IT7803631A0 - Composizioni a base di resine anioniche salificate farmacologicamente attive - Google Patents

Composizioni a base di resine anioniche salificate farmacologicamente attive

Info

Publication number
IT7803631A0
IT7803631A0 IT7803631A IT363178A IT7803631A0 IT 7803631 A0 IT7803631 A0 IT 7803631A0 IT 7803631 A IT7803631 A IT 7803631A IT 363178 A IT363178 A IT 363178A IT 7803631 A0 IT7803631 A0 IT 7803631A0
Authority
IT
Italy
Prior art keywords
salified
pharmacologically active
compositions based
anion resins
anion
Prior art date
Application number
IT7803631A
Other languages
English (en)
Other versions
IT1106718B (it
Inventor
Valerio Borzatta
Manlio Cristoforiangelo Brazzi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of IT7803631A0 publication Critical patent/IT7803631A0/it
Priority to IT03631/78A priority Critical patent/IT1106718B/it
Priority to AT79104010T priority patent/ATE502T1/de
Priority to EP79104010A priority patent/EP0012804B2/de
Priority to DE7979104010T priority patent/DE2961714D1/de
Priority to US06/102,614 priority patent/US4340585A/en
Priority to ES487019A priority patent/ES487019A1/es
Priority to GR60803A priority patent/GR72734B/el
Priority to DK548279A priority patent/DK159660C/da
Priority to JP16493279A priority patent/JPS55115403A/ja
Priority to NO794225A priority patent/NO794225L/no
Priority to YU03130/79A priority patent/YU313079A/xx
Application granted granted Critical
Publication of IT1106718B publication Critical patent/IT1106718B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT03631/78A 1978-12-21 1978-12-21 Composizioni a base di resine anioniche salificate farmacologicamente attive IT1106718B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT03631/78A IT1106718B (it) 1978-12-21 1978-12-21 Composizioni a base di resine anioniche salificate farmacologicamente attive
AT79104010T ATE502T1 (de) 1978-12-21 1979-10-17 Salze von zur dauernden bindung an die gallensaeuren faehigen nicht toxischen aktivierten anionenaustauscherharzen mit 2-(4'-(p-chlorbenzoyl)-ph enoxy)-2-(methyl)-propionsaeure und diese salze enthaltende arzneimittel.
EP79104010A EP0012804B2 (de) 1978-12-21 1979-10-17 Salze eines zur dauernden Bindung an die Gallensäuren fähigen nicht toxischen aktivierten Anionenaustauscherharzes mit 2-(4'-(p-Chlorbenzoyl)-phenoxy)-2-(methyl)-propionsäure und diese Salze enthaltende Arzneimittel
DE7979104010T DE2961714D1 (en) 1978-12-21 1979-10-17 Salts of non toxic, activated anion exchange resins capable of establishing a stable binding with bile acids and 2-(4'-(p-chlorobenzoyl)-phenoxy)-2-(methyl)-propionic acid ans pharmaceutical compositions comprising these salts
US06/102,614 US4340585A (en) 1978-12-21 1979-12-11 Salified anionic resin for cholesterol and lipid lowering
ES487019A ES487019A1 (es) 1978-12-21 1979-12-18 Un procedimiento para la preparacion de sales de resinas de intercambio anionico activadas y atoxicas con acidos fenoxi-propionicos
GR60803A GR72734B (it) 1978-12-21 1979-12-19
DK548279A DK159660C (da) 1978-12-21 1979-12-20 Fremgangsmaade til fremstilling af salte af anionbytterharpiks
JP16493279A JPS55115403A (en) 1978-12-21 1979-12-20 Nontoxic anionic resin and its manufacture
NO794225A NO794225L (no) 1978-12-21 1979-12-20 Fremgangsmaate for fremstilling av salter av anionebytterharpikser med fenoksypropionsyrer
YU03130/79A YU313079A (en) 1978-12-21 1979-12-28 Process for preparing salts of non-toxic activated anionic exchaging resins with phenoxypropionic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03631/78A IT1106718B (it) 1978-12-21 1978-12-21 Composizioni a base di resine anioniche salificate farmacologicamente attive

Publications (2)

