight of the root of Dahurain angelica, 125 parts by weight of Poria cocos, 125 parts by weight of the shell of areca nut, dried pinellia
90 parts by weight, 0.6 parts by volume of 15 parts by weight of extract of licorice root, 1.2 parts by volume of patchouli oil and perilla leaf oil.
A kind of Chinese medicine composition for treating herpangina of embodiment 3
A kind of Chinese medicine composition for treating herpangina, the Traditional Chinese medicine composition formula are as follows: 90 parts by weight of rhizoma atractylodis,
90 parts by weight of dried orange peel, 90 parts by weight of Cortex Magnoliae Officinalis, 125 parts by weight of the root of Dahurain angelica, 125 parts by weight of Poria cocos, 125 parts by weight of the shell of areca nut, dried pinellia
90 parts by weight, 0.6 parts by volume of 15 parts by weight of extract of licorice root, 1.2 parts by volume of patchouli oil and perilla leaf oil.
A kind of preparation method for the Chinese medicine composition for treating herpangina of embodiment 4
1) Cortex Magnoliae Officinalis described in Example 1-3 formula ratio is extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；By formula ratio
The rhizoma atractylodis, the dried orange peel and the root of Dahurain angelica with water as medium distill extract, must distill extraction mixed liquor；By the formula ratio
Shell of areca nut water decoct and filter, obtain shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cold
But to 70-90 DEG C to sufficiently infiltrating and filtering, Poria cocos temperature immersion liquid is obtained；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains
Tuber of pinellia soak；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, obtains the mixing of the tuber of pinellia and rhizoma zingiberis
Soak；
2) by the ethanol extract, distillation extract mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and
The mixed soaking solution of rhizoma zingiberis is sufficiently mixed, and is concentrated into density and is the paste of 1.10-1.20, and the Radix Glycyrrhizae of formula ratio is added
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol, auxiliary material Tween 80 and the patchouli oil, purple is added by medicinal extract
The mixed liquor of folium perillae oil and the aqueous medium of surplus adjust pH value to 5.8-6.2 with sodium hydroxide, obtain the Chinese medicine composition.
A kind of oral preparation of Chinese traditional medicinal for treating herpangina of embodiment 5
4 gained Chinese medicine composition of embodiment is stood, clear solution is filtered to obtain, and preservative, tender taste agent and addition is added
Agent, sterilizing are filling that solution, the tender taste agent are peppermint oil, natural sweetener, saccharin or other artificial sweeteners.
6 clinical research of embodiment
48 damp and hot poison accumulate type herpangina infant and derive from Pediatric Clinic, wherein male 25, female 23；Age
2-7 years old, the course of disease 1-2 days, whole infants had fever, pharyngalgia, and Leukocyte Counts are greater than 10 × 109/L。
Diagnostic criteria: diagnostic criteria is related in " Zhu Futang practical paidonosology (6 editions) " according to " modern Otolaryngology "
Standard formulation；Differential diagnosis in tcm standard according in " tcm clinical practice diagnosis and treatment term " in relation to the pharyngeal blister of standard formulation of " damp and hot poison accumulates card "
Rash fever, pharyngalgia salivation, dysphagia, thirsty, lip is red or dry and cracked, tongue is red, whitish tongue is greasy or yellow greasy, slippery and rapid pulse or floating superficial venule of the index finger
It is purple.
Treatment method:
1. Primary Care using conventional complex treatment, bring down a fever to the ill, keep oral cleaning；
2. treatment group is taken orally, once using the oral preparation of Chinese traditional medicinal for treating herpangina described in embodiment 5 for oral administration
10ml, 2 times a day.
Criterion of therapeutical effect: cure: body temperature is normal, and bleb disappears substantially, he disappears disease；Effective: body temperature is normal, and bleb is most of
Subside or reduce, his disease is obviously improved or improves；Invalid: body temperature does not restore normally, and bleb is without significantly reducing.
Treatment results: as shown in the table, the drug of Chinese medicine composition preparation of the invention, it is always effective to herpangina
Rate is 58.1%, does not find apparent adverse reaction.
| Group | n | Recovery from illness | Effectively | In vain | Total effective rate % |
| Treatment group | 48 | 8 | 20 | 20 | 58.1 |
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to skill of the invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the scope of the claims of invention.
