IT201900022545A1 - Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci - Google Patents

Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci

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Publication number
IT201900022545A1
IT201900022545A1 IT102019000022545A IT201900022545A IT201900022545A1 IT 201900022545 A1 IT201900022545 A1 IT 201900022545A1 IT 102019000022545 A IT102019000022545 A IT 102019000022545A IT 201900022545 A IT201900022545 A IT 201900022545A IT 201900022545 A1 IT201900022545 A1 IT 201900022545A1
Authority
IT
Italy
Prior art keywords
mammals
nadh
humans
plants
identification
Prior art date
Application number
IT102019000022545A
Other languages
English (en)
Inventor
Ciro Leonardo Pierri
Grassi Anna De
Lucia Trisolini
Luna Laera
Nicola Gambacorta
Angelo Onofrio
Original Assignee
Univ Degli Studi Di Bari Aldo Moro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Di Bari Aldo Moro filed Critical Univ Degli Studi Di Bari Aldo Moro
Priority to IT102019000022545A priority Critical patent/IT201900022545A1/it
Publication of IT201900022545A1 publication Critical patent/IT201900022545A1/it

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
IT102019000022545A 2019-11-29 2019-11-29 Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci IT201900022545A1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT102019000022545A IT201900022545A1 (it) 2019-11-29 2019-11-29 Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000022545A IT201900022545A1 (it) 2019-11-29 2019-11-29 Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci

Publications (1)

Publication Number Publication Date
IT201900022545A1 true IT201900022545A1 (it) 2021-05-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000022545A IT201900022545A1 (it) 2019-11-29 2019-11-29 Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci

Country Status (1)

Country Link
IT (1) IT201900022545A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383790B1 (en) 1999-01-11 2002-05-07 Princeton University High affinity protein kinase inhibitors
US20020099506A1 (en) 2000-03-23 2002-07-25 Floriano Wely B. Methods and apparatus for predicting ligand binding interactions
US20050010368A1 (en) 1997-06-02 2005-01-13 Ernesto Freire Method for the prediction of binding targets and the design of ligands

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050010368A1 (en) 1997-06-02 2005-01-13 Ernesto Freire Method for the prediction of binding targets and the design of ligands
US6383790B1 (en) 1999-01-11 2002-05-07 Princeton University High affinity protein kinase inhibitors
US20020099506A1 (en) 2000-03-23 2002-07-25 Floriano Wely B. Methods and apparatus for predicting ligand binding interactions

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
"National Report", 2017, ITALIAN DRUG AGENCY, article "the use of antibiotics in Italy"
ADAM HEIKAL ET AL: "Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation : Structure of bacterial NDH-2", MOLECULAR MICROBIOLOGY., vol. 91, no. 5, 1 March 2014 (2014-03-01), GB, pages 950 - 964, XP055717247, ISSN: 0950-382X, DOI: 10.1111/mmi.12507 *
ANDERSON AC: "The process of structure-based drug design", CHEMISTRY & BIOLOGY, vol. 10, no. 9, September 2003 (2003-09-01), pages 787 - 97, XP055080025, DOI: 10.1016/j.chembiol.2003.09.002
HARBUT, M.B. ET AL.: "Small molecules Targeting Mycobacterium tuberculosis Type II NADH dehydrogenase Exhibit Antimycobacterial Activity", ANGEW. CHEMIE - INT. ED., 2018
HARDS, K.COOK, G.M.: "Targeting bacterial energies to produces new antimicrobials", DRUG RESIST. UPDAT, 2018
HEIKAL ET AL.: "Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase", BIOORGANIC MED. CHEM. LETT., 2018
IMMING PSINNING CMEYER A: "Drugs, their targets and the nature and number of drug targets", NATURE REVIEWS. DRUG DISCOVERY, vol. 5, no. 10, October 2006 (2006-10-01), pages 821 - 34
LU, J: "Inhibition of bacterial thioredoxin reductase: An antibiotic mechanism targeting bacteria lacking glutathione", FASEB J., 2013
LUCIA TRISOLINI ET AL: "FAD/NADH Dependent Oxidoreductases: From Different Amino Acid Sequences to Similar Protein Shapes for Playing an Ancient Function", JOURNAL OF CLINICAL MEDICINE, vol. 8, no. 12, 1 December 2019 (2019-12-01), pages 2117, XP055716958, ISSN: 2077-0383, DOI: 10.3390/jcm8122117 *
MADSEN UKROGSGAARD-LARSEN PLILJEFORS T: "Textbook of Drug Design and Discovery", 2002, TAYLOR & FRANCIS
MURUGESAN, D. ET AL.: "2-mercapto-quinazolinones as inhibitors of Type II NADH dehydrogenase and Mycobacterium tuberculosis: Structure-Activity relationships, mechanism of Action and absorption, Distribution, metabolism, and extraction Characterization", ACS INFECT. OFF., 2018
PETER MAN-UN UNG ET AL: "DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors", ACS CHEMICAL BIOLOGY, vol. 10, no. 1, 9 December 2014 (2014-12-09), pages 269 - 278, XP055717168, ISSN: 1554-8929, DOI: 10.1021/cb500696t *
SATHEESHKUMAR SELLAMUTHU ET AL: "Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery", EXPERT OPINION ON THERAPEUTIC TARGETS, vol. 21, no. 6, 15 May 2017 (2017-05-15), UK, pages 559 - 570, XP055716954, ISSN: 1472-8222, DOI: 10.1080/14728222.2017.1327577 *
SELLAMUTHU, S. ET AL.: "Type-II NADH dehydrogenase (NDH-2): A promoting therapeutic target for antitubercular and antibacterial drug discovery", EXPERT OPIN. THER. TARGETS, 2017
TAYLOR M C ET AL: "The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 64, no. 2, 1 April 1994 (1994-04-01), pages 293 - 301, XP025464479, ISSN: 0166-6851, [retrieved on 19940401], DOI: 10.1016/0166-6851(94)00034-4 *

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IT201900022545A1 (it) Metodo per l’identificazione di regioni di legame specifiche di deidrogenasi fad/nadh-dipendenti di mammiferi e/o di microorganismi patogeni per uomo, altri mammiferi e piante, per il disegno di nuovi farmaci