IT951631B - Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi - Google Patents

Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Info

Publication number
IT951631B
IT951631B IT49167/71A IT4916771A IT951631B IT 951631 B IT951631 B IT 951631B IT 49167/71 A IT49167/71 A IT 49167/71A IT 4916771 A IT4916771 A IT 4916771A IT 951631 B IT951631 B IT 951631B
Authority
IT
Italy
Prior art keywords
geometric
separation
optical isomers
useful compounds
synthesis procedure
Prior art date
Application number
IT49167/71A
Other languages
English (en)
Italian (it)
Inventor
R Viterbo
Original Assignee
Richardson Merrell Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Spa filed Critical Richardson Merrell Spa
Priority to IT49167/71A priority Critical patent/IT951631B/it
Priority to ZA721297A priority patent/ZA721297B/xx
Priority to IL38860A priority patent/IL38860A/xx
Priority to PH13312A priority patent/PH10768A/en
Priority to AU39611/72A priority patent/AU462431B2/en
Priority to CA136,671A priority patent/CA961500A/en
Priority to GB1104172A priority patent/GB1360946A/en
Priority to US00233793A priority patent/US3848030A/en
Priority to SE7203303A priority patent/SE409323B/xx
Priority to DE2212660A priority patent/DE2212660C3/de
Priority to JP2661472A priority patent/JPS5547013B1/ja
Priority to ES400862A priority patent/ES400862A1/es
Priority to NO880/72A priority patent/NO136357C/no
Priority to NL7203574A priority patent/NL7203574A/xx
Priority to DK127372AA priority patent/DK139944B/da
Priority to BE780887A priority patent/BE780887A/xx
Priority to CH395572A priority patent/CH576921A5/xx
Priority to FR7209350A priority patent/FR2129741A5/fr
Application granted granted Critical
Publication of IT951631B publication Critical patent/IT951631B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IT49167/71A 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi IT951631B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
ZA721297A ZA721297B (en) 1971-03-18 1972-02-28 Process of separating optical,geometric,structural isomers and the compounds used for
IL38860A IL38860A (en) 1971-03-18 1972-02-29 Cyclic esters of phosphoric acid and their use for separating optical,geometric and structural isomers
PH13312A PH10768A (en) 1971-03-18 1972-03-03 Optical isomers of binaphthyl phosphoric acids
AU39611/72A AU462431B2 (en) 1971-03-18 1972-03-03 Process of separating optical, geometric structural isomers andthe compounds usedfor
CA136,671A CA961500A (en) 1971-03-18 1972-03-09 Process of separating optical, geometric, structural isomers and the compounds used therefor
GB1104172A GB1360946A (en) 1971-03-18 1972-03-09 Process of separating optical geometric structural isomers and the compounds used therefor
US00233793A US3848030A (en) 1971-03-18 1972-03-10 Optical isomers of binaphthyl-phosphoric acids
SE7203303A SE409323B (sv) 1971-03-18 1972-03-15 Anvendning av en optisk isomer av bi-(4,5,6,7-tetrahydronaftyl)-fosforsyraderivat for kemisk upplosning av basiska optiska cis- och trans-isomerer
DE2212660A DE2212660C3 (de) 1971-03-18 1972-03-16 Optische Einzelisomere von Binaphthylphosphorsäuren, Verfahren zur Trennung eines Racemats aus denselben und deren Verwenung zur Trennung von racemischen Basen
JP2661472A JPS5547013B1 (OSRAM) 1971-03-18 1972-03-17
ES400862A ES400862A1 (es) 1971-03-18 1972-03-17 Procedimiento para redisolver isomeros opticos.
NO880/72A NO136357C (no) 1971-03-18 1972-03-17 Anvendelse av optisisomerer av binafthylfosforsyre ved separasjon av basiske isomerer
NL7203574A NL7203574A (OSRAM) 1971-03-18 1972-03-17
DK127372AA DK139944B (da) 1971-03-18 1972-03-17 Optisk aktive syrer til anvendelse ved adskillelse af isomere af visse kemiske forbindelser.
BE780887A BE780887A (fr) 1971-03-18 1972-03-17 Nouveaux agents de dedoublement et procede de leur utilisation
CH395572A CH576921A5 (OSRAM) 1971-03-18 1972-03-17
FR7209350A FR2129741A5 (OSRAM) 1971-03-18 1972-03-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Publications (1)