Claims (10)
1. a kind of Chinese medicine composition for treating herpangina, which is characterized in that the formula of the Chinese medicine composition is as follows: grey
Art 70-90 parts by weight, dried orange peel 70-90 parts by weight, Cortex Magnoliae Officinalis 70-90 parts by weight, root of Dahurain angelica 110-125 parts by weight, Poria cocos 110-125 weight
Measure part, shell of areca nut 110-125 parts by weight, dried pinellia 70-90 parts by weight, extract of licorice root 5-15 parts by weight, patchouli oil 0.5-1.2
Parts by volume and perilla leaf oil 0.2-0.6 parts by volume.
2. a kind of Chinese medicine composition for treating herpangina according to claim 1, which is characterized in that the Chinese medicine
Composite formula is as follows: rhizoma atractylodis 80-85 parts by weight, dried orange peel 80-85 parts by weight, Cortex Magnoliae Officinalis 80-85 parts by weight, root of Dahurain angelica 120-125 weight
Measure part, Poria cocos 120-125 parts by weight, shell of areca nut 120-125 parts by weight, dried pinellia 80-85 parts by weight, extract of licorice root 8-12 weight
Part, patchouli oil 0.8-1.2 parts by volume and perilla leaf oil 0.4-0.6 parts by volume.
3. a kind of Chinese medicine composition for treating herpangina according to claim 2, which is characterized in that the Chinese medicine
Composite formula is as follows: 80 parts by weight of rhizoma atractylodis, 80 parts by weight of dried orange peel, 80 parts by weight of Cortex Magnoliae Officinalis, 120 parts by weight of the root of Dahurain angelica, 120 weight of Poria cocos
Measure part, 120 parts by weight of the shell of areca nut, 80 parts by weight of dried pinellia, 10 parts by weight of extract of licorice root, 0.8 parts by volume of patchouli oil and purple perilla
0.4 parts by volume of leaf oil.
4. a kind of preparation method for the Chinese medicine composition for treating herpangina described in claim 1-3 any one, packet
Include following steps:
1) it takes the Cortex Magnoliae Officinalis of formula ratio to be extracted with alcohol reflux, obtains the ethanol extract of Cortex Magnoliae Officinalis；By the rhizoma atractylodis of formula ratio,
The dried orange peel and the root of Dahurain angelica are distilled with water as medium to be extracted, and must be distilled and be extracted mixed liquor；The shell of areca nut of the formula ratio is used
Water is decocted and is filtered, and obtains shell of areca nut decoction liquor；After the Poria cocos of the formula ratio is boiled with water as medium, and it is cooled to 70-90
DEG C to sufficiently infiltrating and filtering, Poria cocos temperature immersion liquid is obtained；It takes the dried pinellia of formula ratio sufficiently to be impregnated with aqueous medium, obtains tuber of pinellia immersion
Liquid；And the rhizoma zingiberis for being equivalent to 0.06-0.1 times of dried pinellia weight ratio is taken, it decocts again, obtains the mixed soaking solution of the tuber of pinellia and rhizoma zingiberis；
2) mixed liquor, shell of areca nut decoction liquor, the immersion liquid of Poria cocos temperature and the tuber of pinellia and rhizoma zingiberis are extracted into the ethanol extract, distillation
Mixed soaking solution be sufficiently mixed, be concentrated into density be 1.10-1.20 paste, and be added formula ratio the Radix Glycyrrhizae leaching
The paste is mixed with the extract of licorice root and is recycled ethyl alcohol, the wide leaves of pulse plants of auxiliary material Tween 80 and the formula ratio is added by cream
The aqueous medium of sesame oil, the mixed liquor of perilla leaf oil and surplus adjusts pH value with sodium hydroxide, obtains the Chinese medicine composition.
5. the preparation method according to claim 4, which is characterized in that step 2) adjusts pH value to 5.8-6.2.
6. a kind of Chinese medicine composition for treating herpangina described in claim 1-3 any one treats bleb in preparation
Application in property angina drug.
7. treatment blister prepared by a kind of Chinese medicine composition for treating herpangina described in claim 1-3 any one
The anginal drug of rash.
8. drug according to claim 7, which is characterized in that the drug of the treatment herpangina can be any
The drug of pharmaceutically acceptable dosage form, the treatment herpangina further includes pharmaceutical acceptable carrier and/or auxiliary agent.
9. drug according to claim 8, which is characterized in that the drug of the treatment herpangina is oral system
Agent.
10. drug according to claim 9, which is characterized in that the oral preparation includes tablet, powder, oral solution, sugar
Starch agent and elixir.
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Application publication date: 20190802 |