JP2001104468A - Adhesive gel sheet for organism - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an adhesive gel sheet for organisms having a moisture retaining property, a feeling of coolness, adhesiveness, a feeling of blocking, or the like, to the skin. SOLUTION: In a gel sheet made of a synthetic polymer gel containing at least water as a solvent and having a mesh structure, by hardening the whole or a part of at least one surface, a solvent forming gel oozes out on the surface of the gel.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bioadhesive gel sheet used in the fields of pharmaceuticals, quasi-drugs, cosmetics, sanitary materials, miscellaneous goods, and the like. More specifically, the surface of the gel sheet exudes a solvent constituting the gel. The present invention relates to a pressure-sensitive adhesive gel sheet for a living body, which is characterized by improving familiarity with the skin, facilitating the transfer of contained medicinal ingredients to the skin, or imparting a moisturizing property and a cool feeling to the skin.

[0002]

2. Description of the Related Art Conventionally, packs and patches used for the treatment of beauty, beauty and skin, and the like, or pressure-sensitive adhesive sheets for living bodies such as transdermal absorbents, pressure-sensitive adhesive tapes for wounds, wound dressings, anti-inflammatory analgesics and the like have been used. From the viewpoint of adhesion to the skin and obstructiveness,
A gel sheet typified by a poultice is used. However, such conventional gel sheets are not yet satisfactory in terms of familiarity with the skin, moisturizing properties and cooling feeling given to the skin, or transfer of contained medicinal ingredients to the skin.

[0003] On the other hand, as a similar biological sheet, a sheet obtained by immersing a non-woven fabric or a woven cloth with an aqueous solution containing a liquid lotion or a chemical (hereinafter referred to as a biological impregnated sheet) is directly attached to the skin. Although it is used in some cases, it is superior to the above gel sheet in terms of moisturizing property and cool feeling given to the skin, but it is originally not sticky, and nonwoven fabric or woven fabric is stuck through the impregnated liquid This is a problem in terms of adhesion to the skin and obstruction. In particular, if the application is performed for 10 minutes or more, there is a problem that the application time cannot be lengthened, such as the sheet peeling off from the skin due to drying.

[0004]

As described above, conventional pressure-sensitive adhesive sheets for living bodies or impregnated sheets for living bodies do not satisfy the moisturizing property, cooling feeling, adhesiveness, closing feeling, etc., of the skin. Did not.

A conventional adhesive sheet for a living body is a laminate of a gel and a supporting substrate such as a nonwoven fabric or a woven fabric as represented by a poultice. In order to prevent this, an opaque material with almost no aperture ratio is used, so that it has a large visual discomfort when applied to the skin, and when used, there is a problem that time and place are greatly restricted. . Similarly, in a bio-impregnated sheet,
The non-woven fabric or woven fabric used has a large basis weight so as to contain a liquid to be immersed as much as possible, and as a result, the fabric becomes opaque, causing a sense of visual discomfort when applied to the skin.

Accordingly, an object of the present invention is to provide a living body pressure-sensitive adhesive sheet which satisfies the moisturizing property, the cooling feeling, the adhesiveness, the occluding feeling and the like on the skin in a comprehensive manner. Further, it is possible to provide a biological pressure-sensitive adhesive sheet having a degree of transparency that does not cause visual discomfort as a suitable biological pressure-sensitive adhesive sheet.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, at least a gel sheet comprising a synthetic polymer gel having a network structure containing at least water as a solvent. By applying a curing treatment to the entire surface or a part of one surface, the solvent constituting the gel body oozes out on the surface of the gel body, so that the adhesiveness to the skin and the occlusive property, which are the characteristics of the conventional bioadhesive sheet, A conventional bio-adhesive sheet that is inadequate with conventional bio-adhesive sheets and has excellent moisturizing properties and cooling sensation given to the skin, and its sustainability, or excellent transfer of contained medicinal ingredients to the skin, etc. The gel sheet was completed.

Further, when the curing treatment is performed by applying a curing treatment agent to at least one entire surface of the gel sheet, there is an advantage that the work becomes easy and the production cost can be reduced.

Further, the synthetic polymer gel body for forming the above-mentioned adhesive gel sheet for living body of the present invention is transparent or translucent,
This (semi-) transparency is maintained even when a curing treatment is applied to the entire surface or at least a part of at least one surface of the gel sheet. Accordingly, the appearance of the adhesive gel sheet for living body of the present invention is also transparent or translucent, and when applied to the skin, there is no visual discomfort. And, compared to conventional biological adhesive sheet or biological impregnated sheet,
This gel sheet had a feature of a large heat capacity, could maintain a cool feeling, and had a feature that the gel sheet itself was rich in elasticity, so that it could be more easily fitted to the shape of the skin.

That is, the present invention provides a gel sheet made of a synthetic polymer gel having a network structure containing at least water as a solvent, by subjecting at least one entire surface or a part of the gel to a curing treatment to form the gel. The bioadhesive gel sheet is characterized in that the solvent is exuded on the surface of the gel body. According to a second aspect of the present invention, there is provided the pressure-sensitive adhesive gel sheet for living body, wherein the curing treatment is performed by applying a curing agent to at least one surface of the gel sheet. A third aspect of the present invention is the above-mentioned adhesive gel sheet for living body, which has a transparent or translucent appearance. According to a fourth aspect of the present invention, the synthetic polymer constituting the synthetic polymer gel is a hydrophilic synthetic polymer obtained by polymerizing a polymerizable unsaturated monomer having at least an anionic functional group,
In the above-mentioned pressure-sensitive adhesive gel sheet for living body, the curing agent contains a compound having at least a polyvalent cation.
A fifth aspect of the present invention is the above-mentioned pressure-sensitive adhesive gel sheet for living body, wherein the anionic functional group is a carboxyl group. A sixth aspect of the present invention is the above-mentioned pressure-sensitive adhesive gel sheet for living body, wherein the polyvalent cation is a trivalent or higher ion. According to a seventh aspect of the present invention, there is provided the above-mentioned pressure-sensitive adhesive gel sheet for a living body, which contains therein a woven or nonwoven fabric having a sufficiently large aperture ratio. The eighth present invention provides:
The above-mentioned adhesive gel sheet for living body is characterized in that the gel sheet is contained in a blister container and is sealed.

In the present invention, "adhesive gel sheet for living body" and "adhesive sheet for living body" or "impregnated sheet for living body" refer to a pack material, a patch, a transdermal absorbent, an adhesive tape for living body, a wound covering. It refers to an adhesive sheet or an adhesive sheet that is used by attaching it to the skin for the purpose of treating cosmetics, facial beauty, skin treatment, etc., such as an agent and anti-inflammatory analgesic.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail. [Synthetic Polymer Gel Body] The bioadhesive gel sheet of the present invention comprises a synthetic polymer gel body containing at least water, having a network structure, and having adhesiveness, and is preferably colorless or colored transparent. Or is translucent and has shape retention.

