JP2000516642A - Composition containing electrolyte - Google Patents
Composition containing electrolyteInfo
- Publication number
- JP2000516642A JP2000516642A JP11537161A JP53716199A JP2000516642A JP 2000516642 A JP2000516642 A JP 2000516642A JP 11537161 A JP11537161 A JP 11537161A JP 53716199 A JP53716199 A JP 53716199A JP 2000516642 A JP2000516642 A JP 2000516642A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- clay
- electrolyte
- present
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 100
- 239000003792 electrolyte Substances 0.000 title claims description 36
- 239000004927 clay Substances 0.000 claims abstract description 35
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 15
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 239000003906 humectant Substances 0.000 claims description 9
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- 239000003002 pH adjusting agent Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 4
- 235000011180 diphosphates Nutrition 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 230000008719 thickening Effects 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229920000388 Polyphosphate Polymers 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 239000001205 polyphosphate Substances 0.000 claims 1
- 235000011176 polyphosphates Nutrition 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- -1 ascorbic acid compound Chemical class 0.000 abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 2
- 235000010323 ascorbic acid Nutrition 0.000 abstract description 2
- 229960005070 ascorbic acid Drugs 0.000 abstract description 2
- 239000011668 ascorbic acid Substances 0.000 abstract description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- 239000004615 ingredient Substances 0.000 description 16
- 239000012071 phase Substances 0.000 description 15
- 235000002639 sodium chloride Nutrition 0.000 description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 239000000839 emulsion Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000002562 thickening agent Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000969 carrier Substances 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 8
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 description 4
- 229960001763 zinc sulfate Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 206010040829 Skin discolouration Diseases 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 239000004973 liquid crystal related substance Substances 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 229940048084 pyrophosphate Drugs 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004990 Smectic liquid crystal Substances 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011132 calcium sulphate Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000008406 cosmetic ingredient Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 229940094522 laponite Drugs 0.000 description 2
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical group [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
- 230000002535 lyotropic effect Effects 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 235000011147 magnesium chloride Nutrition 0.000 description 2
- 239000004137 magnesium phosphate Substances 0.000 description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 2
- 229960002261 magnesium phosphate Drugs 0.000 description 2
- 235000010994 magnesium phosphates Nutrition 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- OUHCLAKJJGMPSW-UHFFFAOYSA-L magnesium;hydrogen carbonate;hydroxide Chemical compound O.[Mg+2].[O-]C([O-])=O OUHCLAKJJGMPSW-UHFFFAOYSA-L 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 235000011181 potassium carbonates Nutrition 0.000 description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 description 2
- 235000011151 potassium sulphates Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 2
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 235000011008 sodium phosphates Nutrition 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- NIFDAHUNJVFZAY-UHFFFAOYSA-N 1-nitropropane-1,3-diol Chemical compound OCCC(O)[N+]([O-])=O NIFDAHUNJVFZAY-UHFFFAOYSA-N 0.000 description 1
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- FUWVMBCPMRAWPG-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-hydroxyoctadecanoate Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)OCC(O)CO FUWVMBCPMRAWPG-UHFFFAOYSA-N 0.000 description 1
- RIZUCYSQUWMQLX-UHFFFAOYSA-N 2,3-dimethylbenzoic acid Chemical compound CC1=CC=CC(C(O)=O)=C1C RIZUCYSQUWMQLX-UHFFFAOYSA-N 0.000 description 1
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000186892 Aloe vera Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 229920013683 Celanese Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
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- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
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- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
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- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
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- 230000009881 electrostatic interaction Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- UOVKYUCEFPSRIJ-UHFFFAOYSA-D hexamagnesium;tetracarbonate;dihydroxide;pentahydrate Chemical compound O.O.O.O.O.[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O UOVKYUCEFPSRIJ-UHFFFAOYSA-D 0.000 description 1
- TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical compound CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
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- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
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- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
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- 238000010348 incorporation Methods 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229940031958 magnesium carbonate hydroxide Drugs 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910000273 nontronite Inorganic materials 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940033329 phytosphingosine Drugs 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920002189 poly(glycerol 1-O-monomethacrylate) polymer Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- BHZRJJOHZFYXTO-UHFFFAOYSA-L potassium sulfite Chemical compound [K+].[K+].[O-]S([O-])=O BHZRJJOHZFYXTO-UHFFFAOYSA-L 0.000 description 1
