SG11202111575WA - Engineered microorganisms and methods for improved aldehyde dehydrogenase activity - Google Patents
Engineered microorganisms and methods for improved aldehyde dehydrogenase activityInfo
- Publication number
- SG11202111575WA SG11202111575WA SG11202111575WA SG11202111575WA SG11202111575WA SG 11202111575W A SG11202111575W A SG 11202111575WA SG 11202111575W A SG11202111575W A SG 11202111575WA SG 11202111575W A SG11202111575W A SG 11202111575WA SG 11202111575W A SG11202111575W A SG 11202111575WA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- dehydrogenase activity
- aldehyde dehydrogenase
- engineered microorganisms
- improved aldehyde
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01044—Trans-2-enoyl-CoA reductase (NAD+) (1.3.1.44)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01038—Trans-2-enoyl-CoA reductase (NADPH) (1.3.1.38)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962837888P | 2019-04-24 | 2019-04-24 | |
| US201962860160P | 2019-06-11 | 2019-06-11 | |
| US201962860123P | 2019-06-11 | 2019-06-11 | |
| PCT/US2020/029793 WO2020219863A1 (en) | 2019-04-24 | 2020-04-24 | Engineered microorganisms and methods for improved aldehyde dehydrogenase activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202111575WA true SG11202111575WA (en) | 2021-11-29 |
Family
ID=70740755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202111575WA SG11202111575WA (en) | 2019-04-24 | 2020-04-24 | Engineered microorganisms and methods for improved aldehyde dehydrogenase activity |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20220348890A1 (en) |
| EP (3) | EP3959327A1 (en) |
| JP (1) | JP2022530475A (en) |
| KR (2) | KR20220023339A (en) |
| CN (2) | CN114341344A (en) |
| AU (1) | AU2020262938A1 (en) |
| BR (1) | BR112021021294A2 (en) |
| CA (1) | CA3137571A1 (en) |
| SG (1) | SG11202111575WA (en) |
| WO (3) | WO2020219859A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020005324A (en) * | 2017-11-30 | 2020-08-13 | Toray Industries | Gene-modified microorganism for producing 3-hydroxyadipic acid, î±-hydromuconic acid and/or adipic acid, and production method for said chemical products. |
| KR20230159611A (en) | 2021-03-30 | 2023-11-21 | 아사히 가세이 가부시키가이샤 | Recombinant microorganisms and methods for producing C6 compounds |
| WO2023076966A1 (en) * | 2021-10-27 | 2023-05-04 | Genomatica, Inc. | Engineered enzymes and methods of making and using |
| CN114940950B (en) * | 2022-03-28 | 2023-07-07 | 北京科技大学 | Method for recycling clostridium butyricum fermentation waste liquid |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| RU2496880C2 (en) * | 2008-12-12 | 2013-10-27 | СЕЛЕКСИОН, ЭлЭлСи | Biological synthesis of difunctional alkanes from alpha-keto acids |
| EP2427544B1 (en) * | 2009-05-07 | 2019-07-17 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid |
| WO2012089613A1 (en) * | 2010-12-28 | 2012-07-05 | Dsm Ip Assets B.V. | Process to increase the production of a succinyl-coa derived compound |
| MY197970A (en) * | 2011-11-02 | 2023-07-25 | Genomatica Inc | Microorganisms and methods for the production of caprolactone |
| BR112017013748A2 (en) * | 2014-12-23 | 2018-03-13 | Genomatica Inc | diamines production & processing method |
| US20190300918A1 (en) * | 2015-06-23 | 2019-10-03 | Genomatica, Inc. | Microorganisms and methods for the production of biosynthesized target products having reduced levels of byproducts |
-
2020
- 2020-04-24 EP EP20730132.6A patent/EP3959327A1/en active Pending
- 2020-04-24 BR BR112021021294A patent/BR112021021294A2/en unknown
- 2020-04-24 WO PCT/US2020/029788 patent/WO2020219859A1/en unknown
- 2020-04-24 US US17/605,499 patent/US20220348890A1/en active Pending
- 2020-04-24 AU AU2020262938A patent/AU2020262938A1/en active Pending
- 2020-04-24 KR KR1020217038307A patent/KR20220023339A/en active Search and Examination
- 2020-04-24 WO PCT/US2020/029797 patent/WO2020219866A1/en unknown
- 2020-04-24 CA CA3137571A patent/CA3137571A1/en active Pending
- 2020-04-24 CN CN202080046801.5A patent/CN114341344A/en active Pending
