JP2000355528A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of raising effects on cleaning of foulings on tooth surfaces, enabling the cleaning of an oral cavity gentle to the tooth surfaces and soft dental neck parts, etc., having low abrasiveness and excellent in a high feeling of use by including particles of a water-insoluble or a sparingly water-soluble porous polymeric substance having a specific particle diameter. SOLUTION: This composition is obtained by including preferably 1-80 wt.% of particles of a water-insoluble or a sparingly water-soluble porous polymeric substance having 1-1,000 μm particle diameter (e.g. a polyamide). The above porous polymeric substance preferably has 0.1-2.0 cc/g total pore volume and the particles are preferably spherical particles. The composition is capable of assuming the form such as a toothpaste and a viscous agent (a humectant), a binder, a surfactant, a sweetener, a perfume, a preservative, other polishing agents, etc., can be formulated therein.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing a porous polymer material having high cleaning ability, low abrasion and high feeling of use. More specifically, due to the porous structure of the particles, a high cleaning force is exhibited, and an excessive force that may cause damage to teeth when an external force such as brushing is applied can be alleviated. The present invention relates to an oral composition containing a polymer substance having excellent properties such as

[0002]

2. Description of the Related Art Conventionally, stains adhered and deposited on tooth surfaces,
Stain on tooth surfaces such as plaque, food debris, and tobacco tar is mainly removed by an abrasive compounded in a dentifrice. The properties required of the abrasive include a high tooth surface cleaning effect, a low tooth surface abrasion, and the like. Common toothpaste compositions include:
Inorganic powders such as calcium phosphate and calcium carbonate are blended as an abrasive, but when using a dentifrice composition containing these abrasives, there is a concern that the soft cervical part and the like may be somewhat worn. I have. In order to avoid this, as shown below, inventions ((1) to (4)) in which organic powders such as polyethylene, nylon and crystallized cellulose are blended as abrasives, and inventions in which a water-insoluble polymer is blended ( (5) to (7)) and inventions ((8) to (12)) covering the particle surface have been filed, but in any case, a result that satisfies low polishing and high cleaning is obtained. It is not at present.

(1) Oral composition containing granulated cellulose (JP-A-9-40537) (2) Dentifrice composition containing water-insoluble cellulose powder as an abrasive (JP-A-55-98111) ) A solid dental cleaning material having a hardness of 60 to 120 and comprising an elastomeric polymer resin mixture, an abrasive and a surfactant (JP-A-5-331030). Mouth cleaning agent containing hard water-insoluble powder (JP-A-59-5581)
6) (5) Gingival Massage Agent Incorporating Water-absorbing Polymer Particles in Oral Pasta Base (Japanese Patent Publication No. 7-61932) (6) Oral Composition Including Zirconium Silicate and Thermoplastic Resin (Japanese Patent Publication No. Sho 57-36245) (7) Sodium chloride-containing dentifrice composition in which polyethylene-based or polypropylene-based powder is blended with high-concentration sodium chloride (JP-A-63-57514). (8) Consisting of a pigment and a water-insoluble or poorly water-soluble polymer. A composition in which the surface of particles is coated with inorganic powder to control the time of dentifrice (Japanese Patent Publication No. 63-23168) (9) A dental material (in which a powder of inorganic or organic powder is adhered and fixed to the surface of a spherical fluorine-containing powder glass). Kaihei 3-12
7708) (10) An oral composition containing a powder of an organic powder and an inorganic powder coated with magnesium aluminate silicate (JP-A-3-153766). (11) Meta-silica powder on the surface of the organic powder and the inorganic powder. Oral composition containing powder coated with magnesium aluminate (Japanese Patent Application Laid-Open No. 1-308819) (12) Oral red matter containing powder coated with hydrotalcite on the surface of organic powder and inorganic powder ( JP Hei 3
153767)

[0004]

