JP2000516603A - マンノース―6―リン酸塩組成物および線維性障害治療におけるその使用法 - Google Patents
マンノース―6―リン酸塩組成物および線維性障害治療におけるその使用法Info
- Publication number
- JP2000516603A JP2000516603A JP10509472A JP50947298A JP2000516603A JP 2000516603 A JP2000516603 A JP 2000516603A JP 10509472 A JP10509472 A JP 10509472A JP 50947298 A JP50947298 A JP 50947298A JP 2000516603 A JP2000516603 A JP 2000516603A
- Authority
- JP
- Japan
- Prior art keywords
- mannose
- composition according
- phosphate
- concentration
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.マンノース−6−リン酸塩それ自体、またはマンノース−6−リン酸塩の生 物学的前駆体、またはマンノース−6−リン酸塩残基を少なくとも1個含むポリ マーであるマンノース−6−リン酸塩供与化合物であって、アルカリでpH6. 5〜8にpH調製され、マンノース−6−リン酸塩特異的受容体を含有する化合 物を除くマンノース−6−リン酸塩供与化合物の液剤または懸濁剤を含む組成物 。 2.pHが6.5〜7.5である請求の範囲第1項に記載の組成物。 3.pHが7〜7.5である請求の範囲第2項に記載の組成物。 4.マンノース−6−リン酸塩供与化合物の濃度が50〜400mMである請求 の範囲第1項から第3項のいずれか一項に記載の組成物。 5.マンノース−6−リン酸塩供与化合物の濃度が65〜300mMである請求 の範囲第4項に記載の組成物。 6.マンノース−6−リン酸塩供与化合物の濃度が80〜120mMである請求 の範囲第5項に記載の組成物。 7.マンノース−6−リン酸塩供与化合物がマンノース−6−リン酸塩それ自体 であり、その化合物がさらに、創傷内またはその周囲に保持するに好適な粘性の ゲル剤を提供できるだけの、有効濃度のヒアルロン酸を含む請求の範囲第1項か ら第6項のいずれか一項に記載の組成物。 8.滅菌状態にある請求の範囲第1項から第7項のいずれか一項に記載の組成物 。 9.創傷治癒に使用することを目的とした請求の範囲第1項から第8項のいずれ か一項に記載の組成物。 10.眼の創傷治癒に使用することを目的とした請求の範囲第8項に記載の組成 物。 11.請求の範囲第1項から第8項のいずれか一項に記載の組成物をコーティン グまたは含浸させた創傷用包帯。 12.眼に投与することを目的としてゲル剤、軟膏剤または点眼剤として製剤化 された請求の範囲第1項から第8項のいずれか一項に記載の組成物。 13.眼に好適なゲル剤もしくは軟膏剤を一定量投与するための、または点眼剤 を一定量投与するためのディスペンサであって、請求の範囲第12項に記載の組 成物を収容するディスペン サ。 14.創傷に投与する薬剤の製造における、請求の範囲第1項から第12項のい すれか一項に記載の組成物の使用。 15.眼に投与する薬剤の製造における、請求の範囲第12項に記載の組成物の 使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9616896.8 | 1996-08-12 | ||
GBGB9616896.8A GB9616896D0 (en) | 1996-08-12 | 1996-08-12 | Pharmaceutical compositions |
PCT/GB1997/002076 WO1998006406A1 (en) | 1996-08-12 | 1997-07-31 | Mannose-6-phosphate composition and its use in treating fibrotic disorders |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009129987A Division JP2009221220A (ja) | 1996-08-12 | 2009-05-29 | マンノース−6−リン酸塩組成物および線維性障害治療におけるその使用法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000516603A true JP2000516603A (ja) | 2000-12-12 |
JP4971534B2 JP4971534B2 (ja) | 2012-07-11 |
Family
ID=10798358
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50947298A Expired - Fee Related JP4971534B2 (ja) | 1996-08-12 | 1997-07-31 | マンノース―6―リン酸塩組成物および線維性障害治療におけるその使用法 |
JP2009129987A Pending JP2009221220A (ja) | 1996-08-12 | 2009-05-29 | マンノース−6−リン酸塩組成物および線維性障害治療におけるその使用法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009129987A Pending JP2009221220A (ja) | 1996-08-12 | 2009-05-29 | マンノース−6−リン酸塩組成物および線維性障害治療におけるその使用法 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0921806B1 (ja) |
JP (2) | JP4971534B2 (ja) |
AT (1) | ATE249225T1 (ja) |
AU (1) | AU721224B2 (ja) |
CA (1) | CA2261988C (ja) |
DE (1) | DE69724798T2 (ja) |
DK (1) | DK0921806T3 (ja) |
ES (1) | ES2206737T3 (ja) |
GB (1) | GB9616896D0 (ja) |
PT (1) | PT921806E (ja) |
WO (1) | WO1998006406A1 (ja) |
ZA (1) | ZA977151B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009221220A (ja) * | 1996-08-12 | 2009-10-01 | Btg Internatl Ltd | マンノース−6−リン酸塩組成物および線維性障害治療におけるその使用法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003267356A1 (en) * | 2002-10-01 | 2004-04-23 | Unilever Plc | Proteins having polysaccharidase activity |