Publication Number Publication Date
IT7803631A0 true IT7803631A0 (it) 1978-12-21
IT1106718B IT1106718B (it) 1985-11-18

Family

ID=11110905

Family Applications (1)

Application Number Title Priority Date Filing Date
IT03631/78A IT1106718B (it) 1978-12-21 1978-12-21 Composizioni a base di resine anioniche salificate farmacologicamente attive

Country Status (11)

Country Link
US (1) US4340585A (it)
EP (1) EP0012804B2 (it)
JP (1) JPS55115403A (it)
AT (1) ATE502T1 (it)
DE (1) DE2961714D1 (it)
DK (1) DK159660C (it)
ES (1) ES487019A1 (it)
GR (1) GR72734B (it)
IT (1) IT1106718B (it)
NO (1) NO794225L (it)
YU (1) YU313079A (it)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393145A (en) * 1979-05-01 1983-07-12 Etablissement Texcontor Anionic ion exchange resins with cholesterol-decreasing properties
CH655507B (it) * 1983-01-12 1986-04-30
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4843098A (en) * 1985-02-05 1989-06-27 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4790991A (en) * 1985-02-05 1988-12-13 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4851392A (en) * 1985-02-05 1989-07-25 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
IT1190349B (it) * 1986-06-16 1988-02-16 Prodotti Formenti Srl Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle
US4877775A (en) * 1986-06-16 1989-10-31 E. I. Du Pont De Nemours And Company Polymeric aminosaccharides as antihypercholesterolemic agents
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
US5498678A (en) * 1992-12-21 1996-03-12 Rohm And Haas Company Suspension polymerization process for water-soluble monomers
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5753262A (en) * 1995-06-07 1998-05-19 Aronex Pharmaceuticals, Inc. Cationic lipid acid salt of 3beta N- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
DE60313359T2 (de) * 2002-12-17 2008-01-03 Abbott Gmbh & Co. Kg Fenofibratsäure enthaltende pharmazeutische zusammensetzung und deren physiologisch verträgliche salze und derivate
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
US7259186B2 (en) * 2002-12-17 2007-08-21 Abbott Laboratories Salts of fenofibric acid and pharmaceutical formulations thereof
US20080152714A1 (en) * 2005-04-08 2008-06-26 Yi Gao Pharmaceutical Formulations
SG190433A1 (en) 2010-11-08 2013-06-28 Albireo Ab A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder
DK2637668T3 (en) 2010-11-08 2016-08-29 Albireo Ab Ibat inhibitors for the treatment of liver diseases
US20140243281A1 (en) 2011-10-28 2014-08-28 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
MX363161B (es) 2011-10-28 2019-03-13 Lumena Pharmaceuticals Inc Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica.
KR20230152818A (ko) 2013-03-15 2023-11-03 샤이어 휴먼 지네틱 테라피즈 인크. 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
CA2907214A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
BR112021015799A2 (pt) 2019-02-12 2022-01-18 Mirum Pharmaceuticals Inc Métodos para aumentar o crescimento em pacientes pediátricos com doença colestática do fígado

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB857194A (en) * 1957-07-05 1960-12-29 Clinical Products Ltd Therapeutic agents comprising ion-exchange resins
BE580490A (fr) 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
FR4933M (it) * 1964-09-17 1967-03-28
NL7017227A (it) 1969-12-27 1971-06-29
GB1348642A (en) * 1970-10-15 1974-03-20 Howard A N Hypocholesterolaemic compositions
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol

Also Published As

Publication number Publication date
EP0012804B2 (de) 1987-03-04
NO794225L (no) 1980-06-24
IT1106718B (it) 1985-11-18
EP0012804B1 (de) 1981-12-30
YU313079A (en) 1983-02-28
DE2961714D1 (en) 1982-02-18
ATE502T1 (de) 1982-01-15
JPS6327362B2 (it) 1988-06-02
DK548279A (da) 1980-06-22
DK159660C (da) 1991-04-08
US4340585A (en) 1982-07-20
DK159660B (da) 1990-11-12
ES487019A1 (es) 1980-10-01
JPS55115403A (en) 1980-09-05
EP0012804A1 (de) 1980-07-09
GR72734B (it) 1983-12-01

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