- 2020-04-24 CN CN202080046640.XA patent/CN114269908A/en active Pending
- 2020-04-24 EP EP20726596.8A patent/EP3959310A1/en active Pending
- 2020-04-24 US US17/605,196 patent/US20220235385A1/en active Pending
- 2020-04-24 US US17/605,120 patent/US20220333142A1/en active Pending
- 2020-04-24 JP JP2021563375A patent/JP2022530475A/en active Pending
- 2020-04-24 SG SG11202111575WA patent/SG11202111575WA/en unknown
- 2020-04-24 KR KR1020217038305A patent/KR20220023757A/en active Search and Examination
- 2020-04-24 EP EP20728259.1A patent/EP3959309A1/en active Pending
- 2020-04-24 WO PCT/US2020/029793 patent/WO2020219863A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3959327A1 (en) | 2022-03-02 |
| US20220333142A1 (en) | 2022-10-20 |
| CA3137571A1 (en) | 2020-10-29 |
| CN114341344A (en) | 2022-04-12 |
| KR20220023339A (en) | 2022-03-02 |
| KR20220023757A (en) | 2022-03-02 |
| WO2020219863A1 (en) | 2020-10-29 |
| JP2022530475A (en) | 2022-06-29 |
| EP3959310A1 (en) | 2022-03-02 |
| CN114269908A (en) | 2022-04-01 |
| EP3959309A1 (en) | 2022-03-02 |
| WO2020219866A1 (en) | 2020-10-29 |
| US20220348890A1 (en) | 2022-11-03 |
| BR112021021294A2 (en) | 2022-03-29 |
| US20220235385A1 (en) | 2022-07-28 |
| WO2020219859A1 (en) | 2020-10-29 |
| AU2020262938A1 (en) | 2021-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11202111575WA (en) | Engineered microorganisms and methods for improved aldehyde dehydrogenase activity | |
| IL282092B (en) | Engineered enzymes | |
| IN2012DN00568A (en) | ||
| ZA202004021B (en) | Modified homoserine dehydrogenase, and method for producing homoserine or homoserine-derived l-amino acid using same | |
| AP2011005864A0 (en) | Method of preparing an inhibitor of cytochrome P450 monooxygenase, and intermediates involved. | |
| WO2012097091A3 (en) | Engineered microorganisms with enhanced fermentation activity | |
| EP3480334A4 (en) | Ferritic stainless steel, steel sheet thereof, and methods for producing these | |
| EP3333261A4 (en) | Hexuronate c4-epimerase variant having improved d-tagatose conversion activity, and d-tagatose production method using same | |
| PL3272860T3 (en) | Pyruvate dehydrogenase mutant, microorganism comprising mutant, and method for producing l-amino acid by using microorganism | |
| EP3690036A4 (en) | Modified homoserine dehydrogenase, and method for producing homoserine or homoserine-derived l-amino acid using same | |
| EP3339460A4 (en) | VIBRATION-DAMPING FERRITIC STAINLESS STEEL MATERIAL HAVING HIGH Al CONTENT, AND PRODUCTION METHOD | |
| IL278036A (en) | Hpk1 inhibitors, preparation method and application thereof | |
| IL279883A (en) | Engineered galactose oxidase variant enzymes | |
| EP3438308A4 (en) | Ti-containing ferritic stainless steel sheet, manufacturing method, and flange | |
| PH12017500461A1 (en) | Humanized monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase | |
| EP3318649A4 (en) | Cold-rolled stainless steel sheet material, manufacturing method therefor, and cold-rolled steel sheet | |
| EP3765612A4 (en) | Engineered chimeric guide rna and uses thereof | |
| EP3970511A4 (en) | Strain showing liver function improving activity, and use thereof | |
| EP3561127A4 (en) | Austenitic stainless steel having excellent processability and surface characteristics, and manufacturing method therefor | |
| EP3049529A4 (en) | Engineered enzyme having acetoacetyl-coa hydrolase activity, microorganisms comprising same, and methods of using same | |
| EP3239335A4 (en) | Ferritic stainless steel having excellent ductility and method for manufacturing same | |
| EP3464559A4 (en) | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods | |
| EP4006177A4 (en) | Martensitic stainless steel pipe, and method for manufacturing martensitic stainless steel pipe | |
| EP3978643A4 (en) | Austenitic stainless steel having improved strength, and method for manufacturing same | |
| EP3872218A4 (en) | Ferritic stainless steel having improved corrosion resistance, and manufacturing method therefor |