IT201800020383A1 - XOS corn cob derivatives to enhance the bioavailability and stability of raw materials in the production of nutraceuticals - Google Patents

Description

Title: "XOS derivatives of corn cob to enhance the bioavailability and stability of raw materials in the production of nutraceuticals"

DESCRIPTION

State of the art

The numerous nutraceutical preparations or food supplements placed on the market by numerous manufacturing or commercial companies, despite having similar compositions, show a very different efficacy.

In fact, in addition to the aspects of the mere formulation title of the preparation, there are other technical aspects, not taken into consideration by the formulator, such as the real bioavailability of the active ingredients and the percentage of assimilation by our body.

These two parameters are very important for a correct evaluation of a nutraceutical preparation, since many raw materials, primarily those of natural origin, are not very stable in the presence of an acidic pH, typical of the gastric environment.

Summary

The inventors of the present patent application have found that the xylo-oligosaccharides characterized by a particular degree of polymerization have surprising and advantageous properties; in particular, these are xylooligosaccharides obtained from the cob of the corn cob.

Thanks to these characteristics, they can therefore be used to obtain products with superior characteristics.

Object of the invention

A first object of the present invention, therefore, is represented by a preparation based on xylo-oligosaccharides.

A second object describes the applications of the preparation of the invention for the production of foods, functional foods, beverages, pharmaceutical preparations for human and animal use, supplements, tonic, cosmetics, agrochemical formulations.

Detailed description of the invention

According to a first object of the invention, preparations based on xylo-oligosaccharides are described. Xylo-oligosaccharides (XOS) are a family of functional polysaccharides formed by glucoside chains of 2-7 molecules of xylan:

In a particular aspect of the invention, these xylo-oligosaccharides are obtained from corn cobs (Zea Mays) and, even more preferably, from the cob of the cob.

For this purpose, the cob of the corn cob (unused part of the same) is subjected to acid hydrolysis through the use of L-ascorbic acid in the ratio of 1-1.5%, in the presence of xylanase.

According to a preferred aspect, the xylooligosaccharides used for the preparation of the formulations of the invention are characterized by a degree of polymerization lower than 6 and, even more preferably, between 2 and 4 (xylobiose (DP = 2), xylotriose (DP = 3 ), xylotetraose (DP = 4).

In one aspect of the present invention, the xylo-oligosaccharide preparations described above can be used in combination with one or more active ingredients.

These active ingredients can be chosen from the group which includes:

- mineral salts, elements, microelements, possibly in organic form, such as for example: selenium (for example in the form of selenium methionine), zinc (for example, zincopicolinate), chromium (for example, chromopicolinate);

- vitamins, such as: vitamin B12, folic acid, biotin, vitamin D3;

- proteins and amino acids, such as: L-citrulline, collagen, protein extract (for example, from soy);

- aminosaccharides, such as: glucosamine sulfate, chondroitin sulfate, hyaluronic acid;

- antioxidants, such as: polydatin, resveratrol, lycopene, hydroxytyrosol and Nicotinamide adenine dinucleotide (NAD);

- plant and algae extracts (also including one or more of the compounds indicated above), such as: Serenoa repens (for example, e.s. 30% fatty acids), pomegranate (for example, e.s. 20% ellagic acid), bilberry ( e.g. 36% anthocyanosides), quercetin (e.g. 95%), brassica (e.g. 99% indole-3-carbinol), cranberry (cranberry fruit extract), hibiscus extract, Butea superba, Epidemium (e.g.), spirulina (Arthrospira platensis), Garcinia cambogia, cinnamon, nettle extract, hemp (Cannabis), astragalus extract, echinacea extract, Tabebuia impetiginosa extract, Rose hip oil, sage extract, seaweed extract dunaliella (beta-carotene 14%), rutin, ginger extract, baheda, amla oil, brahmi, bhringraj, shika kai, kapoor, arnica oil;

- other compounds selected from the group which includes: methylsulfonylmethane, caprylic acid, lauric acid, oleuropine, diatomaceous earth;

- microbial preparation including, for example: L. rhamnosus, L. acidophilus, L. plantarum, L. paracasei, L. salivarius, L. bulgaricus, Enterococcus faecium, etc.

