JP2000199761A - Humor-component measuring implement - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a humor-component measuring implement with which the component of a humor can be measured effectively, even when the humor is hardly stuck to parts other than a required part on a housing and when the amount of humor is small by a method, wherein a humor introduction guide part which is used to guide the humor up to a suction port is installed around the suction port. SOLUTION: In this humor-component measuring implement 1, a flow passage part 3 guides a humor up to a sheet of measuring test paper 6, which is attached to the plane of a housing 2, from a suction port 4 by means of a capillary phenomenon. In addition, a humor inlet guide part 5 is installed around the suction port 4, and a humor which comes into contact with its tip part is guided to the suction port 4. At this time, the humor which is guided once to the suction port 4 is spread to the tip part 7 of the housing 2, a suction force becomes insufficient, and the amount of the humor becomes unnecessarily large. As a result, it is desirable that the humor inlet guide part 5 have a shape which does not retain or hold the humor around the suction port 4 and in which the humor does not flow out to other parts. For example, two protrusions 51a, 51b are made to protrude to the outside direction in a rail shape around the suction port 4. It is desirable that their height reaches the rear surface from the surface of the tip part 7. It is preferable that a material whose hydrophilic property is high such as an acrylic resin or the like be used in the same manner as the flow passage part 3.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a body fluid component measuring device for measuring a component of a body fluid such as blood.

[0002]

2. Description of the Related Art With the increase in the number of diabetic patients in recent years, autologous blood glucose measurement for monitoring daily fluctuations in blood glucose level has been recommended. A method for measuring the blood glucose level is to use a puncture device equipped with a needle-like or lancet-like lancet to cut the skin of the fingertip, press the area around the puncture part with a finger or the like, and squeeze out the blood. The test piece to reach the test paper containing the reagent that reacts with glucose in it is touched, and the reaction in the test paper part is measured optically as a color reaction, or the test paper is electrically operated by an electrode provided on the test paper. Is measured and converted to blood sugar level. As a test piece for collecting such blood and body fluid, a test piece for dropping blood or the like onto a test piece, and Japanese Patent Application Laid-Open Nos. 4-264246 and 7-5580.
1 and a type in which a bodily fluid is transferred to a test paper as shown in JP-A-8-247946 by capillary action. In the latter, the squeezed bodily fluid is temporarily held in a part of the test piece, and introduced into the test paper through a capillary tube.

[0003]

However, in such a conventional method of dropping blood or the like, the measured value varies because the time for attaching to the apparatus after dropping is not constant. Even in the type utilizing the capillary phenomenon, an object which does not contribute to the reaction and remains in the capillary is formed. Therefore, the burden on the patient is reduced by minimizing the volume of the capillary portion. However, when the volume of the capillary portion is reduced, the opening portion of the test piece is also reduced, and it becomes difficult for the patient to collect blood. In addition, when bodily fluid adheres to a portion other than the mouthpiece of the capillary by mistake, suction into the capillary becomes worse due to the effect of surface tension at that portion. The same applies to the case where the liquid holding portion is provided, unless the structure guides the periphery of the mouthpiece. Further, when such a holding portion is flush with the test piece main body, the influence of the fingerprint causes the test piece main body to be moved from between the finger and the holding portion unless the blood drop is pressed so strongly when scooping from the finger. Since blood wraps around on the back side, more blood volume is required, which makes the patient more uncertain and unsanitary, and places a burden on the patient.

[0004]

The above object is achieved by the present invention described below. (1) The present invention relates to a bodily fluid component measuring instrument having a body fluid suction port, a measurement test strip capable of measuring components in the body fluid, and a flow path for guiding the body fluid from the suction port to the measurement test strip. A body fluid component measuring device provided with a body fluid introduction guide portion around the suction port for guiding the body fluid to the suction port without holding or holding the body fluid. In the present invention, the body fluid whose components are to be measured particularly refers to blood, but can also measure lymph fluid, urine, sweat, and the like.

