ITTO20010110A0 - Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. - Google Patents

Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.

Info

Publication number
ITTO20010110A0
ITTO20010110A0 IT2001TO000110A ITTO20010110A ITTO20010110A0 IT TO20010110 A0 ITTO20010110 A0 IT TO20010110A0 IT 2001TO000110 A IT2001TO000110 A IT 2001TO000110A IT TO20010110 A ITTO20010110 A IT TO20010110A IT TO20010110 A0 ITTO20010110 A0 IT TO20010110A0
Authority
IT
Italy
Prior art keywords
benzamidinic
inflammatory
new
immunosuppressive activity
derivatives
Prior art date
Application number
IT2001TO000110A
Other languages
English (en)
Inventor
Francesco Makovec
Lucio Rovati
Simona Zanzola
Roberto Artusi
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Priority to IT2001TO000110A priority Critical patent/ITTO20010110A1/it
Publication of ITTO20010110A0 publication Critical patent/ITTO20010110A0/it
Priority to EP02718096A priority patent/EP1363875B1/en
Priority to PT02718096T priority patent/PT1363875E/pt
Priority to DE60228053T priority patent/DE60228053D1/de
Priority to CA2437109A priority patent/CA2437109C/en
Priority to US10/467,624 priority patent/US7202277B2/en
Priority to AT02718096T priority patent/ATE403645T1/de
Priority to ES02718096T priority patent/ES2311600T3/es
Priority to DK02718096T priority patent/DK1363875T3/da
Priority to JP2002569789A priority patent/JP4104984B2/ja
Priority to PCT/EP2002/001201 priority patent/WO2002070468A2/en
Priority to AU2002249183A priority patent/AU2002249183B2/en
Publication of ITTO20010110A1 publication Critical patent/ITTO20010110A1/it
Priority to US11/652,675 priority patent/US20070135523A1/en
Priority to US12/112,299 priority patent/US7560591B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40Acylated substituent nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32N-nitroguanidines
    • C07C279/36Substituted N-nitroguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/70Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74Adamantanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
IT2001TO000110A 2001-02-08 2001-02-08 Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. ITTO20010110A1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT2001TO000110A ITTO20010110A1 (it) 2001-02-08 2001-02-08 Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
AU2002249183A AU2002249183B2 (en) 2001-02-08 2002-02-06 Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity
AT02718096T ATE403645T1 (de) 2001-02-08 2002-02-06 Benzamidinderivate mit entzündungshemmender und immunsuppressiver wirkung
DK02718096T DK1363875T3 (da) 2001-02-08 2002-02-06 Benzamidinderivater med antiinflammatorisk og immunsuppresiv virkning
DE60228053T DE60228053D1 (de) 2001-02-08 2002-02-06 Benzamidinderivate mit entzündungshemmender und immunsuppressiver wirkung
CA2437109A CA2437109C (en) 2001-02-08 2002-02-06 Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity
US10/467,624 US7202277B2 (en) 2001-02-08 2002-02-06 Benzamidine derivatives having anti-inflammatory and immunosuppressive activity
EP02718096A EP1363875B1 (en) 2001-02-08 2002-02-06 Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity
ES02718096T ES2311600T3 (es) 2001-02-08 2002-02-06 Derivados de benzadimina novedosos que tienen actividad antiinflamatoria e inmunosupresora.
PT02718096T PT1363875E (pt) 2001-02-08 2002-02-06 Novos derivados de benzamidina com actividade anti-inflamatória e imunosupressora
JP2002569789A JP4104984B2 (ja) 2001-02-08 2002-02-06 抗炎症性および免疫抑制性活性を有する新規ベンズアミジン誘導体
PCT/EP2002/001201 WO2002070468A2 (en) 2001-02-08 2002-02-06 Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity
US11/652,675 US20070135523A1 (en) 2001-02-08 2007-01-12 Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity
US12/112,299 US7560591B2 (en) 2001-02-08 2008-04-30 Benzamidine derivatives having anti-inflammatory and immunosuppressive activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001TO000110A ITTO20010110A1 (it) 2001-02-08 2001-02-08 Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.

Publications (2)

Publication Number Publication Date
ITTO20010110A0 true ITTO20010110A0 (it) 2001-02-08
ITTO20010110A1 ITTO20010110A1 (it) 2002-08-08

Family

ID=11458519

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001TO000110A ITTO20010110A1 (it) 2001-02-08 2001-02-08 Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.