- 235000019252 potassium sulphite Nutrition 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229910000275 saponite Inorganic materials 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 229910021647 smectite Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
- 235000019354 vermiculite Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/002—Inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
(57)【要約】 アスコルビン酸化合物、結晶性無機鉱物クレー、解凝剤、および乳化キャリヤを含む組成物が開示される。組成物は水中油型エマルジョンの形態で存在する。 (57) [Summary] Disclosed is a composition comprising an ascorbic acid compound, a crystalline inorganic mineral clay, a peptizer, and an emulsifying carrier. The composition is in the form of an oil-in-water emulsion.
Description
【発明の詳細な説明】 電解質を含む組成物 分野 本発明は、局所的組成物に関する。特に、本発明はエマルジョンの形態で電解 質を含む局所的組成物に関する。 背景 消費者はしばしば、その皮膚を保護するために、ならびにその皮膚の健康およ び/または物理的外観を向上させるために化粧品を用いる。消費者が典型的に処 置しようとする皮膚の状態には、粗いおよび/または破損した皮膚、並びに皮膚 を明美化(lightening)し、(皮膚の老化またはヒトの皮膚に対する 環境による損傷に関連する老齢のしみ、そばかす、および茶色の斑点のような) 過剰な色素沈着を処置する。 多数の化粧品が、例えば皮膚の明美化、皮膚の処置などのような必要に応じて 当該技術において記載されてきた。その様な製品のために用いられる広範な材料 および/または成分もまた存在する。それらの材料および/または成分は、その 機能性またはその有効性により、1を超える群にカテゴリー分類され得る。水中 で陽イオンと陰イオンに分離する電解質は、化粧品組成物に一般に用いられる成 分である。クエン酸ナトリウムおよびエチレンジアミン四酢酸二ナトリウムは電 解質の例であり、それらはまた、pH調整剤および防腐剤のそれぞれとして分類 される。 しかしながら、電解質は、エマルジョンの劣化の原因となる傾向がある。電解 質成分により授与される電荷は、エマルジョンの内層の凝集を導き得るものであ り、エマルジョンを2層に不本意に分離させる。加えて、それらの電荷は、増粘 系のゲルネットワークの破壊を引き起こし得る。従って、組成物中に用いられる 電解質はエマルジョンの安定性の減少を引き起こし得る。 前述に基づいて、エマルジョン中に電解質を含む安定な組成物についての必要 が存在する。 概要 本発明は、電解質、結晶性無機鉱物クレー、解凝剤(peptizer)およ び乳化キャリヤを含む組成物に関する。組成物は水中油型エマルジョンの形態で 存在する。 本発明のそれらのおよび他の特徴、側面および利点は、以下の記述および添付 の請求の範囲を読むことによりよりよく理解されるようになるであろう。 詳細な説明 明細書は本発明を特に指摘し、明確に権利請求する請求の範囲で終わるけれど も、本発明は以下の記述からよりよく理解されるであろうと思われる。 本明細書で以後用いられるすべてのパーセンテージ及び比は、別段の指示の無 い限り全組成物の重量によるものである。 ここで言及されるすべての測定は、別段の特定の無い限り25℃でなされる。 ここで言及される成分のすべてのパーセンテージ、比、およびレベルは、別段 の指示の無い限り、成分の実際の量に基づき、成分が商業的に入手可能な製品と して組み合わせられ得る溶媒、フィラー、または他の材料を含まない。 本明細書で言及されるすべての刊行物、特許出願および発行された特許は、参 照によりその全体として本明細書に組み込まれる。いずれの参照文献の引用も、 特許請求された発明に対する先行技術としてのその有用性についてのいずれかの 決定についての承認ではない。 本明細書で、「含む、具備する(comprising)」とは、最終的な結 果に影響を与えない他の工程および他の成分が加えられ得ることを意味する。こ の術語は、「からなる(consisting of)」および「本質的に〜か らなる(consisting essentially of)」という術語 を包含する。 本明細書では、「局所適用」とは皮膚の表面上への材料の適用または材料を広 げることを意味する。 本明細書では、「皮膚の明美化(skin lightening:スキンラ イトニング)」とは、より輝く、より光るおよび/またはより白い外観に皮膚の 外観が変化することおよび処置前に比べて、過剰の色素沈着を改善することを称 する。 本明細書で、「皮膚科学的に許容可能な」とは、その様に記載された組成物ま たはその成分が、過度の毒性、非相容性、不安定性、アレルギー反応などなしに ヒトの皮膚と接触して使用するのに適切であることを意味する。 本明細書で、「安全かつ有効な量」とは、本明細書で開示される利益を独立に 含み、積極的な利益、好ましくは良好な皮膚の外観または感触のよさを有意に誘 発するのに十分であるがしかし、重大な副作用を回避する、すなわち当業者の妥 当な判断の範囲内で合理的な利益対危険比を与えるのに十分に低い、化合物また は組成物の量を意味する。 活性物質(active)およびここで有用な他の成分のようなすべての成分 ば、その化粧についてのおよび/または治療上の利益またはその作用の要求され る形態によりカテゴリー分類され得るかまたは記載され得る。しかしながら、活 性物質およびここで有用な他の成分は、いくつかの事例においては、2以上の化 粧についてのおよび/または治療上の利益を与え得るかまたは2以上の作用の形 態で機能し得ることを理解すべきである。それゆえ、ここでの分類は、便宜の目 的でなされ、成分を特に言及された用途または列挙された用途に限定することを 意図しない。 本発明の組成物は、電解質、結晶性無機鉱物クレー、解凝剤、および乳化キャ リヤを含む。好ましくは、本発明の組成物は、水中油型エマルジョンの形態で存 在する。 エマルジョンは一般的に親水相(例えば、親水性液体キャリヤ)および疎水相 (例えば、油または油性材料)を含む。当業者にとって周知な様に、疎水相は、 組成および/または成分に応じて、連続および/または分散相を形成するように 親水相内に分散されるであろう。分散相はときどき、エマルジョン内で小粒子ま たは液滴として存在し得る。 理論により拘束されないが、エマルジョンの中の電解質は、分散した液滴の間 の静電的斥力を減少させると思われる。その様な静電的相互作用は液滴の凝集を 促進すると思われる。その様な凝集物が顕著になるならば、エマルジョンは2相 に不本意に分離し得る。加えて、その様な電解質は、さらに、組成物中の(ポリ アクリレートのような)増粘剤のゲルネットワークの破壊を引き起こし得る。 組成物中の電解質のレベルを増加させることは、典型的には、電解質の所望の 有効性を向上させるであろう。例えば、クエン酸ナトリウム(それもまた電解質 であるpH調整剤)のレベルを増加させることは、組成物の安定性の利益を一般 的に向上させるであろう。不運にも、その様な増加したレベルの電解質を有する 組成物は、液滴の凝集および増粘剤のゲルネットワークの破壊により不安定であ る傾向がある。 しかしながらわれわれは、電解質を含む組成物中に結晶性無機鉱物クレーおよ び解凝剤を含ませることは、その組成物が比較的高いレベル(すなわち、0.0 5%を超える)の電解質を含むときでさえ、組成物の安定性を向上させ得ること を発見した。その様な安定性の同上は、水性組成物において特に有効である。 好ましくは、本発明の組成物のpHは、約6.0から約10.0であり、より 好ましくは約7.0から約9.0である。 好ましくは、組成物は局所用組成物であり、より好ましくは、スキンケア組成 物である。A.電解質 本発明の組成物は電解質を含む。本明細書では、「電解質」とは、エマルジョ ン(水を含有ずる溶液)中に溶解するときカチオン(例えば、金属イオン)を放 出する化合物を称する。 電解質のレベルは、その原子価数のコンパティビリティに依存する。例えば、 2価の塩による凝結値は、1価の塩によるそれの4倍である(例えば原子価数の 2乗)。好ましくは、本発明の組成物は、約0.05%から約10%の電解質を 含み、より好ましくは約0.1%から約10%を含み、より好ましくは約1%か ら約5%を含む。ここで有用な電解質は、好ましくは実質的に純粋なものである 。 電解質は更に、結晶性無機鉱物クレー、解凝剤、キャリヤ、および任意成分と のその相容性に応じて選択される。ここで有用な電解質は、無機塩、有機塩、お よびそれらの混合物を含む。好ましくは、ここで有用な無機塩には、さらに加湿 を向上させるための化合物が含まれる。ここで有用な無機塩の例には、炭酸カリ ウム、塩化カリウム、硫酸カリウム、亜硫酸カリウム、炭酸ナトリウム、塩化ナ トリウム、硫酸ナトリウム、亜硫酸ナトリウム、硫酸水素ナトリウム、亜硫酸水 素ナトリウム、炭酸カルシウム、塩化カルシウム、硫酸カルシウム、炭酸マグネ シウム、塩化マグネシウム、硫酸マグネシウム、塩化亜鉛、硫酸亜鉛、塩化アル ミニウム、硫酸アルミニウム、およびそれらの混合物を含み、より好ましくは、 塩化ナトリウム、塩化カリウム、硫酸マグネシウム、硫酸亜鉛、またはそれらの 混合物を含む。 好ましくは、ここで有用な有機塩には、防腐剤およびpH調整剤として一般に 用いられる化合物が含まれる。ここで有用な有機塩の発明を限定しない例には、 エチレンジアミン四酢酸二ナトリウム(EDTA−2Na)、エチレンジアミン 四酢酸三ナトリウム(EDTA−3Na)、エチレンジアミン四酢酸四ナトリウ ム(EDTA−4Na)、安息香酸ナトリウム、クエン酸ナトリウム、およびサ リチル酸ナトリウムが含まれる。 ここでの有用な電解質はまた、いずれの目的および/または利益によっても分 類され得る。1つの態様においては、EDTA−2Naは電解質であるがしかし 、防腐剤として一般的に用いられる。B.結晶性無機鉱物クレー 本発明の組成物は結晶性無機鉱物クレーを含む。本明細書では、「結晶性無機 鉱物クレー」および「CIMクレー」は、一群の結晶層を有するクレーを称する 。 好ましくは、組成物は、約0.01%から約20%のCIMクレーを含み、よ り好ましくは約0.1%から約10%、さらにより好ましくは約1%から約5% を含む。高いレベルのNaClおよびEDTA−2Naのような電解質(すなわ ち、0.1%を超える)と併用しての低レベルのCIMクレーは、不十分な安定 性の組成物となるであろうと思われる。また、高い濃度(すなわち、20%を超 える)は、組成物におけるCIMクレーの可溶性を減少させるであろうとも思わ れる。 ここで有用なCIMクレーは、組成物における増粘剤として一般的に用いられ るいずれのクレーをも含む。高いレベルの電解質は組成物の粘度を減少させる傾 向がある。理論により拘束されないが、ここで有用なCIMクレーは、電解質を 含む組成物において審美的かつ物理的に望ましい粘性を維持することに寄与し得 ると思われる。好ましくは、本発明のCIMクレーは合成クレーである。 CIMクレーの構造は、一般的に一群の個別の結晶層(例えば、板状体(pl atelet)の群)である。CIMクレーが水に加えられるとき、水は、CI Mクレーの(板状体の)群を個別の板状体に分離させる。CIMクレーのそれぞ れの板状体の表面上のカチオン性成分(例えば、金属イオン)は、水に放出され る。同時に、板状体の端部上の小さな正の電荷は、表面の負の電荷に対する局在 により誘導される。それらの分離された板状体は、表面の電荷を減少させて、表 面の負の電荷に対応する端部上の正の電荷により結合し、それにより「紙の家の 構造(card house structure)」と称される構造を形成す る。 水溶液に溶解するとき、組成物の電解質は一般的に正の電荷(例えば、水素ま たは金属イオンのようなカチオン)を放出する。それらの正の電荷は一般的に、 特にエマルジョンタイプの組成物の場合において、組成物の不安定を導く。その 様な正の電荷は分散したCIMクレーの負の電荷と関連し得るものであり、電荷 の中和によりその様な負の電荷を減少させ、エマルジョンにおける斥力を減少さ せる結果となる。それゆえ、最適レベルの正の電荷の付加は、特にエマルジョン 形態における組成物の粘性を有意に安定化させる(すなわち、粘性の溶液を維持 する)と思われる。 ここで有用なCIMクレーは、2層のタイプ(例えば、カオリン)および3層 のタイプを含む。3層のタイプは膨張群及び非膨張群(例えばタルク)を含む。 膨張群は、非限定層膨張(Unlimited Layer Expansio n)(例えば、スメクタイト)および限定層膨張(Limited Layer Expansion)(例えば、バーミキュライト)を含む。その様な構造は、 フラグランス・ジャーナル第6巻、65〜71ページ(1994年)において記 載されている。 ここでのCIMクレーの好ましいスメクタイトには、モンモリロナイト(ベン トナイト)、ベイデライト、ノントロナイト、ヘクトライト、およびサポナイト が含まれる。適切なヘクトライトタイプのクレーは、ラポート(Laporte )・インダストリーズLtd.(チェシャー、英国)から商業的に入手可能なラ ポナ イト(Laponite)(登録商標)XLGである。C.解凝剤 本発明の組成物は解凝剤を含む。好ましくは、組成物は約0.001%から約 5%の解凝剤を含み、より好ましくは約0.01%から約3%を含む。 解凝剤はクレー増粘系において電解質の許容度を補強する傾向があり、それに より、CIMクレーにより与えられる安定性の利益について向上させると思われ る。大きなレベルの電解質が組成物において用いられるとき、増加したレベルの CIMクレーもまた組成物の粘度の減少(ゲルネットワークの破壊)を防止する ために必要とされるであろう。 解凝剤は、クレーの板状体の端部上の正の電荷と反応するともまた思われる。 このことは板状体の正の電荷の消失となり、それにより分散した板状体間の斥力 を増加させる。このことは、CIMクレー分散液における負の電荷もまた増加す ることを意味する。それゆえ、より大きなレベルの電解質の正の電荷がクレー増 粘システムを安定化させるためにCIMクレーのそのような負の電荷と結びつき 得るであろう。