Publication Number Publication Date
IT951631B true IT951631B (it) 1973-07-10

Family

ID=11269830

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Country Status (18)

Country Link
US (1) US3848030A (OSRAM)
JP (1) JPS5547013B1 (OSRAM)
AU (1) AU462431B2 (OSRAM)
BE (1) BE780887A (OSRAM)
CA (1) CA961500A (OSRAM)
CH (1) CH576921A5 (OSRAM)
DE (1) DE2212660C3 (OSRAM)
DK (1) DK139944B (OSRAM)
ES (1) ES400862A1 (OSRAM)
FR (1) FR2129741A5 (OSRAM)
GB (1) GB1360946A (OSRAM)
IL (1) IL38860A (OSRAM)
IT (1) IT951631B (OSRAM)
NL (1) NL7203574A (OSRAM)
NO (1) NO136357C (OSRAM)
PH (1) PH10768A (OSRAM)
SE (1) SE409323B (OSRAM)
ZA (1) ZA721297B (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143028A (en) * 1977-12-05 1979-03-06 Ciba-Geigy Corporation Alkylated 1,1'-biphenyl-2,2'-diyl phosphonites and stabilized compositions
US5288914A (en) * 1984-08-27 1994-02-22 The Dow Chemical Company Poly(arylcyclobutenes)
NL8403224A (nl) * 1984-10-24 1986-05-16 Oce Andeno Bv Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
DE3940765A1 (de) * 1989-12-09 1991-06-13 Hoechst Ag Verfahren zur herstellung reiner cyclischer phosphorsaeurediarylester
JPH10503752A (ja) * 1994-05-16 1998-04-07 メリル・フアーマシユウテイカルズ・インコーポレイテツド ラセミ形α−〔４−（１，１−ジメチルエチル）フェニル〕−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノールおよび誘導体化合物の光学分割に有用な方法およびジアステレオマー塩
US6274745B1 (en) 1999-03-24 2001-08-14 Tosoh Corporation Binaphthol monophosphoric acid derivative and its use
JP4725757B2 (ja) * 1999-03-24 2011-07-13 東ソー株式会社 ビナフトールリン酸誘導体及びその利用
AU7949900A (en) 1999-10-22 2001-05-08 Takeda Chemical Industries Ltd. Process for producing optically active naphthalene derivative and optical resolver therefor
CA2390921A1 (en) * 1999-11-10 2001-05-17 Hiroyuki Tawada Process for the production of optically active cyclic enaminone derivative
US6391926B2 (en) * 2000-03-13 2002-05-21 Tosoh Corporation Optically active phosphate derivative
ES2312593T3 (es) 2001-07-09 2009-03-01 Repros Therapeutics Inc. Procedimientos y materiales para el tratamiento de la deficiencia de testosterona en hombres.
WO2004096753A1 (ja) * 2003-04-25 2004-11-11 Toagosei Co., Ltd. キラルなブレンステッド酸による不斉合成用触媒および当該触媒を用いた不斉合成方法
US7229557B2 (en) * 2004-02-04 2007-06-12 Konec, Inc. Method to separate stereoisomers
WO2011042910A2 (en) * 2009-10-09 2011-04-14 Hetero Research Foundation Optical resolution of substituted 2-(2- pyridinylmethylsulphinyl)-1h-benzimidazoles
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
CA2880388A1 (en) 2012-08-21 2014-02-27 Repros Therapeutics Inc. Trans-clomiphene formulations and uses thereof
CN104994877A (zh) 2012-11-02 2015-10-21 利普生物药剂公司 用于癌症治疗的反式-克罗米芬
CN106068121A (zh) * 2014-03-11 2016-11-02 利普生物药剂公司 使用单一溶剂进行克罗米芬合成
HUE051442T2 (hu) 2014-07-24 2021-03-01 Aspen Park Pharmaceuticals Inc Androgén-megvonásos terápia indukálta hõhullámok és csontveszteség kezelése cisz-klomifén alkalmazásával
EP3015453B1 (en) 2014-10-28 2016-10-12 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of Clomiphene
EP3015454A1 (en) * 2014-10-28 2016-05-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Stable solid form of trans-Clomiphene citrate
US10364212B2 (en) 2016-04-22 2019-07-30 F.I.S.—Fabbrica Italiana Sintetici S.p.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit
WO2019051416A1 (en) 2017-09-11 2019-03-14 Atossa Genetics Inc. METHODS FOR THE MANUFACTURE AND USE OF ENDOXIFEN
FR3082842A1 (fr) * 2018-06-21 2019-12-27 Veru Inc. Polymorphe de cis-clomiphene (zuclomiphene) et procedes d'utilisation de celui-ci
WO2021003433A1 (en) 2019-07-03 2021-01-07 Atossa Therapeutics, Inc. Sustained release compositions of endoxifen
CA3098552A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Processes for the preparation of zuclomiphene and intermediates thereof
CA3098725A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Zuclpomiphene salts and crystalline forms thereof
CA3105944A1 (en) 2020-01-22 2021-07-22 Apotex Inc. Crystalline forms of zuclomiphene citrate
EP3907213A1 (en) 2020-05-04 2021-11-10 Pcas Processes for the production of isomerically pure or enriched cis-clomiphene
US11578025B2 (en) 2020-10-19 2023-02-14 Apotex Inc. Processes for the preparation of zuclomiphene intermediates

