ITMI20100041A1 - COSMETIC COMPOSITION WITH MOISTURIZING AND ANTIOXIDANT ACTIVITY. - Google Patents
COSMETIC COMPOSITION WITH MOISTURIZING AND ANTIOXIDANT ACTIVITY. Download PDFInfo
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- ITMI20100041A1 ITMI20100041A1 IT000041A ITMI20100041A ITMI20100041A1 IT MI20100041 A1 ITMI20100041 A1 IT MI20100041A1 IT 000041 A IT000041 A IT 000041A IT MI20100041 A ITMI20100041 A IT MI20100041A IT MI20100041 A1 ITMI20100041 A1 IT MI20100041A1
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Description
Campo dell 'invenzione Field of invention
Costituisce l’oggetto della presente invenzione una composizione cosmetica avente una spiccata attività idratante ed antiossidante, la quale esplica un’efficiente azione nel prevenire o nell 'attenuare, se nel caso, la senescenza della pelle, migliorandone comunque il turgore e la consistenza e, conseguentemente, il suo aspetto esteriore. The object of the present invention is a cosmetic composition having a strong moisturizing and antioxidant activity, which performs an efficient action in preventing or attenuating, if necessary, the senescence of the skin, improving in any case its firmness and texture. and, consequently, its external appearance.
Più specificatamente, la composizione cosmetica dell’invenzione à ̈ costituita da un’adatta miscela di composti fra i quali sono presenti sostanze vitaminiche, proteine, acidi jaluronici di basso e di medio peso molecolare, amminoacidi, sostanze antiossidanti, nonché altre sostanze di natura vegetale o di natura biotecnologica compatibili con le sostanze presenti nella composizione. L’attività dei singoli componenti attivi che costituiscono la composizione cosmetica dell’invenzione risulta, nella composizione stessa, chiaramente potenziata. More specifically, the cosmetic composition of the invention consists of a suitable mixture of compounds including vitamins, proteins, low and medium molecular weight hyaluronic acids, amino acids, antioxidant substances, as well as other substances of a vegetable or biotechnological nature compatible with the substances present in the composition. The activity of the individual active components that make up the cosmetic composition of the invention is clearly enhanced in the composition itself.
Descrizione dell’ invenzione Description of the invention
E’ noto che, con l’avanzare dell’età , la costituzione della pelle delle persone subisce modificazioni sostanziali: tra di esse à ̈ di rilevante importanza la riduzione dei glucosaminglicani (GAGS), presenti nella sostanza fondamentale, il che comporta, quale conseguenza, la diminuzione, in tutta la pelle, della quota idrica inglobata dagli stessi glucosaminglicani e si manifesta, esteriormente, con una sensibile riduzione del turgore, con la perdita di elasticità della pelle e con l’instaurarsi di alterazioni del connettivo che portano alla formazione di rughe, caduta della componente minerale e vitaminica ed aumento dei radicali liberi i quali, a loro volta, hanno effetti devastanti sul benessere ed aspetto esteriore della pelle. It is known that, with advancing age, the constitution of people's skin undergoes substantial changes: among these the reduction of glucosaminglycans (GAGS), present in the fundamental substance, is of considerable importance, which involves , as a consequence, the decrease, throughout the skin, of the amount of water incorporated by the same glucosaminglycans and manifests itself, externally, with a significant reduction of turgor, with the loss of elasticity of the skin and with the establishment of alterations of the connective tissue that lead to the formation of wrinkles, a fall in the mineral and vitamin component and an increase in free radicals which, in turn, have devastating effects on the well-being and appearance of the skin.
Sono note nell’arte composizioni cosmetiche che contengono, nelle loro formulazioni, alcune delle sostanze che costituiscono la composizione della presente invenzione: in cosmesi à ̈, in particolare, largamente diffuso l’uso dei glucosaminglicani, quali gli acidi jaluronici di vario peso molecolare, parimenti a vitamine, amminoacidi, sostanze antiossidanti, proteine e minerali. Cosmetic compositions are known in the art which contain, in their formulations, some of the substances that make up the composition of the present invention: in cosmetics, in particular, the use of glucosaminglycans, such as hyaluronic acids of various weights, is widespread. molecular, as well as vitamins, amino acids, antioxidants, proteins and minerals.
