JPH1149625A - Artificial tooth stabilizing agent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of suppressing the plaque adherence to an artificial tooth base, excellent in preventing effect of stomatitis due to the artificial tooth, ozostomia, etc., and activating effect of mucous membrane tissue under the artificial tooth base by containing an organic and/or an inorganic bactericide in an artificial tooth stabilizing agent. SOLUTION: This artificial tooth stabilizing agent composition is obtained by blending an organic bactericide (e.g. cetylpyridinium chloride, benzalkonium chloride, benzetonium chloride, triclosan and eugenol) and/or an inorganic bactericide (e.g.; a material obtained by loading silver, copper or zinc on apatite, zeolite, silica, etc.), with an artificial tooth stabilizing agent. The amount of blending is preferably 0.001-5 wt.% (solid portion) based on the total of the composition. Especially, it is possible to further impart a suppressing effect on an endotoxin and an exoteric metabolite produced by bacteria by simultaneously using the cetylpyridinium chloride and the benzetonium chloride or simultaneously using glutamic acid and/or lysozyme with the above two bactericides.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention suppresses the adhesion of plaque to a denture base, is excellent in preventing denture stomatitis, bad breath and the like, and is excellent in the effect of activating submucosal tissue under a denture base. About things.

[0002]

2. Description of the Related Art A denture stabilizer is used to temporarily fix an incompatible denture caused by the absorption or deformation of a ridge due to aging to the palatal mucosa,
High effect has been recognized as a supplement for conversation and the like.

[0003] The denture stabilizers currently on the market are roughly classified into two types depending on the mechanism of fixing the denture to the mucous membrane.

One is an "adhesive type" in which a water-soluble adhesive polymer is used as a main ingredient to absorb saliva in the mouth between the denture base and the mucous membrane to exhibit adhesiveness, and to attach the denture to the mucous membrane. For this, various dosage forms such as powders, pastes, liquids and sheets are provided. Overseas, this adhesive type is dominant.

[0005] Adhesive type base materials include, as water-soluble polymers having high viscosity and adhesiveness, natural substances such as karaya gum, gum arabic, tragacanth gum, and sodium alginate, sodium carboxymethylcellulose, and polyacrylic acid. Synthetic or semi-synthetic polymers such as salts, polyethylene oxide, and polyvinylpyrrolidone are used alone or in combination.

The other is a "close contact type" in which a water-insoluble rubber paste-like preparation is buried in a gap between the denture base and the mucous membrane to remove air therebetween and vacuum-adsorb the denture to the mucous membrane. This close contact type is the mainstream of denture stabilizers.

[0007] The main component of this adhesive type is a main agent having a moderate elasticity, generally a vinyl acetate resin having an average degree of polymerization of 200 to 7000 (JP-B-60-21123, JP-B-1-9018). It is used as

[0008] Since the close contact type is rubbery, it has a function as a cushioning material, in addition to a function of fixing a denture, as well as a function of cushioning a pain caused by an unfit part of the denture coming into contact with the gums and mucous membranes and irritating at the time of occlusion. . In addition, since this type is insoluble in water, it can be used continuously for 2 to 3 days, and since the components are not eluted with saliva or the like during use, there is an advantage of having an excellent feeling of use without discomfort and unpleasant taste. is there.

On the other hand, since this type is fixed by vacuum suction, it is difficult to obtain a strong fixing force as compared with the adhesive type. Further, some denture materials have drawbacks such that the preparation cannot be applied because the preparation does not adhere to the denture base. Further, in this type, the preparation remains on the denture base even after use, so that it is necessary to peel it off with the fingers. However, since the conventional product has poor releasability, many studies have been made to improve this (Japanese Patent Application Laid-Open (JP-A) No. 2002-110572). 61-73648
JP-A-62-129210, JP-A-62-265
No. 209, JP-A-1-180807, JP-A-2-12
4808, JP-A-2-292207, JP-A-4-1
49110, JP-A-5-65210, JP-A-5-6
No. 5211, JP-A-7-157408).