DISCLOSURE OF THE INVENTION The present invention provides an oral composition containing an abrasive which enhances the cleaning effect of dirt on the tooth surface and enables gentle oral cleaning of the tooth surface and soft cervix. An object of the present invention is to provide an oral composition containing an abrasive which has low abrasion and is excellent in usability.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have completed the present invention. That is, according to the present invention, the particle size is 1 to 1000 μm.
m (particularly preferably, the total pore volume is 0.1 to 2.0
(cc / g) is provided. The oral composition contains water-insoluble or poorly water-soluble porous polymer particles.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The oral composition of the present invention contains, as a base for imparting a cleaning effect, particles composed of a water-insoluble or poorly water-soluble porous polymer (hereinafter, also simply referred to as porous particles). I do. In the porous particles used in the present invention,
The particle size is 1 to 1000 μm, preferably 5 to 300 μm
m, more preferably 10 to 100 μm. Further, those having a total pore volume of 0.1 to 2.0 cc / g, further those having a total pore volume of 0.3 to 1.5 cc / g,
Those with 1.0 cc / g are extremely excellent. The porous particles can be spherical particles, crushed particles, etc.,
Particular preference is given to spherical particles. The porous particles used in the present invention are conventionally known, and can be produced by various methods, for example, a foaming method, a granulation method, or the like. As the polymer material of the porous particles,
Polyolefin resins such as polyethylene, polypropylene and polybutene, halogen-containing resins such as polyvinyl chloride and polyvinylidene chloride, acrylic resins such as methacrylic resin, formalized resins of polyvinyl acetate or its saponified products, polyamides such as nylon Resin, styrene resin, E
There are VA resin, silicone resin, natural rubber, polyisoprene rubber, silicon rubber, cellulose and the like.

[0007] The porous particles used in the present invention exhibit a high cleaning effect on hard tooth surfaces and soft cervical cervix, show low abrasiveness, and reduce abrasion of the tooth surface and cervical cervix based on the porous structure. It does not cause it. In addition, it exhibits the effect of relieving the particles when excessive force is applied. When the pore volume of the porous particles is smaller than the above range, the flexibility of the particles is impaired, and there is a possibility that abrasion occurs on the tooth surface and the cervical portion.On the other hand, when the pore volume is larger than the above range, the particles become soft. And the polishing power is too low, resulting in an insufficient cleaning effect on the tooth surface and the cervical region.

[0008] The total pore volume shown in this specification is a pore size 9320 manufactured by Shimadzu Corporation by a mercury intrusion method.
Is the value measured in. The amount of the porous particles in the oral composition is 1 to 80% by weight, preferably 5 to 80% by weight of the whole composition.
It is in the range of 50% by weight, and is appropriately selected depending on the dosage form of the oral composition. If the amount is too small, the cleaning effect will be insufficient, while if too large, the composition cannot be formed.

As the form (formulation) of the oral composition of the present invention, various forms such as powder toothpaste, wet toothpaste, toothpaste, liquid toothpaste and chewing gum can be employed. The range is appropriately selected according to the dosage form. For example, components that can be blended in the case of toothpaste, which is a typical form, include thickeners (humectants), binders, surfactants, sweeteners, flavors, preservatives, and the like. Depending on the above, other abrasives may be used together with the porous particles in an appropriate amount. Examples of the thickener include sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactit, and the like.
It is better to mix in the range of t%.

Examples of the binder include synthetic binders such as carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, sodium carboxymethylhydroxymethylcellulose, polyvinyl alcohol and polyvinylpyrrolidone, and natural binders such as xanthan gum, carrageenan and alginic acid. And inorganic binders such as gelling silica, gelled aluminum silica, veegum, and laponite. These binders are preferably blended in the range of 0.5 to 10% by weight.

As the surfactant, any of an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant can be blended. As anionic surfactants, sodium lauryl sulfate,
Sodium N-lauroyl sarcosinate, sodium dodecylbenzenesulfonate, sodium α-sulfofatty acid alkyl ester, sodium myristyl sulfate, N
Sodium myristolyl sarcosinate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-lauroyl glutamate,
N-acyl glutamates such as sodium N-palmitoyl glutamate; N-acyl taurates such as sodium N-methyl-N-acyl taurate;

Examples of nonionic surfactants include sucrose fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, and polyoxyethylene sorbitan monostearate. Fatty acid esters such as polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, maltitol fatty acid ester and lactol fatty acid ester, fatty acid ethanolamide such as alkylol amite, lauric acid mono- or diethanolamide, polyoxyethylene Higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or pluro Click, and the like.

The zwitterionic surfactants include betaine acetate-type such as betaine alkyldimethylaminoacetate and betaine fatty acid amidopropyldimethylaminoacetate;
There are imidazoline types such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt, and in addition, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-
N-alkyldiaminoethylglycine such as lauryldiaminoethylglycine and N-myristyldiaminoethylglycine; and sodium N-alkyl-1-hydroxyethylimidazoline betaine.

These surfactants may be used alone or in combination of two or more. The compounding amount is 0.1 to 5% by weight of the whole composition, preferably 0.5 to 5% by weight.
2 wt% is good.

As sweeteners, sodium saccharin,
Stevioside, neohesperidihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanine methyl ester, p-methoxycinamic aldehyde, sucrose, fructose, sodium saccharinate, stevia extract, thaumatin and the like.

