JP2000095660A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain skin lotion with excellent thermal insulation effect, having nonsticky feeling when applied and accompanied by no offensive odor as well by including hyaluronic acid (salt) and phytoglycogen. SOLUTION: This skin lotion is obtained by including (A) 0.001-5 (pref. 0.01-3) wt.% of hyaluronic acid (salt) and (B) 0.001-5 wt.% of phytoglycogen in the weight ratio A/B of (1:1,000) to (100:1), pref. (1:100) to (50:1); wherein the ingredient A is a polysaccharide with the repeating constitutive unit consisting of a disaccharide composed of glucuronic acid and N-acetylglucosamine, being afforded, for example, by extraction from animal tissue such as cockscomb or by microorganismal fermentation process; the ingredient B is a cold water-soluble storage polycaccharide derived from plants and same in the fundamental structure as glycogen abundant in the liver and muscle of animals; and the source of the ingredient B is e.g. seeds including corn, barley and rice.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention has an excellent moisturizing effect,
The present invention relates to an external preparation for skin having a sticky use feeling and no unpleasant odor.

[0002]

2. Description of the Related Art Keeping skin moisture in an appropriate range
It is very important in terms of skin health. Therefore, various studies have been made on substances involved in moisturizing the skin, and many skin external preparations containing hyaluronic acid or a salt thereof, which is a natural moisturizing factor for the skin, have recently been found. However, conventional skin external preparations containing hyaluronic acid or a salt thereof are unlikely to have a satisfactory moisturizing effect, and tend to give a sticky feel in use.

On the other hand, a skin external preparation containing glycogen as a humectant has been proposed in Japanese Patent Application Laid-Open No. 62-178505. However, it is difficult to say that the obtained external preparation for skin has a satisfactory moisturizing effect, and since the glycogen used here is derived from animal tissues, it has an unpleasant odor derived from glycogen. there were.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide an external preparation for skin which has an excellent moisturizing effect, has a non-sticky feeling, and is free from unpleasant odor.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, completed the present invention. That is, the present invention provides (1) a skin external preparation containing hyaluronic acid or a salt thereof and phytoglycogen, and (2) a compounding ratio of hyaluronic acid or a salt thereof and phytoglycogen of 1: 1000 to 100: 1 (weight ratio).
(1) the external preparation for skin of (1), (3) the amount of hyaluronic acid or a salt thereof is 0.001 to 5% by weight based on the total amount;
(3) An external preparation for skin according to (1) or (2),

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. In the present invention, all percentages are by weight unless otherwise specified. In the present invention, the term "hyaluronic acid" refers to a polysaccharide having a disaccharide of glucuronic acid and N-acetylglucosamine as a repeating constitutional unit, and is not particularly limited. For example, extraction from animal tissues such as cockscomb and fermentation of microorganisms Obtained by a method. Furthermore, the hyaluronic acid of the present invention also includes those obtained by decomposing the hyaluronic acid obtained by the above-described method and the like to reduce the molecular weight, and those crosslinked with a crosslinking agent. Examples of the salt of hyaluronic acid include, for example, alkali metals such as sodium and potassium, and alkaline earth metals such as magnesium and calcium.

In the present invention, phytoglycogen is
It is a cold water soluble storage polysaccharide derived from plants that has the same basic structure as glycogen, which is abundant in animal liver and muscle. The source of phytoglycogen is not particularly limited as long as it is derived from a plant, and examples thereof include seeds such as corn, barley, and rice. Among them,
Sweet corn seeds are preferred as a source because they contain a higher concentration of phytoglycogen than other plants.

The external preparation for skin of the present invention comprises the above-mentioned hyaluronic acid or a salt thereof and phytoglycogen in a ratio of 1: 1000 to 1: 1.
It is preferable to mix them in a mixing ratio of 00: 1 (weight ratio), more preferably 1: 100 to 50: 1. The mixing ratio of hyaluronic acid or a salt thereof and phytoglycogen is 1:
If the ratio of hyaluronic acid or a salt thereof is less than 1,000, a sufficient moisturizing effect cannot be obtained as shown in the test examples described below, which is not preferable. On the other hand, if the ratio of hyaluronic acid or a salt thereof is higher than 100: 1, a sticky feeling is obtained, which is not preferable.

In the external preparation for skin of the present invention, the amount of hyaluronic acid or a salt thereof is preferably 0.001 to 5%, more preferably 0.01 to 3%, based on the total amount.
If the amount of hyaluronic acid or a salt thereof is less than 0.001%, a sufficient moisturizing effect cannot be obtained, which is not preferable. On the other hand, if the amount is more than 5%, it is difficult to suppress stickiness even when phytoglycogen is used in combination, which is not preferable.