従って、増加したレベルのCIMクレーは解凝剤を含ませること により回避され得るし、組成物全体の安定性は維持されるであろう。 ここで有用な解凝剤は、アクリレート、硫酸水素塩、亜硫酸水素塩、カーボネ ート、ホスフェート、ピロホスフェート、シリケート、サルフェート、スルホネ ートまたはピロホスフェートを含み、好ましくはホスフェートまたはピロホスフ ェートを含む。 本発明の組成物において利用される解凝剤は、例えば、ナトリウム塩、マグネ シウム塩、アルミニウム塩、カリウム塩、カルシウム塩、亜鉛塩またはアンモニ ウム塩のような誘導塩基により異なるものとして分類され得る。 ここで用いられる好ましい解凝剤には、硫酸水素ナトリウム、炭酸ナトリウム 、塩化ナトリウム、亜硫酸水素ナトリウム、リン酸ナトリウム、ピロリン酸ナト リウム、炭酸マグネシウム、炭酸水酸化マグネシウム、塩化マグネシウム、硫酸 マグネシウム、炭酸カリウム、塩化カリウム、硫酸カリウム、炭酸カルシウム、 塩化カルシウム、リン酸二水素カルシウム、リン酸カルシウムおよび硫酸カルシ ウムが含まれ、好ましくはリン酸ナトリウム、およびピロリン酸ナトリウムが含 ま れる。 ある種の態様においては、ここで用いられる解凝剤は、結晶性無機鉱物クレー を有する混合物として組成物に含まれ得るかまたは増粘系を形成するように結晶 性無機クレーに結合し得る。解凝剤は、結晶性無機鉱物クレーの混合物として含 まれるかまたは増粘系を形成するように結合するとき、解凝剤は好ましくは、結 晶性無機クレーの約0.1重量%から約20重量%の量で存在する。 CIMと解凝剤との好ましい組み合わせは、ラポート・インダストリーズLt d.(チェシャー、英国)から商品名ラポナイト(登録商標)XLSの下で商業 的に入手可能である。D.乳化キャリヤ 本発明の組成物は乳化キャリヤを含む。ここで有用な乳化キャリヤには、電解 質、結晶性無機鉱物クレー、および解凝剤が特定の材料および任意成分を適切な 濃度で皮膚に当てることを可能とするように含まれ得るいずれの皮膚科学的に許 容可能なキャリヤも含まれる。従って、乳化キャリヤは、特定の材料が適切な濃 度で、選ばれた標的に適用され、そこにわたって均一に分布することを保証する 。乳化キャリヤはそれ自体不活性であり得るがまたはそれはそれ自体の皮膚科学 的な利益を有し得る。 乳化キャリヤの濃度は、選択されたキャリヤおよび必須成分および任意成分の 意図される濃度に応じて変化し得る。好ましくは、キャリヤは、約1%から約9 9%、より好ましくは約20%から約95%で存在する。 1つの態様において、乳化キャリヤは組成物の油相および水相を含む。その様 な乳化キャリヤはさらに任意成分を含み得る。油相および水相の両方を有する組 成物は本明細書で以後記載される。 ここで有用な乳化キャリヤには、親水性液体キャリヤ、疎水性成分、両親媒性 界面活性剤、およびそれらの混合物が含まれる。 1.親水性液体キャリヤ 乳化キャリヤは、全組成物の約1重量%から約99重量%の親水性液体キャリ ヤ(HLC)を含み、より好ましくは約20%から約95%を含む。HLCは、 水または水と1以上の水溶性または水分散性成分との組み合わせを含み得る。 好ましいHLCは、皮膚科学的に許容可能な非水性親水性希釈剤を含み得る。 親水性希釈剤の発明を限定しない例は、プロピレングリコール、ポリエチレング リコール(例えば、分子量200〜600g/モル)、ポリプロピレングリコー ル(例えば、分子量425〜2025g/モル)、グリセロール、ブチレングリ コール、1,2,4−ブタントリオール、ソルビトールエステル、1,2,6− ヘキサントリオール、エタノール、イソプロパノール、ソルビトールエステル、 ブタンジオール、エーテルプロパノール、エトキシル化エーテル、プロポキシル 化エーテルおよびそれらの組み合わせを含む低級1価アルコール(たとえば、C1 −C4)および低分子量グリコールおよびポリオールのような有機親水性希釈剤 である。 2.疎水性成分 乳化キャリヤは、油脂、油、油性または他の疎水性成分を含む疎水性成分を含 む。好ましくは、乳化キャリヤは、全組成物の約1重量%から約98重量%の疎 水性成分を含み、より好ましくは約1%から約50%を含み、さらにより好まし くは約1%から約30%を含む。疎水性成分は、動物、植物、または石油から由 来し得るし、天然または合成(例えば、人造)であり得る。好ましい疎水性成分 は実質的に水に不溶性である。好ましい疎水性成分は、約1気圧の下で約25℃ 以下の融点を有するものである。 広範な適切な疎水性成分が公知であり、ここで用いられ得るものであり、多数 の例が、サガリン(Sagarin)著、化粧品、科学と技術(Cosmeti cs,Science and Technology )第2版、第1巻、32 〜43ページ(1972年)において見出され得る。適切な疎水性成分の発明を 限定しない例には、鉱油、ペトロラタム、C7−C4O直鎖および分岐鎖炭化水素 、C1−C3Oアルコールエステル、グリセリド、アルキレングリコールエステル 、プロポキシル化およびエトキシル化誘導体、糖エステル、植物油および水素化 された植物油、動物油脂、およびポリプロピレングリコールのC4−C20アルキ ルエーテル、ポリプロピレングリコールのC1−C20カルボン酸エステル、およ びジC8−C3Oアルキルエーテルが含まれる。ここで有用な疎水性成分の例は、 1994年4月26日に発行されたレットン(Letton)らへの 米国特許第5,306,514号、メルクインデックス第10版、エントリー7 048第1033ページ(1983年)、および国際化粧品成分事典(Inte rnational Cosmetic Ingredient Dictio nary)第5版、第1巻、第415〜417ページ(1993年)において記 載されている。 3.両親媒性界面活性剤 乳化キャリヤは、さらに、製品が周囲温度または上昇した温度で皮膚に適用さ れるとき、製品においてスメクチックなリオトロピック結晶を形成することが可 能である有機両親媒性界面活性剤を含む。好ましくは、両親媒性界面活性剤は、 約20℃から約40℃の温度で液晶を形成することが可能である。好ましくは、 両親媒性界面活性剤は、スメクチックなリオトロピック液晶を形成することが可 能である。一旦皮膚への製品の適用が完了すると、液晶は皮膚表面すなわち角質 層上では確認し得ない。両親媒性界面活性剤は好ましくは全組成物の約0.1重 量%から約20重量%、好ましくは約0.1%から約10%のレベルで存在する 。 ここで有用な両親媒性界面活性剤の例は、1998年8月14日に発行された タンナー(Tanner)らへのWO97/28785において記載されている 。E.任意成分 本明細書で以後記載される様に、乳化キャリヤは更に、1以上のスキンコンデ ィショニングまたはスキントリーティング機能をなし得る広範な水溶性または水 混和性任意成分を含み得る。 好ましくは、任意成分は、皮膚科学的に許容可能な成分である。任意成分は、 本明細書で記載される必須成分と物理的および化学的に相容性であるべきであり 、安定性、有効性または本発明の組成物と関連する他の使用上の利益を不等に損 なうべきではない。本発明の組成物の好ましい成分は、通常の使用状況の下で組 成物の有効性を実質的に減少させるであろう相互作用が存在しないような様式で 混合されることが可能であるべきである。 好ましくは、任意成分には、pH調整剤、保湿剤、親水性ゲル化剤、シリコー ン含有相、またはそれらの混合物が含まれる。 1.pH調整剤 乳化キャリヤは更にpH調製剤を含み得る。本明細書では、「pH調整剤」と は、組成物のpH全体を最適pHに大きくするかまたは小さくするために用いら れ、それにより成分(特にアスコルビン酸化合物)の分解を防止するいずれの成 分をも称する。最適pHは、アスコルビン酸化合物の選択に従う。例えば、組成 物がL−アスコルビルリン酸マグネシウム(MAP)を含むとき、最適pHは7 .0から約8.0周辺である。ここでの適切なpH調整剤には、酢酸塩、リン酸 塩、クエン酸塩、トリエタノールアミンおよび炭酸塩が含まれる。前述の物の組 み合わせが、しばしば組成物についての固有の最適pHに調節するために用いら れる。pH調整剤の全レベルは、全組成物の約0.01重量%から約5.0重量 %であり、好ましくは、約0.5%から約2.0%である。 2.保湿剤 乳化キャリヤはさらに保湿剤を含み得る。ここでの使用のための適切な保湿剤 には、ソルビトール、プロピレングリコール、ブチレングリコール、ヘキシレン グリコール、エトキシル化グルコース誘導体、ヘキサントリオール、グリセリン 、グリシン、ヒアルウロン酸、アルギニン、アジデュー(Ajidew)(Na PCA)、水溶性ポリグリセリルメタクリレート潤滑剤およびパンテノールが含 まれる。ここでの好ましい保湿剤はグリセリン(ときどきグリセロールまたはグ リセリンとして知られる)である。化学的には、グリセリンは、1,2,3−プ ロパントリオールである。グリセリンは、加湿の増強の観点から本発明の組成物 において特に好ましい。また、ここでの使用にとって好ましいものはブチレング リコールである。加湿の増強の観点から特に好ましいものはグリセリンと尿素と の組み合わせである。 本発明の組成物において、保湿剤は好ましくは、全組成物の約0.1重量%か ら約20重量%、より好ましくは約1%から約15%、および特に約5%から約 15%のレベルで存在する。 ここで有用な保湿剤の発明を限定しない例は、1994年4月26日に発行さ れたレットン(Letton)らへの米国特許第5,306,516号および第 5,306,515号において記載されている。 3.親水性増粘剤 乳化キャリヤは更に、親水性増粘剤を含み得る。好ましくは、親水性増粘剤は 、全組成物の約0.01重量%から約10重量%、より好ましくは約0.02% から約5%のレベルで存在する。親水性増粘剤は好ましくは、少なくとも約40 00mPa・s、より好ましくは少なくとも約10,000mPa・sおよび特 に少なくとも20,000mPa・sの粘度(20℃、ブルックフィールドRV T)を有する。 親水性増粘剤は一般的に、水溶性またはコロイド形成して水溶性のポリマーと して記載され得る。ここで有用な親水性増粘剤には、多糖、ガム、ムコ多糖(例 えばヒアルウロン酸、硫酸コンドロイチン)、カルボン酸ポリマー、架橋ポリア クリレートポリマー、天然起源(例えば、マルメロの種子)に由来する材料およ びそれらの混合物が含まれ、好ましくは多糖、ガム、寒天、またはそれらの混合 物が含まれる。例えば、1983年6月7日に発行されたクライン(Klein )らへの米国特許第4,387,107号および「化粧品のためのポリマーと増 粘剤の百科事典(Encyclopedia of Po1ymer and Thickeners for Cosmetics)」R.Y、ロックヘッド (Lochhead)およびW.R.フロン(Fron)編集、化粧品&トイレ トリー 、第108巻、95〜135ページ(1993年5月)を参照されたい。 4.シリコーン含有相 乳化キャリヤは更に、油相の全部または一部のいずれかとして、架橋ポリオル ガノシロキザンポリマーおよびシリコーンオイルを含む第1シリコーン含有相を 含み得る。好ましくは、乳化キャリヤは組成物の約0.1重量%から約20重量 %の第1シリコーン含有相を含み、より好ましくは約0.5%から約10%、よ り好ましくは約0.5%から約50%を含む。 好ましくは、架橋ポリオルガノシロキサンポリマー対シリコーンオイルの比は 、第1シリコーン含有相の重量で約1;9から約4:6、より好ましくは約2: 8から約7:3である。 ここで有用なシリコーン含有相の発明を限定しない例は、1998年3月31 日に発行されたホリングシェッド(Hollingshead)らへの米国特許 第5,733,535号において記載されている。5.その他 本発明の組成物において有用であり得る付加的な任意成分には、ビタミンおよ びその誘導体(例えば、トコフェノール、酢酸トコフェノール、トレチン酸(t retinoic acid)、レチノールなど)、D−パンテノールのような パンテノール加湿剤、サリチル酸のような角質溶解剤/剥離剤、タンパク質およ びポリペプチドおよびその誘導体、好ましくは約0.1%から約50%のレベル での、ジャーモール(Germall)115、ヒドロキシ安息香酸のメチル、 エチル、プロピルおよびブチルエステル、ベンジルアルコール、EDTA、ユー キシル(Euxyl)(登録商標)K400、プロモポール(2−ブロモ−2− ニトロプロパン−1,3−ジオール)およびフェノキシプロパノールのような水 溶 タノール(好ましくは0.1%から約5%)のような抗菌剤、ヒラロン酸(hy laronic acid)およびアメリカ合衆国バージニア州ポートスミス( Portsmith)のセラニーズ・スーパーアブソーベント・マテリアルズか ら入手可能であり、USA−A−4,076,663において記載されているサ ンウエット(Sanwet)(登録商標)IM−1000、IM−1500およ びIM−2500のようなでんぷんグラフト化ポリアクリル酸ナトリウムのよう な可溶性またはコロイド形成して可溶性の加湿剤、アルファおよびベータヒドロ キシ酸、アロエベラ、スフィンゴシンおよびファイトスフィンゴシン、コレステ ロール、皮膚光沢/均質化剤、N−アセチルシスティン、着色剤、香料および香 料可溶化剤および脂肪アルコールエトキシレート、ポリオールがグリセリン、プ ロピレングリコール、エチレングリコール、ソルビトール、ソルビタン、ポリプ ロピレングリコール、グルコースおよびシュークロースから選択され得るエトキ シル化ポリオール脂肪酸エステルのような付加的な界面活性剤/乳化剤が含まれ る。発明を限定しない例には、グリセリルモノヒドロキシステアレートおよびア ルコールのモル当り平均で10から200モルのエチレンオキサイドでエトキシ ル化されたステアリルアルコールおよびPEG−6カプリリック/カプリックグ リセリドが含まれる。 例 以下の例は、本発明の範囲内の態様を更に記載し、例証する。例は単に例示の 目的のために与えられ、本発明の限定として解さるろべきではない。と言うのは 、その多くの変形が本発明の精神および範囲から逸脱することなく可能であるか らである。適用可能な場合、成分は化学的またはCTFA名称により確認され、 または別に以下で定義される。 以下で示される成分は、当該技術において公知のいずれか通常の方法により調 製され得る。適切な方法および組成は以下に続く通りである。例1〜6 本発明の組成物は、通常の製剤化技術を用いて以下に記載の成分から調製され る。 