JP2000511540A - 鎮痛剤としての新規アナンダミドアミダーゼインヒビター - Google Patents
鎮痛剤としての新規アナンダミドアミダーゼインヒビターInfo
- Publication number
- JP2000511540A JP2000511540A JP09543074A JP54307497A JP2000511540A JP 2000511540 A JP2000511540 A JP 2000511540A JP 09543074 A JP09543074 A JP 09543074A JP 54307497 A JP54307497 A JP 54307497A JP 2000511540 A JP2000511540 A JP 2000511540A
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- heteroaryl
- anandamide
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/658,949 | 1996-05-31 | ||
| US08/658,949 US5688825A (en) | 1996-05-31 | 1996-05-31 | Anandamide amidase inhibitors as analgesic agents |
| PCT/US1997/009613 WO1997045407A1 (en) | 1996-05-31 | 1997-05-30 | Novel anandamide amidase inhibitors as analgesic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000511540A true JP2000511540A (ja) | 2000-09-05 |
| JP2000511540A5 JP2000511540A5 (enExample) | 2005-01-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09543074A Pending JP2000511540A (ja) | 1996-05-31 | 1997-05-30 | 鎮痛剤としての新規アナンダミドアミダーゼインヒビター |
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| Country | Link |
|---|---|
| US (4) | US5688825A (enExample) |
| EP (2) | EP1021406B1 (enExample) |
| JP (1) | JP2000511540A (enExample) |
| AU (1) | AU3229097A (enExample) |
| CA (1) | CA2255620C (enExample) |
| DE (1) | DE69737039T2 (enExample) |
| ES (1) | ES2278391T3 (enExample) |
| WO (1) | WO1997045407A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023075089A (ja) * | 2014-06-06 | 2023-05-30 | ザ スクリプス リサーチ インスティテュート | フッ化硫黄（ｖｉ）化合物およびそれの製造方法 |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
| US20010009965A1 (en) * | 1998-05-04 | 2001-07-26 | Alexandros Makriyannis | Novel analgesic and immunomodulatory cannabinoids |
| ES2224658T3 (es) * | 1998-05-04 | 2005-03-01 | The University Of Connecticut | Nuevos canabinoides selectivos hacia el receptor cb2. |
| CA2337822A1 (en) * | 1998-06-09 | 1999-12-16 | The University Of Connecticut | Inhibitors of the anandamide transporter as analgesic agents |
| US7589220B2 (en) | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
| US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
| US7276613B1 (en) * | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| WO2001028498A2 (en) * | 1999-10-18 | 2001-04-26 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| ATE428495T1 (de) | 1999-04-28 | 2009-05-15 | Toray Industries | Stoffe zur enternung von cannabinoiden und säulen mit diesen stoffen zur entfernung von cannabinoiden |
| GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US7741365B2 (en) * | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| DE60033834T2 (de) | 1999-10-18 | 2007-11-15 | The University Of Connecticut, Farmington | Für periphäre cannabinoid-rezeptoren selektive liganden |
| US7119108B1 (en) * | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
| US6943266B1 (en) | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
| ES2174716B1 (es) * | 2000-07-28 | 2004-08-01 | Universidad Complutense De Madrid | Nuevos derivados de acido araquidonico con afinidad por el transportador de anandamida. |
| ES2181601B2 (es) * | 2001-07-27 | 2004-04-01 | Univ Madrid Complutense | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
| AU2001284061A1 (en) * | 2000-07-28 | 2002-02-18 | Universidad Complutense De Madrid | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
| WO2002058636A2 (en) * | 2001-01-26 | 2002-08-01 | University Of Connecticut | Novel cannabimimetic ligands |
| DE60237431D1 (de) | 2001-01-29 | 2010-10-07 | Univ Connecticut | Rezeptor-selektive cannabimimetische aminoalkylindole |
| WO2002062963A2 (en) * | 2001-02-08 | 2002-08-15 | Nps Pharmaceuticals, Inc. | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
| WO2003005960A2 (en) * | 2001-07-13 | 2003-01-23 | University Of Connecticut | Novel bicyclic and tricyclic cannabinoids |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| CN1589269A (zh) * | 2001-10-26 | 2005-03-02 | 康涅狄格大学 | 杂1,2－二氢化茚:一类新型有效的大麻配体 |
| EP1482917B1 (en) * | 2002-02-01 | 2019-05-08 | GW Pharma Limited | Compositions comprising cannabidiolic acid for treatment of nausea, vomiting, emesis, motion sickness or like conditions |
| US20040063726A1 (en) * | 2002-02-08 | 2004-04-01 | Artman Linda D | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
| IL148244A0 (en) | 2002-02-19 | 2002-09-12 | Yissum Res Dev Co | Anti-nausea and anti-vomiting activity of cannabidiol compounds |
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| CA2496097A1 (en) | 2002-08-23 | 2004-03-04 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
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|---|---|---|---|---|
| US3465024A (en) * | 1966-11-14 | 1969-09-02 | Allied Chem | Process for the preparation of isocyanates |
| US3577458A (en) * | 1966-11-14 | 1971-05-04 | Allied Chem | Process for the preparation of isocyanates |
| US5804601A (en) * | 1995-04-10 | 1998-09-08 | Takeda Chemical Industries, Ltd. | Aromatic hydroxamic acid compounds, their production and use |
| US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
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- 1996-05-31 US US08/658,949 patent/US5688825A/en not_active Expired - Lifetime
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1997
- 1997-05-30 AU AU32290/97A patent/AU3229097A/en not_active Abandoned
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- 1997-05-30 WO PCT/US1997/009613 patent/WO1997045407A1/en not_active Ceased
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- 1997-05-30 EP EP06024572A patent/EP1775286A1/en not_active Withdrawn
- 1997-05-30 JP JP09543074A patent/JP2000511540A/ja active Pending
- 1997-05-30 CA CA002255620A patent/CA2255620C/en not_active Expired - Fee Related
- 1997-05-30 ES ES97927958T patent/ES2278391T3/es not_active Expired - Lifetime
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2000
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2002
- 2002-02-06 US US10/068,588 patent/US6579900B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023075089A (ja) * | 2014-06-06 | 2023-05-30 | ザ スクリプス リサーチ インスティテュート | フッ化硫黄（ｖｉ）化合物およびそれの製造方法 |
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|---|---|
| EP1775286A1 (en) | 2007-04-18 |
| US6579900B2 (en) | 2003-06-17 |
| US20020091153A1 (en) | 2002-07-11 |
| US5688825A (en) | 1997-11-18 |
| EP1021406A1 (en) | 2000-07-26 |
| EP1021406B1 (en) | 2006-11-29 |
| US6391909B1 (en) | 2002-05-21 |
| DE69737039D1 (de) | 2007-01-11 |
| DE69737039T2 (de) | 2007-06-21 |
| CA2255620A1 (en) | 1997-12-04 |
| ES2278391T3 (es) | 2007-08-01 |
| CA2255620C (en) | 2008-01-29 |
| WO1997045407A1 (en) | 1997-12-04 |
| AU3229097A (en) | 1998-01-05 |
| US5874459A (en) | 1999-02-23 |
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