(Solvent) The ratio of water in the synthetic polymer gel constituting the pressure-sensitive adhesive gel sheet for living body of the present invention is 1 to 99.
% (Percentage by mass, the same applies to% of the following compounding amount). When the proportion of water in the gel body is less than 1%, there is a possibility that various additives such as medicinal ingredients and the like to be blended in the gel body cannot be easily dissolved. Conversely, if the proportion of water in the gel body exceeds 99%, the stiffness of the gel body becomes weak, and the shape retention of the gel body becomes unstable. In addition, operability may be deteriorated due to tearing.
The proportion of water in the gel body is preferably 5 to 5 in the above range.
It is preferably 95%, more preferably 10-85%.

The solvent constituting the above-mentioned synthetic polymer gel is not limited to water, but also a solvent which does not cause phase separation with water.
Conventionally, cosmetics, pharmaceuticals, quasi-drugs, sanitary materials, solvents that have been used for transdermal applications in the fields of sundries,
This can be used after mixing with water. Examples of such a solvent include monoalcohols such as ethyl alcohol, glycols such as 1,3-butylene glycol, and polyhydric alcohols such as glycerin. These may be used alone or as a mixture of two or more. be able to.

The proportion of the solvent other than water in the synthetic polymer gel is preferably 98% or less. The ratio is 9
If it exceeds 8%, the content of water as a solvent is reduced, so that various additives and the like blended in the gel body may not be easily dissolved. Furthermore, the stiffness of the gel body becomes weak, the shape retention of the gel body becomes unstable, and the bioadhesive gel sheet thus obtained may be torn off at the time of use, resulting in poor operability.

(Synthetic Polymer Constituting Gel Body) The synthetic polymer constituting the synthetic polymer gel body has an affinity for water, has a network structure, and forms a gel body containing at least water. And it has adhesiveness when the gel body is formed, and is conventionally used as a transdermal application in the fields of cosmetics, pharmaceuticals, quasi-drugs, sanitary materials, sundries and the like. The others are not particularly limited, and various synthetic polymers can be used.

Among them, from the viewpoint of easy manufacture,
(A) a copolymer of one or more polymerizable unsaturated monomers and a crosslinkable unsaturated monomer, or (b) a carboxyl group, a sulfonic acid group, a hydroxyl group, an amide group, A hydrophilic synthetic polymer obtained by polymerizing one or more polymerizable unsaturated monomers having at least one functional group selected from the group consisting of amino groups, and a polyvalent metal ion compound; A crosslinked structure obtained by reacting with at least one crosslinking factor selected from the group consisting of polycarboxylic acids, polyhydric alcohols, polyfunctional epoxides and dialdehydes is preferably used.

The hydrophilic synthetic polymer having a carboxyl group in the side chain, which forms the crosslinked structure of the above (b), includes:
Examples thereof include poly (meth) acrylic acid and those obtained by neutralizing a part or all of the carboxyl groups thereof with an alkali such as sodium hydroxide. Examples of the hydrophilic synthetic polymer having a sulfonic acid group in the side chain include poly-t-butylacrylamide sulfonic acid and those obtained by neutralizing a part or all of the sulfonic acid group with an alkali such as sodium hydroxide. As a hydrophilic synthetic polymer having a hydroxyl group in the side chain,
Examples thereof include polyvinyl alcohol obtained by polymerizing and hydrolyzing a vinyl acetate monomer. Examples of the hydrophilic synthetic polymer having an amide group in a side chain include poly (meth) acrylamide, polyN, N′-dimethyl (meth) acrylamide, polyvinylpyrrolidone, and polyN-vinylacetamide. Examples of the hydrophilic synthetic polymer having an amino group in the side chain include polyallylamine, one in which some or all of the amino groups are neutralized with an acid such as hydrochloric acid, and polymethacryloyltrimethyloxyethylammonium chloride.

The monomer constituting the above-mentioned hydrophilic synthetic polymer may have, in addition to a carboxyl group, a sulfonic acid group, a hydroxyl group, an amide group and an amino group, a functional group obtained by modifying these groups. For example, a treatment for esterifying about 40% of the hydroxyl groups or carboxyl groups in the hydrophilic synthetic polymer to make it lipophilic may be performed for the purpose of improving the adhesion to the skin. Further, when there is a long saturated hydrocarbon portion in the side chain, for the purpose of imparting hydrophilicity to the portion,
Further, a carboxyl group, a sulfonic acid group, a hydroxyl group, an amide group, an amino group, or the like may be introduced, or a treatment with a reagent such as an acid or an alkali may be performed. These treatments may be performed before the polymerization of the monomer or after the polymerization.

As described above, the cross-linking factor for forming the cross-linked structure of (b) is a polyvalent metal ion compound, a polyvalent carboxylic acid, a polyhydric alcohol, a polyfunctional epoxide and a dialdehyde. Is mentioned. Among them, examples of the polyvalent metal ion compound include an aluminum compound, a calcium compound, and a magnesium compound. Among them, from the viewpoint of crosslinking efficiency, aluminum hydroxide and salts thereof, synthetic aluminum silicate, magnesium aluminate metasilicate, magnesium aluminum oxide, aluminum oxide, dihydroxyaluminum amino acetate, magnesium aluminum hydroxide carbonate hydrate, hydroxide Compounds containing trivalent aluminum ions such as aluminum sodium carbonate coprecipitate are preferred, and those having an amorphous structure are more preferred. Examples of the polycarboxylic acid include succinic acid, fumaric acid, phthalic acid, citric acid, malic acid and the like. Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, butanediol, glycerin, diethylene glycol, diglycerin and the like. Examples of the polyfunctional epoxide include ethylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, propylene glycol diglycidyl ether, polypropylene glycol diglycidyl ether, polytetramethylene glycol diglycidyl ether, glycerol polyglycidyl ether, polyglycerol polyglycidyl ether, Examples include sorbitol polyglycidyl ether, sorbitan polyglycidyl ether, trimethylolpropane polyglycidyl ether, pentaerythritol polyglycidyl ether, resorcin diglycidyl ether, neopentyl glycol diglycidyl ether, and 1,6-hexanediol diglycidyl ether. Also,
Examples of the dialdehydes include glyoxal, terephthalaldehyde, glutaraldehyde and the like.

On the other hand, the polymerizable unsaturated monomers forming the copolymer (a) include (meth) acrylic acid and its salts; t-butylacrylamidosulfonic acid and its salts, and N, N'- Derivatives of (meth) acrylamide such as dimethylacrylamide and dimethylaminopropyl methacrylamide; vinylpyrrolidone and the like are preferably used from the viewpoint of easy production, but are not limited thereto. A monomer constituting the hydrophilic synthetic polymer (b) may be used.
The polymerizable unsaturated monomers may be used alone or as a mixture of two or more.

Examples of the crosslinkable unsaturated monomer forming the copolymer (a) include N, N-methylenebisacrylamide, N, N-methylenebismethacrylamide, N, N-ethylenebis Acrylamide,
N, N-ethylenebismethacrylamide, 1,2-diacrylamideethylene glycol and the like can be mentioned.

