JP2000510098A5 - - Google Patents

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Publication number
JP2000510098A5
JP2000510098A5 JP1997532954A JP53295497A JP2000510098A5 JP 2000510098 A5 JP2000510098 A5 JP 2000510098A5 JP 1997532954 A JP1997532954 A JP 1997532954A JP 53295497 A JP53295497 A JP 53295497A JP 2000510098 A5 JP2000510098 A5 JP 2000510098A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1997532954A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000510098A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/004462 external-priority patent/WO1997036860A1/en
Publication of JP2000510098A publication Critical patent/JP2000510098A/ja
Publication of JP2000510098A5 publication Critical patent/JP2000510098A5/ja
Abandoned legal-status Critical Current

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JP09532954A 1996-03-29 1997-03-25 桂皮酸誘導体 Abandoned JP2000510098A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1432596P 1996-03-29 1996-03-29
US60/014,325 1996-03-29
PCT/US1997/004462 WO1997036860A1 (en) 1996-03-29 1997-03-25 Cinnamic acid derivatives and their use as integrin antagonists

Publications (2)

Publication Number Publication Date
JP2000510098A JP2000510098A (ja) 2000-08-08
JP2000510098A5 true JP2000510098A5 (Direct) 2004-12-02

Family

ID=21764797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09532954A Abandoned JP2000510098A (ja) 1996-03-29 1997-03-25 桂皮酸誘導体

Country Status (11)

Country Link
US (1) US5852210A (Direct)
EP (1) EP0894084B1 (Direct)
JP (1) JP2000510098A (Direct)
AT (1) ATE219764T1 (Direct)
AU (1) AU2337197A (Direct)
CA (1) CA2250690A1 (Direct)
DE (1) DE69713582T2 (Direct)
DK (1) DK0894084T3 (Direct)
ES (1) ES2179318T3 (Direct)
PT (1) PT894084E (Direct)
WO (1) WO1997036860A1 (Direct)

Families Citing this family (38)

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TW460460B (en) 1997-11-04 2001-10-21 Chugai Pharmaceutical Co Ltd Heterocyclic compounds having NOS inhibitory activities
ATE542797T1 (de) 1998-04-09 2012-02-15 Meiji Seika Pharma Co Ltd Aminopiperidinderivate als integrin alpha v beta 3 antagonisten
US6329547B1 (en) 1998-05-25 2001-12-11 Santen Pharmaceutical Co., Ltd. Vinylbenzene derivatives
GB9818641D0 (en) * 1998-08-26 1998-10-21 Rh Ne Poulenc Rorer Limited Chemical compounds
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
PL350291A1 (en) 1998-12-23 2002-12-02 Searle & Co Method of using a cyclooxygenase-2 inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6291503B1 (en) 1999-01-15 2001-09-18 Bayer Aktiengesellschaft β-phenylalanine derivatives as integrin antagonists
WO2001007031A1 (en) * 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same
AU6316900A (en) 1999-08-05 2001-03-05 Meiji Seika Kaisha Ltd. Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism
US20050059669A1 (en) * 1999-10-08 2005-03-17 Keiichi Ajito M-substituted benzoic acid derivatives having integrin alpha v beta 3 antagonistic activity
US20030040531A1 (en) * 2000-01-25 2003-02-27 Kazuyuki Fujishima Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist
RU2240826C2 (ru) 2000-02-03 2004-11-27 Эйсай Ко., Лтд. Ингибитор экспрессии интегрина
US6933304B2 (en) 2000-06-15 2005-08-23 Pharmacia Corporation Heteroarylalkanoic acids as integrin receptor antagonists
PE20020665A1 (es) 2000-06-15 2002-08-14 Pharmacia Corp ACIDO CICLOALQUIL FENIL ALCANOICO COMO ANTAGONISTA DE INTEGRINAS OVß3
US20040043988A1 (en) * 2001-06-15 2004-03-04 Khanna Ish Kurmar Cycloalkyl alkanoic acids as intergrin receptor antagonists
CN100560131C (zh) 2001-10-22 2009-11-18 斯克里普斯研究学院 抗体靶向化合物
EP1487489A4 (en) * 2002-03-04 2008-10-01 Medimmune Inc METHOD FOR PREVENTING OR TREATING ILLNESSES BY ADMINISTERING AN INTEGRIN AVB3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE
EP1487492A4 (en) * 2002-03-04 2008-10-01 Medimmune Inc PREVENTION OR TREATMENT OF CANCER WITH INTEGRIN ALPHAVBETA3 ANTAGONISTS IN COMBINATION WITH OTHER MEDICINES
JP2006513218A (ja) * 2002-12-20 2006-04-20 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのピラゾール化合物
WO2004058254A1 (en) * 2002-12-20 2004-07-15 Pharmacia Corporation Heteroarylalkanoic acids as integrin receptor antagonists
AU2003297408A1 (en) * 2002-12-20 2004-07-22 Pharmacia Corporation Thiazole compounds as integrin receptor antagonists derivatives
WO2004066956A2 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
TWI396543B (zh) 2005-05-12 2013-05-21 Sankyo Co 取代丙烯醯胺衍生物及含有它之醫藥組成物
CA2630415A1 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
WO2008053863A1 (en) * 2006-10-30 2008-05-08 Santen Pharmaceutical Co., Ltd. Novel compound having 1,4-benzothiazin-3-one skeleton or 3,4-dihydroquinolin-2-one skeleton
JP2008231088A (ja) * 2006-10-30 2008-10-02 Santen Pharmaceut Co Ltd 1,4−ベンゾオキサジン−3−オン骨格を有する新規化合物
ES2413504T3 (es) 2007-12-21 2013-07-16 Ligand Pharmaceuticals Inc. Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
IN2015DN00099A (Direct) 2012-07-18 2015-05-29 Univ Saint Louis
MX2016015467A (es) 2014-05-30 2017-03-23 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos.
CN105272888B (zh) * 2014-06-24 2018-03-27 中国科学院上海药物研究所 双芳基烯烷酸类化合物及其制备方法和用途
CN108779077A (zh) 2015-12-30 2018-11-09 圣路易斯大学 作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
JP2022529341A (ja) 2019-04-19 2022-06-21 リガンド・ファーマシューティカルズ・インコーポレイテッド 化合物の結晶形、および化合物の結晶形を生成する方法
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
AU3141693A (en) * 1991-11-22 1993-06-15 Friedman, Mark M. Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them
US5523302A (en) * 1993-11-24 1996-06-04 The Du Pont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
DE69528829T2 (de) * 1994-05-27 2003-08-07 Merck & Co., Inc. Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption
IL118325A0 (en) * 1995-05-25 1996-10-31 Pont Merck And Pharmaceutical Integrin receptor antagonists and pharmaceutical compositions containing them

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