The external preparation for skin of the present invention is not particularly limited, but phytoglycogen is preferably incorporated in an amount of about 0.001 to 5% based on the total amount. If the amount of phytoglycogen is less than 0.001%, it is difficult to sufficiently suppress stickiness, which is not desirable. on the other hand,
If the amount is more than 5%, not only no further effect can be obtained, but also a sticky feeling on use, which is not desirable. Further, phytoglycogen is a plant-derived glycogen, so that it does not require an unpleasant odor unlike animal tissue-derived glycogen, and has a odor that does not pose a problem as a raw material for a skin external preparation. Therefore, the external preparation for skin of the present invention is a product that does not have an unpleasant odor.

In the present invention, the external preparation for skin is used on the skin surface including scalp, lips and the like, and includes, for example, lotion, milky lotion, cream, serum, hair restorer, hair restorer, lip balm, foundation and the like. Can be In addition,
In the skin external preparation of the present invention, in addition to the above, other components such as an oily component, a polyhydric alcohol, a surfactant, a lower alcohol, a preservative, a dye, a fragrance, a pigment, an antioxidant, and an ultraviolet absorber are used. Can be appropriately compounded within a range that does not impair the effect of the above.

Next, the present invention will be described in more detail based on examples and test examples. The present invention is not limited to these examples and test examples.

EXAMPLES Example 1 (Lotion) <Formulation> (A) Sodium hyaluronate (average molecular weight: about 1,000,000) 0.1% phytoglycogen ^* (derived from sweet corn) 0.1% 1,3-butylene glycol 5.0% Glycerin 2.0% Purified water 86.55% (B) Vitamin E acetate 0.1% Polyoxyethylene (60) hydrogenated castor oil 1.0% Fragrance 0.05% Methyl paraoxybenzoate 0.1 % Ethanol 5.0% * Product name "Phytoglycogen" manufactured by Kewpie Co., Ltd. <Production method> After uniformly dissolving the aqueous phase part of A and the alcohol part of B, mix while adding B to A, I got a lotion.

The obtained lotion was excellent in moisturizing effect, had no feeling of use, and had no unpleasant odor.

Example 2 (Emulsion) <Formulation> (A) Stearic acid 2.5% Cetyl alcohol 1.5% Vaseline 5.0% Liquid paraffin 10.0% Polyoxyethylene (10) monooleate 2.0% Fragrance 0.05% (B) Sodium hyaluronate (average molecular weight: about 900,000) 0.1% Phytoglycogen ^* (from sweet corn) 0.2% Carboxyvinyl polymer 0.2% Propylene glycol 5.0% Paraoxybenzoic acid Methyl 0.1%
Purified water 73.35% * Product name "Phytoglycogen" manufactured by KP Co., Ltd. <Production method> The oil phase portion of A and the aqueous phase portion of B are each approximately 70%.
After homogeneously dissolving at C, pre-emulsification was performed while adding B to A, and then homogenized using a homomixer. Thereafter, the mixture was cooled to 30 ° C. while stirring to obtain an emulsion.

The obtained emulsion was excellent in moisturizing effect, had no sticky feeling in use, and was free from unpleasant odor.

Example 3 (Foundation) <Formulation> (A) Cetanol 3.5% Stearic acid 2.0% Deodorized lanolin 5.0% Vaseline 2.0% Squalane 8.0% Glyceryl monooleate 2.5% Polyoxyethylene (10) behenyl alcohol 0.5% Ethyl paraoxybenzoate 0.15% Butyl paraoxybenzoate 0.15% (B) Sodium hyaluronate (average molecular weight: about 150,000) 2.0% Phytoglycogen ^* (suite 2.0% 1,3-butylene glycol 3.0% Titanium oxide 5.0% Kaolin 3.0% Talc 5.0% Iron oxide 2.0%
Triethanolamine 0.25% Purified water 53.95% * KP Co., Ltd., trade name "Phytoglycogen"<Productionmethod> The oil phase part of A and the water phase part of B are each about 70
After homogeneously dissolving at C, pre-emulsification was performed while adding B to A, and then homogenized using a homomixer. Thereafter, the mixture was cooled to 30 ° C. with stirring to obtain a foundation.

The obtained foundation was a product having an excellent moisturizing effect, a non-sticky feeling in use, and no unpleasant odor.

[0018]

[Test Example] Test Example 1 In the lotion of Example 1, the amounts of sodium hyaluronate and glycogen were changed to the amounts shown in Table 1, and the obtained moisturizing effects, use feeling (stickiness) and odor of each lotion were obtained. Was evaluated by the method described below.