In the pressure-sensitive adhesive gel sheet for living body of the present invention,
The compounding amount of the synthetic polymer constituting the synthetic polymer gel is preferably 1 to 50% based on the total amount of the synthetic polymer gel. If the amount of the synthetic polymer is less than 1%, the stiffness of the gel body becomes weak, and the shape retention of the gel body becomes unstable, and the bioadhesive gel sheet thus obtained may be torn when used. Operability may be degraded.
Conversely, if it exceeds 50%, the gel strength will increase,
There is a possibility that the polymer structure of the gel body becomes too dense, and the amount of a solvent, a medicinal component and the like that can be retained in the gel body becomes too small. The compounding amount of the synthetic polymer is particularly preferably 3 to 30%, more preferably 5 to 25% in the above range.

When the copolymer (a) is used as the synthetic polymer for forming the synthetic polymer gel, the amount of the crosslinkable unsaturated monomer is 0.00
It is preferably from 5 to 0.5%. 0.005
%, It becomes difficult to obtain a gel body having sufficient waist strength, and the shape retention of the gel body becomes unstable. May be worse. Conversely, if the amount exceeds 0.5%, the brittleness of the obtained gel increases,
Cutting or destruction may easily occur due to tensile stress or compressive stress.

On the other hand, when the crosslinked structure of the above (b) is used as a synthetic polymer forming a synthetic polymer gel, when the crosslinkable factor is a polyvalent metal ion compound,
The compounding amount of the polyvalent metal ion compound is preferably 0.1 to 10% based on the synthetic polymer gel. When the crosslinkable factor is a polycarboxylic acid or a polyhydric alcohol, the amount of the polycarboxylic acid or the polyhydric alcohol is preferably 0.1 to 5% based on the synthetic polymer gel. . When the crosslinkable factor is a polyfunctional epoxide or dialdehyde, the amount of the polyfunctional epoxide or dialdehyde is 0.01 to 3% based on the synthetic polymer gel. Is preferred. When the blending amount of the crosslinking factor such as a polyvalent metal ion compound is below the above range, the stiffness of the gel becomes weak, the shape retention of the gel becomes unstable, and the bioadhesive gel sheet thus obtained is During use, the operability may be deteriorated due to tearing. Conversely, if the compounding amount exceeds the above range, the brittleness of the gel body increases, and there is a possibility that cutting or breaking may easily occur due to tensile stress or compressive stress.

[Curing Treatment] As the curing treatment in the present invention, for example, at least one surface of at least one surface of a gel sheet made of a synthetic polymer gel reacts with the gel to increase its crosslink density. And a method of irradiating ultraviolet rays, electron beams or the like to increase the crosslink density on one surface of the synthetic polymer gel.

Among these methods, the above-mentioned curing agent is applied to the entire surface or at least a part of at least one surface of the gel sheet (more specifically, a method such as applying and spraying the above-mentioned curing agent). Is preferred from the viewpoint of easiness of operation, manufacturing cost, and the like. (Curing Agent) As the curing agent in the present invention, a curing agent containing a crosslinkable factor which can react with a synthetic polymer gel forming a bioadhesive gel sheet and increase the crosslink density of the synthetic polymer gel is used. Used. That is, the curing treatment agent used in the present invention increases the cross-linking density of at least one of the entire surface or a part of the surface of the gel sheet made of the synthetic polymer gel that forms the bioadhesive gel sheet, thereby increasing the inside of the gel. Which is capable of exuding a solvent composed of, and is not particularly limited to, other than those conventionally used as transdermal applications in the fields of cosmetics, pharmaceuticals, quasi-drugs, sanitary materials, sundries, etc. .

The curing agent of the present invention is characterized in that the crosslinking factor contained in the curing agent reacts with the synthetic polymer gel to increase the crosslinking density of the gel. For this reason, the gel body needs a component capable of causing a crosslinking reaction with a crosslinking factor of the curing agent.
Such a component may be a synthetic polymer that itself forms a synthetic polymer gel, or is included together with the solvent in the gel, separately from the synthetic polymer that forms the synthetic polymer gel. Alternatively, it may be an uncrosslinked synthetic polymer.

The combination of the curing agent and the synthetic polymer gel is not particularly limited, but from the viewpoint of easy production, (i) the curing agent is a polyvalent cation or a polyvalent cation. A carboxylic acid, a polyhydric alcohol, having at least one crosslinking factor selected from the group consisting of polyfunctional epoxides and dialdehydes, and
(Ii) The synthetic polymer having a network structure constituting the gel body has at least one selected from the group consisting of a carboxyl group, a sulfonic group, a hydroxyl group, an amide group, and an amino group in a side chain.
A hydrophilic synthetic polymer obtained by polymerizing one or more polymerizable unsaturated monomers having various kinds of functional groups (that is, a synthetic polymer capable of causing a crosslinking reaction with the crosslinking factor of the above (i)) (Polymer).

In the above (ii), a carboxyl group,
A hydrophilic synthetic polymer obtained by polymerizing one or more polymerizable unsaturated monomers having at least one functional group selected from the group consisting of a sulfonic acid group, a hydroxyl group, an amide group, and an amino group. To introduce a network structure into a molecule, a method of copolymerizing the polymerizable unsaturated monomer with a cross-linkable unsaturated monomer, a hydrophilic method obtained by polymerizing the polymerizable unsaturated monomer, Synthetic synthetic polymer, polyvalent metal ion compound, polyvalent carboxylic acid,
A method of forming a crosslinked structure by reacting with at least one type of crosslinkable factor selected from the group consisting of polyhydric alcohols, polyfunctional epoxides and dialdehydes, and the like.

The hydrophilic synthetic polymer having a carboxyl group, a sulfonic acid group, a hydroxyl group, an amide group or an amino group in the side chain described in the above (ii) includes the above-mentioned “synthetic polymer constituting the gel body”. And the same as those described in the column. Further, the monomer constituting the hydrophilic synthetic polymer may have a functional group in which a carboxyl group or the like has been modified, as described in the section of “Synthetic polymer constituting gel body”. The treatment for introducing the functional group and the timing of the treatment are the same as those described in the column of “Synthetic polymer constituting gel body”.

The polymerizable unsaturated monomer forming the hydrophilic synthetic polymer and the crosslinkable unsaturated monomer copolymerizable with the polymerizable unsaturated monomer described in the above (ii) also include: The same polymers as those described in the section of “Synthetic polymer constituting gel body” described above can be used. Regarding the crosslinkable factor used for introducing the network structure into the hydrophilic synthetic polymer, the same as those described in the section of “Synthetic Polymer Constituting Gel Body” described above can be mentioned.

When the copolymerization of a polymerizable unsaturated monomer and a crosslinkable unsaturated monomer is used as a method for introducing a network structure into the hydrophilic synthetic polymer, the blending amount of the crosslinkable unsaturated monomer is used. Is preferably 0.005 to 0.5% with respect to the gel body. When the amount is less than 0.005%, it is difficult to obtain a gel body having sufficient waist strength, and the shape retention of the gel body becomes unstable. The operability may be degraded due to tearing. Conversely, if the compounding amount exceeds 0.5%, the brittleness of the obtained gel body increases, and there is a possibility that cutting or breaking may easily occur due to tensile stress or compressive stress.