Also Published As

Publication number Publication date
CA961500A (en) 1975-01-21
DK139944B (da) 1979-05-21
BE780887A (fr) 1972-07-17
IL38860A0 (en) 1972-04-27
AU3961172A (en) 1973-09-06
AU462431B2 (en) 1975-06-09
ES400862A1 (es) 1976-04-16
DE2212660C3 (de) 1981-09-24
CH576921A5 (OSRAM) 1976-06-30
NO136357C (no) 1977-08-24
SE409323B (sv) 1979-08-13
ZA721297B (en) 1973-03-28
GB1360946A (en) 1974-07-24
NL7203574A (OSRAM) 1972-09-20
DK139944C (OSRAM) 1979-10-22
NO136357B (OSRAM) 1977-05-16
US3848030A (en) 1974-11-12
FR2129741A5 (OSRAM) 1972-10-27
JPS5547013B1 (OSRAM) 1980-11-27
DE2212660A1 (de) 1972-09-28
DE2212660B2 (de) 1980-07-10
IL38860A (en) 1975-06-25
PH10768A (en) 1977-09-05

Similar Documents

Publication Publication Date Title
IT951631B (it) Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
IT961688B (it) Procedimento per la separazione di idrocarburi
AR203626A1 (es) Sintesis de nuevos acidos heterociclico-indol-3-ii-acetic
IT945660B (it) Procedimento per la separazione di idrocarburi
IT943578B (it) Procedimento per la separazione di fasi di una miscela
IT973826B (it) Procedimento per la separazione di idrocarburo
IT947292B (it) Procedimento per la produzione di fluoruro di alluminio
IT963079B (it) Mezzi per la liquefazione degli amidi
IT1016932B (it) Procedimento per la separazione di materiali idrocarburic
IT1021386B (it) Sintesi di diamanti
IT1024490B (it) Procedimento per la produzione continua di solfato di alluminio
IT960973B (it) Procedimento per la separazione di idrocarburi
IT943727B (it) Processo per la preparazione di idrocarburi fluorurati
IT967418B (it) Procedimento di separazione di materie coloranti per adsorbimento
IT940436B (it) Struttura multipla per rivestimen to di superfici di varia geometria
IT965464B (it) Procedimento per la produzione di composti dicianovinilic
IT1002964B (it) Processo per la preparazione di alfa omega dialdeidi
IT1021600B (it) Procedimento per la produzione di paradietil benzene
IT974312B (it) Procedimento per la separazione degli isomeri dei ciclopente noloni
IT964437B (it) Sintesi di alchini mediante deidroalogenazione
IT961538B (it) Preparazione di composti alchinil arilici
IT997736B (it) Procedimento per la parziale essic cazione e separazione di idrocarbu ri mediante distillazione fraziona ta
IT975529B (it) Produzione di composti tetrasila adamantani
IT968608B (it) Preparazione di isomeri di cimene mediante isopropilazione di toluene
IT945738B (it) Procedimento per la produzione di composti metacrilici