JP2000517292A5 - - Google Patents

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Publication number
JP2000517292A5
JP2000517292A5 JP1997537492A JP53749297A JP2000517292A5 JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5 JP 1997537492 A JP1997537492 A JP 1997537492A JP 53749297 A JP53749297 A JP 53749297A JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997537492A
Other languages
English (en)
Japanese (ja)
Other versions
JP4155598B2 (ja
JP2000517292A (ja
Filing date
Publication date
Priority claimed from GBGB9619082.2A external-priority patent/GB9619082D0/en
Priority claimed from GBGB9707394.4A external-priority patent/GB9707394D0/en
Application filed filed Critical
Priority claimed from PCT/NZ1997/000117 external-priority patent/WO1998011101A2/en
Publication of JP2000517292A publication Critical patent/JP2000517292A/ja
Publication of JP2000517292A5 publication Critical patent/JP2000517292A5/ja
Application granted granted Critical
Publication of JP4155598B2 publication Critical patent/JP4155598B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP53749297A 1996-09-12 1997-09-12 抗癌剤としての縮合n−アシルインドール Expired - Fee Related JP4155598B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9619082.2A GB9619082D0 (en) 1996-09-12 1996-09-12 Further cyclopropylindoles and their seco precursors,and their use as prodrugs
GB9619082.2 1997-04-10
GBGB9707394.4A GB9707394D0 (en) 1997-04-10 1997-04-10 Further cyclopropylindoles and their seco precursors, and their use as prodrugs
GB9707394.4 1997-04-10
PCT/NZ1997/000117 WO1998011101A2 (en) 1996-09-12 1997-09-12 Condensed n-aclyindoles as antitumor agents

Publications (3)

Publication Number Publication Date
JP2000517292A JP2000517292A (ja) 2000-12-26
JP2000517292A5 true JP2000517292A5 (enExample) 2005-01-13
JP4155598B2 JP4155598B2 (ja) 2008-09-24

Family

ID=26310030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53749297A Expired - Fee Related JP4155598B2 (ja) 1996-09-12 1997-09-12 抗癌剤としての縮合n−アシルインドール

Country Status (9)

Country Link
EP (1) EP0938474B1 (enExample)
JP (1) JP4155598B2 (enExample)
AT (1) ATE310725T1 (enExample)
AU (1) AU721037B2 (enExample)
CA (1) CA2265874C (enExample)
DE (1) DE69734722T2 (enExample)
ES (1) ES2253786T3 (enExample)
NZ (1) NZ334344A (enExample)
WO (1) WO1998011101A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DK1193270T3 (da) 1998-08-27 2003-09-15 Spirogen Ltd Pyrrolobenzodiazepiner
GB9909612D0 (en) * 1999-04-26 1999-06-23 Cancer Res Campaign Tech N-protected amines and their use as prodrugs
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
RU2002132253A (ru) * 2000-04-28 2004-07-10 Бакстэ Хелскеа СА (CH) Производные 2-ацилиндола, их применение (варианты) и способ получения, лекарственное средство и способ его получения, противоопухолевое средство и способ его получения
DE50104114D1 (de) 2000-05-02 2004-11-18 Tietze Lutz F Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo f]chinolin-derivaten für eine selektive krebstherapie
EP1408960B1 (en) 2001-02-22 2006-05-31 School Of Pharmacy, University Of London Benz-indole and benzo-quinoline derivatives as prodrugs for tumour treatment
US7235578B2 (en) * 2002-05-17 2007-06-26 Auckland Uniservices Limited Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
US7417152B2 (en) 2003-05-02 2008-08-26 Elan Pharmaceuticals, Inc. 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases
EP1635821B1 (en) * 2003-05-02 2009-07-08 Elan Pharmaceuticals, Inc. 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl)amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
NZ536107A (en) * 2004-10-22 2007-06-29 Auckland Uniservices Ltd Nitrobenzindoles and their use in cancer therapy
WO2007059404A2 (en) * 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
AU2007210377B2 (en) * 2006-02-02 2012-08-09 Georg-August-Universitat Gottingen Stiftung Offentlichen Rechts (Ohne Bereich Humanmedizin) Water-soluble CC-1065 analogs and their conjugates
WO2008039087A2 (en) * 2006-09-29 2008-04-03 Auckland Uniservices Limited Indoline derivatives and uses thereof
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
KR20090122439A (ko) 2007-02-21 2009-11-30 메다렉스, 인코포레이티드 단일 아미노산을 갖는 화학적 링커 및 이의 접합체
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
RU2628069C2 (ru) 2008-11-03 2017-08-14 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
DE102009051438A1 (de) 2009-10-30 2011-05-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Fluoreszenzfarbstoffe
LT3108886T (lt) 2010-04-21 2020-08-25 Syntarga B.V. Cc-1065 analogų ir bifunkcinių jungtukų konjugatai
JP6224268B2 (ja) 2014-01-10 2017-11-01 シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. 子宮内膜癌の治療において使用するためのデュオカルマイシンadc
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
HUE029255T2 (en) 2014-01-10 2017-02-28 Synthon Biopharmaceuticals Bv Duocarmycin adcs showing improved in vivo antitumor activity
CN108653288B (zh) * 2018-05-29 2020-05-05 福建医科大学孟超肝胆医院(福州市传染病医院) 一种乏氧响应聚合物纳米粒及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988004659A2 (en) * 1986-12-19 1988-06-30 The Upjohn Company Novel cc-1065 analogs
JP2642165B2 (ja) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 新規dc−89化合物およびその製造法
AU648313B2 (en) * 1990-04-25 1994-04-21 Pharmacia & Upjohn Company Novel CC-1065 analogs
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
WO1997012862A1 (en) * 1995-10-03 1997-04-10 The Scripps Research Institute Cbi analogs of cc-1065 and the duocarmycins
JP2000506168A (ja) * 1996-03-08 2000-05-23 ザ スクリップス リサーチ インスティテュート Cc―1065及びデュオカマイシンのmcbi類似体

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