On the other hand, as a method for introducing a network structure into a hydrophilic synthetic polymer, when a crosslinked structure of a hydrophilic synthetic polymer and a crosslinkable factor is used, the crosslinkable factor is a polyvalent metal ion compound. In this case, the compounding amount of the polyvalent metal ion compound is preferably 0.1 to 10% based on the gel body. When the crosslinking factor is a polycarboxylic acid or a polyhydric alcohol, the amount of the polyvalent carboxylic acid or the polyhydric alcohol to be added is 0.1 to the gel body.
It is preferably 1 to 5%. When the crosslinking factor is a polyfunctional epoxide or dialdehyde,
The compounding amount of the polyfunctional epoxide or dialdehyde is preferably 0.01 to 3% based on the gel. When the amount of the crosslinking factor such as a polyvalent metal ion compound is less than the above range, the resultant synthetic polymer gel body has a low waist strength, and the gel body becomes unstable in shape retention. When used, the adhesive gel sheet for use may be torn off and the operability may be impaired. Conversely, if the compounding amount exceeds the above range, the brittleness of the gel body increases, and there is a possibility that cutting or breaking may easily occur due to tensile stress or compressive stress.

Among the crosslinking factors used as the curing agent, polycarboxylic acids, polyhydric alcohols, polyfunctional epoxides and dialdehydes are listed in the above-mentioned "Synthetic polymer constituting gel body". The same ones as illustrated can be used. In addition, the polyvalent cation among the crosslinkable factors used as a curing agent refers to all divalent or higher cations, and among them, from the viewpoint of crosslinking reaction efficiency, for example, Al ³⁺ , Fe ³⁺ , Ti ^{3 +} , In ³⁺ , Zr
Trivalent or higher-valent ions such as ⁴⁺ and Ta ⁵⁺ are preferably used.

The form of the polyvalent cation may be a water-soluble salt such as aluminum chloride, for example, and an optimum one may be appropriately selected according to the production method. That is, if the purpose is to obtain an immediate effect on the curing treatment, a curing treatment agent to be used or a salt having solubility with the solvent contained in the synthetic polymer gel may be selected. For example, when the purpose is to carry out over 1 hour or more, a salt which is hardly soluble in the solvent contained in the curing agent or the synthetic polymer gel used may be selected.

The combination of the hydrophilic synthetic polymer and the crosslinkable agent in the curing treatment is, among the above, particularly preferred from the viewpoint of easier production, of a polymerizable unsaturated monomer having at least an anionic functional group. A combination of a hydrophilic synthetic polymer obtained by polymerizing a monomer and a crosslinking factor having at least a polyvalent cation is preferred. The anionic functional group refers to all functional groups capable of chemically bonding to cations in water, and from the viewpoint of easy production, a carboxyl represented by -COOH or -COOX (X; counter ion). Groups are preferred.

The curing agent applied to at least one surface of the gel sheet comprising the synthetic polymer gel constituting the pressure-sensitive adhesive gel sheet for living body of the present invention may contain a solvent or the like together with the above-mentioned crosslinking factor. Examples thereof include monoalcohols such as water and ethyl alcohol, glycols such as 1,3-butylene glycol, and polyhydric alcohols such as glycerin. As described above, the crosslinkable factor may be dissolved in such a solvent or may be in the form of a slurry without being dissolved. Further, the curing agent may contain various additives as necessary.

In the curing treatment in the present invention, at least one surface of a gel sheet made of a synthetic polymer gel may be treated, and the treated surface is a surface which comes into contact with a portion to be adhered to the skin. Or a non-contact surface on the opposite side. Further, for the surface to be treated, a uniform treatment amount may be applied to the entire surface, or the treatment amount may be partially non-uniform,
Further, only a part of the surface to be treated may be treated. The curing treatment may be performed using any method as long as the solvent constituting from inside the gel body oozes out by increasing the crosslink density in the vicinity of the treated part of the gel body surface compared to the inside of the gel body. Good. When only a part of the surface of the gel body is cured, it is preferable to treat an area of 10% or more of the whole surface to be treated. If it is less than 10%, the exudation of the constituent solvent from the inside of the gel body caused by the curing treatment does not appear remarkably, and there is a possibility that the moisturizing property and cooling feeling given to the skin become insufficient.

In the curing treatment of the present invention, the amount of the curing agent applied to the surface of the gel sheet composed of the synthetic polymer gel is represented by the crosslinking equivalent of the crosslinking factor when the surface of the gel is treated. It is preferably 1 × 10 ⁻¹⁰ to 1 × 10 ⁻² equivalent per 1 cm ^{2 of} the surface. If the treatment amount is ^less than 1 × 10 ⁻¹⁰ eq / cm ² , the solvent constituting the inside of the synthetic polymer gel does not exude significantly, and the moisture retention and cooling feeling given to the skin may be insufficient. There is. On the other hand, the processing amount is 1 × 10 ^-2 equivalent / cm ²
Is reached, it is no longer sufficient for the hardening treatment to take effect any more. Here, the cross-linking equivalent of the cross-linking factor refers to the amount of the cross-linking points of the cross-linking factor expressed in moles.

In the curing treatment of the present invention, in order to more effectively exude the solvent from the inside of the cured synthetic polymer gel, the synthetic polymer gel having a network structure having a network structure is required. Number of moles of monomer constituting the molecule 1
The amount (molar number) of the cross-linking points constituting the synthetic polymer gel is preferably 0.001 to 8.0, more preferably 0.01 to 5.0 with respect to 00. When the amount of the crosslinking point is below the above range, the shape retention of the gel body becomes unstable, and the bioadhesive gel sheet thus obtained is
During use, the operability may be deteriorated due to tearing. On the other hand, when the amount of the crosslinking point exceeds the above range, the crosslinking density inside the gel body is too high, and the effect of oozing out the solvent from the inside of the gel body becomes small even when the curing treatment is performed. Further, in order to more effectively exude the solvent from the inside of the gel body by the curing treatment, in addition to water as a solvent constituting the synthetic polymer gel body, glycols such as 1,3-butylene glycol, glycerin, etc. It is preferable that the content of the polar solvent such as polyhydric alcohols is 1% or more, more preferably 5% or more, based on the gel body. By including a polar solvent other than water as a solvent for the gel body in this manner, the water itself, which is a solvent for the gel body, can be easily exuded. Furthermore, if the matrix of the network structure constituting the gel body is too large, the ability of the gel body itself to contain the solvent becomes too strong, and even if the gel body is subjected to a curing treatment, the solvent is leached from the inside of the gel body. The degree of is smaller. For example, in the case where the method for producing the synthetic polymer constituting the gel body is a crosslinked structure obtained by reacting the hydrophilic synthetic polymer described in the above (b) with a crosslinkable factor, the hydrophilic synthetic polymer used for the above-mentioned reason is used. Preferably, 50% or more of the polymer has a molecular weight of 100,000 or less. However, when 50% or more of the hydrophilic synthetic polymer used has a molecular weight of less than 1,000, the shape retention of the gel body becomes unstable, and the bioadhesive gel sheet thus obtained is torn when used. Operability may be degraded. The curing agent used in the present invention may contain an additive such as a medicinal component described below as long as the curing of the adhesive gel sheet is not hindered.

