|
US6001968A
(en)
*
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
|
EP0741187A2
(en)
*
|
1995-05-05 |
1996-11-06 |
F. Hoffmann-La Roche Ag |
Recombinant obese (Ob) proteins
|
|
US20030040467A1
(en)
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
|
US6936439B2
(en)
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
|
ATE259243T1
(de)
*
|
1995-11-22 |
2004-02-15 |
Amgen Inc |
Fettleibigkeitsprotein (ob) zur erhögung der mageren körpermasse
|
|
US6025324A
(en)
*
|
1996-05-15 |
2000-02-15 |
Hoffmann-La Roche Inc. |
Pegylated obese (ob) protein compositions
|
|
DK0954588T3
(da)
*
|
1996-12-20 |
2007-05-14 |
Amgen Inc |
OB fusionsprotein-sammensætninger og fremgangsmåder
|
|
AU770897B2
(en)
*
|
1996-12-20 |
2004-03-04 |
Amgen, Inc. |
OB fusion protein compositions and methods
|
|
ES2183351T3
(es)
*
|
1997-04-17 |
2003-03-16 |
Amgen Inc |
Composicones que comprenden conjugados de proteina ob humana activa estable con una cadena fc de inmunoglobulinas y metodos.
|
|
AU2002300605B8
(en)
*
|
1997-04-17 |
2006-02-09 |
Amgen Inc. |
Compositions Comprising Conjugates of Stable, Active, Human OB Protein with Antibody FC Chain and Methods
|
|
US6017876A
(en)
*
|
1997-08-15 |
2000-01-25 |
Amgen Inc. |
Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity
|
|
ATE267215T1
(de)
|
1997-12-08 |
2004-06-15 |
Lexigen Pharm Corp |
Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
|
|
JP4380067B2
(ja)
|
1998-04-23 |
2009-12-09 |
味の素株式会社 |
抗血栓活性物質及びグリコカリシンの検出法
|
|
US6492138B1
(en)
|
1998-05-21 |
2002-12-10 |
Amgen Canada Inc. |
Polynucleotides encoding a novel SHC-binding protein
|
|
US6420339B1
(en)
*
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
ATE316982T1
(de)
|
1999-08-09 |
2006-02-15 |
Lexigen Pharm Corp |
Mehrere zytokin-antikörper komplexen
|
|
JP2003514552A
(ja)
|
1999-11-12 |
2003-04-22 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
改善された性質を有するエリトロポエチンの形態
|
|
AU4314801A
(en)
|
2000-02-11 |
2001-08-20 |
Lexigen Pharm Corp |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
PL358582A1
(en)
|
2000-06-29 |
2004-08-09 |
Merck Patent Gmbh |
Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents
|
|
US7635680B2
(en)
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaceuticals, Inc. |
Attenuation of reperfusion injury
|
|
JP2004528025A
(ja)
*
|
2001-02-21 |
2004-09-16 |
サーロメッド・インコーポレーテッド |
修飾されたアネキシン蛋白質及び血栓症を防ぐための方法
|
|
US7645739B2
(en)
|
2001-02-21 |
2010-01-12 |
Alavita Pharmaceuticals, Inc. |
Modified annexin compositions and methods of using same
|
|
US7635676B2
(en)
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaccuticals, Inc. |
Modified annexin proteins and methods for their use in organ transplantation
|
|
RU2003129528A
(ru)
|
2001-03-07 |
2005-04-10 |
Мерк Патент ГмбХ (DE) |
Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
|
|
US6992174B2
(en)
|
2001-03-30 |
2006-01-31 |
Emd Lexigen Research Center Corp. |
Reducing the immunogenicity of fusion proteins
|
|
MXPA03009924A
(es)
|
2001-05-03 |
2004-01-29 |
Merck Patent Gmbh |
Anticuerpo recombinante especifico de tumor y uso del mismo.
|
|
DK1454138T3
(da)
|
2001-12-04 |
2012-02-13 |
Merck Patent Gmbh |
Immunocytokiner med moduleret selektivitet
|
|
EP1572748B1
(en)
|
2002-12-17 |
2010-06-23 |
MERCK PATENT GmbH |
Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
|
|
EP1578437A4
(en)
|
2002-12-27 |
2006-08-09 |
Diobex Inc |
COMPOSITIONS AND METHODS FOR PREVENTING AND REDUCING INSULIN-INDUCED HYPOGLYCEMIA
|
|
US7655618B2
(en)
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
|
US20050176108A1
(en)
*
|
2003-03-13 |
2005-08-11 |
Young-Min Kim |
Physiologically active polypeptide conjugate having prolonged in vivo half-life
|
|
JP4762904B2
(ja)
*
|
2003-11-13 |
2011-08-31 |
ハンミ ホールディングス カンパニー リミテッド |
免疫グロブリン不変領域の量産方法
|
|
DK1699822T3
(da)
|
2003-12-30 |
2008-08-04 |
Merck Patent Gmbh |
IL-7-fusionsproteiner med antistofdele, fremstilling deraf og anvendelse deraf
|
|
JP2008504008A
(ja)
|
2003-12-31 |
2008-02-14 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
改良された薬物動態を有するFc−エリスロポエチン融合タンパク質
|
|
EP1702069A2
(en)
|
2004-01-05 |
2006-09-20 |
EMD Lexigen Research Center Corp. |
Interleukin-12 targeted to oncofoetal fibronectin
|
|
KR100639397B1
(ko)
*
|
2004-03-18 |
2006-10-26 |
(주)에스제이바이오메드 |
항비만용 면역원성 하이브리드 폴리펩타이드 및 이를포함하는 항비만 백신 조성물
|
|
DE602005020837D1
(de)
|
2004-12-09 |
2010-06-02 |
Merck Patent Gmbh |
Il-7-varianten mit reduzierter immunogenität
|
|
US8227408B2
(en)
|
2005-09-07 |
2012-07-24 |
Neurotez, Inc. |
Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
|
|
EP1972349A1
(en)
*
|
2007-03-21 |
2008-09-24 |
Biocompatibles UK Limited |
GLP-1 fusion peptides conjugated to polymer(s), their production and use
|
|
WO2009143380A2
(en)
|
2008-05-21 |
2009-11-26 |
Neurotez, Inc. |
Methods for treating progressive cognitive disorders related to neurofibrillary tangles
|
|
AU2009313562B2
(en)
|
2008-11-04 |
2012-11-15 |
Neurotez, Inc. |
Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
|
|
SG175233A1
(en)
|
2009-04-22 |
2011-11-28 |
Merck Patent Gmbh |
Antibody fusion proteins with modified fcrn binding sites
|
|
CN104147596A
(zh)
*
|
2013-05-14 |
2014-11-19 |
李荣秀 |
生物药非共价结合聚合物延长治疗浓度的方法及用途
|
|
CN104524568B
(zh)
*
|
2015-01-08 |
2018-04-20 |
中国人民解放军第二军医大学 |
一种治疗肥胖症的药物组合物及其应用
|