For applications in the agronomic field, the preparations of the invention can be combined with one or more of the compounds selected from: iron, magnesium, zinc, manganese, copper (in the form of salts, for example, sulphate salt), urea.

The applications of a preparation according to the present invention are many and include: - functional foods and foods, such as: baked goods (bread, breadsticks, crackers, rusks, biscuits, preparations for pizza dough), fresh pasta or dry, dairy products (cheese, yogurt, ricotta, mozzarella), dairy products (cream-based preparations), preparations for vegetarians or vegans to replace meat, sauces, creams, gravies, puddings, etc;

- functional drinks and beverages, such as: fruit juices, coffee, beverage preparations (coffee, cappuccino, ginseng drinks, chocolate, herbal teas, etc.), vegetable milks or milk-based preparations, broth preparations, mineral salts (for example, for sportsmen), beer, wine, mineral waters;

- pharmaceutical preparations, supplements, tonic;

- cosmetics, for example: for the face, for the body, for the hair.

In addition to what has been described above, the preparations of the present invention can also find application in the agrochemical field, for the preparation, for example, of fertilizer formulations (also for foliar application) and biostimulants.

The term "functional" refers to the fact that the foods and beverages obtained using the preparations of the invention are especially suitable for subjects in particular conditions, such as: sportspeople, the elderly, people subject to stress or fatigue, obese or overweight, insulin-resistant, dyslipidemic , people prone to genitourinary tract infections etc.

In any case, the formulations comprising the preparations of the invention have surprisingly shown that they can be used for one or more of the following purposes:

- control of blood sugar and insulin level,

- systemic and / or local anti-inflammatory activity, for example in the case of prostatitis, cystitis, dermatitis, etc.

- treatment of erectile dysfunction, - antioxidant,

- strengthening of the immune system,

- slimming activity and / or for weight control,

- draining and / or anti-cellulite activity, - detoxifying, - to combat hair loss, to promote hair growth and improve its appearance, to delay graying, to combat dandruff, - for the well-being of the skin and nails, - for joint pain;

- antibacterial and antifungal activity (for example, against Candida).

- to promote the energy metabolism of the cell;

- for mitochondrial dysfunction.

The present invention will be described in more detail in the following non-limiting examples of formulations.

EXAMPLE 1

GLYCEMIC AND INSULINEMIC CURVE CONTROL

i à

It was surprisingly found that between the XOS and the white mulberry extract a synergistic action is created in the inhibition of the insulin woodpecker. This mechanism, in the short term, seems to derive from the hypoglycemic action of the white mulberry. In the long term it seems to derive from the XOS responsible for a gradual release of the sugars taken during meals and for a modulation of the bacterial microflora involved in the digestion and absorption processes of sugars. In addition, the complexing effect of the fiber generates a possible synergy between the hydroxyl groups with the active ingredient of the white mulberry extract (1-deoxy-noirimycin). Folic acid manifests a carrier action against vitamin D3, chromium and zinc.

The formulation of the Example should preferably be taken three times a day.

EXAMPLE 2

PROSTATITES

There is a synergistic action between XOS and the extract of Serenoa repens, the ellagic acid of the pomegranate extract, the anthocyanosides of the bilberry, the quercetin and the indole-3-carbinol, as well as a carrier action of the folic acid against zinc, lycopene and indole-3-carbinol. There is a synergistic action between zinc and lycopene.

