ITMI941494A0 - Derivati del fenilcarbammato atti all'impiego come anticolinesterasici - Google Patents

Derivati del fenilcarbammato atti all'impiego come anticolinesterasici

Info

Publication number
ITMI941494A0
ITMI941494A0 ITMI941494A ITMI941494A ITMI941494A0 IT MI941494 A0 ITMI941494 A0 IT MI941494A0 IT MI941494 A ITMI941494 A IT MI941494A IT MI941494 A ITMI941494 A IT MI941494A IT MI941494 A0 ITMI941494 A0 IT MI941494A0
Authority
IT
Italy
Prior art keywords
anticholinesterases
phenylcarbamate
derivatives
phenylcarbamate suitable
Prior art date
Application number
ITMI941494A
Other languages
English (en)
Inventor
Patrizia Terni
Lucia Mairani
Giacomina Mandelli
Pier Giuseppe Pagella
Donata Marchesini
Stefano Maiorana
Mario Brufani
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Priority to ITMI941494A priority Critical patent/IT1271679B/it
Publication of ITMI941494A0 publication Critical patent/ITMI941494A0/it
Priority to EP95943500A priority patent/EP0772608A1/en
Priority to AU30783/95A priority patent/AU3078395A/en
Priority to US08/776,052 priority patent/US5869484A/en
Priority to PCT/EP1995/002752 priority patent/WO1996002524A1/en
Publication of ITMI941494A1 publication Critical patent/ITMI941494A1/it
Application granted granted Critical
Publication of IT1271679B publication Critical patent/IT1271679B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
ITMI941494A 1994-07-18 1994-07-18 Derivati del fenilcarbammato atti all'impiego come anticolinesterasici IT1271679B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI941494A IT1271679B (it) 1994-07-18 1994-07-18 Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
EP95943500A EP0772608A1 (en) 1994-07-18 1995-07-13 Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
AU30783/95A AU3078395A (en) 1994-07-18 1995-07-13 Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
US08/776,052 US5869484A (en) 1994-07-18 1995-07-13 Phenylcarbamate derivatives suitable to the use as anticholinesterase substances
PCT/EP1995/002752 WO1996002524A1 (en) 1994-07-18 1995-07-13 Phenylcarbamate derivatives suitable to the use as anticholinesterase substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941494A IT1271679B (it) 1994-07-18 1994-07-18 Derivati del fenilcarbammato atti all'impiego come anticolinesterasici

Publications (3)

Publication Number Publication Date
ITMI941494A0 true ITMI941494A0 (it) 1994-07-18
ITMI941494A1 ITMI941494A1 (it) 1996-01-18
IT1271679B IT1271679B (it) 1997-06-04

Family

ID=11369297

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941494A IT1271679B (it) 1994-07-18 1994-07-18 Derivati del fenilcarbammato atti all'impiego come anticolinesterasici

Country Status (5)

Country Link
US (1) US5869484A (it)
EP (1) EP0772608A1 (it)
AU (1) AU3078395A (it)
IT (1) IT1271679B (it)
WO (1) WO1996002524A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
CA2275425C (en) 1996-12-18 2009-08-04 Michael Chorev Aminoindan derivatives
KR100457790B1 (ko) * 2001-08-08 2004-12-08 충남대학교산학협력단 감염성을 갖는 ｈｃｖ 유사입자의 제조
WO2003051841A2 (en) * 2001-12-14 2003-06-26 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
JP4515911B2 (ja) 2002-10-07 2010-08-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アナンダミド加水分解の遮断による不安の調節
AU2004285893B2 (en) * 2003-10-21 2011-12-15 Colucid Pharmaceuticals, Inc. Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
JP2009518433A (ja) 2005-12-09 2009-05-07 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム 神経保護用の低用量ラドスチギルの使用
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
MX2009008288A (es) 2007-02-02 2009-12-01 Colucid Pharmaceuticals Inc Compuestos que inhiben la colinesterasa.
EP2413926A2 (en) * 2009-04-02 2012-02-08 Colucid Pharmaceuticals, Inc. Compositions of cholinesterase inhibitors
AU2017290593A1 (en) 2016-06-27 2019-01-03 Achillion Pharmaceuticals, Inc. Quinazoline and indole compounds to treat medical disorders
EP3628315A1 (en) 2018-09-28 2020-04-01 Université de Caen Normandie Combination of acetylcholinesterase inhibitor and 5-ht4 receptor agonist as neuroprotective agent in the treatment of neurodegenerative diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
IL74497A (en) * 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
JPS63170356A (ja) * 1986-12-30 1988-07-14 Yamanouchi Pharmaceut Co Ltd アニリン誘導体及びその製造法
DE69032046T2 (de) * 1990-06-27 1998-08-27 Hoechst Marion Roussel Inc Tetrahydroisochinolinylcarbamate von 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo [2,3-b] indol
IT1254996B (it) * 1992-06-25 1995-10-11 Mediolanum Farmaceutici Srl Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione

Also Published As

Publication number Publication date
ITMI941494A1 (it) 1996-01-18
EP0772608A1 (en) 1997-05-14
WO1996002524A1 (en) 1996-02-01
US5869484A (en) 1999-02-09
AU3078395A (en) 1996-02-16
IT1271679B (it) 1997-06-04

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Effective date: 19970730