E’ stato ora trovato, e ciò costituisce l’oggetto dell’ invenzione, che l’utilizzo di acido jaluronico di peso molecolare medio, compreso tra 1.200 e 1.500Da, opportunamente miscelato con acido jalobiuronico di peso molecolare compreso tra 300 e 500Da, unitamente ad adatti quantitativi di agenti antiossidanti, fra i quali à ̈ particolarmente preferito Crocus sativus o zafferano, comporta un significativo sinergismo di azione dei singoli componenti attivi della composizione, e determina una migliorata azione di idratazione e di antiossidazione sulla pelle e, conseguentemente, ne migliora l’aspetto rendendola più turgida e levigata. It has now been found, and this constitutes the object of the invention, that the use of hyaluronic acid with an average molecular weight, between 1.200 and 1.500Da, suitably mixed with hyalobiuronic acid with a molecular weight between 300 and 500Da, together with suitable quantities of antioxidant agents, among which Crocus sativus or saffron is particularly preferred, involves a significant synergism of action of the individual active components of the composition, and determines an improved hydration and antioxidation action on the skin and, consequently, it improves its appearance making it more turgid and smooth.
Più specificamente, la composizione cosmetica dell’invenzione à ̈ caratterizzata dalla presenza sia dell’acido jalobiuronico, dimero di base costituente l’acido jaluronico, avente un peso molecolare compreso tra 300 e 500Da, preferibilmente 400Da, che dell’acido jaluronico a medio peso molecolare, più precisamente acido jaluronico di peso molecolare compreso tra 1.200 e 1.500Da, nonché dalla presenza di uno o più agenti antiossidanti, quali Crocus sativus (zafferano), vitamina C e vitamina E, di sostanze proteiche di natura vegetale quali collagene ed elastina. More specifically, the cosmetic composition of the invention is characterized by the presence of both hyalobiuronic acid, basic dimer constituting hyaluronic acid, having a molecular weight between 300 and 500Da, preferably 400Da, and of the acid medium molecular weight hyaluronic acid, more precisely hyaluronic acid with a molecular weight between 1,200 and 1,500Da, as well as the presence of one or more antioxidant agents, such as Crocus sativus (saffron), vitamin C and vitamin E, of vegetable protein substances such as collagen and elastin.
Nella suddetta composizione cosmetica l’attività dei singoli componenti si presenta intensificata allorché essi sono presenti in una quantità che varia entro specifici ambiti: l’acido jalobiuronico à ̈ presente, singolarmente od addizionato all’acido jaluronico a medio peso molecolare, nella quantità da 0,8% a 2,0% in peso rispetto al peso totale della composizione, specificatamente, essendo preferita la composizione cosmetica che contiene l’acido jalobiuronico e l’acido jaluronico a medio peso molecolare, entrambi singolarmente, nella quantità dello 0,8% - 1% in peso rispetto al peso totale della composizione;le vitamine, scelte nel gruppo formato dalle vitamine del gruppo B, dalla vitamina A, dalla vitamina C e dalla vitamina E, sono presenti in quantità da 0,5% a 1% in peso rispetto al peso totale della composizione; gli agenti antiossidanti, scelti nel gruppo formato da Crocus sativus e dalle succitate vitamine C ed E, sono presenti nella quantità da 0,8% a 2,5 % in peso rispetto al peso totale della composizione; gli amminoacidi, scelti nel gruppo formato da alanina, arginina, asparagina, acido aspartico, cistina, glutamina, acido glutamico, glieina, istidina, idrossiprolina, isoleucina, leucina, lisina, metionina, omitina, fenilalanina, prolina, serina, taurina, treonina, triptofano, tirosina, vaiina, sono presenti nella quantità da 0,05 a 1% in peso rispetto al peso totale della composizione; le proteine, preferibilmente costituite dalle proteine vegetali elastina e collagene, sono presenti nella composizione nella quantità da 2 a 6% in peso rispetto al peso totale della composizione. In the aforementioned cosmetic composition the activity of the individual components is intensified when they are present in a quantity that varies within specific areas: hyalobiuronic acid is present, individually or added to hyaluronic acid of medium molecular weight, in the quantity from 0.8% to 2.0% by weight with respect to the total weight of the composition, specifically, the cosmetic composition containing hyalobiuronic acid and medium molecular weight hyaluronic acid, both individually, being preferred, in the quantity of 0,8% - 1% by weight with respect to the total weight of the composition; vitamins, chosen from the group formed by vitamins of group B, vitamin A, vitamin C and vitamin E, are present in quantities of 0, 5% to 1% by weight with respect to the total weight of the composition; the antioxidant agents, selected from the group formed by Crocus sativus and the aforementioned vitamins C and E, are present in the quantity from 0.8% to 2.5% by weight with respect to the total weight of the composition; amino acids, selected from the group formed by alanine, arginine, asparagine, aspartic acid, cystine, glutamine, glutamic acid, glieine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, omithine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, goina, are present in the quantity from 0.05 to 1% by weight with respect to the total weight of the composition; the proteins, preferably constituted by the vegetable proteins elastin and collagen, are present in the composition in the quantity from 2 to 6% by weight with respect to the total weight of the composition.