[0010] However, according to the instructions of the dentist and the manufacturer, when sleeping at night, it is instructed to remove the dentures, clean them, store them in water, and re-attach them the next morning, but cleaning is insufficient. Many people use it for 2-3 days without removing it.

In that case, Candid resident in the oral cavity
Plaques adhere to dentures due to bacteria a and bacterium Fusobacterium, and bacteria are formed, causing extracellular metabolites, cytotoxic substances, endotoxins, and the like, causing discomfort symptoms such as denture stomatitis and bad breath. It is known that As countermeasures against this, the use of denture cleansing agents, the addition of enzymes (Japanese Patent Application Laid-Open No. 51-94693) and antibiotics (Japanese Patent Application Laid-Open No. 55-33143) as denture stabilizers are exemplified.
The effect of inhibiting endotoxins and extracellular metabolites produced by bacteria is insufficient, and it has been demanded to solve this point.

[0012]

Means for Solving the Problems and Embodiments of the Invention The present inventors have responded to the above demands, have the effect of preventing plaque from adhering to dentures, have the effect of preventing denture stomatitis and bad breath, and furthermore have the tissue of the oral mucosa. As a result of intensive studies to impart an activating effect to the denture stabilizer, the combination of organic and inorganic fungicides, more preferably, glutamic acid, lysozyme, cetylpyridinium chloride, two or more selected from benzethonium chloride The present inventors have found that a denture stabilizer composition having an inhibitory effect on endotoxins and extracellular metabolites produced by the bacterium can be obtained by combining and blending, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail.
The present invention is obtained by blending an organic and / or inorganic fungicide with a denture stabilizer. As the organic fungicide, a cationic fungicide and a nonionic fungicide are suitably used.

The fungicides used in the present invention may be those normally used in oral preparations. Examples of the cationic fungicides include cetylpyridinium chloride, benzalkonium chloride, chlorohexidine hydrochloride, chlorohexidine gluconate, and chlorohexidine gluconate. There are decalinium, benzethonium chloride, domiphen bromide and the like, and nonionic fungicides include triclosan, eugenol, thymol and the like. Also,
Examples of the inorganic bactericide include those in which silver, copper, and zinc are supported on apatite, zeolite, silica, and the like, and antibacterial glass in which silver, copper, and the like are bonded to glass.
More than one species can be blended. The compounding amount is 0.001 to 5% of the whole composition (solid content% by weight, the same applies hereinafter),
Preferably it is 0.01 to 3%.

In the present invention, cetylpyridinium chloride and benzethonium chloride are used in combination as the above-mentioned fungicides, or the above-mentioned fungicides are used from the viewpoint of imparting an inhibitory effect on endotoxins and extracellular metabolites produced by the bacteria. In particular, it is preferable to use glutamic acid and / or lysozyme in combination with cetylpyridinium chloride and / or benzethonium chloride. Also in these combinations, the compounding amount to the denture stabilizer is preferably 0.001 to 5%, particularly preferably 0.01 to 3%.

The denture stabilizer component of the present invention may be of an adhesive type or a close-contact type, and known components can be used. For example, natural gums, polysaccharides, synthetic resins, release accelerators, non-toxic oils and fats, waxes, emulsifiers, water-insoluble powders, wetting agents, water, pH adjusters, preservatives,
A pigment, a pigment, a fragrance, and the like are added to produce a powder, liquid, paste, or sheet.

As the natural gum, for example, gum arabic, gum karaya, gum tragacanth, gum acacia, guar gum, xanthan gum and the like can be used. As the polysaccharide, for example, cellulose, alginate, pectin, carboxymethylcellulose salt, starch, agarose and the like can be used. As synthetic resins, for example, vinyl acetate resin, polyacrylate resin, polymethacrylate resin,
Silicone resin and the like can be used.

These natural gums, polysaccharides, synthetic resins and the like, which are the main components of the denture stabilizer, are blended in the composition in an amount of 20 to 80%.

