IT8222635A1 - Quinine pantothenates, processes for their preparation and cosmetic products containing them - Google Patents
Quinine pantothenates, processes for their preparation and cosmetic products containing them Download PDFInfo
- Publication number
- IT8222635A1 IT8222635A1 IT1982A22635A IT2263582A IT8222635A1 IT 8222635 A1 IT8222635 A1 IT 8222635A1 IT 1982A22635 A IT1982A22635 A IT 1982A22635A IT 2263582 A IT2263582 A IT 2263582A IT 8222635 A1 IT8222635 A1 IT 8222635A1
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- Prior art keywords
- quinine
- pantothenate
- solution
- alcohol
- consist
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- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 title claims description 88
- 235000019161 pantothenic acid Nutrition 0.000 title claims description 49
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title claims description 45
- 235000001258 Cinchona calisaya Nutrition 0.000 title claims description 44
- 229960000948 quinine Drugs 0.000 title claims description 44
- 239000002537 cosmetic Substances 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title description 10
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 57
- 239000011713 pantothenic acid Substances 0.000 claims description 45
- 229940014662 pantothenate Drugs 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- 235000019441 ethanol Nutrition 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 210000004209 hair Anatomy 0.000 claims description 14
- 239000002244 precipitate Substances 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 13
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 12
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 12
- 229940055726 pantothenic acid Drugs 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 12
- 230000007935 neutral effect Effects 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 9
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 8
- 229960002079 calcium pantothenate Drugs 0.000 claims description 8
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 235000006408 oxalic acid Nutrition 0.000 claims description 4
- 229930013930 alkaloid Natural products 0.000 claims description 3
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 claims description 3
- 235000011132 calcium sulphate Nutrition 0.000 claims description 3
- ZHNFLHYOFXQIOW-LPYZJUEESA-N quinine sulfate dihydrate Chemical compound [H+].[H+].O.O.[O-]S([O-])(=O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-LPYZJUEESA-N 0.000 claims description 3
- 239000000376 reactant Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 239000001175 calcium sulphate Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- PWVUXRBUUYZMKM-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCO PWVUXRBUUYZMKM-UHFFFAOYSA-N 0.000 claims 1
- FGLBSLMDCBOPQK-UHFFFAOYSA-N 2-nitropropane Chemical compound CC(C)[N+]([O-])=O FGLBSLMDCBOPQK-UHFFFAOYSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 claims 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001570 sorbitan monopalmitate Substances 0.000 claims 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims 1
- 229940029614 triethanolamine stearate Drugs 0.000 claims 1
- 238000002211 ultraviolet spectrum Methods 0.000 claims 1
- 239000003921 oil Substances 0.000 description 5
- 239000002585 base Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- -1 shampooing Substances 0.000 description 2
- AKYHKWQPZHDOBW-UHFFFAOYSA-N (5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol Chemical compound OS(O)(=O)=O.C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 AKYHKWQPZHDOBW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 239000001576 FEMA 2977 Substances 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- KUOJTGZICLSRLI-UHFFFAOYSA-N [N+](=O)([O-])C(CO)CO.[Br] Chemical compound [N+](=O)([O-])C(CO)CO.[Br] KUOJTGZICLSRLI-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003781 hair follicle cycle Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229960003110 quinine sulfate Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
Description
DESCRIZIONE DESCRIPTION
La presente invenzione riguarda nuovi composti chimici: i pantotenati di chinina e anche i procedimenti per la loro preparazione e prodotti cosmetici che li contengono*The present invention relates to new chemical compounds: quinine pantothenates and also the processes for their preparation and cosmetic products containing them *
I nuovi composti presentano il vantaggio di combinare le qualit? dell'acido pantotenico e quelle della chinina sotto forma di composti stabili dotati di efficacia aumentata in rapporto alla relativa instabilit? dell'acido pantotenico? The new compounds have the advantage of combining the qualities? pantothenic acid and those of quinine in the form of stable compounds with increased efficacy in relation to the relative instability? of pantothenic acid?
La combinazione di propriet? dell'acido pantotenico e della chinina ? particolarmente interessante per il trattamento dei capelli e di altre fanere. The combination of properties pantothenic acid and quinine? particularly interesting for the treatment of hair and other hair.