[Structure of Adhesive Gel Sheet] The adhesive gel sheet for living body of the present invention comprises a synthetic polymer gel having a network structure containing at least water as a solvent. For the purpose of improving the tear strength and handleability of the pressure-sensitive adhesive gel sheet without impairing the properties, a woven or nonwoven fabric having a sufficiently large opening ratio can be provided inside the gel body in the thickness direction. In the present invention, a woven fabric or a nonwoven fabric having a large aperture ratio means a material having a wide aperture ratio (maintaining transparency) such that a 10-point type can be read even through a woven fabric or a nonwoven fabric. Say.

The thickness of the pressure-sensitive adhesive gel sheet of the present invention may be appropriately set according to the condition of use, and may be uniform throughout or partially different in thickness. Considering the uncomfortable feeling and strength at the time, the thickness is preferably in the range of 0.1 to 3 mm. If the thickness of the entire adhesive gel sheet is less than 0.1 mm, the strength of the adhesive gel sheet may be reduced. On the other hand, if it exceeds 3 mm, the self-weight of the sheet becomes too large, and there is a possibility that an uncomfortable feeling may be caused when the sheet is attached to the skin. If the entire pressure-sensitive adhesive gel sheet is not thick, it is possible to partially increase the thickness of the sheet to about 6 mm.

[Additives] In the pressure-sensitive adhesive gel sheet for living body of the present invention, the synthetic polymer gel constituting the pressure-sensitive adhesive gel sheet may include not only a synthetic polymer containing at least water but also the purpose of use of the pressure-sensitive adhesive gel sheet. Various additives can be appropriately compounded (that is, depending on the application to cosmetics, quasi-drugs, etc.). However, when obtaining a transparent bioadhesive gel sheet, it is necessary to select and use an additive such as a coloring agent such as a pigment during the production of the gel body so as not to make the gel body opaque. .

The curing agent used in the present invention includes, in addition to a solvent, a crosslinking agent that reacts with the synthetic polymer gel to increase the crosslink density of the gel, and a curing agent. Various additives can be appropriately compounded depending on the use form and the like. As such additives, for example, in addition to medicinal ingredients intended for treatment of beauty, beauty and skin, etc., humectants, thickeners, fragrances, coloring agents, stabilizers, antioxidants, ultraviolet absorbers, tackifiers , PH adjusters, chelating agents, surfactants, preservatives, antibacterial agents and the like.

The above-mentioned medicinal components are not particularly limited as long as they are conventionally used in pharmaceuticals, quasi-drugs, cosmetics, sanitary materials, miscellaneous goods, etc., for example, Ashitaba extract, Avocado extract, Amacha extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Apricot kernel extract, Ginkgo extract, Fennel extract, Turmeric extract, Oolong tea extract, Age extract, Echinashi leaf extract, Ohgon extract, Obaaku extract, Ouren extract, Barley extract, St. John's wort extract, Spicewort extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, sagebrush extract, licorice extract, calcadae Vinegar, song extract, kiwi extract, cinchona, cucumber extract, guanosine,
Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentian extract,
Black tea extract, yeast extract, burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen,
Cowberry extract, Saishin extract, Psychoextract, Saitai extract, Salvia extract, Sabonso extract, Sasa extract, Hawthorn extract, Sansho extract, Shiitake extract, Jio extract, Shikon extract, Perilla extract, Shinanoki extract, Shimotsukeiso extract, Peony extract, Shobu root extract , Birch extract, horsetail extract, vegetative extract, hawthorn extract,
Western elderberry extract, Achillea millefolium extract, Common mint extract, Sage extract, Genus mallow extract, Senkyu extract, Assembly extract, Soybean extract, Tissou extract, Thyme extract, Tea extract, Clove extract, Chigaya extract, Chimpanzee extract, Touki extract, Calendula extract, Tonin extract , Spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, nobara extract, hibiscus extract, bakkumondou extract, parsley extract, honey, hamamelis extract, Parietaria extract, chickpea extract, bisabolol, loquat extract, coltsfoot extract , Fukinotou extract, kukuroyou extract, butcher bloom extract, grape extract, propolis, loofah extract, safflower Vinegar, peppermint extract, lime extract, button extract, hops extract, pine extract, horse chestnut extract, skunk cabbage extract, Sapindus extract, Melissa extract, peach, cornflower extract, eucalyptus extract, saxifrage extract, Yuzuekisu,
Yokuinin extract, mugwort extract, lavender extract,
Examples include apple extract, lettuce extract, lemon extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like.

Also, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes; amino acids, sodium lactate, urea, sodium pyrrolidone carboxylate; Moisturizing ingredients such as betaine, whey, trimethylglycine, raffinose; sphingolipids, ceramide, cholesterol,
Oil components such as cholesterol derivatives and phospholipids; anti-inflammatory agents such as ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, hydrocortisone; vitamins A, B ₂ , B ₆ , C, D,
E, vitamins such as calcium pantothenate, biotin, nicotinamide, and vitamin C ester; active ingredients such as allantoin, diisopropylamine dichloroacetate, and 4-aminomethylcyclohexanecarboxylic acid; tocopherols, carotenoids, flavonoids, tannins, lignans, and saponins Cell activators such as α-hydroxy acids and β-hydroxy acids; blood circulation promoters such as γ-oryzanol and vitamin E derivatives; wound healing agents such as retinol and retinol derivatives; arbutin, kojic acid and placenta Whitening agents such as extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione; cepharanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride,
dl-α-tocopherol, dl-α-tocopherol acetate, nicotinic acid, nicotinic acid derivatives, calcium pantothenate, D-pantothenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinylesteradiol, Capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, tacanal, camphor, salicylic acid, vanillylamide nonylate, vanillylamide nonanoate, pyroctonolamine, glyceryl pentadecanoate, l-menthol, mononitroguaiacol, resorcinol, γ-aminobutyric acid, chloride Benzethonium, mexiletine hydrochloride, auxin, female hormones, cantharistinus, cyclosporine, hydrocortisone,
Polyoxyethylene sorbitan monostearate, peppermint oil, analgesics, tranquilizers, antihypertensives, antibiotics, antihistamines, antibacterials, plant-derived components, seaweed-derived components, and the like are also included. As the medicinal component, it is preferable that one or more components having a whitening effect and a component having an anti-inflammatory effect and an antioxidant effect are blended.

The compounding amount of the medicinal component cannot be specified unconditionally because the amount of the active component varies depending on the material, but is generally 0.001 to 80% with respect to the total amount of the bioadhesive gel sheet.
Is preferably, and more preferably 0.05 to 10%. Examples of the humectant include ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, dipropylene glycol, glycerin, diglycerin, sorbitol, malbitol, trehalose, raffinose, xylitol, mannitol, hyaluronic acid and salts thereof, polyethylene glycol, polyglycerin and the like. Glycols, polyhydric alcohols and polysaccharides. These can be used alone or in combination of two or more.

As the thickening agent, those having a relatively small amount and having a certain viscosity in the mixed solution are preferable, and examples thereof include water-soluble polymers such as polyethylene oxide and hydroxyethyl cellulose. The compounding amount of the thickener is preferably 0.01 to 20% with respect to the compounding liquid and / or the curing agent for forming the synthetic polymer gel, and is preferably 0.05 to 20%.
More preferably, it is 10% to 10%.