Nella composizione cosmetica dell 'invenzione, possono essere inoltre presenti eccipienti, conservanti e piante officinali compatibili con i principi attivi in essa contenuti nonché con la forma desiderata della stessa. Detta composizione cosmetica à ̈ adatta ad essere formulata, unitamente ad opportuni eccipienti, come emulsione cremosa, emulsione fluida, gel, unguento, crema o soluzione. Quali adatti eccipienti, dipendentemente dal tipo di forma cosmetica considerato, possono essere usati, ad esempio, cera d’api, olio di jojoba, olio di oliva, isostearilstearato, glicerilstearato, acidi grassi, trigliceridi, glicole propilenico, idrossipropilmetilcellulosa. Possono inoltre essere incluse nelle succitate formulazioni, sostanze conservati e/o stabilizzanti di comune utilizzo nel campo. In the cosmetic composition of the invention, there may also be present excipients, preservatives and medicinal plants compatible with the active ingredients contained therein as well as with the desired form thereof. Said cosmetic composition is suitable for being formulated, together with suitable excipients, such as creamy emulsion, fluid emulsion, gel, ointment, cream or solution. As suitable excipients, depending on the type of cosmetic form considered, can be used, for example, beeswax, jojoba oil, olive oil, isostearylstearate, glycerylstearate, fatty acids, triglycerides, propylene glycol, hydroxypropylmethylcellulose. In addition, preserved substances and / or stabilizers commonly used in the field can also be included in the aforementioned formulations.
In accordo alla presente invenzione le materie prime per la preparazione della composizione cosmetica vengono pesate e, a seconda della loro natura idrofila o lipofila, vengono poste in adatti recipienti in acciaio aventi la superficie perfettamente speculare e quindi portate alla temperatura desiderata, mescolate o turbinate, allo scopo di ottenere i prodotti finiti. L’acqua deionizzata, chimicamente e microbiologicamente pura, utilizzata nel procedimento di produzione viene fornita da un impianto di osmosi inversa a valle del quale à ̈ posto un filtro assoluto. In accordance with the present invention, the raw materials for the preparation of the cosmetic composition are weighed and, depending on their hydrophilic or lipophilic nature, are placed in suitable steel containers having a perfectly specular surface and then brought to the desired temperature, mixed or swirled, in order to obtain the finished products. The chemically and microbiologically pure deionized water used in the production process is supplied by a reverse osmosis plant downstream of which there is an absolute filter.
Al termine del processo produttivo, il semilavorato viene travasato per mezzo di pompe in recipienti di acciaio aventi la superficie perfettamente speculare e muniti di coperchio a tenuta. Detti recipienti vengono poi trasferiti al reparto confezionamento ed i prodotti, opportunamente pesati e dosati, vengono ripartiti nelle confezioni predisposte per la vendita. Nell’uso la composizione cosmetica della presente invenzione viene applicata sulla zona della pelle da trattare in quantità adeguata, preferibilmente in due trattamenti quotidiani, e distribuita mediante un leggero massaggio sino a suo completo assorbimento. I benefici di detto trattamento sono visibili già dopo quindici/ venti giorni di applicazione. At the end of the production process, the semi-finished product is transferred by means of pumps into steel containers having a perfectly specular surface and equipped with a sealed lid. These containers are then transferred to the packaging department and the products, suitably weighed and dosed, are divided into the packages prepared for sale. In use, the cosmetic composition of the present invention is applied to the area of the skin to be treated in an adequate quantity, preferably in two daily treatments, and distributed by means of a light massage until it is completely absorbed. The benefits of this treatment are visible already after fifteen / twenty days of application.
