JP2000026292A5 - - Google Patents
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- Publication number
- JP2000026292A5 JP2000026292A5 JP1998054124A JP5412498A JP2000026292A5 JP 2000026292 A5 JP2000026292 A5 JP 2000026292A5 JP 1998054124 A JP1998054124 A JP 1998054124A JP 5412498 A JP5412498 A JP 5412498A JP 2000026292 A5 JP2000026292 A5 JP 2000026292A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oral pharmaceutical
- release oral
- composition according
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008203 oral pharmaceutical composition Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229920000881 Modified starch Polymers 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- GTOFKXZQQDSVFH-UHFFFAOYSA-N 2-benzylsuccinic acid Chemical class OC(=O)CC(C(O)=O)CC1=CC=CC=C1 GTOFKXZQQDSVFH-UHFFFAOYSA-N 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 式
【化１】
【請求項２】 式
【化２】
【請求項３】 二酸化ケイ素の含有量が、製剤全重量に対して０．５〜５重量％である、請求項１または２のいずれか一項記載の速放性経口医薬品組成物。
【請求項４】 部分アルファ化デンプンの含有量が、製剤全重量に対して５〜２０重量％である、請求項１または２のいずれか一項記載の速放性経口医薬品組成物。
【請求項５】 剤形が、錠剤である、請求項１乃至４のいずれか一項記載の速放性経口医薬品組成物。
【請求項６】 服用後、有効成分が、２０分以内に７５％以上溶出されることを特徴とする、請求項１乃至５のいずれか一項記載の速放性経口医薬品組成物。
【請求項７】 日本薬局方溶出試験法第２法（パドル法）に従い、試験液として日本薬局方第１液を用い、５０ｒｐｍとする溶出試験において、２０分以内に７５％以上溶出されることを特徴とする、請求項１乃至５のいずれか一項記載の速放性経口医薬品組成物。
[Claims]
1. Expression
Embedded image
(2) formula
Embedded image
(3) 3. The quick-release oral pharmaceutical composition according to claim 1, wherein the content of silicon dioxide is 0.5 to 5% by weight based on the total weight of the preparation.
(4) The immediate release oral pharmaceutical composition according to any one of claims 1 to 2, wherein the content of the partially pregelatinized starch is 5 to 20% by weight based on the total weight of the preparation.
(5) The immediate release oral pharmaceutical composition according to any one of claims 1 to 4, wherein the dosage form is a tablet.
6. The quick-release oral pharmaceutical composition according to any one of claims 1 to 5, wherein 75% or more of the active ingredient is eluted within 20 minutes after administration.
7. According to the Japanese Pharmacopoeia Dissolution Test Method 2 (paddle method), in a dissolution test at 50 rpm using Japanese Pharmacopoeia First Solution as a test solution, at least 75% is eluted within 20 minutes, An immediate release oral pharmaceutical composition according to any one of claims 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP05412498A JP4063386B2 (en) | 1998-01-29 | 1998-01-29 | Rapid-release oral pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP05412498A JP4063386B2 (en) | 1998-01-29 | 1998-01-29 | Rapid-release oral pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007271625A Division JP4072195B2 (en) | 2007-10-18 | 2007-10-18 | Immediate release oral pharmaceutical composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000026292A JP2000026292A (en) | 2000-01-25 |
| JP4063386B2 JP4063386B2 (en) | 2008-03-19 |
| JP2000026292A5 true JP2000026292A5 (en) | 2009-01-08 |
Family
ID=12961859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP05412498A Expired - Fee Related JP4063386B2 (en) | 1998-01-29 | 1998-01-29 | Rapid-release oral pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4063386B2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4568398B2 (en) * | 2000-03-22 | 2010-10-27 | キッセイ薬品工業株式会社 | Hexahydroisoindoline acid addition salt and method of use thereof |
| JP2001261645A (en) * | 2000-03-22 | 2001-09-26 | Kissei Pharmaceut Co Ltd | (3s)-3-methoxycarbonyl-4-phenylbutyryl chloride and method for using the same |
| EP1552830A4 (en) * | 2002-06-28 | 2007-07-18 | Kissei Pharmaceutical | Drug composition for prevention or inhibition of advance of diabetic complication |
| US20050267195A1 (en) * | 2002-06-28 | 2005-12-01 | Imao Mikoshiba | Drug composition for blood sugar control |
| JP4575654B2 (en) * | 2003-09-05 | 2010-11-04 | エスエス製薬株式会社 | Pharmaceutical composition with improved solubility and fluidity |
| JP4733120B2 (en) * | 2005-05-26 | 2011-07-27 | 大日本住友製薬株式会社 | Pharmaceutical composition |
| JP5100634B2 (en) * | 2006-03-24 | 2012-12-19 | 興和株式会社 | Orally rapidly disintegrating tablets |
| CA2714524A1 (en) | 2008-02-11 | 2009-08-20 | Makiko Yanagida | Tablet having improved elution properties |
| US20120040001A1 (en) | 2009-02-12 | 2012-02-16 | Fuji Chemical Industry Co., Ltd. | Disintegrating particle composition and rapidly disintegrating compression-molded material used the same |
-
1998
- 1998-01-29 JP JP05412498A patent/JP4063386B2/en not_active Expired - Fee Related
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