JP2000515171A - 生物活性荷重支持性の骨結合用組成物 - Google Patents
生物活性荷重支持性の骨結合用組成物Info
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- JP2000515171A JP2000515171A JP09521420A JP52142097A JP2000515171A JP 2000515171 A JP2000515171 A JP 2000515171A JP 09521420 A JP09521420 A JP 09521420A JP 52142097 A JP52142097 A JP 52142097A JP 2000515171 A JP2000515171 A JP 2000515171A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C10/00—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
- C03C10/0009—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition containing silica as main constituent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2002/3208—Bipolar or multipolar joints, e.g. having a femoral head articulating within an intermediate acetabular shell whilst said shell articulates within the natural acetabular socket or within an artificial outer shell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4631—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor the prosthesis being specially adapted for being cemented
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 重合性マトリックス;および 無機充填材、この充填材の少なくとも10%は、少なくとも約2容量%の コンベイト領域および不規則形態を有するコンベイトガラス−セラミックよりな る、 を含む硬化性組成物。 2. コンベイトが、コンベイトガラス−セラミックの少なくとも約3容量%を 構成する、請求項1の組成物。 3. コンベイトが、コンベイトガラス−セラミックの少なくとも約5容量%を 構成する、請求項1の組成物。 4. コンベイトが、コンベイトガラス−セラミックの少なくとも約10容量% を構成する、請求項1の組成物。 5. コンベイトが、コンベイトガラス−セラミックの少なくとも約5〜50容 量%を構成する、請求項1の組成物。 6. コンベイトが、コンベイトガラス−セラミックの少なくとも約10〜20 容量%を構成する、請求項1の組成物。 7. コンベイトガラス−セラミックが不均質粒子の形で存在する、請求項1の 組成物。 8. 上記粒子の少なくとも95重量%が約0.1ミクロンより大きな粒度を有 する、請求項7の組成物。 9. 上記粒子の少なくとも95重量%が約0.2ミクロンより大きな粒度を有 する、請求項7の組成物。 10. 上記粒子の少なくとも95重量%が約300ミクロン未満の粒度を有す る、請求項7の組成物。 11. 上記粒子の少なくとも95重量%が約100ミクロン未満の粒度を有す る、請求項7の組成物。 12. 上記粒子の少なくとも95重量%が約0.2〜300ミクロンの粒度を 有する、請求項7の組成物。 13. 上記粒子の少なくとも95重量%が約0.2〜100ミクロンの粒度を 有する、請求項7の組成物。 14. 上記粒子の少なくとも95重量%が約0.5〜50ミクロンの粒度を有 する、請求項7の組成物。 15. コンベイトガラス−セラミック充填材が、図1bと実質的に一致するX 線回折スペクトルを有する、請求項1の組成物。 16. コンベイトガラス−セラミックが、不規則な形態を有する不均質粒子の 形で存在する、請求項1の組成物。 17. コンベイトガラス−セラミック充填材がブレンドである、請求項1の組 成物。 18. 無機充填材が、少なくとも1種の追加無機物質をさらに含んでいる、請 求項1の組成物。 19. 追加無機物質が、ヒドロキシアパタイト、フルオルアパタイト、オキシ アパタイト、珪灰石、灰長石、フッ化カルシウム、アグレライト、デビトライト 、カナサイト、金雲母、モネタイト、ブラッシュ石、リン酸八カルシウム、ウイ トロック石、リン酸四カルシウム、菫青石、ベルリナイトまたはそれらの混合物 である、請求項18の組成物。 20. 重合性マトリックスがアクリル成分を含む、請求項1の組成物。 21. 重合性マトリックスがビスフェノール−A ジメタクリレートを含む、 請求項1の組成物。 22. ビスフェノール−A ジメタクリレートがビスフェノール−A グリシ ジルジメタクリレートである、請求項21の組成物。 23. ジメタクリレートがウレタン修飾されている、請求項22の組成物。 24. 重合性マトリックスが熱−または光−重合触媒を含む、請求項1の組成 物。 25. 