ITTO20010110A0 - Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. - Google Patents
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.Info
- Publication number
- ITTO20010110A0 ITTO20010110A0 IT2001TO000110A ITTO20010110A ITTO20010110A0 IT TO20010110 A0 ITTO20010110 A0 IT TO20010110A0 IT 2001TO000110 A IT2001TO000110 A IT 2001TO000110A IT TO20010110 A ITTO20010110 A IT TO20010110A IT TO20010110 A0 ITTO20010110 A0 IT TO20010110A0
- Authority
- IT
- Italy
- Prior art keywords
- benzamidinic
- inflammatory
- new
- immunosuppressive activity
- derivatives
- Prior art date
Links
- 230000000947 anti-immunosuppressive effect Effects 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001TO000110A ITTO20010110A1 (it) | 2001-02-08 | 2001-02-08 | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
AU2002249183A AU2002249183B2 (en) | 2001-02-08 | 2002-02-06 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
AT02718096T ATE403645T1 (de) | 2001-02-08 | 2002-02-06 | Benzamidinderivate mit entzündungshemmender und immunsuppressiver wirkung |
DK02718096T DK1363875T3 (da) | 2001-02-08 | 2002-02-06 | Benzamidinderivater med antiinflammatorisk og immunsuppresiv virkning |
DE60228053T DE60228053D1 (de) | 2001-02-08 | 2002-02-06 | Benzamidinderivate mit entzündungshemmender und immunsuppressiver wirkung |
CA2437109A CA2437109C (en) | 2001-02-08 | 2002-02-06 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
US10/467,624 US7202277B2 (en) | 2001-02-08 | 2002-02-06 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
EP02718096A EP1363875B1 (en) | 2001-02-08 | 2002-02-06 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
ES02718096T ES2311600T3 (es) | 2001-02-08 | 2002-02-06 | Derivados de benzadimina novedosos que tienen actividad antiinflamatoria e inmunosupresora. |
PT02718096T PT1363875E (pt) | 2001-02-08 | 2002-02-06 | Novos derivados de benzamidina com actividade anti-inflamatória e imunosupressora |
JP2002569789A JP4104984B2 (ja) | 2001-02-08 | 2002-02-06 | 抗炎症性および免疫抑制性活性を有する新規ベンズアミジン誘導体 |
PCT/EP2002/001201 WO2002070468A2 (en) | 2001-02-08 | 2002-02-06 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
US11/652,675 US20070135523A1 (en) | 2001-02-08 | 2007-01-12 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
US12/112,299 US7560591B2 (en) | 2001-02-08 | 2008-04-30 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001TO000110A ITTO20010110A1 (it) | 2001-02-08 | 2001-02-08 | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITTO20010110A0 true ITTO20010110A0 (it) | 2001-02-08 |
ITTO20010110A1 ITTO20010110A1 (it) | 2002-08-08 |
Family
ID=11458519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2001TO000110A ITTO20010110A1 (it) | 2001-02-08 | 2001-02-08 | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
Country Status (12)
Country | Link |
---|---|
US (3) | US7202277B2 (it) |
EP (1) | EP1363875B1 (it) |
JP (1) | JP4104984B2 (it) |
AT (1) | ATE403645T1 (it) |
AU (1) | AU2002249183B2 (it) |
CA (1) | CA2437109C (it) |
DE (1) | DE60228053D1 (it) |
DK (1) | DK1363875T3 (it) |
ES (1) | ES2311600T3 (it) |
IT (1) | ITTO20010110A1 (it) |
PT (1) | PT1363875E (it) |
WO (1) | WO2002070468A2 (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITTO20010110A1 (it) * | 2001-02-08 | 2002-08-08 | Rotta Research Lab | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
US8450302B2 (en) * | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
CN100491374C (zh) | 2002-08-02 | 2009-05-27 | Ab科学公司 | 2-(3-氨基芳基)氨基-4-芳基-噻唑及其作为c-kit抑制剂的应用 |
US7208491B2 (en) | 2003-02-07 | 2007-04-24 | Hoffmann-La Roche Inc. | N-monoacylated o-phenylenediamines |
SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
ITTO20030668A1 (it) | 2003-09-02 | 2005-03-03 | Rotta Res Lab S P A O Ra Rottapharm | Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione. |
FR2865133B1 (fr) * | 2004-01-19 | 2008-01-18 | Rytek | Compositions pour le traitement de pathologies digestives |
