WO2017035176A8 - Method of preventing or treating obesity with an emc10 inhibitor - Google Patents
Method of preventing or treating obesity with an emc10 inhibitor Download PDFInfo
- Publication number
- WO2017035176A8 WO2017035176A8 PCT/US2016/048271 US2016048271W WO2017035176A8 WO 2017035176 A8 WO2017035176 A8 WO 2017035176A8 US 2016048271 W US2016048271 W US 2016048271W WO 2017035176 A8 WO2017035176 A8 WO 2017035176A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- emc10
- preventing
- inhibitor
- treating obesity
- obesity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compositions and methods for inhibiting Emc10 expressing or activity and preventing, treating, or delaying the onset of metabolic diseases such obesity are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562209108P | 2015-08-24 | 2015-08-24 | |
US62/209,108 | 2015-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017035176A1 WO2017035176A1 (en) | 2017-03-02 |
WO2017035176A8 true WO2017035176A8 (en) | 2017-05-04 |
Family
ID=56889209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/048271 WO2017035176A1 (en) | 2015-08-24 | 2016-08-24 | Method of preventing or treating obesity with an emc10 inhibitor |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2017035176A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107998397B (en) * | 2017-12-07 | 2020-09-04 | 复旦大学附属华山医院 | Application of EMC10 protein as biomarker in diagnosis of male infertility |
CN108845142A (en) * | 2018-06-19 | 2018-11-20 | 上海伦泽生物科技有限公司 | Application of the EMC10 Protein Detection object in the diagnosis of preparation obesity and scale evaluation and Bariatric effect assessment product |
CN114149499B (en) * | 2020-09-07 | 2023-12-05 | 复旦大学附属华山医院 | Monoclonal antibodies against human EMC10 and their use in the treatment and/or prevention of obesity |
CN114149500B (en) * | 2020-09-07 | 2023-12-01 | 复旦大学附属华山医院 | Application of monoclonal antibody against human EMC10 in preparation of products for treating and/or preventing fatty liver |
WO2022048577A1 (en) * | 2020-09-07 | 2022-03-10 | 复旦大学附属华山医院 | Use of monoclonal antibody against human emc10 in preparation of products for preventing and/or treating metabolic diseases |
CN114149498B (en) * | 2020-09-07 | 2023-12-05 | 复旦大学附属华山医院 | Application of monoclonal antibody against human EMC10 in preventing and treating type 2 diabetes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101985475A (en) * | 2009-07-28 | 2011-03-16 | 复旦大学附属华山医院 | Novel polyclonal antibody of secretive peptide INM02 and preparation method and use thereof |
EP2726108B1 (en) * | 2011-06-29 | 2018-01-10 | The Trustees of Columbia University in the City of New York | Inhibitor of neuronal connectivity linked to schizophrenia susceptibility and cognitive dysfunction |
-
2016
- 2016-08-24 WO PCT/US2016/048271 patent/WO2017035176A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2017035176A1 (en) | 2017-03-02 |
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