JOP20200014A1 - توليفة علاجية لمثبط كيناز تيروزين egfr من الجيل الثالث ومثبط raf - Google Patents

توليفة علاجية لمثبط كيناز تيروزين egfr من الجيل الثالث ومثبط raf

Info

Publication number
JOP20200014A1
JOP20200014A1 JOP/2020/0014A JOP20200014A JOP20200014A1 JO P20200014 A1 JOP20200014 A1 JO P20200014A1 JO P20200014 A JOP20200014 A JO P20200014A JO P20200014 A1 JOP20200014 A1 JO P20200014A1
Authority
JO
Jordan
Prior art keywords
inhibitor
tyrosine kinase
combination
egfr tyrosine
generation egfr
Prior art date
Application number
JOP/2020/0014A
Other languages
English (en)
Inventor
Jeffrey Engelman
Susan Moody
Lilli Petruzzelli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of JOP20200014A1 publication Critical patent/JOP20200014A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بتوليفة صيدلانية تشتمل على (أ) مثبط كيناز تيروزين EGFR من الجيل الثالث و(ب) مثبط Raf، تحديداً لعلاج السرطان، تحديداً سرطان رئة. يتعلق الاختراع الحالي أيضاً باستخدامات تلك التوليفة لتحضير دواء لعلاج سرطان؛ بطرق لعلاج سرطان في كائن بحاجة لذلك تشمل إعطاء الكائن المذكور كمية فعّالة علاجياً بصورة مشتركة من التوليفة المذكورة؛ بتركيبات صيدلانية تشمل تلك التوليفة وبعبوات تجارية لها.
JOP/2020/0014A 2017-08-03 2018-08-01 توليفة علاجية لمثبط كيناز تيروزين egfr من الجيل الثالث ومثبط raf JOP20200014A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762540595P 2017-08-03 2017-08-03
PCT/IB2018/055792 WO2019026007A1 (en) 2017-08-03 2018-08-01 THERAPEUTIC ASSOCIATION OF THIRD GENERATION TYFRSINE KINASE INHIBITOR AND RAF INHIBITOR

Publications (1)

Publication Number Publication Date
JOP20200014A1 true JOP20200014A1 (ar) 2022-10-30

Family

ID=63405289

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0014A JOP20200014A1 (ar) 2017-08-03 2018-08-01 توليفة علاجية لمثبط كيناز تيروزين egfr من الجيل الثالث ومثبط raf

Country Status (18)

Country Link
US (1) US20200237773A1 (ar)
EP (1) EP3661516A1 (ar)
JP (1) JP2020529411A (ar)
KR (1) KR20200036880A (ar)
CN (1) CN110996960A (ar)
AU (1) AU2018311523A1 (ar)
BR (1) BR112020001916A2 (ar)
CA (1) CA3069564A1 (ar)
CL (1) CL2020000270A1 (ar)
IL (1) IL272350A (ar)
JO (1) JOP20200014A1 (ar)
MX (1) MX2020001254A (ar)
PH (1) PH12020500096A1 (ar)
RU (1) RU2020108192A (ar)
SG (1) SG11201913249SA (ar)
TW (1) TW201909920A (ar)
WO (1) WO2019026007A1 (ar)
ZA (1) ZA201908392B (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115701996A (zh) * 2020-06-25 2023-02-14 托雷莫治疗股份公司 用于治疗EGFR突变型NSCLC的CBP/p300溴结构域抑制剂和EGFR抑制剂的组合
CN111991559B (zh) * 2020-09-03 2022-03-22 中山大学 受体酪氨酸激酶抑制剂在制备预防和/或治疗新型冠状病毒感染药物中的应用
WO2023141659A2 (en) * 2022-01-24 2023-07-27 The Trustees Of Columbia University In The City Of New York Targeting s100a9-aldh1a1-retinoic acid signaling to suppress brain relapse in egfr-mutant lung cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
PL2882440T3 (pl) * 2012-08-07 2019-07-31 Novartis Ag Kombinacje farmaceutyczne zawierające inhibitor b-raf, inhibitor egfr i opcjonalnie inhibitor pi3k-alfa
US9242969B2 (en) * 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) * 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa

Also Published As

Publication number Publication date
JP2020529411A (ja) 2020-10-08
RU2020108192A (ru) 2021-09-03
EP3661516A1 (en) 2020-06-10
MX2020001254A (es) 2020-03-20
TW201909920A (zh) 2019-03-16
US20200237773A1 (en) 2020-07-30
KR20200036880A (ko) 2020-04-07
BR112020001916A2 (pt) 2020-07-28
CL2020000270A1 (es) 2020-08-28
PH12020500096A1 (en) 2020-09-14
CA3069564A1 (en) 2019-02-07
AU2018311523A1 (en) 2020-01-16
SG11201913249SA (en) 2020-02-27
CN110996960A (zh) 2020-04-10
WO2019026007A1 (en) 2019-02-07
ZA201908392B (en) 2021-05-26
IL272350A (en) 2020-03-31

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