L'invenzione ha per oggetto nuovi composti chimici caratterizzati dal fatto di essere costituiti, almeno in parte, da un pantotenato di chinina di formula The invention relates to new chemical compounds characterized by the fact that they consist, at least in part, of a quinine pantothenate of formula
Si distingue il pantotenato neutro di chinina, di formula The neutral pantothenate of quinine is distinguished, of formula
che ha un peso molecolare di 563,64 circa. which has a molecular weight of approximately 563.64.
E* particolarmente interessante impiegare questi nuovi composti sotto forma di soluzioni acquose di pantotenato neutro di chinina aventi un potere ro? tatorio [a]D = - 110 a - 120?f il cui spettro nell'ultravioletto presenta due massimi di assorbimento a 325 e 275 nm, che presentano una fluorescenza blu, che precipitano con i reagenti generali degli alcaloidi e che liberano mediante idrolisi la ?-alanina in quantit? corrispondente al loro contenuto in acido pantotenico. It is particularly interesting to employ these new compounds in the form of aqueous solutions of neutral quinine pantothenate having a red power. tatory [a] D = - 110 a - 120? f whose spectrum in the ultraviolet has two absorption maxima at 325 and 275 nm, which exhibit a blue fluorescence, which precipitate with the general alkaloid reagents and which release the ? -alanine in quantity? corresponding to their pantothenic acid content.
Cos?, i nuovi panto tenati di chinina danno le reazioni classiche degli alcaloidi di precipitazione in mezzo acquoso leggermente acido. Thus, the new panto tenates of quinine give the classic reactions of the alkaloids of precipitation in a slightly acidic aqueous medium.
I reattivi iodati, come iodio-bismutito di potassio, danno un precipitato di colore araneione-rosso; gli iodo-mercurati alcalini danno precipitato bianco e il reattivo iodo-iodurato d? un precipitato bruno. I reattivi acidi come l'acido picrico, d?nno un precipitato giallo; i reattivi di metalli pesanti come l'acido silico-tungstico oppure l'acido fosfo-tungsti^ co d?nno un precipitato bianco. The iodized reagents, such as potassium iodine-bismuthite, give an orange-red precipitate; the alkaline iodo-mercurates give a white precipitate and the iodo-iodinated reagent d? a brown precipitate. Acidic reactants such as picric acid give a yellow precipitate; heavy metal reactants such as silico-tungstic acid or phospho-tungstic acid give a white precipitate.
La soluzione acquosa di tannino d? un precipitato di colore nocciola. The aqueous solution of tannin d? a hazelnut colored precipitate.
II pantotenato neutro ? il pi? solubile in acqua e in alcool e per questo fatto il suo impiego ? in modo generale, pi? interessante di quello del pantotenato basico? Neutral pantothenate? the pi? soluble in water and alcohol and for this reason its use? in a general way, more? interesting than that of basic pantothenate?
L'invenzione ha parimenti per oggetto un procedimento di fabbricazione di pantotenati di chinina, caratterizzato dal fatto che si fa reagire una soluzione acquosa di acido pantotenico su una soluzione di chinina in presenza di alcool per ottenere una soluzione idroalcoolica di pantotenato di chinina. The invention also relates to a process for manufacturing quinine pantothenates, characterized in that an aqueous solution of pantothenic acid is reacted on a quinine solution in the presence of alcohol to obtain a hydroalcoholic solution of quinine pantothenate.
Cos?, si pu? far reagire una soluzione acquosa di pantotenato di calcio con una soluzione acquosa di acido ossalico, si elimina mediante filtrazione il precipitato formatosi di ossalato di calcio e si fa reagire iL filtrato su una soluzione di chinina base in etanolo per ottenere una soluzione idroalcoolica di pantotenato di chinina. So, can you? reacting an aqueous solution of calcium pantothenate with an aqueous solution of oxalic acid, the precipitate formed of calcium oxalate is eliminated by filtration and the filtrate is reacted on a solution of quinine base in ethanol to obtain a hydroalcoholic solution of pantothenate of quinine.