The association between Serenoa repens, lycopene and selenium leads to a significant reduction in inflammation of the prostate, inhibiting the expression of proteins involved in the inflammatory process. There is a particular antioxidant and anti-inflammatory effect produced precisely by the synergistic action of the active ingredients with XOS.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 3

CYSTITIS

i à

There is a synergistic activity between cranberry extract and XOS, such as to induce the proliferation of Lactobacillus rhamnosus capable of reducing the aggressiveness of urinary infections caused by E. coli on two fronts: firstly it prevents E coli can attach itself to the walls of the urinary tract and, secondly, activates the immune defenses, so that they can fight the infection more quickly. There is a synergistic action between the XOS and the anthocyanins of the cranberry and hibiscus extract, as well as a prebiotic action of the XOS against the intestinal microflora (bifidobacteria and lactobacilli) to the detriment of the gram-negative ones. This formulation, thanks to the ability to restore intestinal balance, has a combined effect on enteric and genitourinary disorders.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 4

ERECTILE DYSFUNCTION

There is a carrier action of XOS against the phytosterols present in the Butea superba extract. This interaction allows to obtain a high bioavailability of the active ingredients through a double mechanism, that is: a carrier action and a greater bioavailability by means of the biomodulation of the useful bacterial microflora and an adjuvant action of XOS against icariin, the active ingredient of the epimedium, with vasoprotective and vasodilating action. XOS improve the vasodilating action of L-citrulline, acting positively on the microbiota. The formulation of the Example should preferably be taken three times a day.

EXAMPLE 5

ENHANCEMENT IMMUNE SYSTEM, ACTION

ANTIOXIDANT AND ANTI-INFLAMMATORY

XOS show a carrier action towards all the substances contained in the formulation, in particular towards polydatin, a highly antioxidant and highly water-soluble and bioavailable stilbene compared to other molecules such as, for example, resveratrol. In addition, it exhibits an antibacterial and antiviral action, and enhances the signaling pathways of the vitamin D3 receptor involved in antiproliferative and immunoregulatory mechanisms. The preparation also has a protective action at the cardiovascular level, inhibiting the oxidation of LDL cholesterol. The synergistic antioxidant and anti-inflammatory action of these molecules would also seem to favor the physiological mechanisms related to weight loss, insulin resistance and, therefore, also to diabetes and obesity.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 6

WEIGHT LOSS AND DETOXIFICATION OF THE BODY

There is a complexing and carrying action of XOS against the active ingredient of Garcinia cambogia (hydroxycitric acid) which, in synergy with chromium picolinate, acts on the metabolism of sugars. There is also a secondary laxative action for the elimination of fat. There is a particular synergy between garcinia and spirulina, with an effect on accelerating the metabolism combined with a fat-burning action.

The formulation of the Example should preferably be taken in two tablets three times a day, preferably half an hour before meals (morning, noon and evening).

EXAMPLE 7

TO STRENGTHEN HAIR AND SKIN

XOS enhance the bioavailability and assimilability of the components present in the formulation, favoring the restorative and regenerating action of the hair and skin. Furthermore, they enhance the synergy between biotin and zinc to promote hair regrowth. Cinnamon promotes and stimulates blood circulation, helping natural hair regrowth. The antimicrobial property exerted by cinnamon is increased by the activity of selenium and XOS. The use of this supplement has shown surprising results for the treatment of dry skin, against wrinkles, and more generally as an anti-aging. These surprising results are attributable to the prebiotic action of XOS in the intestine, which counteracts chronic inflammatory states linked to the onset of directly related dermatological diseases such as, for example: psoriasis, eczema, etc.

This action is enhanced, as previously stated, by the stimulating and antioxidant effect of cinnamic aldehyde and selenium.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 8

JOINT PAIN - ARTHROSIS

XOS carry out a dual action of molecular carriers favoring the transport and release of anti-inflammatory and reconstituting molecules in the joints and, at the same time, by determining an improvement in the intestinal inflammatory state, it determines an improvement of inflammatory pathologies related to rheumatoid arthritis and arthrosis.

The XOS allow to improve the bioavailability of the active ingredients contained in the formulation, favor the repair and synthesis of cartilage. There is a marked synergistic anti-inflammatory action on the joints between XOS, selenium and chondroitin sulfate. This action is also induced by the presence of XOS which, by carrying out a positive action on intestinal dysbiosis states, influence the severity of joint pain by modulating the levels of cytokines and autoantibodies.

The formulation of the Example should preferably be taken three times a day.

