JP2000333973A - Denture stabilizer including xylitol - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve a plaque sticking/propagation restraining effect to a denture, and to provide a high preventive effect to intraoral contagion of the true fungi such as Candida fungi by including xylitol in a denture stabilizer. SOLUTION: Xylitol is included in this denture stabilizer. Except for including the xylitol as a blending component of the denture stabilizer, the other blending component and the shape are performed according to a formerly publicly known denture stabilizer, and are not particularly limited. This denture stabilizer shows a plaque sticking/propagation restraining effect to a denture by gradually releasing the xylitol in the oral cavity at using time, and prevents an oral disease caused by the true fungi of candidiasis by restraining propagation of the true fungi such as Candida fungi in the oral cavity, and is high in safety.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a denture stabilizer having an excellent effect of inhibiting plaque adhesion and growth on dentures and having a high preventive effect against oral infections of fungi such as Candida fungi.

[0002]

2. Description of the Related Art Candidiasis is a disease in which the mucous membrane in the mouth is covered with a white pseudomembrane, and when it is peeled off, redness and pain appear, and it often occurs in elderly people and long-term users of antibiotics. is there. The cause is said to be a kind of infection of a fungus (mold) called Candida albicans. Conventionally, bactericides have been widely used to prevent caries and periodontal disease. As a bactericide, an antibacterial organic substance such as triclosan and cetylpyridinium chloride, an antibacterial zeolite, and an inorganic antibacterial substance such as a silver phosphate are used. These antibacterial agents are contained in oral compositions such as dentifrices and mouthwashes, and are properly used in various situations. On the other hand, antifungal (mold) agents are used in various materials such as paving agents, packaging boxes, pet excrement disposal agents, resin belts for food transportation, decorative sheets, and materials for room air conditioners, and exhibit antifungal effects. are doing. Examples of the edible fungicide include a technique for suppressing the generation of mold in foods from a solvent extract of propolis with an alcohol or hexane (JP-A-6-133748).
A technique for keeping rice in good quality for a long period of time (JP-A-6-38678) by the antifungal effect of spice components (alysin, capsaicin), using monoglyceride polycarboxylic acid esters or salts thereof and organic acids, There is a technique (Japanese Patent Application Laid-Open No. 9-206045) that exerts a fungicide effect without impairing the taste and color of food. on the other hand,
When using the denture stabilizer specified by the manufacturer, it is instructed to remove the denture at bedtime at night, wash the denture, store it in water, and then re-attach it the next morning. At present, there are not a few people who use it for two to three days. In that case, Cand that is resident in the oral cavity
It is known that plaques adhere to and proliferate on dentures due to ida bacteria and produce extracellular metabolites, endotoxins, and the like, thereby causing unpleasant symptoms such as denture stomatitis and bad breath. As a countermeasure, use of denture cleaning agent, denture stabilizer, enzyme (JP-A-51-94693) and antibiotics (JP-A-55-3
No. 3143) is disclosed, but the inhibitory effect of endotoxins and extracellular metabolites produced by the bacterium or the safety is insufficient, and some components have safety problems depending on the components. Therefore, it has been desired to solve these points. In addition, there is no technique for using an antibacterial agent and an antifungal agent as a denture stabilizer and gradually releasing them into the oral cavity to prevent fungal diseases such as candidiasis.

[0003]

DISCLOSURE OF THE INVENTION The present invention relates to a denture stabilizer, which has an excellent effect of inhibiting plaque adhesion and growth on dentures and a high preventive effect against oral infection of fungi such as Candida. The challenge is to provide things.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that the problems can be solved by using xylitol, and have completed the present invention. Was. That is, according to the present invention, there is provided a denture stabilizer containing xylitol.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Xylitol used in the present invention is
It is a conventionally known substance and is known as a non-fermentable sugar. This is S. mutan, the causative bacteria of caries.
Although suppression of s growth has been widely reported, it has not been known to add it to denture stabilizers. The amount of xylitol contained in the denture stabilizer is not particularly limited, but is usually 0.05 to 30% by weight, preferably 1 to 30% by weight.
15% by weight.

[0006] The denture stabilizer of the present invention is characterized by containing xylitol as a compounding component as described above, but the other compounding components and the form thereof are in accordance with conventionally known denture stabilizers. There is no particular limitation.