(2) The present invention is the body fluid component measuring device according to the above (1), wherein the body fluid introduction guide portion is two or more projections provided around the suction port. The body fluid component measuring device according to the above (1), which is particularly preferably provided with two projections. (3) The present invention is the humor component measuring device according to the above (1) or (2), wherein the surface tension in the humor introduction guide section is smaller than the surface tension in the flow path section.

(4) The present invention is the bodily fluid component measuring device according to any one of (1) to (3), wherein the inside of the bodily fluid introduction guide portion becomes wider as the distance from the inlet increases. (5) The invention is characterized in that the bodily fluid introduction guide section has a suction port for bodily fluid, a measurement test strip capable of measuring components in the bodily fluid, and a flow path section for guiding the bodily fluid from the suction port to the measurement test strip. The body fluid component measuring device according to any one of the above (1) to (4), which is provided at an angle with respect to a longitudinal axis direction of the housing having:

(6) The present invention is the body fluid component measuring device according to any one of the above (1) to (5), wherein the flow channel portion introduces a body fluid to a measurement test paper by capillary action. (7) The present invention relates to a bodily fluid component measuring instrument having a body fluid suction port, a measurement test strip capable of measuring a component in the body fluid, and a channel portion for guiding the body fluid from the suction port to the measurement test strip. And a body fluid component measuring device provided with two outwardly extending projections around the inlet.

(8) The body fluid component measuring device according to the above (7), wherein a portion of each of the two projections facing each other has a shape that becomes wider as the distance from the suction port increases. is there. (9) In the present invention, the two projections may include a body fluid inlet,
The measurement test strip capable of measuring a component in the body fluid, and the housing having a flow path portion for guiding the body fluid from the suction port to the measurement test strip are provided at an angle with respect to a longitudinal axis direction of the housing. It is a body fluid component measuring device according to 7) to (8).

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of a body fluid component measuring device according to the present invention will be described with reference to the drawings. FIG. 1 is a plan view of the body fluid component measuring device 1 of the present embodiment, and FIG. A rectangular housing 2, a measurement test paper 6 attached on a plane of the housing 2, and a body fluid measuring test paper 6
And a body fluid introduction guide portion 5 for guiding the body fluid to the inlet 4 of the channel portion 3. In addition, the shape of the housing 2 is not particularly limited, and may be any shape as long as other components can be provided.

The flow path 3 is a path for guiding bodily fluid from the suction port 4 to the test strip 6 by capillary action. The cross-sectional shape and length depend on the amount of body fluid required for measurement, but are preferably designed so that the dead volume does not increase. Specifically, the cross-sectional shape may be a tube, a V-shaped groove, or a rectangle, but a thin rectangle is preferable in consideration of the dead volume. The thickness is preferably about 0.05 to 0.5 mm, and the width is preferably about 0.5 to 3 mm. The length is preferably as short as possible, preferably about 1 mm to 15 mm, although it depends on the position of the optical member used for measurement. The flow path portion 3 is formed integrally with the housing 2 by injection molding, or is provided integrally with the housing 2 by notching or pressing the housing 2, and is obtained by fixing the tubular body or the groove member. It may be something.

The housing 2 is made of ABS, polyethylene,
Used in injection molding of polypropylene, polystyrene, polyvinyl chloride, polyvinylidene chloride resin, polyphenylene oxide, thermoplastic polyurethane, polymethylene methacrylate, polyoxyethylene, fluorine resin, polycarbonate, polyamide, acetal resin, acrylic resin, polyethylene terephthalate, etc. Thermosetting resins such as thermoplastic resins, phenol resins, epoxy resins, silicone resins, and unsaturated polyesters may be used. Also,
In the optical measurement in which the detection principle captures the color reaction on the test paper, an opaque material is preferable so as not to be easily affected by disturbance light in terms of measurement accuracy. Translucent colored resin may be used so that the patient can see the situation.

The material used for the flow path section 3 may be the same as the material used for the housing 2. Preferably, a material having a high hydrophilicity such as an acrylic resin or a material having a hydrophilic surface is used to increase the suction force. good. Examples of the means for making hydrophilic include ozone treatment, plasma treatment, glow discharge, corona discharge, physical activation treatment such as ultraviolet irradiation, and application of a surfactant, water-soluble silicon, hydroxypropyl cellulose, polyethylene glycol, polypropylene glycol, and the like. Can be performed.

