JP2001089381A - Preparation for external use for skin - Google Patents
Preparation for external use for skinInfo
- Publication number
- JP2001089381A JP2001089381A JP26134899A JP26134899A JP2001089381A JP 2001089381 A JP2001089381 A JP 2001089381A JP 26134899 A JP26134899 A JP 26134899A JP 26134899 A JP26134899 A JP 26134899A JP 2001089381 A JP2001089381 A JP 2001089381A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- preparation
- external preparation
- mucopolysaccharide
- external use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 229920002527 Glycogen Polymers 0.000 claims abstract description 14
- 229940096919 glycogen Drugs 0.000 claims abstract description 14
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 13
- 239000002628 heparin derivative Substances 0.000 claims abstract description 7
- 235000013311 vegetables Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 abstract description 11
- 238000009472 formulation Methods 0.000 abstract description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract description 5
- 230000003020 moisturizing effect Effects 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 229920002387 Phytoglycogen Polymers 0.000 description 9
- BYSGBSNPRWKUQH-UJDJLXLFSA-N glycogen Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)O1 BYSGBSNPRWKUQH-UJDJLXLFSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000008213 purified water Substances 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 6
- 239000008346 aqueous phase Substances 0.000 description 5
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 229920002567 Chondroitin Polymers 0.000 description 3
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229920002971 Heparan sulfate Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- -1 Polyoxyethylene Polymers 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 241000209149 Zea Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 102220240796 rs553605556 Human genes 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- XEFAJZOBODPHBG-UHFFFAOYSA-N 1-phenoxyethanol Chemical compound CC(O)OC1=CC=CC=C1 XEFAJZOBODPHBG-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940094517 chondroitin 4-sulfate Drugs 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は皮膚外用剤に関し、
さらに詳しくは良好な使用感を有し、優れた保湿効果を
有する皮膚外用剤に関する。TECHNICAL FIELD The present invention relates to an external preparation for skin,
More specifically, the present invention relates to a skin external preparation having a good feeling in use and an excellent moisturizing effect.
【０００２】[0002]
【従来の技術】皮膚外用剤は、商品性の点から良好な使
用感を得ることが重要である。特に、肌に対する保湿効
果を期待する外用剤については、その使用感が効き目感
にもつながるため、使用感は商品性の点から特に重要で
ある。2. Description of the Related Art It is important for a skin external preparation to obtain a good feeling in use from the viewpoint of marketability. In particular, with regard to external preparations that are expected to have a moisturizing effect on the skin, the feeling of use is also effective, and the feeling of use is particularly important from the viewpoint of commercial properties.
【０００３】植物性グリコーゲンは、トウモロコシなど
の植物中に存在する貯蔵多糖であり、植物性グリコーゲ
ンであるフィトグリコーゲン（商品名）はα−１，４結
合からなるグルコース鎖がα−１，６結合で高度に枝分
かれした構造を持つ、グルコースからなる多糖類であ
り、保湿剤などとして使用されている（FRAGRANCE JOUR
NAL 1998-3 49）。また、植物性グリコーゲンは、特開
平１１−１８０８１８号公報記載のように外用剤の使用
感を向上させるために有用であることが開示されてい
る。[0003] Vegetable glycogen is a storage polysaccharide that is present in plants such as corn. Phytoglycogen (trade name), which is a vegetable glycogen, has a glucose chain composed of α-1,4 bonds having α-1,6 bonds. Is a polysaccharide composed of glucose with a highly branched structure and is used as a humectant (FRAGRANCE JOUR
NAL 1998-3 49). Further, as disclosed in JP-A-11-180818, it is disclosed that vegetable glycogen is useful for improving the feeling of use of an external preparation.
【０００４】従来、その他にもムコ多糖類をはじめとし
て多数の成分が保湿剤として使用されている。[0004] Conventionally, many other components such as mucopolysaccharides have been used as humectants.
【０００５】しかし、保湿効果、使用感共により良いも
のが求められていた。[0005] However, there has been a demand for a better moisturizing effect and a better feeling in use.
【０００６】[0006]
【発明が解決しようとする課題】本発明は従来の保湿剤
と比較して、さらに保湿効果が有り、使用感が良好な外
用剤を得ることを目的とする。SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation having a more moisturizing effect and a better feeling of use as compared with conventional humectants.