触媒が、第3アミンと混合した状態のキノンを含む、請求項24の組成 物。 26. 触媒が過酸化物を含む、請求項24の組成物。 27. へら操作または広口注射器による送り出しで扱い易い粘度を有する、請 求項1の組成物。 28. 約5,000〜75,000センチポアズの粘度を有する、請求項27 の組成物。 29. コンベイトの領域が微結晶よりなる、請求項1の組成物。 30. コンベイトガラス−セラミック充填材が 40〜55重量%のSiO2、 10〜32重量%のNa2O、 4〜12重量%のP2O5、および 10〜32重量%のCaO を有する、請求項1の組成物。 31. コンベイトガラス−セラミック充填材が 42〜48重量%のSiO2、 14〜28重量%のNa2O、 5〜10重量%のP2O5、および 20〜29重量%のCaO を有する、請求項1の組成物。 32. 上記コンベイトガラス−セラミック充填材が 約45%のSlO2;24.5%のNa2O;24.5%のCaOおよび6% のP2O5 を有する、請求項1の組成物。 33. 少なくとも1種のアクリルモノマー; 重合触媒;および 無機充填材、この充填材の少なくとも10%は、少なくとも約2容量% のコンベイト微結晶領域を有するコンベイトガラス−セラミックよりなる、 を含む硬化性で生物適合性の修復用組成物。 34. 不規則な形態およびコンベイト微結晶領域を有する不均質粒子よりなる 、 ガラス−セラミック組成物。 35. コンベイトが、粒子の少なくとも約2容量%を構成する、請求項34の 組成物。 36. コンベイトが、粒子の少なくとも約3容量%を構成する、請求項34の 組成物。 37. コンベイトが、粒子の少なくとも約5容量%を構成する、請求項34の 組成物。 38. コンベイトが、粒子の少なくとも約10容量%を構成する、請求項34 の組成物。 39. コンベイトが、粒子の少なくとも約5〜50容量%を構成する、請求項 34の組成物。 40. 粒子の少なくとも95%が約0.1ミクロンより大きい粒度を有する、 請求項34の組成物。 41. 粒子の少なくとも95重量%が、約0.2ミクロンより大きい粒度を有 する、請求項34の組成物。 42. 粒子の少なくとも95重量%が、約300ミクロン未満の粒度を有する 、請求項34の組成物。 43. 粒子の少なくとも95重量%が、約100ミクロン未満の粒度を有する 、請求項34の組成物。 44. 粒子の少なくとも95重量%が、約0.2〜300ミクロンの粒度を有 する、請求項34の組成物。 45. 粒子の少なくとも95重量%が、約0.5〜50ミクロンの粒度を有す る、請求項3の組成物。 46. 様々な粒度のブレンドの形の請求項38の組成物。 47. 少なくとも1種のアクリルモノマー、少なくとも1種の重合性触媒、お よび少なくとも10%は、少なくとも約2容量%のコンベイト領域を有するコン ベイトガラス−セラミックよりなる無機充填材を、一緒にブレンドすることを含 む、硬化性組成物の製造方法。 48. アクリルモノマーが少なくとも1種のビスフェノール−A メタクリレ ートを含む、請求項47の方法。 49. アクリルモノマーが少なくとも1種のビスフェノール−A グリシジル メタクリレートを含む、請求項47の方法。 50. コンベイトがコンベイトガラス−セラミックの少なくとも約3容量%を 構成する、請求項47の方法。 51. コンベイトがコンベイトガラス−セラミックの少なくとも約5容量%を 構成する、請求項47の方法。 52. コンベイトがコンベイトガラス−セラミックの少なくとも約10容量% を構成する、請求項47の方法。 53. コンベイトがコンベイトガラス−セラミックの約5〜50容量%を構成 する、請求項47の方法。 54. 骨に、重合性マトリックス、および少なくとも10%は、少なくとも約 2容量%のコンベイト領域を有するコンベイトガラス−セラミックよりなる無機 充填材を含む硬化性組成物を施すことを含む、骨の修復方法。 55. コンベイトがコンベイトガラス−セラミックの少なくとも約3容量%を 構成する、請求項54の方法。 56. コンベイトがコンベイトガラス−セラミックの少なくとも約5容量%を 構成する、請求項54の方法。 57. コンベイトがコンベイトガラス−セラミックの少なくとも約10容量% を構成する、請求項54の方法。 58. コンベイトがコンベイトガラス−セラミックの約5〜50容量%を構成 する、請求項54の方法。 59. コンベイトがコンベイトガラス−セラミックの約10〜20容量%を構 成する、請求項54の方法。 60. コンベイトガラス−セラミックが不均質粒子の形で存在する、請求項5 4の方法。 61. 粒子の少なくとも95%が約0.1ミクロンより大きい粒度を有する、 請求項60の方法。 62. 粒子の少なくとも95重量%が、約0.2ミクロンより大きい粒度を有 する、請求項60の方法。 63. 粒子の少なくとも95重量%が、約300ミクロン未満の粒度を有する 、請求項60の方法。 64. 粒子の少なくとも95重量%が、約100ミクロン未満の粒度を有する 、請求項60の方法。 65. 粒子の少なくとも95重量%が、約0.2〜300ミクロンの粒度を有 する、請求項60の方法。 66. 粒子の少なくとも95重量%が、約0.2〜100ミクロンの粒度を有 する、請求項60の方法。 67. 粒子の少なくとも95重量%が、約0.5〜50ミクロンの粒度を有す る、請求項60の方法。 68. コンベイトガラス−セラミック充填材が、図1bと実質的に一致するX 線回折スペクトルを有する、請求項54の方法。 69. 無機充填材が、少なくとも1種の追加無機物質をさらに含む、請求項5 4の方法。 