Country Status (12)

Country Link
US (3) US7202277B2 (it)
EP (1) EP1363875B1 (it)
JP (1) JP4104984B2 (it)
AT (1) ATE403645T1 (it)
AU (1) AU2002249183B2 (it)
CA (1) CA2437109C (it)
DE (1) DE60228053D1 (it)
DK (1) DK1363875T3 (it)
ES (1) ES2311600T3 (it)
IT (1) ITTO20010110A1 (it)
PT (1) PT1363875E (it)
WO (1) WO2002070468A2 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITTO20010110A1 (it) * 2001-02-08 2002-08-08 Rotta Research Lab Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
CN100491374C (zh) 2002-08-02 2009-05-27 Ab科学公司 2-(3-氨基芳基)氨基-4-芳基-噻唑及其作为c-kit抑制剂的应用
US7208491B2 (en) 2003-02-07 2007-04-24 Hoffmann-La Roche Inc. N-monoacylated o-phenylenediamines
SE0301446D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
ITTO20030668A1 (it) 2003-09-02 2005-03-03 Rotta Res Lab S P A O Ra Rottapharm Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione.
FR2865133B1 (fr) * 2004-01-19 2008-01-18 Rytek Compositions pour le traitement de pathologies digestives
EP1704860B1 (en) * 2005-03-24 2010-10-27 Rottapharm S.P.A. Benzamidine derivatives for treatment and prevention of mucositis
UY30048A1 (es) 2005-12-23 2007-07-31 Astrazeneca Ab Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
WO2011020116A1 (en) * 2009-08-14 2011-02-17 University Of Virginia Patent Foundation Imidamide sphingosine kinase inhibitors
CN102344391B (zh) * 2011-07-28 2013-12-25 山东新华制药股份有限公司 N-(4-乙酰氨基苯基)-n′,n′-二甲基乙脒的合成方法
WO2013083813A2 (en) * 2011-12-07 2013-06-13 Universität Zürich Modulators of spermine/spermidine n'-acetyltransferase (ssat) and ssat associated proteins for use in prevention or treatment of rheumatoid arthritis

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
DE950637C (de) * 1944-05-27 1956-10-11 Hoechst Ag Verfahren zur Herstellung von 4-Aminochinaldinverbindungen
US2559085A (en) * 1948-10-22 1951-07-03 Honorary Advisory Council Sci Preparation of n-substituted-n'-nitroguanidines
GB1311432A (en) * 1971-01-07 1973-03-28 Ici Ltd Guanidine derivatives their preparation and antiviral compositions containing them
FR2456731A1 (fr) 1979-05-16 1980-12-12 Choay Sa Nouveaux derives substitues d'ary
US5028627A (en) 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5240694A (en) * 1991-09-23 1993-08-31 University Of Virginia Combined antiviral and antimediator treatment of common colds
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9312761D0 (en) 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US6028223A (en) 1995-08-30 2000-02-22 G. D. Searle & Co. Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof
WO1997036862A1 (en) 1996-03-29 1997-10-09 G.D. Searle & Co. META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS
DK0891325T3 (da) * 1996-03-29 2002-05-21 Searle & Co Para-substituerede phenylpropansyrederivater som integrinantagonister
EP1242366A1 (en) * 1999-12-15 2002-09-25 Axys Pharmaceuticals, Inc. Salicylamides as serine protease and factor xa inhibitors
ITTO20010110A1 (it) * 2001-02-08 2002-08-08 Rotta Research Lab Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.

Also Published As

Publication number Publication date
ES2311600T3 (es) 2009-02-16
ATE403645T1 (de) 2008-08-15
WO2002070468A2 (en) 2002-09-12
US20040110801A1 (en) 2004-06-10
US7560591B2 (en) 2009-07-14
EP1363875B1 (en) 2008-08-06
US20080207764A1 (en) 2008-08-28
EP1363875A2 (en) 2003-11-26
ITTO20010110A1 (it) 2002-08-08
US20070135523A1 (en) 2007-06-14
DK1363875T3 (da) 2008-11-24
CA2437109A1 (en) 2002-09-12
WO2002070468A3 (en) 2003-09-04
CA2437109C (en) 2010-07-06
JP2004531489A (ja) 2004-10-14
US7202277B2 (en) 2007-04-10
PT1363875E (pt) 2008-08-22
AU2002249183B2 (en) 2006-11-16
JP4104984B2 (ja) 2008-06-18
DE60228053D1 (de) 2008-09-18

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