Si pu? ancora sciogliere il pantotenato di calcio in acqua, aggiungere alcool etilico quindi una soluzione acquosa di solfato neutro di chinina ed eliminare mediante filtrazione il solfato di calcio precipitato nella soluzione idroalcoolica di pantotenato di chinina. Can you? again dissolve the calcium pantothenate in water, add ethyl alcohol and then an aqueous solution of neutral quinine sulphate and filter out the calcium sulphate precipitated in the hydroalcoholic solution of quinine pantothenate.
In generale ? vantaggioso evaporare sotto vuoto la soluzione idroalcoolica fino ad ottenere pantotenato di chinina sotto forma di una sostanza vetrosa di colore da bianco fino a bianco-giallognolo molto igroscopica, solubile in acqua e in alcool? In general ? Is it advantageous to evaporate the hydroalcoholic solution under vacuum until quinine pantothenate is obtained in the form of a very hygroscopic white to yellowish-white vitreous substance, soluble in water and in alcohol?
I procedimenti di preparazione differiscono tra il pantotenato neutro e il pantotenato basico unicamente per la quantit? di acido pantotenico impiegato. The preparation procedures differ between the neutral pantothenate and the basic pantothenate only for the quantity? of pantothenic acid used.
L?invenzione ha parimenti per oggetto nuovi prodotti cosmetici, in particolare per la cura dei capelli e di altre fanere, caratterizzati dal fatto che essi contengono pantotenato di chinina in quantit? attiva. The invention also relates to new cosmetic products, in particular for the care of hair and other hair care products, characterized by the fact that they contain quinine pantothenate in large quantities. active.
La quantit? attiva media ? di 1% Concentrazioni pi? basse possono venire impiegate ma rischiano di essere meno efficaci, mentre concentrazioni pi? elevate saranno generalmente inutilmente onerose. The quantity active media? of 1% Concentrations pi? low can be used but risk being less effective, while concentrations more? high will generally be unnecessarily burdensome.
Si possono impiegare i nuovi pantotenati di chinina in tutte le forme cosmetiche generalmente impiegate con le quali essi sono compatibili. The new quinine pantothenates can be used in all generally used cosmetic forms with which they are compatible.
Si possono cos? realizzare lozioni per capelli idroalcooliche, shampooing, oli oppure emulsioni cremose del tipo acqua in olio e anche del tipo olio in acqua. Can you do so? make hydroalcoholic hair lotions, shampooing, oils or creamy emulsions of the water-in-oil type and also of the oil-in-water type.
I prodotti cosmetici secondo l'invenzione vengono impiegati in modo classico. The cosmetic products according to the invention are used in a classical way.
Gli shampooing vengono impiegati da 1 volta fino a 3 volte la settimana, mentre gli oli e le creme e anche le lozioni rappresentano in generale l'oggetto di una applicazione giornaliera* Shampoos are used from 1 to 3 times a week, while oils and creams and also lotions are generally the object of a daily application *
L'applicazione sulle unghie viene effettuata preferibilmente insistendo a livello della cuticola, mentre perle ciglia e i capelli l'applicazione interessa essenzialmente la base dei peli, l'azione esercitandosi a livello dei follicoli. The application on the nails is preferably carried out by insisting at the level of the cuticle, while for eyelashes and hair the application essentially affects the base of the hair, the action being exercised at the level of the follicles.
Per i capelli, in generale ? pi? facile applicare una lozione, una crema oppure un olio con un tampone lungo strisce precedentemente predisposte con il pettine, For hair in general? pi? easy to apply a lotion, cream or oil with a swab along strips previously prepared with the comb,
E' necessario proseguire le applicazioni giornaliere per 3 settimane almeno prima di constatare gli effetti dei prodotti. Questa durata corrisponde sensibilmente a quella del ciclo dei follicoli piliferi. It is necessary to continue the daily applications for at least 3 weeks before noticing the effects of the products. This duration corresponds significantly to that of the hair follicle cycle.
L'applicazione dei prodotti secondo l'invenzione favorisce la ricrescita dei capelli che generalmente sono pi? abbondanti e fini nel primo ciclo per restare abbondanti ma di grandezza normale a partire dal secondo ciclo. The application of the products according to the invention favors the regrowth of the hair which is generally longer? abundant and fine in the first cycle to remain abundant but of normal size starting from the second cycle.
