ITMI952614A0 - - Google Patents

Info

Publication number
ITMI952614A0
ITMI952614A0 ITMI952614A ITMI952614A ITMI952614A0 IT MI952614 A0 ITMI952614 A0 IT MI952614A0 IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A ITMI952614 A IT MI952614A IT MI952614 A0 ITMI952614 A0 IT MI952614A0
Authority
IT
Italy
Application number
ITMI952614A
Other languages
Italian (it)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI952614A0 publication Critical patent/ITMI952614A0/it
Publication of ITMI952614A1 publication Critical patent/ITMI952614A1/it
Application granted granted Critical
Publication of IT1277073B1 publication Critical patent/IT1277073B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT95MI002614A 1994-12-23 1995-12-13 Derivati antraciclinici IT1277073B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9426075A GB2296495B (en) 1994-12-23 1994-12-23 Anthracycline derivatives

Publications (3)

Publication Number Publication Date
ITMI952614A0 true ITMI952614A0 (en, 2012) 1995-12-13
ITMI952614A1 ITMI952614A1 (it) 1997-06-13
IT1277073B1 IT1277073B1 (it) 1997-11-04

Family

ID=10766488

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI002614A IT1277073B1 (it) 1994-12-23 1995-12-13 Derivati antraciclinici

Country Status (4)

Country Link
JP (1) JP4081148B2 (en, 2012)
DE (1) DE19547958B4 (en, 2012)
GB (1) GB2296495B (en, 2012)
IT (1) IT1277073B1 (en, 2012)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
EP1242438B1 (en) * 1999-12-29 2006-11-08 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
WO2004082579A2 (en) * 2003-03-18 2004-09-30 Pharmacia Italia S.P.A. Nemorubicin as radiosensitizer in combination with radiation therapy against tumors
MXPA05009849A (es) * 2003-03-18 2005-12-06 Pharmacia Italia Spa Terapia combinada que comprende nemorubicina y un inhibidor de la ciclooxigenasa-2.
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
RU2455307C1 (ru) * 2008-04-11 2012-07-10 Тяньцзинь Химэй Байо-Тек Ко., Лтд Тетрациклические антибиотические производные антрахинона с высокой активностью, способ их получения и их применение
WO2009124468A1 (zh) * 2008-04-11 2009-10-15 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
AU2009270988A1 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
CA2818713C (en) 2010-12-02 2019-03-26 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
JP6104287B2 (ja) * 2012-03-06 2017-03-29 天津和美生物技術有限公司 四環系アントラキノン誘導体
ES2695162T3 (es) 2013-04-29 2019-01-02 Nerviano Medical Sciences Srl Nuevos derivados de morfolinil antraciclina
JP6785780B2 (ja) 2014-11-05 2020-11-18 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 官能基化モルホリニルアントラサイクリン誘導体
CN110776501B (zh) * 2019-08-22 2021-04-02 联宁（苏州）生物制药有限公司 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体
WO2025092728A1 (zh) * 2023-10-30 2025-05-08 上海皓元生物医药科技有限公司 一种pnu-159682的中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
JPS59212499A (ja) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
GB2296495B (en) 1998-04-15
GB9426075D0 (en) 1995-02-22
ITMI952614A1 (it) 1997-06-13
JP4081148B2 (ja) 2008-04-23
IT1277073B1 (it) 1997-11-04
JPH08231581A (ja) 1996-09-10
DE19547958B4 (de) 2015-01-22
DE19547958A1 (de) 1996-06-27
GB2296495A (en) 1996-07-03

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Legal Events

Date Code Title Description
0001 Granted