EXAMPLE 9

ANTI-CELLULITE AND ANTI-INFLAMMATORY ACTION:

XOS show an exceptional carrier action against hyaluronic acid and collagen, whose assimilation is favored by organic silicon. Nettle extract and XOS promote the absorption of organic silicon. The formulation has an exceptional anti-aging (on wrinkles) and plumping action, thanks to an improvement in skin elasticity and a restorative effect.

EXAMPLE 10

CANNABIS FOR MEDICAL USE

XOS show an important gastroprotective action, as well as improving the bioavailability of the active ingredients.

EXAMPLE 11

VAGINAL OVULES

The prebiotic action of the XOS used on site acts synergistically with the selective antibacterial activity of astragalus and karkadè extract and with the fungicidal activity (in particular against candida) of caprylic acid, in order to rebalance the microflora vaginal.

The effectiveness of this phytotherapeutic formulation is supported by the synergistic general and local immune stimulation, which counteracts inflammation and inhibits the penetration of pathogenic microorganisms into the urothelium cells.

EXAMPLE 12

FACE CREAM

It has been observed that XOS, interacting synergistically with polydatin, favor its immunostimulating action on the skin. Polydatin and rutin have an anti-aging and antioxidant action and, penetrating deeply, they also act at the intracellular level. Sage extract has antibacterial, antifungal, virus-static, sebum-regulating and astringent activities, it is used for the treatment of oily, impure and acne-prone skin. The β-carotene, present in the microalgae (up to 14% of its dry weight) as a precursor of vitamin A (retinol), exerts a strong antioxidant action for our cells and a role in the physiological balance of our organism through the strengthening of immune defenses due to T and B lymphocytes

Also in this case the surprising anti-aging activity is given by the synergy of action between the XOS, which by modulating the intestinal parameters, favor the well-being of the skin and the soothing and antioxidant effects of the other constituents.

The mechanism of action is twofold, fighting aging from the inside and providing topical nutrients.

EXAMPLE 13

INSULIN STABILIZING SUPPLEMENT

compound quantity XOS 500 mg OLIVE OIL EXTRACT (20% OLEUROPINE)

CHROMOPICOLINATE 120 mcg ZINGER EXTRACT 20% (GINGEROLI)

CINNAMON (KYNAMIC ALDEHYDE) 100 mg The stabilizing effect on insulin is manifested by a double synergistic action: in the short term: oleuropin, gingerol and cinnamic aldehyde regulate insulin secretion and sensitivity; the XOS, on the other hand, positively modulate the bacterial intestinal microflora which influences metabolic parameters, cholesterol, glycaemia, and blood pressure. Furthermore, XOS determine a gradual release of sugars in the intestine, causing a gradual increase in the insulin peak. This stabilizing action shows positive effects in the prevention and improvement of the metabolic conditions of type 2 diabetes, insulin resistance and metabolic syndrome.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 14

HAIR LOSS LOTION

composed

XOS

BAHEDA

AMLA OILS

BRAHMI

BHRINGRAJ

SHIKA KAI

KAPOOR

OLEUROPINE

ARNICA OILS

The synergy of XOS with the other components aims at rebalancing the bacterial microflora of the scalp, at the selective antiseptic and bactericidal action and at stimulating hair regrowth. Its usefulness therefore extends to the treatment of dandruff, seborrheic dermatitis, but also of cicatricial alopecia due to lichen plano pilare. It has been noted that XOS enhance the effects of the active ingredients of the Ayurvedic plants in the formulation, promoting both better absorption and creating a substrate suitable for the proliferation of beneficial microflora at the topical level.

EXAMPLE 15

BIOSTIMULANT FORMULATION FOR AGRICULTURE

BIOLOGICAL

EXAMPLE 16

FERTILIZER FORMULATION

The formulation is preferably used for foliar application.

EXAMPLE 17

FORMULATION FOR ANIMAL USE

Indicated in cases of dysbiosis caused by bacterial, viral, parasitic infections, intestinal disorders from nutrition, chronic inflammation, imbalances caused by the use of antibiotics, anti-inflammatories, or stressful situations.