[0007] The denture stabilizer is an agent that temporarily fixes an incompatible denture caused by the absorption or deformation of the ridge due to aging to the palatal mucosa and supplements the occlusion, mastication, conversation, etc., but is currently commercially available. Denture stabilizers are roughly classified into two types depending on the mechanism of fixing the denture to the mucous membrane. One is a "contact type" in which a water-insoluble rubber paste-like preparation is buried in the gap between the denture base and the mucous membrane to remove air therebetween and vacuum-adsorb the denture to the mucous membrane. The other is a "adhesive type", which uses a water-soluble adhesive polymer as the main agent, absorbs saliva in the mouth between the denture base and the mucous membrane to exhibit adhesiveness, and sticks the denture to the mucous membrane. Various dosage forms such as powders, pastes, liquids and sheets are provided. The denture stabilizer according to the present invention includes both the above-mentioned adhesive type and adhesive type.

One preferred embodiment of the denture stabilizer of the present invention is, for example, a denture stabilizer containing, for example, polyisobutylene and / or polybutene and, as an auxiliary component thereof, a conventional release agent or a softener. Can be. In this case, the polyisobutylene has an average molecular weight of 870 represented by the average molecular weight described in the official food additive standard.
0 to 200,000, preferably 8700 to 50,000. This polyisobutylene may be used alone or in combination of two or more polyisobutylenes having different average molecular weights. Its content in the product is 60-99% by weight,
Preferably it is 70 to 85% by weight. On the other hand, in the case of polybutene, the average molecular weight is 500 to 5500, preferably 3000 to 5500. This polybutene is 1
Two or more kinds of polybutenes having different species or different average molecular weights may be used in combination. The amount of the compound in the composition is 6
It is from 0 to 99% by weight, preferably from 70 to 90% by weight.

The above-mentioned polyisobutylene and polybutene can be used in combination. In this case, the total blending amount of both polymers is 60 to 99% by weight, preferably 80 to 99% by weight in the composition. In that case, the polyisobutylene used has an average molecular weight of 8700 to 200,000, preferably 8700 to 50,000.
The polybutene has an average molecular weight of 500 to 5500, preferably 500 to 3000.

Auxiliary components that act as release agents or softeners include polyalkylene oxide polymers, polyhydric alcohols, higher alcohols, fatty acids or their esters, natural waxes, paraffins and the like. The total amount of the auxiliary components is 1 to 40% by weight, preferably 5 to 40% by weight.
30% by weight.

As the polyalkylene oxide-based polymer, for example, all of the polyoxyalkylene chains are a polyethylene oxide chain, a polypropylene oxide chain or the like. Examples include homopolymers, polyethylene oxides containing two or more types of polyalkylene chains, and polypropylene oxide copolymers. The compounding amount of the polyalkylene oxide-based polymer is 0.1 to 20% by weight, preferably 0.5 to 15% by weight.

As the polyhydric alcohol, dihydric and / or
Or trivalent, for example, ethylene glycol,
Examples include polyethylene glycol, propylene glycol, and glycerin. As the higher alcohol,
Cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol,
Hexyldecanol, isostearyl alcohol, octyldecanol, decyltetradecanol, decyl alcohol, lauryl alcohol, mystyl alcohol, cetyl alcohol, aralkyl alcohol and the like.

[0013] The fatty acid chain of the fatty acid alkyl ester has 5 to 20 carbon atoms, preferably 9 to 18 carbon atoms. When the chain length is less than 4 carbon atoms, irritation to the mucous membrane is felt,
If the carbon number is 21 or more, it bleeds and contaminates the denture base. The alkyl moiety is composed of a monohydric or polyhydric alcohol having a chain length of 1 to 20 carbon atoms, and the alkyl chain is preferably an alkyl group having 3 to 18 carbon atoms.
Specifically, isopropyl pentanoate, stearyl pentanoate, isocetyl octoate, cetyl 2-ethylhexanoate, methyl isononanoate, isononyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, hexyldecyl dimethyloctanoate, hexyl laurate, Isocetyl myristate, isopropyl myristate, myristyl myristate, ethyl isostearate, hexyl isostearate, isopropyl isopalmitate, octyl isopalmitate, isocetyl stearate, ethyl stearate, eicosyl stearate, isopropyl palmitate, isopropyl palmitate, stearyl eicosanate, Cetyl octoate, cetostearyl octoate, glyceryl trioctanoate, hexyl laurate,
Octyl dodecyl myristate, octyl palmitate, cetyl palmitate, butyl stearate, octyl stearate, stearyl stearate, isoprohyl isostearate, butyl isostearate, isocetyl isostearate, glyceryl triisostearate, ethyl oleate, glyceryl trioctanoate, Triacetylglycerin, diacetylglycerin, ethylene glycol diacetate and the like.