70. 追加無機物質が、ヒドロキシアパタイト、フルオルアパタイト、オキシ アパタイト、珪灰石、灰長石、フッ化カルシウム、アグレライト、デビトライト 、カナサイト、金雲母、モネタイト、ブラッシュ石、リン酸八カルシウム、ウイ トロック石、リン酸四カルシウム、菫青石、ベルリナイトまたはそれらの混合物 である、請求項69の方法。 71. 重合性マトリックスがアクリル成分を含む、請求項54の方法。 72. 重合性マトリックスがビスフェノール−A ジメタクリレートを含む、 請求項54の方法。 73. ビスフェノール−A ジメタクリレートがビスフェノール−A グリシ ジルジメタクリレートである、請求項54の方法。 74. ジメタクリレートがウレタン修飾されている、請求項73の方法。 75. 重合性マトリックスが熱−または光−重合触媒を含む、請求項54の方 法。 76. 触媒が、第3アミンと混合した状態のキノンを含む、請求項75の方法 。 77. 触媒が過酸化物を含む、請求項75の方法。 78. 組成物がへら操作または広口注射器による送り出しで扱い易い粘度を有 する、請求項54の方法。 79. 組成物が約5,000〜75,000センチポアズの粘度を有する、請 求項78の方法。 80. 組成物を硬化することをさらに含む、請求項54の方法。 81. 生物活性無機粒状充填材の製造方法であって、 約34重量%のSlO2、約31重量%のNa2CO3、約26.5重量%のC aCO3、および約8.5重量%のCaHPOF4を、実質的な均質性を得るのに 有効な時間および条件下で共に溶融すること; 溶融物を流し込み、結晶化および冷却して物体にすること; 物体を微粉砕して不規則な形態を有する粒子を形成すること; 粒子中のコンベイト微結晶領域の有無および量を測定すること; 粒子中のコンベイト微結晶領域の容量が2%より上の所定値より少ないという 測定に答えて、コンベイト微結晶領域の容量が少なくとも上記所定値である粒子 をもたらすのに有効な時間および温度条件下で、上記粒子を熱処理すること を含む方法。 82. 上記領域量が少なくとも約3容量%である、請求項81の方法。 83. 上記領域量が少なくとも約5容量%である、請求項81の方法。 84. 粒子が、図1bと実質的に一致するX線回折スペクトルを有する、請求 項81の方法。 85. 生物活性無機粒状充填材の製造方法であって、 約45重量%のSiO2、約24.5重量%のNa2O、約24.5重量%のC aO、および約6重量%のP2O5を、実質的な均質性を得るのに有効な時間およ び条件下で共に溶融すること; 溶融物を液体中で急冷して脆いフリットを形成すること; フリットを微粉砕して不規則な形態を有する粒子を形成すること; 粒子中のコンベイト微結晶領域の有無および量を測定すること; 粒子中のコンベイト微結晶領域の容量が2%より上の所定値より少ないという 測定に答えて、コンベイト微結晶領域の容量が少なくとも上記所定値である粒子 をもたらすのに有効な時間および温度条件下で、上記粒子を熱処理すること を含む方法。 86. 上記領域量が少なくとも約3容量%である、請求項85の方法。 87. 上記領域量が少なくとも約5容量%である、請求項85の方法。 88. 粒子が、図1bと実質的に一致するX線回折スペクトルを有する、請求 項85の方法。 89. 無機充填材で充填された重合マトリックスを含む成形体であって、充填 材の少なくとも10%が、少なくとも2容量%のコンベイトの領域および不規則 形態を有するコンベイトガラス−セラミックよりなる成形体。 90. 整形外科用ピン、ネジ、ロッド、プレート、または接合部材の形の請求 項89の成形体。 91. 歯内治療用ポイントの形の請求項89の成形体。 92. 整形外科用装置の形の請求項100の成形体。
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JP2017048393A (ja) * | 2010-07-14 | 2017-03-09 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリThe Curators Of The University Of Missouri | ポリマー複合体およびその作製 |
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EP0874601A1 (en) | 1998-11-04 |
AU1329497A (en) | 1997-06-27 |
ES2284175T3 (es) | 2007-11-01 |
IL124798A0 (en) | 1999-01-26 |
DE69636989T2 (de) | 2007-12-06 |
EP0874601B1 (en) | 2007-03-21 |
ATE357193T1 (de) | 2007-04-15 |
PT874601E (pt) | 2007-07-02 |
EP0874601A4 (en) | 2004-12-15 |
IL124798A (en) | 2003-02-12 |
DE69636989D1 (de) | 2007-05-03 |
AU710751B2 (en) | 1999-09-30 |
WO1997020521A1 (en) | 1997-06-12 |
US5681872A (en) | 1997-10-28 |
JP3788517B2 (ja) | 2006-06-21 |
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