[Manufacturing Method of Biological Adhesive Gel Sheet] The manufacturing method of the biological adhesive sheet of the present invention will be described below, but the present invention is not limited thereto, but is only an example. As described above, the synthetic polymer gel forming the bioadhesive gel sheet of the present invention is characterized in that the synthetic polymer constituting the gel is (a) one or more polymerizable unsaturated monomers. And a copolymer of a monomer and a crosslinkable unsaturated monomer, or (b)
Polymerizing one or more polymerizable unsaturated monomers having at least one functional group selected from the group consisting of a carboxyl group, a sulfonic acid group, a hydroxyl group, an amide group, and an amino group on a side chain Reacting the resulting hydrophilic synthetic polymer with at least one crosslinking agent selected from the group consisting of polyvalent metal ion compounds, polycarboxylic acids, polyhydric alcohols, polyfunctional epoxides and dialdehydes The crosslinked structure obtained is preferred.

Production of a synthetic polymer gel when the copolymer of the polymerizable unsaturated monomer and the crosslinkable unsaturated monomer (a) is used as a synthetic polymer constituting a gel. Examples of the method include a method in which a polymerizable unsaturated monomer, a crosslinkable unsaturated monomer, and a polymerization initiator are added to a solvent constituting the gel to perform polymerization. For the polymerization, a system in which the polymerization is started by heating or light irradiation or by adding a polymerization initiator may be selected.

On the other hand, when the crosslinked structure obtained by reacting the hydrophilic synthetic polymer of (b) with a crosslinkable factor is used as the synthetic polymer constituting the gel, the production of the synthetic polymer gel is carried out. As a method, for example, previously dissolving a hydrophilic synthetic polymer polymerized in the same manner as described above,
A method of adding a crosslinking factor to this solution to carry out a crosslinking reaction may be mentioned. The crosslinking reaction may be initiated by heating,
It may be started by adding a reaction initiator. Alternatively, a system in which a crosslinking reaction starts immediately upon addition of a crosslinking factor may be selected.

In the case where a gel is obtained by polymerizing the unsaturated monomer of the above (a), when thermal polymerization is carried out using a solution containing the above-mentioned monomer and solvent, azobiscyanovaleric acid or Azo-based polymerization initiators such as azobisaminopropane dihydrochloride, or reducing agents such as ferrous sulfate, dithionite, pyrosulfite and hydrogen peroxide, t-butyl hydroperoxide, peroxodisulfate The polymerization can be carried out by adding a redox polymerization initiator comprising a peroxide such as These azo-based polymerization initiators and redox-based polymerization initiators may be used alone or in combination as needed. In the case where a redox polymerization initiator is used, a system in which polymerization is initiated only by adding it without heating may be used. In the case of photopolymerization, photoradical polymerization initiators such as acetophenone, benzoin ether, phosphorus, benzophenone, thioxanthone, and azo, and cationic photopolymerization such as diazonium salts, diallyliodonium salts, and triarylsulfonium salts. Polymerization can be carried out by adding an initiator or the like.

The thickness of the synthetic polymer gel forming the pressure-sensitive adhesive gel sheet of the present invention is adjusted by, for example, using an extruder or a doctor blade with respect to the gel-forming composition before the curing of the gel. It is performed by spreading using a container or filling a container having a predetermined thickness.
In the latter method of filling a container having a predetermined thickness, if the shape of such a container is formed according to the shape of the bioadhesive gel sheet at the time of use, the in-line manufacturing process becomes easy, which is preferable in the manufacturing process. Becomes further,
Compared to the method of forming a long belt-like gel body and punching it into the intended shape at the time of use, the amount of generated gel to be discarded is suppressed, and since there is no contact between the gel body and the punching blade, it is sanitary. It is also preferable from the viewpoint of certain things.

The bioadhesive gel sheet of the present invention is obtained by subjecting at least one entire surface or a part of a gel sheet made of a synthetic polymer gel body to a curing treatment, whereby the gel body in the vicinity of the cured part is crosslinked. By increasing the density compared to the inside of the gel body, it is characterized by exuding the solvent constituting the inside of the gel body, thereby maintaining the close contact and the feeling of occlusion of the gel body with the skin. It is characterized in that a bioadhesive gel sheet excellent in moisture retention and cooling sensation imparted to the skin can be obtained.

The time at which the entire surface or at least a part of the surface of the gel sheet made of the synthetic polymer gel is subjected to the curing treatment, even after the completion of the curing of the synthetic polymer gel, May be before the end. In addition, "the hardening of the gel body is completed" in the present invention.
"It means that the formulation before gelation caused a gelling reaction to be in a state having shape retention.

Among the above-mentioned curing treatments, in the treatment for applying the curing treatment agent as described above, the curing treatment agent is applied to at least one surface of the cured gel body by using, for example, a coater, a printing machine, a brush or the like. The curing agent may be applied by a method such as spray coating or spraying. The method of applying the curing agent may be the same as described above, even when the surface of the gel body is subjected to the treatment before the curing is completed. It is desirable to have the above viscosity. Such a viscosity is 1,000 when the thickness has been adjusted.
Millipascal seconds or more are preferred. When the viscosity of the gel-forming composition at the time of processing with the curing agent is less than 1,000 millipascal seconds, the gel-forming composition and the curing agent are mixed, and the surface of the resulting adhesive gel sheet is The difference in the crosslink density between the inside and the inside hardly appears, and as a result, there is a possibility that the solvent does not ooze out from the inside of the gel body.

In the case where the curing agent is applied before the curing of the gel body is completed, by applying the curing agent before adjusting the thickness of the gel-forming composition, the surface of the produced adhesive gel sheet can be Differences in crosslink density can also be generated internally. In this case, a curing treatment agent is interposed in a sheet in which a curing treatment agent can be interposed (hereinafter, referred to as an interposition sheet), and the interposition sheet is placed on the gel-forming composition before the completion of curing. The thickness of the gel-forming composition before curing is adjusted using a doctor blade, a squeegee, or the like. As a result, the curing agent held by the interposed sheet can be transferred to the gel-forming composition,
By allowing this to stand until the completion of the curing of the gel body, an adhesive gel sheet having a different cross-linking density between the target surface and the inside can be obtained. When a curing treatment is performed before adjusting the thickness as in such a production method, the viscosity of the gel-forming composition is preferably 10,000 to 2,000,000 millipascal seconds. When the viscosity is less than 10,000 millipascal seconds, the gel-forming composition and the curing agent are mixed, and the difference in the crosslink density between the surface and the inside of the obtained pressure-sensitive adhesive gel sheet is less likely to appear. ,
Exudation of the solvent from the inside of the gel body may not occur much. Conversely, if it exceeds 2,000,000 millipascal seconds, it becomes difficult to adjust the thickness of the gel-forming composition itself.

The interposed sheet may be any sheet as long as it can interpose a curing agent, for example, a plastic sheet, a sponge sheet,
Paper, woven fabric, non-woven fabric and the like can be used. Above all, the intervening sheet is preferably a plastic sheet or the like which can be easily peeled off since the living body adhesive gel sheet is peeled off by the time of use. Further, a thickener can be added to the curing agent in order to facilitate the interposition of the curing agent in the interposed sheet.