Si constata nell'applicazione una leggera iperemia accompagnata da una colorazione rosa della pelle. A slight hyperemia accompanied by a pink color of the skin is noted in the application.
Non si constata alcuna azione sulla canizie e sui capelli biforcuti. There is no action on gray hair and forked hair.
L'invenzione verr? meglio compresa esaminando la descrizione che segue di alcuni esempi non limitativi. Will the invention come? better understood by examining the following description of some non-limiting examples.
Esempio 1 Example 1
Preparazione di pantotenato neutro di chinina mediante azione di una soluzione acquosa di acido pantotenico su una soluzione alcoolica di chinina base: Preparation of neutral pantothenate of quinine by the action of an aqueous solution of pantothenic acid on an alcoholic solution of quinine base:
A 22 mi di una soluzione acquosa di concentrazione 10 g per 100 mi di acido pantotenico si aggiungono 1,62 g di chinina base sciolta precedentemente in 25 mi di alcool etilico a 96?? To 22 ml of an aqueous solution with a concentration of 10 g per 100 ml of pantothenic acid, 1.62 g of quinine base previously dissolved in 25 ml of ethyl alcohol at 96% are added.
Si effettua la reazione a temperatura ambiente normale. The reaction is carried out at normal room temperature.
Esempio 2 Example 2
Preparazione dell'acido pantotenico partendo dal pantotenato di calcio mediante precipitazione di calcio con acido ossalico; Preparation of pantothenic acid starting from calcium pantothenate by precipitation of calcium with oxalic acid;
Si sciolgono 2,40 g di pantotenato di calcio in 15 mi di acqua distillata. Si aggiungono 0,634 g di acido ossalico sciolti in 10 mi di acqua, si lascia depositare il precipitato di ossalato di calcio e si separa mediante filtrazione. Si lava il precipitato con 2 mi di acqua. Il filtrato costituisce una soluzione di acido pantotenico puro. 2.40 g of calcium pantothenate are dissolved in 15 ml of distilled water. 0.634 g of oxalic acid dissolved in 10 ml of water are added, the calcium oxalate precipitate is left to settle and is separated by filtration. The precipitate is washed with 2 ml of water. The filtrate is a pure pantothenic acid solution.
Esempio 3 Example 3
Preparazione di pantotenato basico di chinina: Al filtrato dell'esempio 2, si aggiungono 0,81 g di chinina base precedentemente sciolti in 12,5 mi di alcool etilico a 96?? Preparation of basic quinine pantothenate: To the filtrate of Example 2, 0.81 g of basic quinine previously dissolved in 12.5 ml of ethyl alcohol at 96% are added.
Si ottiene cos? una soluzione idroalcoolica di pantotenato di chinina basico. Is this obtained? a hydroalcoholic solution of basic quinine pantothenate.
Esempio 4 Example 4
Preparazione di pantotenato neutro di chinina mediante doppia decomposizione tra pantotenato di calcio e solfato di chinina: Preparation of Neutral Quinine Pantothenate by Double Decomposition of Calcium Pantothenate and Quinine Sulfate:
Si sciolgono 2,40 g di pantotenato di calcio in 15 mi di acqua distillata. Si aggiungono 50 mi di alcool etilico a 96?, quindi lentamente si aggiungono 2,74 g di solfato neutro di chinina sciolti in 35 mi di acqua distillata. Il solfato di calcio precipita. La sua separazione viene facilitata dalla presenza di alcool. Dopo aver lasciato a s? per 24 ore, si filtra su fritta di vetro lavando il precipitato lentamente con alcool, queste operazioni venendo effettuate a temperatura ambiente normale. 2.40 g of calcium pantothenate are dissolved in 15 ml of distilled water. Add 50 ml of 96? Ethyl alcohol, then slowly add 2.74 g of neutral quinine sulphate dissolved in 35 ml of distilled water. Calcium sulfate precipitates. Its separation is facilitated by the presence of alcohol. After leaving to s? for 24 hours, it is filtered on a glass frit washing the precipitate slowly with alcohol, these operations being carried out at normal room temperature.