【０００７】[0007]
【課題を解決するための手段】本発明者らは種々検討し
た結果、皮膚外用剤中にムコ多糖類および植物性グリコ
ーゲンを同時に配合すると、それぞれ単独では得られな
い優れた保湿効果と、良好な使用感を併せ持つ皮膚外用
剤となることを見出し本発明を完成した。As a result of various studies, the present inventors have found that, when mucopolysaccharide and vegetable glycogen are simultaneously added to a skin external preparation, an excellent moisturizing effect which cannot be obtained by itself and a good moisturizing effect can be obtained. The present inventors have found that the composition is an external preparation for skin having a feeling of use and completed the present invention.
【０００８】すなわち本発明はムコ多糖類および植物性
グリコーゲンからなる皮膚外用剤である。That is, the present invention is an external preparation for skin comprising mucopolysaccharide and vegetable glycogen.
【０００９】[0009]
【発明の実施の形態】本発明でムコ多糖類とはコンドロ
イチン４−硫酸、コンドロイチン６−硫酸、デルマタン
硫酸、ヒアルロン酸、ヘパラン硫酸、ケラタン硫酸、ヘ
パリン、低分子ヘパリン、ヘパリン類似物質またはそれ
らの塩などがあげられるが、保湿効果および使用感の点
からヘパリン類似物質が特に好ましい。BEST MODE FOR CARRYING OUT THE INVENTION The mucopolysaccharide in the present invention is chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate, hyaluronic acid, heparan sulfate, keratan sulfate, heparin, low molecular weight heparin, heparin analog or a salt thereof. And the like, but a heparin-like substance is particularly preferred from the viewpoint of moisturizing effect and feeling of use.
【００１０】ここで、ヘパリン類似物質とは、コンドロ
イチン多硫酸ともいわれるコンドロイチン硫酸をさらに
硫酸化した半合成のムコ多糖である。[0010] Here, the heparin-like substance is a semi-synthetic mucopolysaccharide in which chondroitin sulfate, which is also called chondroitin polysulfate, is further sulfated.
【００１１】ムコ多糖類の配合量は保湿効果の点から皮
膚外用剤全量の０．０１〜５重量％が好ましく、０．０
５〜２重量％がさらに好ましい。The amount of mucopolysaccharide is preferably 0.01 to 5% by weight of the total amount of the external preparation for skin from the viewpoint of moisturizing effect,
More preferred is 5 to 2% by weight.
【００１２】本発明で植物性グリコーゲンとは、植物由
来の分岐多糖体であるグリコーゲンのことであり、特に
トウモロコシ由来のものが好ましい。本発明で用いる植
物性グリコーゲンとしてはフィトグリコーゲンが特に好
ましい。In the present invention, the vegetable glycogen is glycogen which is a plant-derived branched polysaccharide, and is preferably a corn-derived glycogen. Phytoglycogen is particularly preferred as the vegetable glycogen used in the present invention.
【００１３】本発明で植物性グリコーゲンの配合量は、
皮膚外用剤全量の０．０１〜２０重量％が好ましく、
０．１〜１０重量％がさらに好ましい。In the present invention, the amount of the vegetable glycogen is as follows:
0.01-20% by weight of the total amount of the external preparation for skin is preferable,
0.1 to 10% by weight is more preferred.
【００１４】本発明の皮膚外用剤は、通常使用される配
合剤（薬効成分、吸収促進剤など）を配合し、通常の方
法で、液剤、ローション剤、クリーム剤、軟膏剤などの
一般的な製剤とすることができる。The external preparation for skin of the present invention is blended with commonly used compounding agents (medicinal ingredients, absorption enhancers, etc.) and prepared in a usual manner using a general solution such as a liquid, lotion, cream, ointment or the like. It can be a formulation.
【００１５】[0015]
【発明の効果】本発明により、良好な使用感を保ちつ
つ、皮膚に対する保湿効果を向上させる皮膚外用剤を提
供することが可能となった。According to the present invention, it has become possible to provide a skin external preparation which improves the moisturizing effect on the skin while maintaining a good feeling of use.