On the surface of the adhesive gel sheet for a living body of the present invention, an interposed sheet of a plastic film such as polyethylene, polypropylene, polyethylene terephthalate or the like is exposed or a gel body is exposed until it is actually used. It is preferable from the viewpoint of hygiene that the surface of the plastic film is applied or baked with a release agent such as a silicone resin on the surface of the plastic film as a release sheet. That is, it is preferable to attach a release sheet or the like so that both sides of the gel body are not exposed from the viewpoint of preventing drying of the adhesive gel sheet and hygiene considerations.

It is necessary to peel off the released release sheet or the like at the time of use since the release sheet or the like cannot sufficiently follow the movement of the skin surface due to its poor flexibility.
If the release sheet or the like is used with the release sheet or the like adhered to the surface that is not adhered to the skin, the release sheet or the like will be peeled off from the adhesive gel sheet during use, making it difficult to handle. The release sheet may be used as an underlay or a surface material during the gel production process of the adhesive gel sheet, or may be attached after the production of the adhesive gel sheet is completed.

The shape of the bioadhesive gel sheet of the present invention is not particularly limited, but may be elliptical, circular, heart-shaped, semicircular, semielliptical, square, rectangular, trapezoidal, triangular, shaped along the application site, Alternatively, a combination of these may be used, and a shape that can be most appropriately stuck to a part to be used may be appropriately designed. In addition, if a convex portion or a concave portion is provided at the center portion or the peripheral portion of the adhesive gel sheet for the purpose of alignment or the like, or a notch or a hollow portion is provided according to the shape of the used portion, the handleability of the adhesive gel sheet is improved. Can be. The pressure-sensitive adhesive gel sheet of the present invention is, for example, housed in a sealed aluminum laminated bag, or vacuum molded or pressure-formed a plastic sheet of polypropylene, polyester, or the like, or formed a concave portion obtained by plastic injection molding. The gel sheet is stored in the concave portion of the molded product having the gel product, and the surface of the molded product is stored in a blister container thermally bonded with an aluminum sheet on which a thermal adhesive layer is laminated. In particular,
It is preferable that the molded article be housed in a transparent blister container because the housed adhesive gel sheet can be seen through and confirmed.

The application site of the bioadhesive gel sheet of the present invention includes a face (lips, cheeks, eyes, upper and lower eyes, nose,
Forehead), arms, legs, chest, abdomen, back, neck and the like. The shape, area, and thickness of the pressure-sensitive adhesive gel sheet for living body, the pressure-sensitive adhesive properties of the pressure-sensitive adhesive surface, and the like may be appropriately adjusted according to the application site. For example, when forming an adhesive gel sheet in which the application site is the entire face, as shown in FIG. 1, a portion corresponding to the position of the eyes and the mouth is cut out, and a portion corresponding to the position of the nose is cut. Further, since the bonding area is large, it is preferable to make an adjustment such as increasing the adhesive strength of the adhesive surface or reducing the thickness.

The adhesive gel sheet of the present invention preferably uses a basic cosmetic or pharmaceutical such as lotion, cream, emulsion, essence, ointment or the like before and after its use. Is possible. Further, it is preferable to use the pressure-sensitive adhesive gel sheet of the present invention after cooling in a refrigerator in advance, since the cooling feeling is maintained and the effect becomes clear. In addition, it is preferable to use the product after warming it with warm water or a bath because it can promote blood circulation in autumn and winter and enhance the transdermal absorbability of medicinal ingredients.
When the pressure-sensitive adhesive gel sheet of the present invention is used as a cosmetic, it depends on the properties and amounts of the components, for example, a whitening effect,
Skin conditioning, moisturizing, calming hot after sunburn,
Wrinkle improvement effect, anti-aging effect, rough skin improvement effect, swelling improvement effect, lipolysis effect (slimming effect), waste removal effect, makeup glue improvement effect, skin turnover optimization effect, bear improvement effect, blood circulation promotion effect And so on.

[0065]

The following examples, comparative examples and drawings are used.
The present invention will be described in more detail. [Manufacture of Living Body Adhesive Gel Sheet] Example 1 A living body adhesive gel sheet was manufactured by the following manufacturing method. Table 1 shows the compositions of the synthetic polymer gel-forming composition (gel-forming composition) and the curing agent used in the production of the bioadhesive gel sheet.

(Table 1) Composition (%) --------------------------------------- -------------------------- <Formulation for forming gel body> Hydrophilic synthetic polymer polyacrylic acid (molecular weight: about 10,000) 5 Sodium polyacrylate (molecular weight: about 4 million) 4.0 Crosslinking factor Synthetic aluminum silicate (Al content: 5.6%) 2.3 Moisturizer 1,3-butylene glycol 10.0 Preservative Sodium dehydroacetate 0.3 Pharmaceutical Ingredients Vitamin C 3.0 Purified Water Remaining Total 100.0 <Curing Agent> Crosslinking Factor Aluminum Chloride Hexahydrate (Al Content: 11%) 10.0 Solvent Purified Water Remaining Total 100 .0

The components excluding the crosslinking factor (synthetic aluminum silicate) among the gel-forming compounds shown in Table 1 were mixed and kneaded at 50 ° C. for about 30 minutes to make them uniform. Then
The crosslinking factor was added, and the mixture was further kneaded at 60 ° C. for about 10 minutes to be uniform. The gel-forming composition thus obtained was applied to a polypropylene sheet (thickness 10) as an underlaying material.
0 μm) with a doctor blade to a thickness of 0.8 mm
And the mixture was left at room temperature for about 2 hours to complete the curing of the gel, thereby obtaining a sheet-shaped synthetic polymer gel.

On one surface of the sheet-shaped synthetic polymer gel, a curing agent shown in Table 1 (ie, a crosslinking factor (aluminum chloride hexahydrate) dissolved in a solvent (purified water)) was brushed. The hardening treatment of the synthetic polymer gel was carried out by applying the same uniformly using the above method.The amount of the hardening agent applied was 3 m per 1 cm ² of the surface of the synthetic polymer gel.
g (that is, 1 × 10 ⁻⁶ equivalent / cm ^{2 in} terms of crosslinking equivalent).

Further, a release sheet of a 50 μm-thick polypropylene sheet is placed on the surface of the synthetic polymer gel body on which the curing agent has been applied, and the shape shown in FIG. 1 (face mask shape; length) X = 180mm, y = 2
20 mm) to obtain the desired final product of the adhesive gel sheet. This was stored and stored in a bag laminated with aluminum.

Example 2 A woven fabric was prepared in the same manner as in Example 1 except that a 15-denier nylon tulle woven fabric having a large aperture ratio was immersed in the intermediate layer of the gel-forming composition. Was obtained and a laminated final product was obtained. This was housed in a bag laminated with aluminum and sealed.

Example 3 In Example 1, instead of the polypropylene sheet as the underlaying material, a small aperture ratio and a basis weight of 100 g / m ^{2 were used.}
In the same manner as in Example 1 except that the nonwoven fabric of Example 1 was used, an intended final product in which a gel body was laminated on the nonwoven fabric was obtained. This was housed in a bag laminated with aluminum and sealed.