The bodily fluid introduction guide section 5 has a function of guiding the bodily fluid to the suction port 4 when the bodily fluid comes into contact with the tip. In terms of shape, once the bodily fluid that has been guided to the inlet 4 spreads to the distal end portion 7 of the housing 2, the suction force decreases and the amount of the bodily fluid increases unnecessarily, which burdens the patient. Alternatively, it is desirable that the body fluid is not held and that the body fluid does not flow out. Specifically, two protrusions 51a and 51b are provided in a rail shape around the suction port 4 so as to protrude outward. The number of projections may be two or more, or may be continuous circumferentially. Further, when an angle α is provided with the housing 2 as described later, a semicircular shape or a dome shape that covers the patient's skin may be used. The height of the bodily fluid introduction guide portion 5 is such that when an unnecessarily large amount of bodily fluid flows into the bodily fluid introduction guide portion, the bodily fluid spreads out from between the bodily fluid introduction guide portions 5 (between the two protrusions 51a and 51b). In order to prevent such a situation, it is desirable that the height be from the upper surface to the lower surface of the distal end portion 7 of the housing 2 as shown in FIG. The material may be the same as that of the housing 2 and the flow path 3, and it is preferable to perform a hydrophilic treatment like the flow path 3.

When the body fluid is actually measured by the body fluid component measuring device 1, the body fluid introduction guide 5
To bring the body fluid introduction guide 5 into contact with the body fluid. At that time, it is expected that the distal end of the body fluid introduction guide 5 is brought close to the patient's skin while touching the body fluid introduction guide 5 and the housing 2 are on the same plane. Since the gap between the patient's skin and the housing back surface 8 is small when the tip is not touched, there is a possibility that bodily fluids are erroneously attached to the housing back surface 8 and it becomes difficult to aspirate the body fluid. Therefore, it is desirable to provide an angle α between the body fluid introduction guide portion 5 and the housing 2. By providing the angle α between the body fluid introduction guide portion 5 and the housing 2, the gap between the patient's skin and the housing back surface 8 is increased, and the body fluid does not flow around the housing back surface 8.

Further, it is desirable that the body fluid introduction guide section 5 has a surface tension in the body fluid introduction guide section 5 smaller than a surface tension in the flow path section 3, so that the supply of the body fluid from the patient's skin is possible. Smooth and body fluid introduction guide part 5
Since all the body fluid in the body fluid is supplied to the flow path section 3, there is no need to consider the dead volume in the body fluid introduction guide section 5, and the burden on the patient can be reduced. The shape for this purpose is not particularly limited. Specifically, as shown in FIG. 4, the portions of the two projections 51a and 51b that face each other become wider as the distance from the inlet increases, and the body fluid is spotted. It is desirable to make the shape to make the side to be widened. The surface tension can also be adjusted by the material and surface treatment of the bodily fluid introduction guide 5.

Specific body fluid introduction guide 5 or projection 5
The size of each of 1a and 51b is preferably about 1 to 3 mm in width, about 0.5 to 3 mm in height, and about 1 to 3 mm in length (distance protruding from the front end surface). This is because when the body fluid is squeezed out by about 4 μl, the size becomes about 3 mm. Therefore, it is considered that the size of the body fluid introduction guide is desirably the same as the maximum required blood volume. Can be The angle α with the housing 2 is 10 to 80 degrees, and considering the ease of use of the patient, an angle of about 10 to 45 degrees is appropriate.

The measurement test paper 6 is fixed on the plane of the housing 2 via measurement test paper fixing tables 10a and 10b.
The fixing method is not particularly limited, and examples include adhesion and fusion. In the present embodiment, the measurement test paper fixing end of the flow path portion 3 is provided at the center of the measurement test paper fixing base 10a. However, it is not particularly limited to this shape.
0a and the end portion of the flow path portion 3 on the measurement test paper side may be provided separately. In addition, the measurement test paper fixing base is also 1
The two types 0a and 10b are not required, and the shape is not particularly limited as long as the measurement test paper 6 can be fixed.