【００１６】[0016]
【実施例】以下、実施例および試験例により本発明をさ
らに詳細に説明する。 実施例１ 以下の処方の精製水に水相成分を溶かし、ジプロピレン
グリコールにフェノキシエタノールを溶かしたものを混
合し、ローション剤を得た。 ヘパリン類似物質 ０．３（重量％） フィトグリコーゲン ０．５ ウシ胎盤抽出物 ２．０ グリチルリチン酸ジカリウム ０．１ ジプロピレングリコール ５．０ グリセリン １０．０ パラベン ０．１ フェノキシエタノール ０．２ 精製水 全１００．０The present invention will be described in more detail with reference to the following Examples and Test Examples. Example 1 An aqueous phase component was dissolved in purified water having the following formulation, and a mixture of dipropylene glycol and phenoxyethanol was mixed to obtain a lotion. Heparin analog 0.3 (% by weight) Phytoglycogen 0.5 Bovine placenta extract 2.0 Dipotassium glycyrrhizinate 0.1 Dipropylene glycol 5.0 Glycerin 10.0 Paraben 0.1 Phenoxyethanol 0.2 Purified water Total 100 .0
【００１７】実施例２ 精製水に以下の組成の水相成分を溶解し、ここにエチル
アルコール、ジプロピレングリコールを混合し、ローシ
ョン剤を得た。 コンドロイチン４−硫酸ナトリウム １．０（重量％） フィトグリコーゲン ５．０ グリチルリチン酸モノアンモニウム ２．０ ジプロピレングリコール ３．０ ポリオキシエチレンソルビタン ３．０ モノラウリン酸エステル（２０Ｅ．Ｏ．） １．５ エチルアルコール ５．０ 乳酸ナトリウム 適量 精製水 全１００．０Example 2 An aqueous phase component having the following composition was dissolved in purified water, and ethyl alcohol and dipropylene glycol were mixed therein to obtain a lotion. Chondroitin 4-sodium sulfate 1.0 (% by weight) Phytoglycogen 5.0 Monoammonium glycyrrhizinate 2.0 Dipropylene glycol 3.0 Polyoxyethylene sorbitan 3.0 Monolaurate (20EO) 1.5 Ethyl Alcohol 5.0 Sodium lactate Appropriate amount Purified water Total 100.0
【００１８】実施例３ 以下処方を混合溶解し、ローション剤を得た。 ヒアルロン酸ナトリウム ０．１（重量％） フィトグリコーゲン ３．０ グリセリン ３．０ １，３−ブチレングリコール ２．０ ポリオキシエチレン硬化ヒマシ油 １．５ エチルアルコール ２．０ パラベン ０．１ 精製水 全１００．０Example 3 The following formulations were mixed and dissolved to obtain a lotion. Sodium hyaluronate 0.1 (% by weight) Phytoglycogen 3.0 Glycerin 3.0 1,3-butylene glycol 2.0 Polyoxyethylene hydrogenated castor oil 1.5 Ethyl alcohol 2.0 Paraben 0.1 Purified water All 100 .0
【００１９】実施例４ 以下の処方の油相成分を加温溶解し、これに加温した水
相成分を添加し、常法による乳化法により乳液を得た。 コンドロイチン６−硫酸ナトリウム ０．２（重量％） フィトグリコーゲン ０．５ グリチルレチン酸ステアリル ２．５ スクワラン ２．０ ステアリルアルコール ０．２ ポリオキシエチレン硬化ヒマシ油 １．０ ポリオキシエチレンソルビタンモノステアレート ０．５ クエン酸ナトリウム ２．０ プロピレングリコール ５．０ エタノール １０．０ 精製水 全１００．０Example 4 An oil phase component having the following formulation was heated and dissolved, and a heated aqueous phase component was added thereto, and an emulsion was obtained by a conventional emulsification method. Chondroitin 6-sodium sulfate 0.2 (% by weight) Phytoglycogen 0.5 Stearyl glycyrrhetinate 2.5 Squalane 2.0 Stearyl alcohol 0.2 Polyoxyethylene hydrogenated castor oil 1.0 Polyoxyethylene sorbitan monostearate 5 Sodium citrate 2.0 Propylene glycol 5.0 Ethanol 10.0 Purified water Total 100.0
【００２０】実施例５ 以下処方の油相成分を加温溶解し、これに加温した水相
成分を添加し、常法による乳化法によりクリーム剤を得
