IT202000021664A1 - Formulazione amminoacidica bilanciata - Google Patents

Formulazione amminoacidica bilanciata Download PDF

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Publication number
IT202000021664A1
IT202000021664A1 IT102020000021664A IT202000021664A IT202000021664A1 IT 202000021664 A1 IT202000021664 A1 IT 202000021664A1 IT 102020000021664 A IT102020000021664 A IT 102020000021664A IT 202000021664 A IT202000021664 A IT 202000021664A IT 202000021664 A1 IT202000021664 A1 IT 202000021664A1
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IT
Italy
Prior art keywords
amino acid
preparation according
acid preparation
amino acids
valine
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IT102020000021664A
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English (en)
Inventor
Gabriele Trapani
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Iaf Network S P A
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Application filed by Iaf Network S P A filed Critical Iaf Network S P A
Priority to IT102020000021664A priority Critical patent/IT202000021664A1/it
Priority to US17/473,254 priority patent/US20220079861A1/en
Priority to DE21196270.9T priority patent/DE21196270T9/de
Priority to EP21196270.9A priority patent/EP3967304A1/en
Publication of IT202000021664A1 publication Critical patent/IT202000021664A1/it

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Description

Titolo: ?Formulazione amminoacidica bilanciata?
DESCRIZIONE
Campo della tecnica dell?invenzione
La presente invenzione trova applicazione nel settore della nutraceutica e, in particolare, della nutrizione clinica e della medicina funzionale.
Stato dell?arte
Sono note preparazioni a base di amminoacidi come integratori alimentari.
La necessit? di integrare l?alimentazione con un surplus di amminoacidi ? tipico dei periodi di forte stress fisico, come ad esempio il periodo di recupero da una malattia, oppure nei periodi di intensa attivit? sportiva.
Le preparazioni oggi disponibili seguono una linea standard, che prevede i nove amminoacidi essenziali, anche se spesso formulati con un bilanciamento discutibile dal punto di vista fisiologico, che non ottimizza i processi di sintesi proteica.
In altri casi, invece, il profilo amminoacidico proposto ricalca quello della carne rossa, con i medesimi effetti negativi e pro-invecchiamento della metionina.
Riassunto dell?invenzione
La presente domanda di brevetto mette a disposizione
una formulazione con un ottimale bilanciamento
amminoacidico, che supera gli inconvenienti delle
formulazioni note.
Oggetto dell?invenzione
Un primo oggetto della presente invenzione ?
rappresentato da una preparazione amminoacidica.
In altri oggetti della presente invenzione, la
preparazione ? descritta per l?uso nel campo
nutraceutico e cosmetico.
Descrizione dettagliata dell?invenzione
Un primo oggetto della presente invenzione ?
rappresentato da una preparazione comprendente i
seguenti amminoacidi:
Leucina
Valina
Isoleucina
Lisina
Fenilalanina
Treonina
Metionina
Istidina
Cisteina
Triptofano
Tirosina
In un aspetto preferito, all?interno della formulazione descritta, gli amminoacidi leucina, isoleucina e valina sono presenti in un rapporto molare fra di loro di circa 2:1:1.
Secondo un aspetto della presente invenzione, gli amminoacidi sopra riportati sono contenuti nella preparazione in un quantitativo di:
Amminoacido % (g/100g composizione serving) Leucina 30,76
Valina 15,38
Isoleucina 15,38
Lisina 16,92
Fenilalanina 2,30
Treonina 8,46
Metionina 1,53
Istidina 3,07
Cisteina 4,61
Triptofano 0,76
Tirosina 0,76
Secondo un aspetto preferito della presente invenzione, la preparazione descritta comprende:
Amminoacido quantit?
(mg)
Leucina 2000
Valina 1000
Isoleucina 1000
Lisina 1100
Fenilalanina 150
Treonina 550
Metionina 100
Istidina 200
Cisteina 300
Triptofano 50
Tirosina 50
Secondo un aspetto preferito della presente invenzione, gli amminoacidi descritti sono tutti ottenuti da fermentazione di origine vegetale; in questo modo, la preparazione pu? essere vantaggiosamente assunta o somministrata anche a soggetti vegetariani i vegani.
Secondo un aspetto della presente invenzione, la preparazione descritta deve essere assunta prima e/o dopo la performance e preferibilmente sia prima sia dopo, che si tratti di un?attivit? sportiva o di un?intensa giornata lavorativa.
L?assunzione viene riferita in termini di serving, che corrispondono a circa 100 g di miscela amminoacidica.
In un aspetto preferito, l?assunzione deve avvenire lontano dai pasti per consentire un migliore assorbimento dei componenti amminoacidici.
La preparazione dell?invenzione pu? essere formulata in polvere, da dosare opportunamente secondo le necessit? oppure pu? essere nella forma di compresse deglutibili.
Nella formulazione saranno eventualmente presenti ulteriori componenti come dolcificanti e/o aromatizzanti o eventuali additivi per aumentare la solubilit? della preparazione.
Non si esclude, tuttavia, che la preparazione descritta possa essere riformulata come componente di preparazioni alimentari pi? complesse, come ad esempio, bevande a base di latte, barrette energetiche, etc.
Tali preparazioni alimentari comprendono pertanto la preparazione dell?invenzione.
In accordo con altri oggetti della presente invenzione, la preparazione ? descritta per l?uso nel campo nutraceutico.
In particolare, tale preparazione ? descritta per l?uso nella nutrizione clinica e nella medicina funzionale antiaging.
Secondo un ulteriore aspetto della presente invenzione, la preparazione descritta trova impiego in cosmetica.
In particolare, la preparazione funzionale dell?invenzione trova impiego per il benessere e la tonicit? della pelle, per la bellezza dei capelli e per la robustezza delle unghie.
Dalla descrizione sopra fornita risulteranno evidenti alla persona esperta nel settore i numerosi vantaggi offerti dalla presente invenzione.
In particolare, la preparazione descritta consente un bilanciamento ottimale fra amminoacidi ramificati e amminoacidi essenziali o ?condizionatamente essenziali?.
In questo modo, sono vantaggiosamente superati gli inconvenienti delle preparazioni note attualmente, in cui lo sbilanciamento del rapporto fra metionina e cisteina si traduce in un effetto pro-invecchiamento che, a lungo termine, pu? portare a condizioni di omocistinemia.
La preparazione dell?invenzione ? quindi un ottimo strumento di integrazione alimentare a fronte di condizioni fisiologiche particolarmente stressanti, come allenamenti intensi e lunghi, condizioni di digiuno o di recupero da malattie, stati di chetosi o diete non equilibrate, ad esempio carenti di carboidrati.
Inoltre, grazie alla sua composizione, la preparazione dell?invenzione consente di prevenire e combattere la sarcopenia e di conferire o aumentare la resistenza anabolica indotta dall?invecchiamento.
Come sopra riportato, dato che gli amminoacidi impiegati sono tutti ottenuti mediante fermentazione di origine vegetale, la preparazione dell?invenzione risponde anche alle esigenze di soggetti vegetariani o vegani.