上記組成物は以下のように適切に作られる、すなわち、 (1)水性ケイ酸マグネシウムの水分散液を調製し、その分散液を約75℃まで 加熱する、 (2)(1)を除く水溶性成分ならびに炭酸マグネシウム、硫酸亜鉛および塩化 ナトリウムを溶解し、約75℃まで溶液を加熱する、 (3)(1)および(2)を混合し、温度を約75℃に維持すろ、 (4)界面活性剤、油分およびシリコーンの混合物を約80℃に加熱する、 (5)混合物(4)を水相(3)に加え、続いて高圧ホモジェナイズする、 (6)混合物(5)が約40℃を下まわるように冷却されて後に、炭酸マグネシ ウム、硫酸亜鉛および塩化ナトリウムの別々の水溶液を加える。 本発明の例および態様の前述の詳細な説明は単に例示として与えられ、多数の 修正および変形が本発明の精神および範囲から逸脱することなく当業者に明らか になり得ることが理解される。その様な明らかな修正および変形は添付された請 求の範囲に含まれるべきである。DETAILED DESCRIPTION OF THE INVENTION Composition containing electrolyte Field The present invention relates to topical compositions. In particular, the invention relates to electrolysis in the form of an emulsion. Topical compositions, including qualities. background Consumers often protect their skin, as well as the health and Cosmetics are used to improve the physical appearance. Consumers typically Skin conditions to be placed include rough and / or damaged skin, as well as skin (Lightening of skin or against human skin) Such as old age spots, freckles, and brown spots associated with environmental damage) Treat excessive pigmentation. Numerous cosmetics can be used as needed, e.g. skin lightening, skin treatment, etc. It has been described in the art. Wide range of materials used for such products And / or components are also present. Those materials and / or ingredients Depending on the functionality or its effectiveness, it can be categorized into more than one group. Underwater The electrolyte that separates into cations and anions in the composition is a component commonly used in cosmetic compositions. Minutes. Sodium citrate and disodium ethylenediaminetetraacetate Examples of degrading, which are also classified as pH adjusters and preservatives respectively Is done. However, electrolytes tend to cause emulsion degradation. electrolytic The charge imparted by the quality component can lead to aggregation of the inner layer of the emulsion. This causes the emulsion to unintentionally separate into two layers. In addition, their charge increases It can cause disruption of the system's gel network. Therefore, it is used in the composition The electrolyte can cause a decrease in the stability of the emulsion. Based on the foregoing, the need for stable compositions containing electrolytes in emulsions Exists. Overview The present invention relates to electrolytes, crystalline inorganic mineral clays, peptizers and And an emulsifying carrier. The composition is in the form of an oil-in-water emulsion Exists. These and other features, aspects, and advantages of the present invention are described in the following description and accompanying claims. Will be better understood by reading the appended claims. Detailed description Although the specification ends with claims which particularly point out and distinctly claim the invention, Nevertheless, it is believed that the present invention will be better understood from the following description. All percentages and ratios used hereinafter are unless otherwise indicated. As far as the weight of the total composition is concerned. All measurements mentioned herein are made at 25 ° C. unless otherwise specified. All percentages, ratios, and levels of ingredients referred to herein are not otherwise stated. Unless otherwise indicated, based on the actual amounts of the ingredients, the ingredients may not be compatible with commercially available products. It does not include solvents, fillers, or other materials that can be combined together. All publications, patent applications, and issued patents mentioned herein are referenced by Is incorporated herein by reference in its entirety. The citation of any reference is Any of its usefulness as prior art to the claimed invention It is not a decision approval. As used herein, the term "comprising" refers to the final conclusion. It means that other steps and other ingredients which do not affect the fruit can be added. This The terms are "consisting of" and "essentially (Consisting essentially of) Is included. As used herein, "topical application" refers to the application or spreading of a material onto the surface of the skin. Means As used herein, "skin lightening: skin lightening "Toning)" means that the skin has a brighter, shinier and / or whiter appearance. Change of appearance and improvement of hyperpigmentation compared to before treatment I do. As used herein, “dermatologically acceptable” refers to compositions so described. Or its constituents without excessive toxicity, incompatibility, instability, allergic reactions, etc. It means that it is suitable for use in contact with human skin. As used herein, “safe and effective amount” independently refers to the benefits disclosed herein. And significantly aggressive benefits, preferably good skin appearance or feel Sufficient to produce, but avoid significant side effects, i.e. Compounds or compounds that are low enough to give a reasonable benefit-to-risk ratio within reasonable judgment. Means the amount of the composition. All ingredients such as actives and other ingredients useful herein Required for its cosmetic and / or therapeutic benefit or its action Can be categorized or described by some form. However, live Sexual agents and other components useful herein may, in some cases, be more than one compound. A form of action that can provide cosmetic and / or therapeutic benefits or more than one It should be understood that it can function in a state. Therefore, the classification here is for convenience only. And limit the ingredients to those specifically mentioned or listed. Not intended. The composition of the present invention comprises an electrolyte, a crystalline inorganic mineral clay, a peptizer, and an emulsifying agent. Including rear. Preferably, the compositions of the present invention are in the form of an oil-in-water emulsion. Exist. Emulsions generally contain a hydrophilic phase (eg, a hydrophilic liquid carrier) and a hydrophobic phase. (Eg, oil or oily material). As is well known to those skilled in the art, the hydrophobic phase Depending on the composition and / or components, to form a continuous and / or dispersed phase Will be dispersed in the hydrophilic phase. Dispersed phases sometimes contain small particles in the emulsion. Or as droplets. Without being bound by theory, the electrolyte in the emulsion is It appears to reduce the electrostatic repulsion of. Such electrostatic interactions can cause the droplets to agglomerate. Seems to promote. If such aggregates become noticeable, the emulsion is May be unintentionally separated. In addition, such electrolytes