JO2695B1 - معالجة السل الكامن - Google Patents

معالجة السل الكامن

Info

Publication number
JO2695B1
JO2695B1 JO2005194A JOP20050194A JO2695B1 JO 2695 B1 JO2695 B1 JO 2695B1 JO 2005194 A JO2005194 A JO 2005194A JO P20050194 A JOP20050194 A JO P20050194A JO 2695 B1 JO2695 B1 JO 2695B1
Authority
JO
Jordan
Prior art keywords
alkyl
hydrogen
het
alkyloxy
alkylthio
Prior art date
Application number
JO2005194A
Other languages
English (en)
Inventor
جوزيف لودويجيك مارسيل اندريس كووينراد
كويل انيل
Original Assignee
جانسن فارماسوتيكا ان. في
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by جانسن فارماسوتيكا ان. في filed Critical جانسن فارماسوتيكا ان. في
Application granted granted Critical
Publication of JO2695B1 publication Critical patent/JO2695B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

استخدام مركب من الصيغه ( Ia) او (Ib) لتصنيع دواء لمعالجة الدرن الكامن، حيث يكون مركب الصيغه ( Ia) او (Ib) هو: ملح امين رباعي(quaternary amine) ، N – اكسيد ( N-oxide form) شكل توتومري او شكل ايزومري كيميائي فراغيا مقبول دوائيا من ذلك حيث يكون R1 هو هيدروجين هالو, هالو الكيل،سيانو ، هيدروكسي,الكيل, الكيل اوكسي الكيل ثيو, الكيل اوكسي الكيل,الكيل ثيو ,الكيل(alkylthioalkyl) Ar الكيل(Ar-alkyl) او ثنائي (Ar) الكيل (di(Ar)alkyl) p هو 1، 2، 3 او 4، R2 هو هيدروجين هيدروكسي(، مركابتو, الكيل اوكسي ، الكيل اوكسي الكيل اوكسي, الكيل ثيو ، احادي او ثنائي ( الكيل) امينو (mono or di(alkyl)amino) او شق من الصيغه ، R3 هو الكيل( alkyl) ، Ar – الكيل ( Ar-alkyl) ، Het اوHet – الكيل(Het –alkyl) ، q هو صفر، 1، 2 ، 3 او 4، R4 و R5 كل منهما على حدة هيدروجين , الكيل او بنزيل او R4 و R5 قد يؤخذان معا مع ذرة N المرتبطة معهما، R6 هو هيدروجين، هالو، هالو الكيل, هيدروكسي,الكيل ثيو,الكيل اوكسي الكيل,الكيل ثيو الكيل – الكيل (Ar-alkyl) او ثنائي(Ar) الكيل(di(Ar)alkyl) او قد يؤخذ شقان R6 متجاوين معا لتشكيل شق ثنائي التكافؤ من الصيغه CH=CH-CH=CH-، r هو 1، 2، 3، 4 او 5 هو هيدروجين الكيل( alkyl) ، Ar او Het، R8 هو هيدروجين او الكيل( alkyl) ، R9 هو اكسو او R8 و R9 يشكلان معا الشق N-CH=CH-
JO2005194A 2004-12-24 2005-12-06 معالجة السل الكامن JO2695B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04078529 2004-12-24

Publications (1)

Publication Number Publication Date
JO2695B1 true JO2695B1 (ar) 2013-03-03

Family

ID=36736133

Family Applications (1)

Application Number Title Priority Date Filing Date
JO2005194A JO2695B1 (ar) 2004-12-24 2005-12-06 معالجة السل الكامن

Country Status (9)

Country Link
JP (5) JP2006182755A (ar)
KR (2) KR101301573B1 (ar)
CN (1) CN101087608A (ar)
BG (1) BG66437B1 (ar)
EA (1) EA009779B1 (ar)
ES (1) ES2362886T3 (ar)
JO (1) JO2695B1 (ar)
UA (1) UA88766C2 (ar)
ZA (1) ZA200705160B (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
CN103664877A (zh) * 2013-12-25 2014-03-26 重庆医药工业研究院有限责任公司 一种喹啉衍生物、其制备方法和应用
BR122021024097B1 (pt) * 2016-03-07 2024-04-30 The Global Alliance For Tb Drug Development, Inc Composto antibacteriano, uso do mesmo e composição farmacêutica
CN109384716B (zh) * 2017-08-11 2021-06-29 海创药业股份有限公司 一种氘代喹啉化合物及其制备和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075024A (en) * 1991-11-27 2000-06-13 Sepracor Inc. Methods for treating infection using optically pure (S)-lomefloxacin
DE60332023D1 (de) * 2002-07-25 2010-05-20 Janssen Pharmaceutica Nv Chinolinderivate und deren verwendung als mycobakterielle inhibitoren
WO2005117875A1 (en) * 2004-05-28 2005-12-15 Janssen Pharmaceutica N.V. Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Also Published As

Publication number Publication date
ES2362886T3 (es) 2011-07-14
JP6426530B2 (ja) 2018-11-21
JP2015157847A (ja) 2015-09-03
EA009779B1 (ru) 2008-04-28
JP2017141259A (ja) 2017-08-17
JP2006182755A (ja) 2006-07-13
EA200500802A1 (ru) 2006-06-30
KR20130041872A (ko) 2013-04-25
ZA200705160B (en) 2008-09-25
CN101087608A (zh) 2007-12-12
JP2013049704A (ja) 2013-03-14
BG66437B1 (bg) 2014-07-31
UA88766C2 (ru) 2009-11-25
KR101301573B1 (ko) 2013-09-04
JP2017141262A (ja) 2017-08-17
BG109180A (bg) 2006-06-30
KR20060073416A (ko) 2006-06-28

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