Claims (9)

RIVENDICAZIONI
1. Una preparazione amminoacidica comprendente amminoacidi e altri componenti, in cui detti amminoacidi sono rappresentati da:
Leucina
Valina
Isoleucina
Lisina
Fenilalanina
Treonina
Metionina
Istidina
Cisteina
Triptofano
Tirosina
2. La preparazione amminoacidica secondo la rivendicazione precedente, in cui gli amminoacidi leucina, isoleucina e valina sono presenti in un rapporto molare di 2:1:1.
3. La preparazione amminoacidica secondo la rivendicazione 1 o 2, in cui detti amminoacidi sono contenuti nei seguenti quantitativi:
amminoacido % (g/100 g composizione serving) Leucina 30,76
Valina 15,38
Isoleucina 15,38
Lisina 16,92
Fenilalanina 2,30
Treonina 8,46
Metionina 1,53
Istidina 3,07
Cisteina 4,61
Triptofano 0,76
Tirosina 0,76
4. La preparazione amminoacidica secondo una qualsiasi delle rivendicazioni precedenti, comprendente:
amminoacido quantit? (mg) Leucina 2000
Valina 1000
Isoleucina 1000
Lisina 1100
Fenilalanina 150
Treonina 550
Metionina 100
Istidina 200
Cisteina 300
Triptofano 50
Tirosina 50
5. La preparazione amminoacidica secondo una qualsiasi delle rivendicazioni precedenti, in cui detti amminoacidi sono ottenuti da fermentazione di origine vegetale.
6. La preparazione amminoacidica secondo una qualsiasi delle rivendicazioni precedenti in forma di polvere oppure in forma di compresse deglutibili.
7. Una preparazione alimentare comprendente la preparazione amminoacidica secondo una qualsiasi delle rivendicazioni da 1 a 6.
8. Uso della preparazione amminoacidica secondo una qualsiasi delle rivendicazioni da 1 a 6 oppure della preparazione alimentare secondo la rivendicazione 7 nella nutrizione clinica e nella medicina funzionale antiaging.
9. Uso della preparazione amminoacidica secondo una qualsiasi delle rivendicazioni da 1 a 6 oppure della preparazione alimentare secondo la rivendicazione 7 in cosmetica.
IT102020000021664A 2020-09-14 2020-09-14 Formulazione amminoacidica bilanciata IT202000021664A1 (it)