EP1704860B1 (en) * | 2005-03-24 | 2010-10-27 | Rottapharm S.P.A. | Benzamidine derivatives for treatment and prevention of mucositis |
UY30048A1 (es) | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
WO2011020116A1 (en) * | 2009-08-14 | 2011-02-17 | University Of Virginia Patent Foundation | Imidamide sphingosine kinase inhibitors |
CN102344391B (zh) * | 2011-07-28 | 2013-12-25 | 山东新华制药股份有限公司 | N-(4-乙酰氨基苯基)-n′,n′-二甲基乙脒的合成方法 |
WO2013083813A2 (en) * | 2011-12-07 | 2013-06-13 | Universität Zürich | Modulators of spermine/spermidine n'-acetyltransferase (ssat) and ssat associated proteins for use in prevention or treatment of rheumatoid arthritis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE950637C (de) * | 1944-05-27 | 1956-10-11 | Hoechst Ag | Verfahren zur Herstellung von 4-Aminochinaldinverbindungen |
US2559085A (en) * | 1948-10-22 | 1951-07-03 | Honorary Advisory Council Sci | Preparation of n-substituted-n'-nitroguanidines |
GB1311432A (en) * | 1971-01-07 | 1973-03-28 | Ici Ltd | Guanidine derivatives their preparation and antiviral compositions containing them |
FR2456731A1 (fr) | 1979-05-16 | 1980-12-12 | Choay Sa | Nouveaux derives substitues d'ary |
US5028627A (en) | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
US5240694A (en) * | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
GB9127376D0 (en) | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
GB9312761D0 (en) | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US6028223A (en) | 1995-08-30 | 2000-02-22 | G. D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof |
WO1997036862A1 (en) | 1996-03-29 | 1997-10-09 | G.D. Searle & Co. | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS |
DK0891325T3 (da) * | 1996-03-29 | 2002-05-21 | Searle & Co | Para-substituerede phenylpropansyrederivater som integrinantagonister |
EP1242366A1 (en) * | 1999-12-15 | 2002-09-25 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease and factor xa inhibitors |
ITTO20010110A1 (it) * | 2001-02-08 | 2002-08-08 | Rotta Research Lab | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
-
2001
- 2001-02-08 IT IT2001TO000110A patent/ITTO20010110A1/it unknown
-
2002
- 2002-02-06 WO PCT/EP2002/001201 patent/WO2002070468A2/en active IP Right Grant
- 2002-02-06 PT PT02718096T patent/PT1363875E/pt unknown
- 2002-02-06 CA CA2437109A patent/CA2437109C/en not_active Expired - Fee Related
- 2002-02-06 EP EP02718096A patent/EP1363875B1/en not_active Expired - Lifetime
- 2002-02-06 ES ES02718096T patent/ES2311600T3/es not_active Expired - Lifetime
- 2002-02-06 JP JP2002569789A patent/JP4104984B2/ja not_active Expired - Fee Related
- 2002-02-06 DK DK02718096T patent/DK1363875T3/da active
- 2002-02-06 AT AT02718096T patent/ATE403645T1/de active
- 2002-02-06 US US10/467,624 patent/US7202277B2/en not_active Expired - Fee Related
- 2002-02-06 AU AU2002249183A patent/AU2002249183B2/en not_active Ceased
- 2002-02-06 DE DE60228053T patent/DE60228053D1/de not_active Expired - Lifetime
-
2007
- 2007-01-12 US US11/652,675 patent/US20070135523A1/en not_active Abandoned
-
2008
- 2008-04-30 US US12/112,299 patent/US7560591B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2311600T3 (es) | 2009-02-16 |
ATE403645T1 (de) | 2008-08-15 |
WO2002070468A2 (en) | 2002-09-12 |
US20040110801A1 (en) | 2004-06-10 |
US7560591B2 (en) | 2009-07-14 |
EP1363875B1 (en) | 2008-08-06 |
US20080207764A1 (en) | 2008-08-28 |
EP1363875A2 (en) | 2003-11-26 |
ITTO20010110A1 (it) | 2002-08-08 |
US20070135523A1 (en) | 2007-06-14 |
DK1363875T3 (da) | 2008-11-24 |
CA2437109A1 (en) | 2002-09-12 |
WO2002070468A3 (en) | 2003-09-04 |
CA2437109C (en) | 2010-07-06 |
JP2004531489A (ja) | 2004-10-14 |
US7202277B2 (en) | 2007-04-10 |
PT1363875E (pt) | 2008-08-22 |
AU2002249183B2 (en) | 2006-11-16 |
JP4104984B2 (ja) | 2008-06-18 |
DE60228053D1 (de) | 2008-09-18 |
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