(1) Moisturizing effect Each lotion obtained from 20 women in their 20s and 40s suffering from rough skin is used twice a day (morning / evening) for one month, and before and after use. The reduction rate of the TWL value was calculated from the TWL value (transepidermal water loss), and the moisturizing effect was evaluated. TWL value The skin (cheek) of the panel was sealed with a cell for measurement, forced air was passed through the cell, and the inside of the cell was sufficiently replaced with dry air. Then, the ventilation of dry air was stopped and the cell at that time was stopped. obtains the relative humidity RH _S (%) of the inner, and then left for 10 minutes to determine the relative humidity RH ₁₀ (%) in the cell again, TWL value by the following equation from the humidity change when the (mg / cm ² / hr) was calculated. TWL value = (RH ₁₀ −RH _S ) × Dt × V × 6 / (S ×
100) Here, Dt: density of saturated water vapor in air at measurement temperature (t ° C.) (mg / L) V: cell volume (L) S: measurement area (cm ² ) Reduction rate of TWL value TWL value The reduction rate of TWL before and after using lotion, TW
Calculate by substituting L _A and TWL _B into the following equation,
"Effective" when the reduction rate of the value is 20% or more, the reduction rate is 2
A case of less than 0% was regarded as “invalid”. The test results indicate the number of "effective" panels out of 20. TWL value reduction rate = (1−TWL _B / TWL _A ) × 100
(%) Where TWL _A : TWL value before use TWL _B : TWL value after use

(2) Feeling of Use Twenty female panels in their 20s and 40s were used to evaluate the feeling of use regarding stickiness.

(3) Odor Twenty female panels in their 20s and 40s were used to evaluate the odor.

[0022]

[Table 1]

From Table 1, it can be understood that by blending sodium hyaluronate and phytoglycogen, an external preparation for skin having an excellent moisturizing effect, a non-sticky feeling, and free from unpleasant odor can be obtained. .

Test Example 2 In order to examine the effects of the mixing ratio of sodium hyaluronate and phytoglycogen on the moisturizing effect and the feeling of use (stickiness), the amounts of sodium hyaluronate and phytoglycogen in the lotion of Example 1 were shown. 2 and the moisturizing effect and feeling of use (stickiness) of each of the obtained lotions were evaluated in the same manner as in Test Example 1.

[0025]

[Table 2]

According to Table 2, the mixing ratio of sodium hyaluronate and phytoglycogen is 1: 1000 to 100: 1.
(Weight ratio), more preferably 1: 100 to 50: 1,
It is understood that an external preparation for skin which has an excellent moisturizing effect and has no sticky feeling during use can be obtained.

Test Example 3 In order to examine the effect of the amount of sodium hyaluronate on the moisturizing effect and the feeling of use (stickiness), in the lotion of Example 1, sodium hyaluronate having an average molecular weight of about 300,000 was used. The amounts of sodium and phytoglycogen were changed to the amounts shown in Table 3, and the moisturizing effect and feeling of use (stickiness) of each of the obtained lotions were evaluated in the same manner as in Test Example 1.

[0028]

[Table 3]

From Table 3, it can be seen that the amount of sodium hyaluronate is 0.001 to 5%, more preferably 0.01 to 3%, based on the total amount, and is excellent in moisturizing effect and has no sticky feeling for external use on skin. It is understood that an agent is obtained.

[0030]

As described above, the external preparation for skin of the present invention has an excellent moisturizing effect, has a non-sticky feeling, and has no unpleasant odor as compared with conventional products. Demand for salt and phytoglycogen for skin external preparations is expected to increase.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/728 A61K 31/715 611 F term (Reference) 4C083 AB232 AB242 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC172 AC242 AC402 AC432 AC482 AC542 AD092 AD211 AD212 AD331 AD332 AD512 AD662 CC02 CC04 CC05 CC12 DD23 DD31 EE06 EE07 EE12 FF05 4C086 AA01 AA02 EA21 EA22 EA25 MA02 MA16 MA22 MA63 NA14

Claims (3)

[Claims] 1. An external preparation for skin, characterized by blending hyaluronic acid or a salt thereof and phytoglycogen. 2. The external preparation for skin according to claim 1, wherein the mixing ratio of hyaluronic acid or a salt thereof to phytoglycogen is 1: 1000 to 100: 1 (weight ratio). 3. The composition according to claim 1, wherein the amount of the hyaluronic acid or a salt thereof is 0.001 to 5% by weight based on the total amount.
The topical skin preparation according to the above.