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Application Number Priority Date Filing Date Title
IT102020000021664A IT202000021664A1 (it) 2020-09-14 2020-09-14 Formulazione amminoacidica bilanciata
US17/473,254 US20220079861A1 (en) 2020-09-14 2021-09-13 Balanced amino acid formulation
DE21196270.9T DE21196270T9 (de) 2020-09-14 2021-09-13 Ausgewogene aminosäureformulierung
EP21196270.9A EP3967304A1 (en) 2020-09-14 2021-09-13 Balanced amino acid formulation

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002092A2 (en) * 2000-07-04 2002-01-10 Professional Dietetics S.R.L. Compositions based on aminoacids, suitable for improving muscle performance
EP2196203A2 (en) * 2003-10-07 2010-06-16 Professional Dietetics S.r.l. Use of amino-acid based compositions for the treatment of sarcopenia
US20130237577A1 (en) * 2010-01-12 2013-09-12 Francesco Saverio Dioguardi Compositions comprising amino acids for prevention and/or treatment of renal disorders
CN108618997A (zh) * 2017-03-15 2018-10-09 昕慕（上海）科技发展有限公司 一种用于皮肤护理的含维生素与透明质酸钠的复合物
WO2019021135A1 (en) * 2017-07-28 2019-01-31 Professional Dietetics S.P.A. COMPOSITIONS COMPRISING AMINO ACIDS FOR USE IN THE TREATMENT OF DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233013A1 (en) * 2004-03-02 2005-10-20 Lee Steve S Methods for enhancing the transport of glucose for balancing blood sugar levels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002092A2 (en) * 2000-07-04 2002-01-10 Professional Dietetics S.R.L. Compositions based on aminoacids, suitable for improving muscle performance
EP2196203A2 (en) * 2003-10-07 2010-06-16 Professional Dietetics S.r.l. Use of amino-acid based compositions for the treatment of sarcopenia
US20130237577A1 (en) * 2010-01-12 2013-09-12 Francesco Saverio Dioguardi Compositions comprising amino acids for prevention and/or treatment of renal disorders
CN108618997A (zh) * 2017-03-15 2018-10-09 昕慕（上海）科技发展有限公司 一种用于皮肤护理的含维生素与透明质酸钠的复合物
WO2019021135A1 (en) * 2017-07-28 2019-01-31 Professional Dietetics S.P.A. COMPOSITIONS COMPRISING AMINO ACIDS FOR USE IN THE TREATMENT OF DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOLERTE S B ET AL: "Nutritional Supplements with Oral Amino Acid Mixtures Increases Whole-Body Lean Mass and Insulin Sensitivity in Elderly Subjects with Sarcopenia", AMERICAN JOURNAL OF CARDIOLOGY, CAHNERS PUBLISHING CO., NEWTON, MA, US, vol. 101, no. 11, 2 June 2008 (2008-06-02), pages S69 - S77, XP022703181, ISSN: 0002-9149, [retrieved on 20080529], DOI: 10.1016/J.AMJCARD.2008.03.004 *

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US20220079861A1 (en) 2022-03-17
DE21196270T1 (de) 2022-06-02
DE21196270T9 (de) 2022-08-04

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