As the fragrance, spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, eucalyptus oil, sage oil, mayonnaise oil, thyme oil, lemon oil, orange oil, rosemary oil, cinnamon oil, and Pimento oil , Katsura oil, perilla oil, winter green oil, 1-menthol, carvone, anethole, methyl salicylate, eugenol,
Limonene, n-decyl alcohol, citronellol, α
-Terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, crocodile or thymol.

As described above, the porous particles of the present invention can be used in combination with other abrasives. Examples of other abrasives that can be used in combination are crystalline silica, amorphous silica, other silica-based abrasives, and alumino. Examples include silicate, alumina, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, dicalcium phosphate dihydrate, heavy calcium carbonate, light calcium carbonate, and the like.

In the composition of the present invention, in addition to these components, p-acids such as citric acid, malic acid, maleic acid, and succinic acid are used.
H regulator, chelating agent such as sodium pyrophosphate, sodium tripolyphosphate, EDTA, etc., bactericide such as triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, methyl parahydroxybenzoate, butyl paraoxybenzoate, sodium benzoate, etc. Preservatives, epsilon aminocaproic acid, tranexamic acid, dextronase, amylase, protease, mutanase, lysozyme, bacteriolytic enzyme, enzymes such as ritek enzyme, alkali metal monofluorophosphates such as sodium monofluorophosphate, sodium fluoride, Fluorides such as stannous fluoride, chlorohexidine salts, hydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, chlorophyca, caropeptides, vitamins, azulene, lysoti chloride Arm, anti-tartar agents, anti-plaque agents, potassium nitrate, it can be incorporated active ingredient or medicinal ingredient, such as aluminum lactate. In addition, about the compounding quantity of these arbitrary components, it can be used suitably in the same range as a general dentifrice composition.

[0019]

EXAMPLES Hereinafter, the features and excellent effects of the present invention will be specifically described by showing Examples and Comparative Examples, but the present invention is not limited by these Examples. Examples 1 to 4 and Comparative Examples 1 to 5 Evaluation tests 1 to 3 were performed on sample liquids containing the porous polymer particles shown in Table 1. This sample liquid contains the following components in addition to the components shown in Table 1. Sorbite 30 wt% Sodium carboxymethylcellulose 1.2 wt% Sodium lauryl sulfate 1.5 wt% Propylene glycol 4 wt% Sodium saccharin 0.15 wt% Purified water Remaining total 100 wt% The porous particles used in these Examples and Comparative Examples were all used. It is a kind of nylon powder such as polyamide powder, and its blending amount is 30 wt%. Table 1 shows the evaluation results.
The evaluation test method is as follows.

(Evaluation Test 1: Cleaning Performance) A hydroxyapatite disk (Asahi Optical Co., Ltd., φ7 × 3 mm, hereinafter referred to as an HA plate) was fixed to a mouthpiece and attached to the mouth (mandibular tongue side). A pellicle was formed on the HA plate. This was placed in an apparatus for alternately immersing it in a stain solution and drying in the air, and operated for 24 hours to deposit stain on the surface of the HA plate. The composition of this stain solution is as follows. Stain solution composition Ferrous chloride hydrate 0.05 wt% Instant coffee 0.37 wt% Instant black tea 0.37 wt% The above stain-attached HA plate was added to the sample solution shown in Table 1 for 5%.
Immersion for 5 minutes, brushing back and forth 5 times, 10w
The stained pellicle was stained with a t% phloxine solution, and the color difference (Lab color system) was measured. This removal operation (immersion → brushing → color difference measurement) was repeated until the stain was completely removed (until the color difference of the HA plate became equal to that before the stain was attached). The smaller the number of times of brushing, the higher the cleaning effect was evaluated. ○: less than 15 times of brushing △: more than 15 times less than 30 times ×: more than 30 times of brushing

(Evaluation Test 2: Abrasion) The HA
The plate was subjected to reciprocal brushing 30,000 times with the same sample solution as in Test 1, then the HA plate was washed with water, and the surface was observed by SEM. It was evaluated that the less abrasive scratches on the HA plate, the less abrasion to the tooth surface and the cervical region. ：: No polishing scratches on HA surface △: Some polishing scratches on HA surface ×: Innumerable polishing scratches on HA surface

(Evaluation Test 3: Use Feeling) The same sample solution as in Tests 1 and 2 was used in the oral cavity, and whether or not it was felt as a foreign substance was evaluated by an evaluation by three persons. ：: No problem in use △: Slightly felt as foreign matter in use ×: Feel as foreign matter in use

The results of the evaluation tests 1 to 3 are as shown in Table 1. From the results, the particle size of the porous particles was 1 μm.
m and 1000 μm or less, and the total pore volume is 0.1 cc / g or more and 2.0 c or more.
It can be seen that those having c / g or less are extremely superior.

