ITMI20011763A0 - Processo di preparazione di cefuroxime axelite ad elevata purezza - Google Patents

Processo di preparazione di cefuroxime axelite ad elevata purezza

Info

Publication number
ITMI20011763A0
ITMI20011763A0 IT2001MI001763A ITMI20011763A ITMI20011763A0 IT MI20011763 A0 ITMI20011763 A0 IT MI20011763A0 IT 2001MI001763 A IT2001MI001763 A IT 2001MI001763A IT MI20011763 A ITMI20011763 A IT MI20011763A IT MI20011763 A0 ITMI20011763 A0 IT MI20011763A0
Authority
IT
Italy
Prior art keywords
axelite
preparation process
high purity
cefuroxime
purity cefuroxime
Prior art date
Application number
IT2001MI001763A
Other languages
English (en)
Inventor
Walter Cabri
Marco Alpegiani
Davide Longoni
Claudio Felisi
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Priority to IT2001MI001763A priority Critical patent/ITMI20011763A1/it
Publication of ITMI20011763A0 publication Critical patent/ITMI20011763A0/it
Priority to US10/486,098 priority patent/US20040210050A1/en
Priority to KR10-2004-7001969A priority patent/KR20040043184A/ko
Priority to EP02794534A priority patent/EP1423395A1/en
Priority to JP2003519075A priority patent/JP2005502651A/ja
Priority to PCT/EP2002/008583 priority patent/WO2003014126A1/en
Publication of ITMI20011763A1 publication Critical patent/ITMI20011763A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
IT2001MI001763A 2001-08-10 2001-08-10 Processo di preparazione di cefuroxime axelite ad elevata purezza ITMI20011763A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT2001MI001763A ITMI20011763A1 (it) 2001-08-10 2001-08-10 Processo di preparazione di cefuroxime axelite ad elevata purezza
US10/486,098 US20040210050A1 (en) 2001-08-10 2002-08-01 Process for the preparation of highly pure cefuroxime axetil
KR10-2004-7001969A KR20040043184A (ko) 2001-08-10 2002-08-01 고도로 순수한 세푸록심 악세틸의 제조방법
EP02794534A EP1423395A1 (en) 2001-08-10 2002-08-01 Process for the preparation of highly pure cefuroxime axetil
JP2003519075A JP2005502651A (ja) 2001-08-10 2002-08-01 高純度セフロキシムアキセチルの製造方法
PCT/EP2002/008583 WO2003014126A1 (en) 2001-08-10 2002-08-01 Process for the preparation of highly pure cefuroxime axetil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001763A ITMI20011763A1 (it) 2001-08-10 2001-08-10 Processo di preparazione di cefuroxime axelite ad elevata purezza

Publications (2)

Publication Number Publication Date
ITMI20011763A0 true ITMI20011763A0 (it) 2001-08-10
ITMI20011763A1 ITMI20011763A1 (it) 2003-02-10

Family

ID=11448272

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001MI001763A ITMI20011763A1 (it) 2001-08-10 2001-08-10 Processo di preparazione di cefuroxime axelite ad elevata purezza

Country Status (6)

Country Link
US (1) US20040210050A1 (it)
EP (1) EP1423395A1 (it)
JP (1) JP2005502651A (it)
KR (1) KR20040043184A (it)
IT (1) ITMI20011763A1 (it)
WO (1) WO2003014126A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011925A1 (it) * 2001-09-14 2003-03-14 Antibioticos Spa Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
CN100448879C (zh) * 2004-07-22 2009-01-07 北京化工大学 一种无定型头孢呋辛酯的制备方法
JPWO2014027696A1 (ja) 2012-08-17 2016-07-28 中外製薬株式会社 抗ｈｃｖ作用を有する経口投与可能なビリジオファンジン誘導体
CN103435632B (zh) * 2013-09-12 2016-03-02 广东立国制药有限公司 一种头孢呋辛酯的制备方法
CN110950892A (zh) * 2019-12-16 2020-04-03 山东金城柯瑞化学有限公司 一种头孢呋辛中间体(3-去氨甲酰基-头孢呋酸)优化除杂的方法
CN111732599A (zh) * 2020-07-08 2020-10-02 江苏正大清江制药有限公司 一种合成头孢呋辛酯二聚体的方法
CN114354800B (zh) * 2021-12-31 2023-04-28 山东大学 头孢呋辛酯中乙酰溴含量的分析方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
TW293010B (en) * 1994-04-20 1996-12-11 Hui-Po Wang Method for preparing cephalosporin derivatives
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
ITMI20011925A1 (it) * 2001-09-14 2003-03-14 Antibioticos Spa Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino

Also Published As

Publication number Publication date
EP1423395A1 (en) 2004-06-02
KR20040043184A (ko) 2004-05-22
US20040210050A1 (en) 2004-10-21
JP2005502651A (ja) 2005-01-27
ITMI20011763A1 (it) 2003-02-10
WO2003014126A1 (en) 2003-02-20

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