Examples of the release accelerator include polypropylene glycol, acrylic copolymer, nonionic surfactant and the like. Non-toxic oils and waxes include hardened vegetable oils, beeswax, wood wax, candelilla wax, microcrystalline wax, paraffin wax, carnauba wax and the like. Examples of the emulsifier include stearic acid mono-triglyceride, oleic acid mono-triglyceride, sucrose fatty acid ester, acetylated glyceryl monostearate, and sorbitan monostearate. As the water-insoluble powder, calcium carbonate,
Calcium hydrogen phosphate, silica, zeolite, plastic powder such as polyethylene and polypropylene, cellulose powder and the like are used. As the wetting agent, ethanol, propanol, glycerin, sugar alcohol, ethylene glycol, polyethylene glycol, triacetyl glycerin, diacetyl glycerin, ethylene glycol diacetate and the like are used. These components can be blended in usual doses.

The denture stabilizer composition of the present invention can be produced in the same manner as known denture stabilizers, and can be used in the same manner as conventional ones.

[0021]

Industrial Applicability The denture stabilizer composition of the present invention suppresses plaque adhesion to a denture base, prevents denture stomatitis, bad breath and the like, and has excellent effects such as activation of mucous tissue under a denture base. is there.

[0022]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, all% in each example are weight%.

Example 1 (adhesion type) Vinyl acetate resin (average degree of polymerization: 1500) 60.0% Cetylpyridinium chloride 0.2 60% Ethanol Balance meter 100.0%

Example 2 (Adhesive Type, Powder) Carboxymethylcellulose 75.0% Polyethylene oxide 23.99 Benzethonium chloride 0.5 Perfume 0.01 Total 100.0%

Example 3 (Adhesive type, paste) Carboxymethyl cellulose 15.0% Methyl vinyl ether / maleic anhydride copolymer 30.0 Chlorohexidine hydrochloride 1.0 Vaseline 40.0 pH adjuster 0.2 Perfume 0 01 Liquid paraffin balance meter 100.0%

Example 4 (Adhesive Type, Sheet) Carboxymethyl Cellulose 30.0% Polyethylene Oxide 10.0 Domiphen Bromide 1.0 Polyethylene Glycol 20.0 Fragrance 0.03 Vaseline Balance Meter 100.0%

Example 5 (Adhesive Type, Liquid) Carboxymethyl Cellulose 45.0% Polyethylene Oxide 15.0 Decalinium Bromide 1.0 Fragrance 0.03 Liquid Paraffin Balance Meter 100.0%

Example 6 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Triclosan 0.4 60% Ethanol Balance meter 100.0%

Example 7 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Cetylpyridinium chloride 0.8 L-glutamic acid 1.2 60% Ethanol Balance meter 100.0%

Example 8 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Silver-supported apatite 0.8 60% Ethanol Balance meter 100.0%

Example 9 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Cetylpyridinium chloride 0.5 Benzethonium chloride 1.6 60% Ethanol Balance meter 100.0%

Example 10 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Benzethonium chloride 0.3 Lysozyme chloride 0.5 60% Ethanol Balance meter 100.0%

Example 11 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Benzethonium chloride 0.5 L-glutamic acid 1.5 60% Ethanol Balance meter 100.0%

Example 12 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Lysozyme chloride 1.0 Glutamic acid 1.0 60% Ethanol Balance meter 100.0%

Example 13 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 Cetylpyridinium chloride 0.4 Benzethonium chloride 0.6 Lysozyme chloride 1.0 60% Ethanol Balance meter 100.0%

Example 14 (Adhesive Type, Powder) Carboxymethylcellulose 75.0% Polyethylene oxide 22.99 Lysozyme chloride 1.0 Cetylpyridinium chloride 1.0 Fragrance 0.01 Total 100.0%

Example 15 (Adhesive Type, Paste) Carboxymethyl Cellulose 15.0% Methyl Vinyl Ether / Maleic Anhydride Copolymer 30.0 Lysozyme Chloride 1.0 Cetylpyridinium Chloride 1.0 Vaseline 40.0 pH Adjuster 0.2 Perfume 0.01 Liquid paraffin Balance meter 100.0%