may further comprise (poly) in the composition. It can cause disruption of the gel network of thickeners (such as acrylates). Increasing the level of electrolyte in the composition typically involves increasing the desired level of electrolyte. Will improve effectiveness. For example, sodium citrate (also electrolyte Increasing the level of a pH adjuster, which is a Will be improved. Unfortunately, having such increased levels of electrolytes The composition is unstable due to aggregation of the droplets and disruption of the thickener gel network. Tend to However, we have found that crystalline inorganic mineral clays and Incorporation of a peptizing agent results in relatively high levels of the composition (ie, 0.0 (More than 5%) of the electrolyte can be improved in the stability of the composition Was found. Such stability, as described above, is particularly useful in aqueous compositions. Preferably, the pH of the composition of the present invention is from about 6.0 to about 10.0, and more preferably Preferably it is from about 7.0 to about 9.0. Preferably, the composition is a topical composition, more preferably a skin care composition Things.A. Electrolytes The compositions of the present invention include an electrolyte. As used herein, “electrolyte” refers to Release cations (eg, metal ions) when dissolved in water (a solution containing water). Outgoing compound. The level of the electrolyte depends on its valence compatibility. For example, The setting value with a divalent salt is four times that of a monovalent salt (eg, Squared). Preferably, the compositions of the present invention comprise from about 0.05% to about 10% electrolyte. And more preferably from about 0.1% to about 10%, more preferably about 1% About 5%. Electrolytes useful herein are preferably substantially pure . The electrolyte further comprises a crystalline inorganic mineral clay, a peptizer, a carrier, and optional components. Is selected depending on its compatibility. Useful electrolytes here are inorganic salts, organic salts, And mixtures thereof. Preferably, the inorganic salts useful herein further include humidified And a compound for improving the Examples of inorganic salts useful herein include potassium carbonate , Potassium chloride, potassium sulfate, potassium sulfite, sodium carbonate, sodium chloride Thorium, sodium sulfate, sodium sulfite, sodium hydrogen sulfate, sulfite water Sodium hydrogen, calcium carbonate, calcium chloride, calcium sulfate, magnecarbonate Cium, magnesium chloride, magnesium sulfate, zinc chloride, zinc sulfate, aluminum chloride Minium, aluminum sulfate, and mixtures thereof, more preferably, Sodium chloride, potassium chloride, magnesium sulfate, zinc sulfate, or a mixture thereof Contains mixtures. Preferably, the organic salts useful herein generally include preservatives and pH adjusters, generally The compounds used are included. Non-limiting examples of useful organic salts herein include: Disodium ethylenediaminetetraacetate (EDTA-2Na), ethylenediamine Trisodium tetraacetate (EDTA-3Na), tetrasodium ethylenediaminetetraacetate (EDTA-4Na), sodium benzoate, sodium citrate, Sodium lithylate is included. Useful electrolytes herein may also be separated for any purpose and / or benefit. Can be classified. In one embodiment, EDTA-2Na is an electrolyte but Commonly used as a preservative.B. Crystalline inorganic mineral clay The composition of the present invention comprises a crystalline inorganic mineral clay. In the present specification, the term `` crystalline inorganic "Mineral clay" and "CIM clay" refer to clays having a group of crystalline layers. . Preferably, the composition comprises from about 0.01% to about 20% CIM clay. More preferably, from about 0.1% to about 10%, even more preferably, from about 1% to about 5% including. High levels of electrolytes such as NaCl and EDTA-2Na (i.e., (More than 0.1%) in combination with low levels of CIM clay It is likely that the composition will be of a sexual nature. Also, high concentrations (ie, greater than 20%) Would also reduce the solubility of CIM clay in the composition It is. CIM clays useful herein are commonly used as thickeners in compositions. Including any clay. Higher levels of electrolytes tend to reduce the viscosity of the composition There is a direction. Without being bound by theory, CIM clays useful herein include electrolytes. May contribute to maintaining an aesthetically and physically desirable viscosity in a composition comprising It seems to be that. Preferably, the CIM clay of the present invention is a synthetic clay. The structure of a CIM clay is generally a group of individual crystalline layers (eg, platelets (pl) atetet). When CIM clay is added to water, the water Separate the groups of M clay (plates) into individual plates. Each of CIM clay Cationic components (eg, metal ions) on the surface of these plates are released into water. You. At the same time, a small positive charge on the edge of the platelet is localized to the negative charge on the surface Is induced by These separated plates reduce the surface charge and increase the surface Combined by a positive charge on the edge corresponding to the negative charge on the surface, To form a structure referred to as a "card house structure". You. When dissolved in aqueous solution, the electrolyte of the composition will generally have a positive charge (e.g., hydrogen or Or cations such as metal ions). Their positive charge is generally Particularly in the case of an emulsion type composition, it leads to instability of the composition. That Such positive charge may be associated with the negative charge of the dispersed CIM clay, Neutralization reduces such negative charges and reduces repulsion in the emulsion. Result. Therefore, the optimal level of positive charge addition is especially Significantly stabilizes the viscosity of the composition in its form (ie, maintains a viscous solution) To do). CIM clays useful herein include two-layer types (eg, kaolin) and three-layer Including the type. The three-layer type includes an inflatable group and a non-expandable group (eg, talc). The expansion group is an unlimited layer expansion (Unlimited Layer Expansion) n) (eg, smectite) and Limited Layer Swelling (Limited Layer) Expansion) (for example, vermiculite). Such a structure is Written in Fragrance Journal, Volume 6, pages 65-71 (1994) It is listed. Preferred smectites for the CIM clay herein include