た。 ヘパリン類似物質 ０．３（重量％） フィトグリコーゲン ０．３ ステアリン酸 １．０ イソステアリン酸 １．０ セタノール ０．５ ステアリルアルコール ０．５ 白色ワセリン ２．０ スクワラン １０．０ モノオレイン酸グリセリン １．５ グリセリンモノステアリルエーテル １．５ イソプロピルメチルフェノール ０．１ ビタミンＥアセテート ０．１ プロピレングリコール ３．０ カルボキシビニルポリマー ０．１ クエン酸 適量 精製水 全１００．０Example 5 An oil phase component having the following formulation was heated and dissolved, and a heated aqueous phase component was added thereto, and a cream was obtained by a conventional emulsification method. Heparin analog 0.3 (wt%) phytoglycogen 0.3 stearic acid 1.0 isostearic acid 1.0 cetanol 0.5 stearyl alcohol 0.5 white petrolatum 2.0 squalane 10.0 glycerol monooleate 1.5 Glycerin monostearyl ether 1.5 Isopropyl methyl phenol 0.1 Vitamin E acetate 0.1 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Citric acid Suitable amount Purified water Total 100.0
【００２１】実施例６ 以下処方の油相成分を加温溶解し、これに加温した水相
成分を添加し、常法による乳化法によりクリーム剤を得
た。 ヘパラン硫酸カリウム ０．５（重量％） フィトグリコーゲン ２．０ 流動パラフィン ３．０ ＶＥアセテート ０．２ パンテノール ０．５ ステアリルアルコール ７．０ メチルポリシロキサン ０．２ モノステアリン酸ソルビタン ３．０ ポリソルベート６０ ７．０ グリセリン ７．０ ジプロピレングリコール ３．０ パラベン ０．２ 精製水 全１００．０Example 6 An oil phase component having the following formulation was heated and dissolved, and a heated aqueous phase component was added thereto, and a cream was obtained by a conventional emulsification method. Heparan potassium sulfate 0.5 (% by weight) Phytoglycogen 2.0 Liquid paraffin 3.0 VE acetate 0.2 Panthenol 0.5 Stearyl alcohol 7.0 Methylpolysiloxane 0.2 Sorbitan monostearate 3.0 Polysorbate 60 7.0 Glycerin 7.0 Dipropylene glycol 3.0 Paraben 0.2 Purified water Total 100.0
【００２２】試験例１（皮膚水分含有量） 健常成人５人の前腕内側に直径２．８cmの円状に３０mg
の被験薬を塗布し、６時間放置した後、流水洗浄した。
その後、温度２０℃、湿度５０％の恒温恒湿室に入り、
１５分後に皮膚水分量を高周波に対する伝導度測定装置
（インピーダンスメーター：ＩＢＳ社製）で測定し、保
湿性を評価した。表１に５人の平均値を示した。なお、
測定値が大きい程電気抵抗が小さく保湿性が良いことを
示す。Test Example 1 (Skin moisture content) 30 mg in a 2.8 cm diameter circle on the inner side of the forearm of 5 healthy adults
Was applied and left for 6 hours, followed by washing with running water.
After that, it enters a constant temperature and humidity room with a temperature of 20 ° C and a humidity of 50%,
After 15 minutes, the moisture content of the skin was measured with a conductivity measuring device for high frequency (impedance meter: manufactured by IBS) to evaluate the moisture retention. Table 1 shows the average value of five persons. In addition,
The larger the measured value, the smaller the electric resistance and the better the moisture retention.
【００２３】[0023]
【表１】 [Table 1]
【００２４】試験例２（使用感試験） 乾燥肌を訴える女性１０名で使用感テストを行い、良い
（５点）、やや良い（４点）、どちらでもない（３
点）、やや悪い（２点）、悪い（１点）の５段階で評価
した。各処方の平均点を表２に示した。Test Example 2 (Usability test) A usability test was conducted on 10 women who complain of dry skin, and neither good (5 points) nor good (4 points) was used (3
Points), slightly bad (2 points), and bad (1 point). Table 2 shows the average score of each formulation.
【００２５】[0025]
【表２】 [Table 2]
【００２６】基剤については、試験例１と同じものを使
用した。The same base as in Test Example 1 was used.