US9517023B2 (en) | 2009-06-01 | 2016-12-13 | Profusa, Inc. | Method and system for directing a localized biological response to an implant |
GB0910078D0 (en) | 2009-06-11 | 2009-07-22 | Renovo Ltd | Uses of mannose-6-phosphate |
GB0916333D0 (en) | 2009-09-17 | 2009-10-28 | Renovo Ltd | Improvement of tendon repair |
US10010272B2 (en) | 2010-05-27 | 2018-07-03 | Profusa, Inc. | Tissue-integrating electronic apparatus |
JP5827999B2 (ja) | 2010-10-06 | 2015-12-02 | プロフューザ,インコーポレイティド | 組織集積センサー |
EP3763292A1 (en) | 2013-03-14 | 2021-01-13 | Profusa, Inc. | Method and device for correcting optical signals |
WO2014197786A2 (en) | 2013-06-06 | 2014-12-11 | Kintz Gregory J | Apparatus and methods for detecting optical signals from implanted sensors |
WO2018119400A1 (en) | 2016-12-22 | 2018-06-28 | Profusa, Inc. | System and single-channel luminescent sensor for and method of determining analyte value |
GB201904469D0 (en) * | 2019-03-29 | 2019-05-15 | Givaudan Sa | Cosmetic composition |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5244651A (en) * | 1991-09-04 | 1993-09-14 | Kao Corporation | Method of desensitizing hypersensitive dentin |
GB9205800D0 (en) * | 1992-03-17 | 1992-04-29 | British Tech Group | Treatment of fibrotic disorders |
GB9616896D0 (en) * | 1996-08-12 | 1996-09-25 | British Tech Group | Pharmaceutical compositions |
-
1996
- 1996-08-12 GB GBGB9616896.8A patent/GB9616896D0/en active Pending
-
1997
- 1997-07-31 WO PCT/GB1997/002076 patent/WO1998006406A1/en active IP Right Grant
- 1997-07-31 DK DK97934624T patent/DK0921806T3/da active
- 1997-07-31 JP JP50947298A patent/JP4971534B2/ja not_active Expired - Fee Related
- 1997-07-31 CA CA002261988A patent/CA2261988C/en not_active Expired - Fee Related
- 1997-07-31 AU AU37769/97A patent/AU721224B2/en not_active Ceased
- 1997-07-31 DE DE69724798T patent/DE69724798T2/de not_active Expired - Lifetime
- 1997-07-31 ES ES97934624T patent/ES2206737T3/es not_active Expired - Lifetime
- 1997-07-31 AT AT97934624T patent/ATE249225T1/de active
- 1997-07-31 EP EP97934624A patent/EP0921806B1/en not_active Expired - Lifetime
- 1997-07-31 PT PT97934624T patent/PT921806E/pt unknown
- 1997-08-11 ZA ZA977151A patent/ZA977151B/xx unknown
-
2009
- 2009-05-29 JP JP2009129987A patent/JP2009221220A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009221220A (ja) * | 1996-08-12 | 2009-10-01 | Btg Internatl Ltd | マンノース−6−リン酸塩組成物および線維性障害治療におけるその使用法 |
Also Published As
Publication number | Publication date |
---|---|
DK0921806T3 (da) | 2003-12-08 |
ZA977151B (en) | 1999-02-11 |
AU721224B2 (en) | 2000-06-29 |
CA2261988C (en) | 2006-11-07 |
AU3776997A (en) | 1998-03-06 |
JP4971534B2 (ja) | 2012-07-11 |
CA2261988A1 (en) | 1998-02-19 |
PT921806E (pt) | 2003-12-31 |
ATE249225T1 (de) | 2003-09-15 |
WO1998006406A1 (en) | 1998-02-19 |
ES2206737T3 (es) | 2004-05-16 |
DE69724798T2 (de) | 2004-07-15 |
JP2009221220A (ja) | 2009-10-01 |
EP0921806B1 (en) | 2003-09-10 |
EP0921806A1 (en) | 1999-06-16 |
DE69724798D1 (de) | 2003-10-16 |
GB9616896D0 (en) | 1996-09-25 |
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