[0024]

[Table 1]

Hereinafter, the formulation examples corresponding to the oral composition of the present invention will be specifically shown, but the present invention is not limited by these formulation examples.

Formulation Example 1 Sorbit 30 wt% Sodium lauryl sulfate 1.5 wt% Carboquin methyl cellulose sodium 1.1 wt% Saccharin sodium 0.1 wt% Propylene glycol 5 wt% Fragrance 1.2 wt% Sodium monofluorophosphate 0.05 wt% Paraoxybenzoic acid Methyl 0.15 wt% Polymer particles (* 1) 30 wt% Water Remaining total 100.0 wt% (* 1: nylon having a particle size of 20 to 40 μm, an average particle size of 30 μm, and a pore volume of 0.5 cc / g)

Formulation Example 2 Sorbit 35 wt% sodium lauryl sulfate 1.5 wt% sodium carboxymethyl cellulose 0.9 wt% sodium polyacrylate 0.5 wt% sodium saccharin 0.1 wt% propylene glycol 5 wt% Flavor 1.2 wt% sodium monofluorophosphate 0.05 wt% methyl paraoxybenzoate 0.15 wt% Polymer powder (* 2) 20 wt% Water Remaining total 100.0 wt% (* 2: particle size 30 to 70 μm, average particle size 50 μm, pore volume 1. 3cc / g polyethylene)

Formulation Example 3 Dicalcium phosphate dihydrate 10 wt% Sorbit 30 wt% Sodium lauryl sulfate 1.5 wt% Sodium carboxymethyl cellulose 1.1 wt% Saccharin sodium 0.1 wt% Propylene glycol 5 wt% Flavor 1.2 wt% Monofluorophosphine Sodium acid salt 0.05 wt% Methyl paraoxybenzoate 0.15 wt% Polymer particles (* 3) 10 wt% Water Remaining total 100.0 wt% (* 3: particle size 20 to 40 μm, average particle size 30 μm, pore volume 0 .9 cc / g nylon)

Formulation Example 4 Silicic anhydride 10 wt% Sorbit 30 wt% Sodium lauryl sulfate 1.5 wt% Sodium carboxymethyl cellulose 0.8 wt% Sodium polyacrylate 0.8 wt% Sodium saccharin 0.1 wt% Propylene glycol 5 wt% Perfume 1.2 wt% Sodium monofluorophosphate 0.05 wt% Methyl paraoxybenzoate 0.15 wt% Polymer particles (* 4) 20 wt% Water Remaining total 100.0 wt% (* 4: particle size 20 to 40 μm, average particle size 30 μm, fine Nylon with a pore volume of 0.9 cc / g)

Formulation Example 5 Silicic anhydride 5 wt% 60% sorbite solution 25 wt% Glycerin 25 wt% Propylene glycol 5 wt% Xanthan gum 0.2 wt% Sodium N-lauroylglutamate 0.5 wt% Sodium lauryl sulfate 0.5 wt% Carrageenan 0.5 wt% Alginic acid 1 wt% Sodium fluoride 0.22 wt% Textlanase (1 million U / g) 0.5 wt% Saccharin sodium 0.1 wt% Fragrance 1 wt% Sodium pyrophosphate 3 wt% Polymer particles (* 5) 10 wt% Water remaining ( * 5: nylon having a particle size of 10 to 30 μm, an average particle size of 20 μm, and a pore volume of 1.2 cc / g)

With respect to the oral composition of the above-mentioned formulation example,
When the same evaluations as in the examples were carried out, the cleaning performance was high, the abrasion (low abrasion) was low, and the usability was excellent without any foreign substance feeling.

[0032]

According to the present invention, the use of porous particles makes it possible to provide an oral composition having a high cleaning performance, a low abrasion and an excellent feeling upon use. Is played.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Tatsuhiko Tsutsui 1-3-7 Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C083 AB282 AB292 AB372 AB472 AC122 AC132 AC482 AC662 AC782 AC862 AD011 AD042 AD071 AD072 AD092 AD272 AD302 AD352 AD472 BB55 CC41 DD23 DD27 EE35

Claims (3)

[Claims] 1. An oral composition containing a water-insoluble or poorly water-soluble porous polymer having a particle size of 1 to 1000 μm. 2. The porous polymer substance has a total pore volume of 0.1%.
The oral composition according to claim 1, wherein the composition is 2.0 to 2.0 cc / g. 3. The oral composition according to claim 1, wherein the porous polymer substance is a polyamide.