【００２７】表１および２から明らかなように、ムコ多
糖類とフィトグリコーゲンを組み合わせることにより、
良好な使用感を確保し、かつ良好な保湿効果を有する皮
膚外用剤を得ることができた。As is evident from Tables 1 and 2, by combining the mucopolysaccharide with phytoglycogen,
An external preparation for skin having a good feeling of use and a good moisturizing effect was obtained.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 31/727 Ａ６１Ｋ 31/727 Ａ６１Ｐ 17/16 Ａ６１Ｐ 17/16 (72)発明者 宇田 晴美 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 満山 俊平 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 Ｆターム(参考） 4C083 AA072 AB052 AC012 AC022 AC072 AC102 AC122 AC172 AC182 AC242 AC262 AC302 AC352 AC422 AC432 AC442 AC472 AC482 AC642 AD042 AD092 AD152 AD241 AD242 AD311 AD312 AD342 AD532 CC02 CC05 DD27 DD31 EE12 4C086 AA01 AA02 EA20 EA26 EA27 MA02 MA04 MA63 NA05 ZA89 ZC75 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 31/727 A61K 31/727 A61P 17/16 A61P 17/16 (72) Inventor Harumi Uda Toshima-ku, Tokyo 3-24-1, Takada Taisho Pharmaceutical Co., Ltd. (72) Inventor Shunpei Mitsuyama 3-24-1, Takada, Toshima-ku, Tokyo F-term in Taisho Pharmaceutical Co., Ltd. 4C083 AA072 AB052 AC012 AC022 AC072 AC102 AC122 AC172 AC182 AC242 AC262 AC302 AC352 AC422 AC432 AC442 AC472 AC482 AC642 AD042 AD092 AD152 AD241 AD242 AD311 AD312 AD342 AD532 CC02 CC05 DD27 DD31 EE12 4C086 AA01 AA02 EA20 EA26 EA27 MA02 MA04 MA63 NA05 ZA89 ZC75
Claims (4)
なる皮膚外用剤。1. An external preparation for skin comprising mucopolysaccharide and vegetable glycogen.
項１記載の皮膚外用剤。2. The external preparation for skin according to claim 1, wherein the mucopolysaccharide is a heparin-like substance.
０．０１〜５重量％である請求項１記載の皮膚外用剤。3. The external preparation for skin according to claim 1, wherein the amount of the mucopolysaccharide is 0.01 to 5% by weight of the total amount of the external preparation for skin.
全量の０．０１〜２０重量％である請求項１記載の皮膚
外用剤。4. The external preparation for skin according to claim 1, wherein the amount of the vegetable glycogen is 0.01 to 20% by weight of the total amount of the external preparation for skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26134899A JP2001089381A (en) | 1999-09-16 | 1999-09-16 | Preparation for external use for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26134899A JP2001089381A (en) | 1999-09-16 | 1999-09-16 | Preparation for external use for skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001089381A true JP2001089381A (en) | 2001-04-03 |
Family
ID=17360600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26134899A Pending JP2001089381A (en) | 1999-09-16 | 1999-09-16 | Preparation for external use for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001089381A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004026766A (en) * | 2002-06-27 | 2004-01-29 | Kyoei Kagaku Kogyo Kk | Skin care preparation for external use |
| WO2008018144A1 (en) | 2006-08-10 | 2008-02-14 | House Wellness Foods Corporation | Moisturizing agent |
| WO2008018143A1 (en) | 2006-08-10 | 2008-02-14 | House Wellness Foods Corporation | Moisturizing agent |
| US20190151352A1 (en) * | 2016-05-05 | 2019-05-23 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Ophthalmic composition comprising a synergistic combination of glycogen and hyaluronic acid or a salt thereof |
| JP2020094010A (en) * | 2018-12-14 | 2020-06-18 | 大正製薬株式会社 | External composition |
-
1999
- 1999-09-16 JP JP26134899A patent/JP2001089381A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004026766A (en) * | 2002-06-27 | 2004-01-29 | Kyoei Kagaku Kogyo Kk | Skin care preparation for external use |
| WO2008018144A1 (en) | 2006-08-10 | 2008-02-14 | House Wellness Foods Corporation | Moisturizing agent |
| WO2008018143A1 (en) | 2006-08-10 | 2008-02-14 | House Wellness Foods Corporation | Moisturizing agent |
| US20190151352A1 (en) * | 2016-05-05 | 2019-05-23 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Ophthalmic composition comprising a synergistic combination of glycogen and hyaluronic acid or a salt thereof |
| JP2020094010A (en) * | 2018-12-14 | 2020-06-18 | 大正製薬株式会社 | External composition |
| JP7271927B2 (en) | 2018-12-14 | 2023-05-12 | 大正製薬株式会社 | external composition |
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