The body fluid is supplied to the suction port 4 using the flow path 3.
It is desirable to provide an air vent since the capillary phenomenon stops halfway in the closed system when the test paper 6 is introduced from to the test paper 6. Specifically, as shown in FIG. 5 which is an enlarged view of the insertion portion of the measurement test paper 6 of the housing 2 (the measurement test paper 6 is not inserted), the periphery of the measurement test paper 6 is partially covered with an adhesive and a melt. A measurement test paper fixing table 10b is provided so as to be fixed to the housing 2 by attachment, and a space is formed between the measurement test paper 6 and the housing 2 to secure a passage through which air can escape. The width of the space at that time is preferably about 0.01 to 0.3 mm. Then, on the measurement test paper fixing base 10a, an air vent 9 communicating the end of the flow path portion 3 provided at the center with the measurement test paper side and the space may be formed.

The air bleeding is not limited to the above-mentioned shape, and the structure thereof is not limited to the one shown in FIG. 6 which is a longitudinal sectional view of another embodiment of the present invention. A measurement test paper 26 is provided on a side surface in the middle of the part 23,
The air bleed portion 29 is defined as an end of the flow path portion 23 and the housing 2
It may be provided on the second plane. In the body fluid component measuring device 21, other components such as the suction port 24 and the body fluid introduction guide portion 25 are the same as those of the body fluid component measuring device 1.
Is similar to

The measurement test paper 6 is obtained by impregnating a test paper with glucose oxidase, peroxidase and a color reagent as reagents, for example, when measuring glucose in blood. As the test paper, a porous film is desirable, and examples of the form include a nonwoven fabric, a woven fabric, and a stretched sheet. Examples of the material include polyesters, polyamides, polyolefins, polysulfones, and celluloses. In addition, since a reagent is impregnated or a body fluid is impregnated, a hydrophilic material or a material subjected to a hydrophilic treatment is preferable. In addition, measurement test paper 6
May be a single-layer film or a multilayer structure. In the case of a structure in which a body fluid is impregnated from the back end of the measurement test paper 26 as in a body fluid component measuring device 21 described later, a multilayer structure is better.

In the present invention, even if the measurement test paper is provided in a structure in which the body fluid is impregnated from near the center of the back of the measurement test paper 6 like the body fluid component measurement tool 1, the measurement test paper is like the body fluid component measurement tool 21. It may be provided with a structure in which the body fluid is impregnated from the back end of the paper 26. As described above, it is desirable that the measurement test paper is partially stopped when it is fixed, and that there is a passage through which air can escape. Further, it is preferable that steps 11 and 31 are provided in the housings 2 and 22 so that the mounting positions of the measurement test papers 6 and 26 can be adjusted.

Next, a method of using the body fluid component measuring device 1 will be described. First, a fingertip or the like of a patient is punctured with a needle or a puncture device having a needle, and blood is allowed to flow out onto the skin in a droplet form. Then, the blood is brought close to the drop while the tip of the body fluid introduction guide section 5 of the body fluid component measuring tool 1 is in contact with the skin of the patient, and the blood is brought into contact with the body fluid introduction guide section 5.
Then, the blood is guided to the suction port 4 via the body fluid introduction guide part 5 by the surface tension without adhering to other parts such as the housing back surface 8 of the body fluid component measuring device 1 by the surface tension, and from the suction port 4. It is guided to the measurement test paper 6 by the capillary phenomenon via the flow path section 3 and is developed on the measurement test paper 6. After that, the blood spread on the measurement test paper 6 is subjected to quantification of blood components and qualitative analysis, for example, measurement of blood glucose level, using a measuring device or the like. The measuring device includes a light source and a light receiving element, and the light receiving element captures light emitted from the light source and reflected from the measurement test paper 6 to measure the degree of coloration and convert it into a blood glucose level or the like. 6, an electrode method in which two electrodes are provided and a component of body fluid is measured by an electrode method of detecting by measuring a current value between the electrodes.