Esempio 5 Example 5
Ottenimento del pantotenato di chinina anidro: Si evaporano sotto vuoto le soluzioni idroalcooliche degli esempi precedenti? Si ottiene cos? una sostanza vetrosa di colore da bianco fino a bianco giallognolo molto igroscopica solubile in acqua e in alcool? Obtaining the anhydrous quinine pantothenate: Are the hydroalcoholic solutions of the previous examples evaporated under vacuum? Is this obtained? a very hygroscopic white to yellowish white vitreous substance soluble in water and alcohol?
Esempio 6 Example 6
Preparazione di un olio cosmetico: Preparation of a cosmetic oil:
Si aggiunge ?% di pantotenato di chinina a olio di ricino e si aggiunge sotto agitazione alcool a 96?, fino ad ottenere una soluzione limpida. ?% Quinine pantothenate is added to castor oil and 96? Alcohol is added under stirring until a clear solution is obtained.
Esempio 7 Example 7
Preparazione di una lozione per capelli: Preparation of a hair lotion:
Si scioglie 1 g di pantotenato di chinina in circa 100 mi di alcool a 30?? 1 g of quinine pantothenate is dissolved in about 100 ml of alcohol at 30 ??
Esempio 8 Example 8
Preparazione di uno shampooing: Preparation of a shampooing:
Si procede in modo usuale secondo la seguente formula: We proceed in the usual way according to the following formula:
pantotenato di chinina 1 g alcool laurico 1,50 g amfoliti betainici 8,25 g amido-alchi lbetaina 11,20 g ammino ossido di ammine 1,30 g immidazolidimilurea 0,150 g acqua demineralizzata 67 g 2 bromo 2 nitropropano 1,3 diolo 0,050 g quinine pantothenate 1 g lauric alcohol 1.50 g betainic ampholytes 8.25 g starch-alkali lbetaine 11.20 g amino amine oxide 1.30 g imidazolidimylurea 0.150 g demineralized water 67 g 2 bromine 2 nitropropane 1.3 diol 0.050 g
Claims (3)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8115852A FR2511676A1 (en) | 1981-08-18 | 1981-08-18 | QUININE PANTOTHENATES, PROCESSES FOR THEIR PREPARATION AND COSMETOLOGICAL PRODUCTS COMPRISING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT8222635A0 IT8222635A0 (en) | 1982-07-29 |
| IT8222635A1 true IT8222635A1 (en) | 1984-01-29 |
| IT1152476B IT1152476B (en) | 1986-12-31 |
Family
ID=9261534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT22635/82A IT1152476B (en) | 1981-08-18 | 1982-07-29 | KININE PANTOTENATES, PROCESS FOR THEIR PREPARATION AND COSMETIC PRODUCTS THAT CONTAIN THEM |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE894134A (en) |
| CH (1) | CH659250A5 (en) |
| DE (1) | DE3226705A1 (en) |
| FR (1) | FR2511676A1 (en) |
| GB (1) | GB2104517B (en) |
| IT (1) | IT1152476B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2244541A1 (en) * | 1973-08-01 | 1975-04-18 | Fabre Sa Pierre | Amino acid salts of quinine alkaloids - as phospho-lipase inhibitors and anti-acne agents |
-
1981
- 1981-08-18 FR FR8115852A patent/FR2511676A1/en active Granted
-
1982
- 1982-07-16 DE DE19823226705 patent/DE3226705A1/en not_active Withdrawn
- 1982-07-28 GB GB08221822A patent/GB2104517B/en not_active Expired
- 1982-07-29 IT IT22635/82A patent/IT1152476B/en active
- 1982-07-29 CH CH4605/82A patent/CH659250A5/en not_active IP Right Cessation
- 1982-08-17 BE BE0/208831A patent/BE894134A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE894134A (en) | 1983-02-17 |
| GB2104517A (en) | 1983-03-09 |
| CH659250A5 (en) | 1987-01-15 |
| FR2511676B1 (en) | 1984-02-10 |
| DE3226705A1 (en) | 1983-03-03 |
| GB2104517B (en) | 1985-11-06 |
| FR2511676A1 (en) | 1983-02-25 |
| IT1152476B (en) | 1986-12-31 |
| IT8222635A0 (en) | 1982-07-29 |
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