The symbiotic action of this product is enhanced by the pesticide effect of diatomaceous earth and has a triple effect: antibacterial, antiviral and fungicidal thanks to lauric acid, for a rebalancing of the bacterial intestinal microflora.

The formulation of the Example should preferably be taken once a day.

EXAMPLE 18

ANTI-AGE FORMULATION

compound quantity

XOS 400 mg

NADH 15 mg

POLYDATIN 50 mg

The aforementioned preparation has a marked antioxidant and anti-aging activity.

Thanks to the stabilizing and carrier action of XOS, NADH, involved in energy metabolism and a key element in the production of ATP, acts by strengthening the immune system and protects against cell damage produced by free radicals. Furthermore, XOS act by increasing the already high stability and solubility of polydatin so that it can perform its preventive and curative action to the maximum.

The formulation of the Example should preferably be taken three times a day.

EXAMPLE 19

FORMULATION FOR MITOCHONDRAL DYSFUNCTION

compound quantity

XOS 300 mg

Lactobacillus 150 mg

spp

NADH 5 mg

COQ10 200 mg

Α-LIPOIC ACID 200 mg

ACETYL-L- 250 mg

CARNITINE PIRROLOQUINOLINA 20 mg This formulation has been specially developed in order to combat chronic fatigue and stimulate mitochondrial metabolism.

The specific symbiotic formulation induces, through specific molecular mechanisms, the activation of the cell's energy metabolism, fighting the sense of chronic fatigue and asthenia, typical of pathological states such as fibromyalgia.

Furthermore, NADH (coenzyme that participates in cellular energy production processes) and COQ10 (antioxidant cofactor required in ATP synthesis and cellular bioenergetic activity) act in synergy with α-lipoic acid, a substance that produces and optimizes energy. cellular, which enhances the energy and antioxidant action of the formulation.

The results obtained from the simultaneous intake of these molecules, made even more bioavailable by the XOS, demonstrate a better performance of this formulation compared to a separate intake of the individual components.

This formulation also has an important action on improving sports performance thanks to the synergy of N-acetyl-carnitine, α-lipoic acid and CoQ10.

This formulation is therefore particularly indicated for subjects suffering from myopathies, fibromyalgia, mitochondrial dysfunction, elderly subjects with chronic fatigue and obesity and for athletes.

The formulation of the Example should preferably be taken three times a day.

Example 20

FORMULATION SUITABLE FOR OXIDATIVE STRESS

compound quantity

XOS 500 mg SOD from carrot 20 mg (as d.e.) lycopene 50 mg Vit A 600 mcg Vit C 40 mg Vit E 10 mg Zinc 50 mg picolinate COQ10 50 mg

This formulation was specifically designed in order to counteract damage and chronic degenerative diseases induced by the action of free radicals. The prebiotic, antioxidant and energy metabolism stimulating activities of this formulation are the result of a synergy of action between XOS and antioxidant molecules such as vitamins A, C, E, COQ10, SOD, lycopene and zinc picolinate.

A synergistic action has been noted between XOS, zinc and lycopene not otherwise reproducible individually. This formulation is particularly suitable for combating cellular aging, chronic diseases such as cardio-circulatory disorders, diabetes, cancer and neurodegenerative diseases.

These activities appear to be attributable once again to the dual effect of XOS.

To the carrier action against antioxidant molecules, is added the ability to increase their bioavailability and assimilation by the body, by modulating the bacterial intestinal microflora. At the same time, vitamins, by changing the intestinal redox state, are able to control the sub-populations of the microbiota which represents the main target of this formulation for the prevention of pathologies mediated by oxidative stress.

The formulation of the Example should preferably be taken twice a day.

EXAMPLE 21

FORMULATION SUITABLE FOR ANEMIA

compound quantity

XOS 1 mg / day

FERROPICOLINATE 10 mg / day

VITAMIN B12 3 µg / day

VITAMIN B9 0.5 mg / day

VITAMIN B6 2 mg / day

Vit C 150 mg / day

Vit E 60 mg / day

PICOLINATE COPPER 2 mg / day

Zinc picolinate 10 mg / day

This formulation acts by counteracting the states of intestinal dysbiosis related to anemic pictures and malabsorbing syndromes and making the iron highly bioavailable and assimilable, favoring the normal formation of red blood cells and hemoglobin, the transport of oxygen and the reduction of tiredness and fatigue. .