The body fluid component measuring instrument 1 may be used by being attached to a puncturing instrument having a needle or an apparatus having a puncturing mechanism and a measuring mechanism integrally provided. For example, the body fluid component measuring device 1 is attached to the tip of a puncture device or device, and the body fluid introduction guide unit 5 is placed directly on or close to the skin of the patient, and the projections 51a and 51b of the body fluid introduction guide unit 5 are provided. The blood passing through the skin immediately after the puncture comes into contact with the bodily fluid introduction guide portion 5 and is spread on the measurement test paper 6.

[0024]

The body fluid component measuring device of the present invention makes it difficult for body fluids such as blood to adhere to the front and back surfaces of the housing other than the suction port and the body fluid introduction guide, thereby minimizing the danger of the patient or measurer touching the body fluid. In addition, it is possible to effectively, quickly and reliably guide the body fluid to the measurement test paper even with a small amount of the body fluid, and measure the components of the body fluid.

[Brief description of the drawings]

FIG. 1 is a plan view of a body fluid component measuring device 1. FIG.

FIG. 2 is a longitudinal sectional view of the body fluid component measuring device 1.

FIG. 3 is a front view of the body fluid component measuring device 1.

FIG. 4 is a plan view of a bodily fluid component measuring instrument 1 having another form of the bodily fluid introduction guide section 5;

FIG. 5 is a plan view of an insertion portion of the body fluid component measuring device 1 into which the measurement test paper 6 is inserted.

FIG. 6 is a longitudinal sectional view of the body fluid component measuring device 2.

[Explanation of symbols]

 1, 21 Body fluid component measuring tool 2, 22 Housing part 3, 23 Flow path part 4, 24 Inlet port 5, 25 Body fluid introduction guide part 51a, 51b Projection 6, 26 Measurement test paper 7 Tip part 8 Housing back surface 9, 29 Air Dropouts 10a, 10b Measurement test paper fixing base 11, 31 Step

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Claims (9)

[Claims] 1. A body fluid component measuring instrument having a body fluid suction port, a measurement test strip capable of measuring a component in the body fluid, and a flow passage for guiding the body fluid from the suction port to the measurement test strip. A bodily fluid component measuring device provided with a bodily fluid introduction guide for guiding bodily fluid to the suction port around the suction port. 2. The body fluid component measuring device according to claim 1, wherein the body fluid introduction guide is two or more projections provided around the suction port. 3. The body fluid component measuring device according to claim 1, wherein a surface tension in the body fluid introduction guide portion is smaller than a surface tension in the flow passage portion. 4. The body fluid component measuring device according to claim 1, wherein the inside of the body fluid introduction guide portion becomes wider as the distance from the suction port increases. 5. The body fluid introduction guide section has a body fluid suction port, a measurement test strip capable of measuring a component in the body fluid, and a flow path section for guiding the body fluid from the suction port to the measurement test strip. The body fluid component measuring device according to any one of claims 1 to 4, wherein the body fluid component measuring device is provided at an angle with respect to a longitudinal axis direction of the housing. 6. The humor component measuring device according to claim 1, wherein the flow channel introduces humor to the measurement test strip by capillary action. 7. A bodily fluid component measuring device having a suction port for bodily fluid, a measurement test strip capable of measuring components in the bodily fluid, and a channel portion for guiding bodily fluid from the suction port to the measurement test strip. A body fluid component measuring device provided with two outwardly extending projections around an inlet. 8. The body fluid component measuring device according to claim 7, wherein portions of each of the two projections facing each other have a shape that becomes wider as the distance from the inlet increases. 9. A housing having said two projections having a body fluid suction port, a measurement test strip capable of measuring components in the body fluid, and a flow path for guiding the body fluid from said suction port to said measurement test strip. The body fluid component measuring device according to claim 7, wherein the body fluid component measuring device is provided at an angle with respect to a longitudinal axis direction of the body fluid component.