montmorillonite (Ben Tonite), beiderite, nontronite, hectorite, and saponite Is included. Suitable hectorite-type clays are available from Laporte )-Industries Ltd. (Commercially available from Cheshire, UK) Pona It is Laponite (registered trademark) XLG.C. Deflocculant The compositions of the present invention include a peptizer. Preferably, the composition comprises from about 0.001% to about It contains 5% of a peptizer, more preferably from about 0.01% to about 3%. Peptizers tend to reinforce electrolyte tolerance in clay thickening systems, Would improve the stability benefits provided by the CIM clay You. When large levels of electrolytes are used in the composition, increased levels of CIM clay also prevents the viscosity of the composition from decreasing (broken gel network) Will be needed for It is also believed that the deflocculant reacts with a positive charge on the edges of the clay platelet. This leads to the disappearance of the positive charge of the plate, and the repulsive force between the dispersed plate Increase. This also increases the negative charge in the CIM clay dispersion. That means. Therefore, higher levels of electrolyte positive charge increase clay. Combined with such negative charge of CIM clay to stabilize the viscous system Will get. Therefore, increased levels of CIM clay should include peptizers And the stability of the overall composition will be maintained. Useful peptizers here include acrylates, bisulfates, bisulfites, carbonates Phosphate, pyrophosphate, silicate, sulfate, sulfone Phosphate or pyrophosphate, preferably phosphate or pyrophosphate. Including Peptizers utilized in the compositions of the present invention include, for example, sodium salts, Cium salt, aluminum salt, potassium salt, calcium salt, zinc salt or ammonia Can be classified as different depending on the derivatized base, such as a salt. Preferred peptizers used herein are sodium hydrogen sulfate, sodium carbonate , Sodium chloride, sodium bisulfite, sodium phosphate, sodium pyrophosphate Lium, magnesium carbonate, magnesium carbonate hydroxide, magnesium chloride, sulfuric acid Magnesium, potassium carbonate, potassium chloride, potassium sulfate, calcium carbonate, Calcium chloride, calcium dihydrogen phosphate, calcium phosphate and calcium sulfate And preferably sodium phosphate and sodium pyrophosphate. Ma It is. In certain embodiments, the peptizer used herein is a crystalline inorganic mineral clay. Crystals that can be included in the composition as a mixture having Can bind to non-organic inorganic clay. The peptizer is included as a mixture of crystalline inorganic mineral clay. When combined to form a thinned or thickened system, the peptizer is preferably It is present in an amount from about 0.1% to about 20% by weight of the crystalline inorganic clay. A preferred combination of CIM and deflocculant is Laport Industries Ltd. d. Commercialized under the trade name Laponite® XLS from Cheshire, UK Is available.D. Emulsifying carrier The compositions of the present invention include an emulsifying carrier. Electrolyte carriers useful here include electrolytic Minerals, crystalline inorganic mineral clays, and peptizers Any dermatological permission that can be included to allow Acceptable carriers are also included. Therefore, emulsified carriers are those in which a particular material has the appropriate concentration. Degree, applied to the selected target, ensuring even distribution over it . Emulsifying carriers can be inert per se or they are their own dermatology Benefits. The concentration of the emulsified carrier depends on the chosen carrier and the essential and optional ingredients. It can vary depending on the intended concentration. Preferably, the carrier is from about 1% to about 9%. It is present at 9%, more preferably from about 20% to about 95%. In one embodiment, the emulsified carrier comprises an oil phase and an aqueous phase of the composition. Like that Such emulsifying carriers may further comprise optional ingredients. A pair having both an oil phase and an aqueous phase The composition is described hereinafter. Emulsifying carriers useful herein include hydrophilic liquid carriers, hydrophobic components, amphiphilic Surfactants, and mixtures thereof. 1. Hydrophilic liquid carrier The emulsifying carrier comprises from about 1% to about 99% by weight of the total composition of a hydrophilic liquid carrier. (HLC), more preferably from about 20% to about 95%. HLC is It may include water or a combination of water and one or more water-soluble or water-dispersible components. Preferred HLCs may include a dermatologically acceptable non-aqueous hydrophilic diluent. Non-limiting examples of hydrophilic diluents include propylene glycol and polyethylene glycol. Recall (for example, a molecular weight of 200 to 600 g / mol), polypropylene glycol (For example, a molecular weight of 425 to 2025 g / mol), glycerol, butylene glycol Chole, 1,2,4-butanetriol, sorbitol ester, 1,2,6- Hexanetriol, ethanol, isopropanol, sorbitol ester, Butanediol, ether propanol, ethoxylated ether, propoxyl Lower monohydric alcohols containing fluorinated ethers and combinations thereof (eg, C1 -CFour) And organic hydrophilic diluents such as low molecular weight glycols and polyols It is. 2.Hydrophobic component Emulsifying carriers contain hydrophobic components, including fats, oils, oily or other hydrophobic components. No. Preferably, the emulsified carrier comprises from about 1% to about 98% by weight of the total composition. An aqueous component, more preferably from about 1% to about 50%, even more preferably From about 1% to about 30%. Hydrophobic components can be derived from animals, plants, or petroleum And can be natural or synthetic (eg, man-made). Preferred hydrophobic component Is substantially insoluble in water. A preferred hydrophobic component is about 25 ° C. under about 1 atmosphere. It has the following melting point. A wide variety of suitable hydrophobic components are known and can be used herein, An example of this is by Sagarin,Cosmetics, science and technology(Cosmeti cs, Science and Technology ) Second Edition, Volume 1, 32 4343 (1972). Invention of a suitable hydrophobic component Non-limiting examples include mineral oil, petrolatum, C7-C4OStraight and branched chain hydrocarbons , C1-C3OAlcohol ester, glyceride, alkylene glycol ester , Propoxylated and ethoxylated derivatives, sugar esters, vegetable oils and hydrogenated Of vegetable oils, animal fats and polypropylene glycolsFour-C20Archi C of ruthel ether and polypropylene glycol1-C20Carboxylic acid esters, and Bi-C8-C3OAlkyl ethers are included. Examples of useful hydrophobic components here are: To Letton et al., Issued April 26, 1994. US Patent No. 5,306,514, Merck Index 10th Edition, Entry 7 048, page 1033 (1983), and the International Cosmetic Ingredients Dictionary (Inte rational Cosmetic Ingredient Dictio nary) 5th Edition, Vol. 1, pp. 415-417 (1993). It is listed. 