ITMI942632A1 - Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. - Google Patents
Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid.Info
- Publication number
- ITMI942632A1 ITMI942632A1 IT94MI002632A ITMI942632A ITMI942632A1 IT MI942632 A1 ITMI942632 A1 IT MI942632A1 IT 94MI002632 A IT94MI002632 A IT 94MI002632A IT MI942632 A ITMI942632 A IT MI942632A IT MI942632 A1 ITMI942632 A1 IT MI942632A1
- Authority
- IT
- Italy
- Prior art keywords
- alpha
- acid
- beta
- pure
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 238000001816 cooling Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- NEEIOMGUTSQVRZ-WNOQBHAASA-N (4r)-4-[(8r,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2,2-dihydroxypentanoic acid Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CC(O)(O)C(O)=O)C)[C@@]1(C)CC2 NEEIOMGUTSQVRZ-WNOQBHAASA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
This is the procedure for preparation of very pure 3 alpha-7 beta-dihydroxycholanic acid from a raw product containing up to 20 percent in weight of 3 alpha-7 alpha-dihydroxycholanic acid and up to 2 percent in weight of 3 alpha-hydroxycolanic acid. The process includes treatment of the raw product with an organic base chosen from triazole, imidazole, pirazole or their derivatives in a medium consisting of a polar organic solvent or a mixture of the solvent with water at boiling point. The product of the reaction is then crystallised by cooling. The crystallised product is dissolved in an acetated mixture of ethyl + water. The acidification to pH 3 crystallisation of 3 alpha-7 beta dihydroxycholanic acid is then obtained by cooling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI942632A0 ITMI942632A0 (en) | 1994-12-23 |
| ITMI942632A1 true ITMI942632A1 (en) | 1995-12-22 |
Family
ID=11370072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT94MI002632A ITMI942632A1 (en) | 1994-12-23 | 1994-12-23 | Procedure for the preparation of very pure 3 alpha-7 beta-dihydroxidolanic acid. |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | ITMI942632A1 (en) |
-
1994
- 1994-12-23 IT IT94MI002632A patent/ITMI942632A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI942632A0 (en) | 1994-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0003 | Withdrawn |