The effectiveness of the formulation is due to a dual prebiotic and carrier mechanism of XOS which show a significant increase in the assimilation of iron picolinate in combination with Vit C and an increased carrier action of Vit B9 against copper and zinc picolinate.

The prebiotic action of XOS, together with the supply of micronutrients and vitamins, favor the improvement of blood parameters in anemic subjects.

This formulation is therefore indicated in cases of low iron intake with the diet, an increased need for these nutrients or in the case of intestinal malabsorption.

The advantages offered by the preparations described are immediately evident from the description provided of the present invention.

As described above, the preparation of xylooligosaccharides of the present invention has surprising and unexpected properties compared to preparations of other polysaccharides, such as fructooligosaccharides (FOS) and inulin.

Furthermore, the group of xylo-oligosaccharides characterized by a degree of polymerization up to 6 and, more particularly, between 2 and 4, have shown even more surprising properties.

This allows the use of preparations with surprisingly advantageous properties from different points of view.

For example, such preparations are very stable at acid pH, typically gastric.

It has also been noted how the preparations of the invention can be used as carriers for other active ingredients, for example represented by vitamins (especially B1, B2, B6, B12, niacinic acid and folic acid), antioxidants, proteins, mineral salts, improving them widely the activity and bioavailability.

Furthermore, it should not be forgotten that the preparations of the invention can increase the absorption of the same active ingredients; this was seen more particularly with reference to calcium (with an increase in the digestion rate of 23% and the persistence rate of 21%).

From the point of view of prebiotic activity, the preparations described have shown an excellent proliferative capacity towards the intestinal bacterial flora, even higher than that of inulin. In particular, a good selectivity towards bifidobacteria was noted; this determines an increase in the already excellent benefits in the intestine.

These benefits can be reflected in a lower probability of developing intestinal diseases, such as colon cancer (as shown by numerous studies), or other pathologies, thanks to a general improvement in the function of the immune system.

Competitive activity towards pathogenic microorganisms is not only expressed in the intestine; in fact, xylo-oligosaccharides, and more particularly xylo-oligosaccharides having a degree of polymerization lower than 6 and more preferably between 2 and 4, also compete with bacteria of the oral cavity, especially streptococci. Consequently, the preparations of the invention inhibit the proliferation of bacteria responsible for the formation of caries.

As a further advantage, the preparations of the invention have been shown to reduce the production of lactic acid during exercise, amply justifying their use in the sports nutrition sector.

In vaginal application, the preparations of the invention have demonstrated exceptional stability at low pH (2-4) typical of the female genital tract, allowing optimal effectiveness of the components and a gradual and timed release of the active ingredients.

The product has been shown to enhance the natural immune defenses, stimulates and strengthens the organic-tissue defenses and the immune response, blocks the adhesion of bacteria, viruses and fungi to the mucous membranes.

In the cosmetic application, the preparations of the invention have shown an important and favorable carrier effect of XOS on the active ingredients, favoring their penetration deep into the skin.

XOS rebalances the skin microflora favoring the proliferation of Bifidus and Lactobacilli which play a key role in the anti-aging and regenerative process of the skin, protecting it and representing an additional immune defense for the skin, protecting it from external aggressions, inflammation and infections, regulating its pH and helping it to counteract the proliferation of pathogenic bacteria.

The formulations described have also shown surprising results in the treatment of numerous hair related problems.

Lastly, the present invention makes it possible to exploit by-products of the corn cob, which otherwise would represent a waste product, with great advantages both from an economic, environmental and ecological point of view, since an efficient bioconversion of otherwise recalcitrant lignocellulosic materials is determined.

The expert, in order to meet specific contingent needs, may make changes, additions or replacements of components with other functionally equivalent ones, without however departing from the scope of the attached claims.