3. Amphiphilic surfactant The emulsifying carrier can also be applied to the skin at ambient or elevated temperatures when the product is Can form smectic lyotropic crystals in the product Organic amphiphilic surfactants that are active. Preferably, the amphiphilic surfactant is Liquid crystals can be formed at temperatures from about 20 ° C to about 40 ° C. Preferably, Amphiphilic surfactants can form smectic lyotropic liquid crystals Noh. Once the application of the product to the skin is complete, the liquid crystal is It cannot be confirmed on the layer. The amphiphilic surfactant is preferably about 0.1 weight of the total composition. Present in an amount of from about 20% to about 20% by weight, preferably from about 0.1% to about 10%. . Examples of amphiphilic surfactants useful herein are published August 14, 1998. Described in WO 97/28785 to Tanner et al. .E. FIG. Optional ingredients As described hereinafter, the emulsifying carrier may further comprise one or more skin conditioners. Wide range of water-soluble or water that can perform the function of It may include miscible optional ingredients. Preferably, the optional component is a dermatologically acceptable component. Optional components are Should be physically and chemically compatible with the essential ingredients described herein. Unequally compromise the stability, efficacy or other use benefits associated with the compositions of the present invention. You should not. Preferred components of the composition of the present invention are assembled under normal conditions of use. In a manner such that there are no interactions that would substantially reduce the effectiveness of the product It should be possible to mix. Preferably, the optional components include a pH adjuster, a humectant, a hydrophilic gelling agent, silicone Phase, or mixtures thereof. 1. pH adjuster The emulsifying carrier may further comprise a pH adjusting agent. In the present specification, "pH adjuster" Is used to increase or decrease the overall pH of the composition to an optimal pH. Any component that prevents the degradation of components, especially ascorbic acid compounds, Also referred to as minutes. The optimum pH depends on the choice of the ascorbic acid compound. For example, the composition When the product contains L-ascorbyl magnesium phosphate (MAP), the optimum pH is 7 . It is around 0 to about 8.0. Suitable pH adjusters here include acetate, phosphoric acid Includes salts, citrates, triethanolamine and carbonates. The aforementioned set of things Combinations are often used to adjust the pH to a specific optimum for the composition. It is. The total level of pH adjuster may range from about 0.01% to about 5.0% by weight of the total composition. %, Preferably from about 0.5% to about 2.0%. 2. Moisturizer The emulsifying carrier may further comprise a humectant. Suitable humectant for use here Includes sorbitol, propylene glycol, butylene glycol, hexylene Glycol, ethoxylated glucose derivative, hexanetriol, glycerin , Glycine, hyaluronic acid, arginine, Ajidew (Na PCA), water-soluble polyglyceryl methacrylate lubricant and panthenol I will. The preferred humectant here is glycerin (sometimes glycerol or glycerol). (Also known as Lyserin). Chemically, glycerin is 1,2,3-p Lopantriol. Glycerin is a composition of the present invention from the viewpoint of enhancing humidification. Is particularly preferred. Also preferred for use here is butylene Recall. Particularly preferred from the viewpoint of enhancing humidification are glycerin and urea. It is a combination of In the compositions of the present invention, the humectant is preferably present at about 0.1% by weight of the total composition. From about 20% by weight, more preferably from about 1% to about 15%, and especially from about 5% to about Present at 15% level. A non-limiting example of a humectant useful herein is published on April 26, 1994. No. 5,306,516 to Letton et al. No. 5,306,515. 3. Hydrophilic thickener The emulsifying carrier may further include a hydrophilic thickener. Preferably, the hydrophilic thickener is From about 0.01% to about 10%, more preferably from about 0.02% by weight of the total composition To about 5%. The hydrophilic thickener is preferably at least about 40 00 mPa · s, more preferably at least about 10,000 mPa · s and Has a viscosity of at least 20,000 mPa · s (20 ° C., Brookfield RV T). Hydrophilic thickeners are generally water-soluble or colloidally formed with water-soluble polymers. It can be described as: Hydrophilic thickeners useful herein include polysaccharides, gums, mucopolysaccharides (eg, For example, hyaluronic acid, chondroitin sulfate), carboxylic acid polymer, cross-linked polymer Acrylate polymers, materials and materials derived from natural sources (eg, quince seeds) And mixtures thereof, preferably polysaccharides, gums, agar, or mixtures thereof. Things are included. For example, Klein issued on June 7, 1983 U.S. Pat. No. 4,387,107 to U.S. Pat. Encyclopedia of Polymer and Encyclopedia Thickeners for Cosmetics). Y, lock head (Lochhead) and W.W. R. Fron editing,Cosmetics & toilet Tree 108, pages 95-135 (May 1993). 4.Silicone-containing phase The emulsified carrier may further comprise a crosslinked polyol as either all or part of the oil phase. A first silicone-containing phase comprising a ganosiloxan polymer and silicone oil; May be included. Preferably, the emulsifying carrier comprises from about 0.1% to about 20% by weight of the composition. % Of the first silicone-containing phase, more preferably from about 0.5% to about 10%, More preferably, from about 0.5% to about 50%. Preferably, the ratio of crosslinked polyorganosiloxane polymer to silicone oil is From about 1: 9 to about 4: 6, more preferably from about 2: 9, by weight of the first silicone-containing phase. 