Example 16 (Adhesive Type, Sheet) Carboxymethyl Cellulose 30.0% Polyethylene Oxide 10.0 Lysozyme Chloride 1.0 Cetylpyridinium Chloride 1.0 Polyethylene Glycol 20.0 Fragrance 0.03 Vaseline Balance Meter 100. 0%

Example 17 (Adhesive Type, Liquid) Carboxymethyl Cellulose 45.0% Polyethylene Oxide 15.0 Lysozyme Chloride 1.0 Cetylpyridinium Chloride 1.0 Fragrance 0.03 Liquid Paraffin Balance Meter 100.0%

Comparative Example 1 (Adhesion type) Vinyl acetate resin 60.0% Polypropylene glycol 3.0 60% Ethanol Balance meter 100.0%

Comparative Example 2 (Adhesive Type, Paste) Carboxymethyl Cellulose 15.0% Methyl Vinyl Ether / Maleic Anhydride Copolymer 30.0 Vaseline 40.0 pH Adjuster 0.2 Fragrance 0.01 Liquid Paraffin Balance Meter 100.0%

Using the denture stabilizer compositions of Examples and Comparative Examples having the above compositions, an antibacterial activity test was conducted by the following method. Table 1 shows the results. Antibacterial activity test method Candida albicans (hereinafter C. alb)
icans) includes Sabouraud agar medium (Nissui), Fu
sobacterium nucleatum (hereinafter, referred to as
F. nucleatum) contains THB 3% and agar 1.5
%, Respectively, to prepare a plate medium,
m holes were drilled. Thereafter, 0.5 g of each denture stabilizer was placed in the hole. After culturing each test bacterium for 12 hours, 0.5 ml of the bacterium solution is used as an overlay medium (agar in each of the above-mentioned media is adjusted to 0.5%).
After inoculating and spreading in 4 ml, it is overlaid on the above test plate,
After anaerobic cultivation at 37 ° C. for 24 hours, the width of the bacterial growth inhibition zone was measured with a pair of calipers for each sample.

[0043]

[Table 1]

Next, an in vitro endotoxin suppression test was performed by the following method using the denture stabilizers of Examples and Comparative Examples having the above composition. Table 2 shows the results.

In Vitro Endotoxin Inhibition Test Method An endospace method (Seikagaku Corporation) was carried out with a modification. Actinobacillus actino
mycetemcommitants Y4, Porphy
Romanas gingivalis 381, Fu
endotoxin of S. nucleatum (hereinafter, Aa LPS, Pg LPS, FnL)
1 μg / ml of PS) and 1 ml of the eluate of the above-mentioned denture stabilizer composition (prepared by immersing 1 g of the denture stabilizer composition in 100 ml of distilled water for 1 hour) at 37 ° C. for 30 minutes, and then incubating each LPS Was adjusted to 100 pg / ml, and endotoxin activity suppression by the endospace method was evaluated.

[0046]

[Table 2]

From the results shown in Tables 1 and 2, it was found that the combination of the compositions of the Examples, in which the bactericide was blended alone, inhibited the growth of bacteria and suppressed the endotoxin activity. It has been found that the effect can be enhanced by combining two or more selected from glutamic acid, lysozyme, cetylpyridinium chloride, and benzethonium chloride with the denture stabilizer.

Claims (3)

[Claims] 1. A denture stabilizer composition comprising a denture stabilizer and an organic and / or inorganic fungicide. 2. The fungicide is cetylpyridinium chloride, benzalkonium chloride, chlorohexidine hydrochloride, chlorohexidine gluconate, decalinium chloride, benzethonium chloride, domiphen bromide, triclosan, eugenol, thymol, and silver on apatite, zeolite or silica. The denture stabilizer composition according to claim 1, wherein the composition is at least one selected from a substance carrying copper or zinc and an antibacterial glass obtained by bonding silver or copper to glass. 3. The denture stabilizer composition according to claim 1, wherein glutamic acid and / or lysozyme are used in combination.