Gli esempi che seguono hanno lo scopo di meglio descrivere l’invenzione senza tuttavia limitarne l’ambito. The following examples are intended to better describe the invention without limiting its scope.
Esempio 1 Example 1
Preparazione di una crema cosmetica che ha la composizione come indicata nelle fasi di seguito riportate: Preparation of a cosmetic cream that has the composition as indicated in the following steps:
- fase A - phase A
aperoxide TLA 0,30 g aperoxide TLA 0.30 g
sorbilene S 13,00 g sorbylene S 13.00 g
sorbirai 13,00 g you will drink 13.00 g
losorbo ACS 25,00 g losorbo ACS 25.00 g
fluido 350 2,00 g fluid 350 2.00 g
olio di oliva raffinato 55,00 g refined olive oil 55.00 g
olio di mandorle dolci 40,00 g sweet almond oil 40.00 g
olio dijojoba 10,00 g dijojoba oil 10.00 g
alfa bisabololo 1>50 g alpha bisabolol 1> 50 g
lipacide C & G 7,00 g lipacid C & G 7.00 g
vitamina E 3,00 g vitamin E 3.00 g
vitamina A 0,50 g vitamin A 0.50 g
helastab HP 100 1 ,00 g helastab HP 100 1, 00 g
- fase B - phase B
glicerina vegetale al 99,5% 23,00 g 99.5% vegetable glycerin 23.00 g
allantoina 0,30 g allantoin 0.30 g
collagene liofilizzato 2,00 g lyophilized collagen 2.00 g
cibafast H liquido 1 ,00 g cibafast H liquid 1, 00 g
Tea 90% 8,00 g Tea 90% 8.00 g
pantenolo 50P 20,00 g panthenol 50P 20.00 g
acido jaluronico 0,80 g hyaluronic acid 0.80 g
acido jalobiuronico 2,00 g hyalobiuronic acid 2.00 g
elastina 2,00 g elastin 2.00 g
Crocus sativus 2,00 g Crocus sativus 2.00 g
abiol 3,00 g abiol 3.00 g
fondix G. 5,00 g fondix G. 5.00 g
lisina 0,60 g lysine 0.60 g
acqua demineralizzata q.b. a 100,00 g demineralized water q.s. to 100.00 g
- fase C - phase C
polygel CA 6,00 g polygel CA 6.00 g
- fase D - phase D
profumo a 0,4 g perfume at 0.4 g
In un fusore di acciaio, a superficie speculare, termostatato, portare la temperatura dei componenti della fase A a 75 °C ed, analogamente, operare per i componenti della fase B. Unire le due fasi a e B. Ridurre la temperatura della miscela e dell’acqua a 30 °C ed aggiungere il componente della fase C. Omogeneizzare per 30 minuti sottovuoto, quindi aggiungere il componente della fase D, cioà ̈ il profumo ed infine miscelare per 30 minuti e scaricare. In a steel melter, with a specular surface, thermostated, bring the temperature of the components of phase A to 75 ° C and, similarly, operate for the components of phase B. Combine the two phases a and B. Reduce the temperature of the mixture and of the € ™ water at 30 ° C and add the component of phase C. Homogenize for 30 minutes under vacuum, then add the component of phase D, ie the perfume and finally mix for 30 minutes and drain.
Esempio 2 Example 2
Preparazione di un gel avente composizione come di seguito riportato: Preparation of a gel having a composition as follows:
acido jaluronico 8,00 g hyaluronic acid 8.00 g
acido jalobiuronico 16,00 g hyalobiuronic acid 16.00 g
collagene liofilizzato, 2,00 g lyophilized collagen, 2.00 g
elastina 2,00 g elastin 2.00 g
vitamina A 1 ,00 g vitamin A 1, 00 g
cellosize QP100 2,50 g cellosize QP100 2.50 g
abiol 3,00 g abiol 3.00 g
fondix 5,00 g fondix 5.00 g
Crocus sativus 2,00 g Crocus sativus 2.00 g
cibafast H liquido 1 ,00 g cibafast H liquid 1, 00 g
lisina 0.60 g lysine 0.60 g
acqua demineralizzata q.b. a 1.000,00 g demineralized water q.s. to 1,000.00 g
Portare l’acqua alla temperatura di 0°C, aggiungere celloside QP100 e gli acidi jaluronico ed jalobiuronico. Omogeneizzare per 30 minuti sottovuoto quindi aggiungere i restanti componenti della formulazione, miscelare per 60 minuti sotto vuoto e scaricare la macchina. Bring the water to a temperature of 0 ° C, add celloside QP100 and the hyaluronic and hyalobiuronic acids. Homogenize for 30 minutes under vacuum then add the remaining components of the formulation, mix for 60 minutes under vacuum and unload the machine.