8 to about 7: 3. A non-limiting example of a silicone-containing phase useful herein is described in March 31, 1998. U.S. Patent to Hollingshed et al. No. 5,733,535.5. Other Additional optional ingredients that may be useful in the compositions of the present invention include vitamins and And its derivatives (for example, tocophenol, tocophenol acetate, tretic acid (t retinic acid), retinol, etc.), such as D-panthenol Panthenol humectants, keratolytic / stripping agents such as salicylic acid, proteins and And polypeptides and derivatives thereof, preferably at a level of about 0.1% to about 50% Germall 115, methyl hydroxybenzoate, Ethyl, propyl and butyl esters, benzyl alcohol, EDTA, Euxyl® K400, Promopol (2-bromo-2- Water such as nitropropane-1,3-diol) and phenoxypropanol Dissolution An antimicrobial agent such as tanol (preferably 0.1% to about 5%); laronic acid) and Port Smith, Virginia, USA ( Portsmith) Celanese Super Absorbent Materials And are described in USA-A-4,076,663. Sanwet (registered trademark) IM-1000, IM-1500 and Starch-grafted sodium polyacrylates, such as PEG and IM-2500 Soluble or colloid forming soluble humectants, alpha and beta hydro Xylic acid, aloe vera, sphingosine and phytosphingosine, cholesteric Rolls, skin gloss / homogenizer, N-acetyl cysteine, colorants, fragrances and incense Solubilisers and fatty alcohol ethoxylates and polyols are glycerin, Propylene glycol, ethylene glycol, sorbitol, sorbitan, polyp A ethoxy tree that can be selected from propylene glycol, glucose and sucrose Contains additional surfactants / emulsifiers such as silylated polyol fatty acid esters You. Non-limiting examples include glyceryl monohydroxystearate and acetonitrile. Ethoxy with an average of 10 to 200 moles of ethylene oxide per mole of alcohol Stearyl Alcohol and PEG-6 Caprylic / Capric Group Contains lyceride. An example The following examples further describe and illustrate embodiments within the scope of the present invention. The example is merely illustrative They are provided for purposes and should not be construed as limiting the invention. To say , Many variations thereof are possible without departing from the spirit and scope of the invention It is. Where applicable, ingredients are identified by chemical or CTFA name, Or otherwise defined below. The components shown below are prepared by any conventional method known in the art. Can be made. Suitable methods and compositions are as follows.Examples 1 to 6 The compositions of the present invention are prepared from the ingredients described below using conventional formulation techniques. You. The composition is suitably made as follows: (1) Prepare an aqueous dispersion of aqueous magnesium silicate and bring the dispersion up to about 75 ° C. Heating, (2) Water-soluble components other than (1) and magnesium carbonate, zinc sulfate and chloride Dissolve the sodium and heat the solution to about 75 ° C. (3) mix (1) and (2) and maintain the temperature at about 75 ° C. (4) heating the mixture of surfactant, oil and silicone to about 80 ° C. (5) adding the mixture (4) to the aqueous phase (3), followed by high-pressure homogenization, (6) After the mixture (5) has been cooled to below about 40 ° C., Separate aqueous solutions of sodium, zinc sulfate and sodium chloride are added. The foregoing detailed description of the examples and embodiments of the present invention is given by way of example only and Modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. It will be appreciated that Such obvious modifications and variations will not Should be included in the scope of the request.
───────────────────────────────────────────────────── フロントページの続き (81)指定国 EP(AT,BE,CH,CY, DE,DK,ES,FI,FR,GB,GR,IE,I T,LU,MC,NL,PT,SE),OA(BF,BJ ,CF,CG,CI,CM,GA,GN,ML,MR, NE,SN,TD,TG),AP(GH,GM,KE,L S,MW,SD,SZ,UG,ZW),EA(AM,AZ ,BY,KG,KZ,MD,RU,TJ,TM),AL ,AM,AT,AU,AZ,BA,BB,BG,BR, BY,CA,CH,CN,CU,CZ,DE,DK,E E,ES,FI,GB,GE,GH,GM,GW,HU ,ID,IL,IS,JP,KE,KG,KP,KR, KZ,LC,LK,LR,LS,LT,LU,LV,M D,MG,MK,MN,MW,MX,NO,NZ,PL ,PT,RO,RU,SD,SE,SG,SI,SK, SL,TJ,TM,TR,TT,UA,UG,US,U Z,VN,YU,ZW────────────────────────────────────────────────── ─── Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, I T, LU, MC, NL, PT, SE), OA (BF, BJ , CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, L S, MW, SD, SZ, UG, ZW), EA (AM, AZ , BY, KG, KZ, MD, RU, TJ, TM), AL , AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, E E, ES, FI, GB, GE, GH, GM, GW, HU , ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, M D, MG, MK, MN, MW, MX, NO, NZ, PL , PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, U Z, VN, YU, ZW
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1998/009348 WO1999056703A1 (en) | 1998-05-07 | 1998-05-07 | Oil-in-water emulsion containing an electrolyte |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000516642A true JP2000516642A (en) | 2000-12-12 |
Family
ID=22266997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11537161A Ceased JP2000516642A (en) | 1998-05-07 | 1998-05-07 | Composition containing electrolyte |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP2000516642A (en) |
AU (1) | AU7473998A (en) |
WO (1) | WO1999056703A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020128345A (en) * | 2019-02-07 | 2020-08-27 | 株式会社マンダム | Oil-in-water type emulsion composition |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2804015B1 (en) | 2000-01-21 | 2005-12-23 | Oreal | NANEMULSION CONTAINING AMPHIPHILIC LIPIDS AND NONIONIC POLYMER AND USES THEREOF |
DE202012000469U1 (en) * | 2012-01-19 | 2012-01-31 | Bk Giulini Gmbh | Cosmetic additive containing alkali polyphosphates |
US20210236403A1 (en) * | 2019-07-10 | 2021-08-05 | Planet Lindsay, LLC | Cosmetic, personal care, and cleaning products |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5695109A (en) * | 1979-12-28 | 1981-08-01 | Kanebo Ltd | Three-layer type skin cosmetic |
JPS61245836A (en) * | 1985-04-24 | 1986-11-01 | Shiseido Co Ltd | Water in oil type emulsion composition |
JP2929024B2 (en) * | 1990-02-27 | 1999-08-03 | 花王株式会社 | Water-in-oil emulsion cosmetics |
-
1998
- 1998-05-07 JP JP11537161A patent/JP2000516642A/en not_active Ceased
- 1998-05-07 WO PCT/US1998/009348 patent/WO1999056703A1/en active Application Filing
- 1998-05-07 AU AU74739/98A patent/AU7473998A/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020128345A (en) * | 2019-02-07 | 2020-08-27 | 株式会社マンダム | Oil-in-water type emulsion composition |
Also Published As
Publication number | Publication date |
---|---|
WO1999056703A1 (en) | 1999-11-11 |
AU7473998A (en) | 1999-11-23 |
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