Each of the features described as belonging to a possible embodiment can be realized independently of the other described embodiments.

Claims (14)

CLAIMS: 1. Functional preparation comprising xylooligosaccharides having a degree of polymerization lower than 6 and preferably between 2 and 4. The functional preparation according to the preceding claim comprising xylobiose, xylotriose and xylotetralose. The functional preparation according to claim 1 or 2 wherein said xylo-oligosaccharides are obtained from the cob of corn and preferably from the cob of the corn cob. The functional preparation according to any one of claims 1 to 3, further comprising one or more functionalizing substances selected from the group which includes: mineral salts, elements, microelements, vitamins, proteins and amino acids, aminosaccharides, antioxidants, plant and algae extracts , microbial preparation. The functional preparation according to any one of claims 1 to 4, possibly comprising further compounds selected from the group which comprises: methylsulfonylmethane, caprilic acid, lauric acid, oleuropine. The functional preparation according to claim 4 or 5, wherein: - mineral salts, elements, microelements, possibly in organic form, are selected from the group which includes: selenium, zinc (for example, zincopicolinate), chromium (for example, chromopicolinate); - vitamins are chosen from the group which includes: vitamin B12, folic acid, biotin, vitamin D3; - proteins and amino acids, are chosen from the group that includes: L-citrulline, collagen, protein extract; - aminosaccharides are selected from the group which includes: glucosamine sulfate, chondroitin sulfate, hyaluronic acid; - antioxidants are selected from the group that includes: polydatin, resveratrol, lycopene, hydroxytyrosol and Nicotinamide adenine dinucleotide (NAD); - plant and algae extracts are chosen from the group that includes: Serenoa repens, pomegranate, bilberry, quercetin, brassica, American cranberry, hibiscus extract, Butea superba, Epidemium, spirulina (Arthrospira platensis), Garciniacambogia, cinnamon, extract of nettle, hemp (Cannabis), astragalus extract, echinacea extract, Tabebuia impetiginosa extract, Rose hip oil, sage extract, dunaliella seaweed extract, diatomaceous earth, rutin, ginger extract, baheda, amla oil , brahmi, bhringraj, shika kai, kapoor, arnica oil; - the other compounds selected from the group which includes: methylsulfonylmethane, caprylic acid, lauric acid, oleuropine; - microbial preparation comprising microorganisms selected from the group which includes, for example: L. rhamnosus, L. acidophilus, L. plantarum, L. paracasei, L. salivarius, L. bulgaricus, Enterococcus faecium, etc; 7. A functional preparation according to any one of the preceding claims comprising one or more compounds of the agrochemical sector. The functional preparation according to the preceding claim, in which said compounds are selected from the group which includes: iron, magnesium, zinc, manganese, copper (in the form of salts, for example, sulphate salt), urea. A functional preparation according to any one of the preceding claims from 1 to 6, which is represented by food preparations, functional food preparations, beverages, pharmaceutical preparations for human and animal use, supplements, tonic, cosmetics. 10. A preparation according to the previous claim for use as a medicament. 11. A preparation according to the preceding claim for use as a medicament in the control of blood sugar and insulin level, as a systemic or local anti-inflammatory, for the treatment of erectile dysfunction, as an antioxidant, for strengthening the immune system, as a slimming o for the control of body weight, as a draining or anti-cellulite, as a detoxifier, to combat hair loss, to promote growth and improve the appearance of hair, to delay hair graying, to combat dandruff, for the well-being of the skin and nails, for joint pain; as an antibacterial and antifungal, to promote the energy metabolism of the cell, for mitochondrial dysfunction. 12. The functional preparation according to the previous claim, for human or veterinary use. A functional preparation according to claim 7 or 8 which is represented by a fertilizer or biostimulant formulation. 14. Use of the preparation according to any one of the preceding claims 1 to 3 to increase the bioavailability of functional compounds present in food preparations, functional food preparations, beverages, pharmaceutical preparations for human and animal use, supplements, tonic, cosmetics, agrochemical formulations.