Claims (6)
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|---|---|---|---|---|
| US3991184A (en) * | 1973-10-05 | 1976-11-09 | Martin Kludas | Agent for the care of skin |
| FR2473887A1 (en) * | 1980-01-22 | 1981-07-24 | Curri Sergio | NOVEL USE OF GLUCOSAMINO-GLYCAN BIOCHEMICAL PRECURSORS AND RESPECTIVE PHARMACEUTICAL AND COSMETIC COMPOSITIONS |
| JPS61289016A (en) * | 1985-06-17 | 1986-12-19 | Pola Chem Ind Inc | Skin external agent |
| US4983382A (en) * | 1987-01-27 | 1991-01-08 | Avon Products, Inc. | Cosmetic preparation incorporating stabilized ascorbic acid |
| WO1992007587A1 (en) * | 1990-10-25 | 1992-05-14 | Narhex Limited | Methods and compositions for amelioration of skin wrinkles |
| US5801192A (en) * | 1995-08-25 | 1998-09-01 | Lvmh Recherche | Use of vitamin C or derivatives or analogues thereof promoting skin elastin synthesis |
| US6335023B1 (en) * | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
| WO2007050178A2 (en) * | 2005-10-24 | 2007-05-03 | Kevin Meehan | Skin care composition for accelerated production of collagen proteins and method of fabricating same |
| FR2894827A1 (en) * | 2005-12-21 | 2007-06-22 | Galderma Res & Dev | Pharmaceutical/cosmetic preparation, useful, e.g. to treat and/or prevent dermatological disorders, comprises hyaluronic acid, a retinoid, an oligosaccharide and a hyaluronic acid degradation inhibitor |
| FR2932086A1 (en) * | 2008-06-06 | 2009-12-11 | Lvmh Rech | ANTI-AGE COSMETIC CARE METHOD BY STIMULATING THE EXPRESSION OF SURVIVAL |
-
2010
- 2010-01-18 IT ITMI2010A000041A patent/IT1397735B1/en active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991184A (en) * | 1973-10-05 | 1976-11-09 | Martin Kludas | Agent for the care of skin |
| FR2473887A1 (en) * | 1980-01-22 | 1981-07-24 | Curri Sergio | NOVEL USE OF GLUCOSAMINO-GLYCAN BIOCHEMICAL PRECURSORS AND RESPECTIVE PHARMACEUTICAL AND COSMETIC COMPOSITIONS |
| JPS61289016A (en) * | 1985-06-17 | 1986-12-19 | Pola Chem Ind Inc | Skin external agent |
| US4983382A (en) * | 1987-01-27 | 1991-01-08 | Avon Products, Inc. | Cosmetic preparation incorporating stabilized ascorbic acid |
| WO1992007587A1 (en) * | 1990-10-25 | 1992-05-14 | Narhex Limited | Methods and compositions for amelioration of skin wrinkles |
| US5801192A (en) * | 1995-08-25 | 1998-09-01 | Lvmh Recherche | Use of vitamin C or derivatives or analogues thereof promoting skin elastin synthesis |
| US6335023B1 (en) * | 1999-06-30 | 2002-01-01 | Ruey J. Yu | Oligosaccharide aldonic acids and their topical use |
| WO2007050178A2 (en) * | 2005-10-24 | 2007-05-03 | Kevin Meehan | Skin care composition for accelerated production of collagen proteins and method of fabricating same |
| FR2894827A1 (en) * | 2005-12-21 | 2007-06-22 | Galderma Res & Dev | Pharmaceutical/cosmetic preparation, useful, e.g. to treat and/or prevent dermatological disorders, comprises hyaluronic acid, a retinoid, an oligosaccharide and a hyaluronic acid degradation inhibitor |
| FR2932086A1 (en) * | 2008-06-06 | 2009-12-11 | Lvmh Rech | ANTI-AGE COSMETIC CARE METHOD BY STIMULATING THE EXPRESSION OF SURVIVAL |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1397735B1 (en) | 2013-01-24 |
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