Examples of the natural wax include beeswax, wood wax, candelilla wax, microcrystalline wax, paraffin wax, carnauba wax, rice wax and the like. Paraffins are liquid or solid at room temperature and have 5 carbon atoms. ~ 25.

[0015] The denture stabilizer composition of the present invention may contain other components as required, for example, non-toxic oils and fats, emulsifiers, water-insoluble powders, wetting agents, water, pH adjusters, preservatives, dyes or pigments. , Flavors, etc., gum, paste (cream),
It can be processed into a dosage form of a sheet. Examples of the non-toxic oils include vegetable hardened oils. Examples of the emulsifier include mono-triglyceride of stearic acid, mono-triglyceride of oleic acid, saccharified fatty acid esters, acetylated glyceryl monostearate such as acetyl glyceryl monostearate, and sorbitan monostearate. Examples of the water-insoluble powder include calcium carbonate, calcium hydrogen phosphate, silica, zeolite, plastic powder such as polyethylene and polypropylene, and cellulose powder.

[0016]

The denture stabilizer of the present invention can be produced in the same manner as known denture stabilizers, and can be used in the same manner as conventional ones. The denture stabilizer of the present invention exhibits a plaque adhesion / proliferation inhibitory effect on dentures by releasing xylitol into the oral cavity at the time of use during use, and suppresses the growth of fungi in the oral cavity such as Candida bacteria. And prevent oral diseases caused by fungi such as candidiasis and are highly safe.

[0017]

Next, the present invention will be described in more detail by way of examples.
In addition,% shown below is% by weight. In the following examples, the component compositions (% by weight) of the denture stabilizer of the present invention are shown.

Example 1 Carboxymethylcellulose 70 (%) Polyethylene oxide 19.99 Xylitol 10 Fragrance 0.01

Example 2 Carboxymethylcellulose 15 (%) Methyl vinyl ether / maleic anhydride copolymer 30 Xylitol 5 Vaseline 40 pH adjuster 0.19 Fragrance 0.01 Liquid paraffin balance

Example 3 Carboxymethylcellulose 50 (%) Polyethylene oxide 10 Xylitol 7 Fragrance 0.01 Liquid paraffin Balance

Example 4 Vinyl acetate resin (average degree of polymerization: 1600) 60 (%) polypropylene glycol 5 xylitol 15 60% ethanol balance

Example 5 Vinyl acetate resin (average degree of polymerization: 1600) 60 (%) Polypropylene glycol 5 L-glutamic acid 1 Cetylpyridinium chloride 0.5 Xylitol 12 60% Ethanol Balance

Example 6 Vinyl acetate resin (average degree of polymerization: 1600) 62 (%) Polypropylene glycol 6 L-glutamic acid 1 Xylitol 15 60% Ethanol Balance

Comparative Example 1 Carboxymethylcellulose 15 (%) Methyl vinyl ether / maleic anhydride copolymer 30 Vaseline 40 pH adjuster 0.19 Fragrance 0.01 Liquid paraffin balance

Comparative Example 2 Vinyl acetate resin (average degree of polymerization: 1600) 62 (%) Polypropylene glycol 6 L-glutamic acid 1 60% ethanol Balance

Next, the denture stabilizer compositions shown in the above Examples and Comparative Examples were formed into sheets of 10 mm × 10 mm × 5 mm, and their microbiological performance was evaluated as follows. A plate medium was prepared using a Sabouraud agar medium (Nissui). A hole having the same size as the sheet was made in the center of the flat plate, and the sheet was embedded. Candida
albicans (hereinafter referred to as C. a) was cultured, and a bacterial solution 0.4 was collected.
The resulting suspension was suspended in 4 ml of a medium for baking soda and layered on the above plate. After anaerobic culture at 37 ° C for 24 hours, C.I. The width of the growth inhibition zone of bacteria a was measured at two points with a vernier caliper for each sample. Table 1 shows the results.

[Table 1]

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Koichi Saito 1-37 Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C089 AA04 BC03

Claims (1)

[Claims] 1. A denture stabilizer comprising xylitol.