Comparative Example 1 A conventional pressure-sensitive adhesive sheet obtained by laminating a gel body on a nonwoven fabric in Example 1 using a nonwoven fabric having a basis weight of 100 g / m ² instead of the polypropylene sheet as an underlaying material without treating with a curing agent I got This was housed in a bag laminated with aluminum and sealed.

Comparative Example 2 A commercially available lotion was applied to a nonwoven fabric having a basis weight of 100 g / m ² punched into the shape shown in FIG. 1 to produce an impregnated sheet type conventional product, which was laminated with aluminum. And sealed.

Each of the products obtained above was used as a specialized panel 1
The results of the comprehensive evaluation based on the following criteria are shown below with the number of people who used and attached sensory evaluations to the face, and evaluated each item as good. ○: 7 to 10 people ×: 0 to 6 people

<Effects> Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 ----------------------------- ---------------------------------- Moisture retention ○ ○ ○ × ○ Cool feeling ○ ○ ○ × ○ Adhesion ○ ○ ○ ○ × Occlusion feeling ○ ○ ○ ○ × Transparency ○ ○ × × × Cool feeling persistence ○ ○ ○ × ×

Example 4 In the same manner as in Example 1, a plurality of target adhesive gel sheets (1) were punched into the five shapes shown in FIG. 2 using the components shown in Table 2 below. Then, an adhesive gel sheet (1) is housed in each concave portion (5) of a vacuum molded product (4) made of a transparent polypropylene sheet and having five concave portions (5), and an aluminum sheet on which a thermal adhesive layer is laminated. It was sealed and stored in the blister container thermally bonded in (6).

(Table 2) Composition (%) --------------------------------------- -------------------------- <Formulation for forming gel body> Hydrophilic synthetic polymer polyacrylic acid (molecular weight about 10,000) 20. 0 Sodium polyacrylate (molecular weight of about 4 million) 4.0 Crosslinking factor Synthetic aluminum silicate (Al content: 5.6%) 3.1 Humectant 1,3-butylene glycol 10.0 Preservative Sodium dehydroacetate 0.3 Pharmaceutical Ingredient Vitamin C 3.0 Purified Water Remaining Total 100.0 <Curing Agent> Crosslinking Factor Aluminum Chloride Hexahydrate (Al Content: 11%) 1.0 Solvent Purified Water Remaining Total 100 .0

The amount of the curing agent applied was 3 mg per 1 cm ² of the surface of the synthetic polymer gel body (that is, 1 ×
10 ^-7 equivalents / cm ² ).

Example 5 In the same manner as in Example 4, using the components shown in Table 3 below, a plurality of target adhesive gel sheets (1) were punched into the five shapes shown in FIG. . Then, an adhesive gel sheet (1) is housed in each recess (5) of a vacuum molded product (4) made of a transparent polypropylene sheet and having a recess (5), and an aluminum sheet (6) on which a thermal adhesive layer is laminated. And sealed in a blister container that was heat bonded.

(Table 3) Composition (%) --------------------------------------- -------------------------- <Formulation for forming gel body> Hydrophilic synthetic polymer polyacrylic acid (molecular weight: about 10,000) 0 Sodium polyacrylate (molecular weight about 4,000,000) 6.0 Crosslinking factor Synthetic aluminum silicate (Al content: 5.6%) 3.1 Humectant 1,3-butylene glycol 10.0 Preservative Sodium dehydroacetate 0.3 Pharmaceutical Ingredients Vitamin C 3.0 Purified Water Remaining Total 100.0 <Curing Agent> Crosslinking Factor Ferric Chloride (Fe Content: 35%) 10.0 Solvent Purified Water Remaining Total 100.0

The amount of the curing agent applied was 3 mg per 1 cm ² of the surface of the synthetic polymer gel (that is, 2 ×
10 ⁻⁶ equivalents / cm ² ).

[0082]

The adhesive gel sheet for a living body of the present invention satisfies the moisturizing property and the cooling sensation or the adhesiveness and the occlusive feeling on the skin.

[Brief description of the drawings]

FIG. 1 is a plan view showing an adhesive gel sheet according to one embodiment of the present invention.

FIG. 2 is a plan view showing a state in which an adhesive gel sheet according to another embodiment of the present invention is housed in a blister container.

FIG. 3 is a cross-sectional view of the blister container of FIG. 2 sealed with an aluminum sheet and cut in the XX ′ direction.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Adhesive gel sheet 2 Underlay material 3 Release sheet 4 Vacuum molded product 5 Depression 6 Aluminum sheet

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61L 15/16 C08J 7/00 CEYA C08J 7/00 CER C08L 33:02 CEY 101: 00 // C08L 33:02 A61L 15 / 06 101: 00 15/01 (72) Inventor Yasushi Hayashi 7-1-33, Oanji, Nara City, Nara Prefecture (72) Inventor Kozo Sakai 8-1-1407, Hakuhoji-cho, Nara City, Nara Prefecture (72) Inventor, Sato Shin-city Osaka, Higashi-Osaka Pref. 2-8-34 Tamagashi Motomachi (72) Inventor Takashi Higashi 585 Sakurai, Sakurai-shi, Nara No. 706 Laurel Coat Sakurai Minami 706 F term (reference) 4C076 AA71 BB31 CC24 DD23 DD27 DD38 DD59 EE09 EE47 4C081 AA03 AA12 BB01 BB06 CA081 CB041 CC05 DA02 4C083 AB222 AB232 AB372 AC122 AC842 AD091 AD092 AD642 BB36 BB60 CC02 DD01 DD12 DD41 DD47 EE06 EE07 FF01 4F073 AA05 AA08 BA18 EA56

Claims (8)

[Claims] 1. A gel sheet comprising a synthetic polymer gel body having at least water as a solvent and having a network structure, by subjecting at least one entire surface or a part thereof to a curing treatment so that the solvent constituting the gel body becomes a gel. An adhesive gel sheet for a living body, which is exuded on the body surface. 2. The living body adhesive gel sheet according to claim 1, wherein the curing treatment is to apply a curing treatment agent to at least one surface of the gel sheet. 3. The method according to claim 1, wherein the appearance is transparent or translucent.
Alternatively, the adhesive gel sheet for a living body according to claim 2. 4. The synthetic polymer constituting the synthetic polymer gel body is a hydrophilic synthetic polymer obtained by polymerizing a polymerizable unsaturated monomer having at least an anionic functional group, and
The bioadhesive gel sheet according to claim 2 or 3, wherein the curing agent contains a compound having at least a polyvalent cation. 5. The adhesive gel sheet for living body according to claim 4, wherein the anionic functional group is a carboxyl group. 6. The adhesive gel sheet for living body according to claim 4, wherein the polyvalent cation is an ion having three or more valences. 7. The bioadhesive gel sheet according to claim 1, wherein a woven or nonwoven fabric having a sufficiently large aperture ratio is contained therein. 8. The adhesive gel sheet for living body according to claim 1, wherein the gel sheet is contained in a blister container and is sealed.