ITMI942632A1 - Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. - Google Patents
Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid.Info
- Publication number
- ITMI942632A1 ITMI942632A1 IT94MI002632A ITMI942632A ITMI942632A1 IT MI942632 A1 ITMI942632 A1 IT MI942632A1 IT 94MI002632 A IT94MI002632 A IT 94MI002632A IT MI942632 A ITMI942632 A IT MI942632A IT MI942632 A1 ITMI942632 A1 IT MI942632A1
- Authority
- IT
- Italy
- Prior art keywords
- alpha
- acid
- beta
- pure
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 238000001816 cooling Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- NEEIOMGUTSQVRZ-WNOQBHAASA-N (4r)-4-[(8r,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2,2-dihydroxypentanoic acid Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CC(O)(O)C(O)=O)C)[C@@]1(C)CC2 NEEIOMGUTSQVRZ-WNOQBHAASA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
This is the procedure for preparation of very pure 3 alpha-7 beta-dihydroxycholanic acid from a raw product containing up to 20 percent in weight of 3 alpha-7 alpha-dihydroxycholanic acid and up to 2 percent in weight of 3 alpha-hydroxycolanic acid. The process includes treatment of the raw product with an organic base chosen from triazole, imidazole, pirazole or their derivatives in a medium consisting of a polar organic solvent or a mixture of the solvent with water at boiling point. The product of the reaction is then crystallised by cooling. The crystallised product is dissolved in an acetated mixture of ethyl + water. The acidification to pH 3 crystallisation of 3 alpha-7 beta dihydroxycholanic acid is then obtained by cooling.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI942632A0 ITMI942632A0 (en) | 1994-12-23 |
ITMI942632A1 true ITMI942632A1 (en) | 1995-12-22 |
Family
ID=11370072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Country Status (1)
Country | Link |
---|---|
IT (1) | ITMI942632A1 (en) |
-
1994
- 1994-12-23 IT IT94MI002632A patent/ITMI942632A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ITMI942632A0 (en) | 1994-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO982849D0 (en) | Separation of medium high boiling fractions from a mixture of low, medium and high boiling fractions | |
AU4106589A (en) | Process for the preparation of 1-adamantane derivatives | |
EP0167008A3 (en) | 1,4:3,6-dianhydro-hexite derivatives, process for their preparation and their use as medicaments | |
DE3472407D1 (en) | Process for preparing cyanohydrine derivatives containing phosphorus | |
ES8400772A1 (en) | Process for preparing human insulin or b-30 esters thereof. | |
ITMI942632A1 (en) | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. | |
EP0243615A3 (en) | 1-phenylimidazole-carbon acid amides, process for their preparation and their use as growth regulators | |
ES2160909T3 (en) | PROCEDURE FOR THE PREPARATION OF 4-AMINO-1,2,4-TRIAZOLS. | |
IL70720A0 (en) | (-)-antipode of(e)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene,its preparation and its use as plant growth regulant | |
PL285062A1 (en) | Method of obtaining novel 2-hydroxy-3-phenoxypropylamine derivatives | |
IT1228972B (en) | PROCEDURE FOR THE PREPARATION OF 3 ALPHA 7 ACID DIHYDROXICOLANIC BETA OF HIGH PURITY. | |
FI874956A0 (en) | PROTECTION OF FRUIT PROCESSING OF BLOOD SUBSTANCES 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOLOLINER. | |
IE810547L (en) | Stabilization of pleuromutilin derivatives against oxidation | |
DE3750117D1 (en) | Process for the preparation of indolinone-2 derivatives. | |
JPS5618989A (en) | Imidazole derivative and its preparation | |
PT85624A (en) | 13 alpha-alkylgonan-delta 9(11)-5,10-epoxide | |
JPS5711818A (en) | Novel crystalline silicate and its preparation | |
JPS5557566A (en) | N-methyl-8-chloro-3,4-dihydro-2-quinolinone, its preparation, and germicide containing the same | |
DE3465737D1 (en) | Process for the preparation of 4-quinolinones | |
JPS5726677A (en) | Preparation of oxirane compound | |
FR2573753B1 (en) | PROCESS FOR THE PREPARATION OF A-HYDROXY-ACIDS AND COMPOUNDS OBTAINED THEREBY | |
JPS56122348A (en) | 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation | |
JPS5531029A (en) | Preparation of 4-substituted amido-3-arylamino-5- pyrazolones | |
BG49444A1 (en) | Acylureidoamynotiasolylni derivatives and method for their preparation | |
JPS57169476A (en) | Novel preparation of benzothiazepine derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0003 | Withdrawn |