IT201800004350A1 - COSMETIC PREPARATION - Google Patents
COSMETIC PREPARATION Download PDFInfo
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- IT201800004350A1 IT201800004350A1 IT102018000004350A IT201800004350A IT201800004350A1 IT 201800004350 A1 IT201800004350 A1 IT 201800004350A1 IT 102018000004350 A IT102018000004350 A IT 102018000004350A IT 201800004350 A IT201800004350 A IT 201800004350A IT 201800004350 A1 IT201800004350 A1 IT 201800004350A1
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Description
DESCRIZIONE DESCRIPTION
PREPARATO COSMETICO COSMETIC PREPARATION
La presente invenzione ha per oggetto un preparato cosmetico del tipo precisato nel preambolo della prima rivendicazione. The present invention relates to a cosmetic preparation of the type specified in the preamble of the first claim.
5 In particolare, l’invenzione riguarda un preparato atto a essere utilizzato per la realizzazione di un prodotto ad azione cosmetica quale una crema, un gel o una lozione. 5 In particular, the invention relates to a preparation suitable to be used for the production of a product with a cosmetic action such as a cream, a gel or a lotion.
Come noto l'invecchiamento della pelle è il risultato di diversi fattori. Oltre alla predisposizione genetica di ogni persona, ci sono, infatti, fattori esterni e legati allo 10 stile e alla qualità di vita che influiscono sul nostro corpo pelle compresa. As known, skin aging is the result of several factors. In addition to the genetic predisposition of each person, there are, in fact, external factors linked to style and quality of life that affect our body including skin.
Tali alterazioni variano a seconda dell’età. These alterations vary according to age.
Per esempio già dopo i trenta anni di età è possibile notare alcuni segni dell'invecchiamento cutaneo, dovuti al rallentamento di alcuni processi fisiologici. In questa fascia di età i principali meccanismi compromessi sono il rinnovamento 15 cellulare; i sistemi di difesa della pelle contro i radicali liberi; la barriera naturale d’idratazione della pelle; e i precursori del sistema elastico e del collagene della pelle. For example, already after thirty years of age it is possible to notice some signs of skin aging, due to the slowdown of some physiological processes. In this age group the main compromised mechanisms are cell renewal 15; the skin's defense systems against free radicals; the skin's natural moisture barrier; and precursors of the skin's elastic system and collagen.
Dai quarantacinque anni i meccanismi fisiologici della pelle sono la produzione di collagene; produzione dei precursori e organizzazione delle fibre di collagene; 20 l’indurimento delle fibre di collagene; degradazione dell'elastina; perdita della barriera naturale di idratazione della pelle; e il sistema dei precursori della pelle elastica. From the age of forty-five the physiological mechanisms of the skin are the production of collagen; production of precursors and organization of collagen fibers; 20 hardening of collagen fibers; degradation of elastin; loss of the skin's natural moisture barrier; and the system of elastic skin precursors.
Dai sessant’anni i meccanismi fisiologici compromessi sono la produzione di acido ialuronico; riduzione intensificata e disorganizzazione delle principali strutture 25 elastiche; aumento della degradazione delle fibre della matrice extracellulare; i precursori del sistema elastico della pelle e del precursore del collagene. Si sottolinea infine come l’entità della compromissione di tali aspetti sia, come sopra accennato, influenzata in modo rilevante da altri fattori come l’alimentazione, il clima o la qualità dell’aria. From the age of sixty, the physiological mechanisms that have been compromised have been the production of hyaluronic acid; intensified reduction and disorganization of the main elastic structures 25; increased degradation of the fibers of the extracellular matrix; the precursors of the elastic system of the skin and the precursor of collagen. Finally, it is emphasized that the extent of the impairment of these aspects is, as mentioned above, significantly influenced by other factors such as nutrition, climate or air quality.
5 La tecnica nota descritta comprende alcuni importanti inconvenienti. 5 The known art described includes some important drawbacks.
Infatti, i prodotti cosmetici a oggi esistenti si occupano solo di alcuni punti specifici, ma mai tutti i meccanismi di cui sopra contemporaneamente. In fact, the cosmetic products existing today only deal with some specific points, but never all the above mechanisms at the same time.
Inoltre i prodotti cosmetici a oggi esistenti hanno un’efficacia non particolarmente elevata e quindi non risolvono in maniera adeguata i problemi sopra esposti. Furthermore, the existing cosmetic products to date have a not particularly high efficacy and therefore do not adequately solve the problems described above.
10 Un altro inconveniente importante è rappresentato dal fatto che il consumatore, risolvendo i prodotti cosmetici noti solo alcuni problemi (in più in modo parziale), è costretto a usare più prodotti e, soprattutto, a individuare da solo la combinazione di prodotti in grado di soddisfare le proprie specifiche esigenze. 10 Another important drawback is represented by the fact that the consumer, by solving cosmetic products known only some problems (moreover in a partial way), is forced to use more products and, above all, to identify by himself the combination of products capable of meet your specific needs.
Si evidenzia come tale aspetto sia reso ancora più complicato dalla variazione con 15 l’età e dall’azione indefinita di fattori esterni peculiari/esterni come alimentazione, clima e qualità dell’aria. It is highlighted that this aspect is made even more complicated by the variation with age 15 and by the indefinite action of peculiar / external factors such as nutrition, climate and air quality.
In questa situazione il compito tecnico alla base della presente invenzione è ideare un prodotto cosmetico in grado di ovviare sostanzialmente ad almeno parte degli inconvenienti citati. In this situation, the technical task underlying the present invention is to devise a cosmetic product capable of substantially obviating at least part of the aforementioned drawbacks.
20 Nell'ambito di detto compito tecnico è un importante scopo dell'invenzione ottenere un prodotto cosmetico che tratti, in maniera particolarmente efficace i principali meccanismi compromessi con il passare del tempo e sopra esposti. 20 Within the scope of said technical task, it is an important object of the invention to obtain a cosmetic product which deals, in a particularly effective manner, with the main mechanisms compromised with the passage of time and described above.
Un altro importante scopo dell'invenzione è quindi realizzare un prodotto cosmetico avente un’azione completa e in grado così di soddisfare le specifiche 25 esigenze di ciascun utilizzatore. Another important purpose of the invention is therefore to create a cosmetic product having a complete action and thus able to meet the specific 25 needs of each user.
Il compito tecnico e gli scopi specificati sono raggiunti da un prodotto cosmetico come rivendicato nell’annessa rivendicazione 1. Esempi di realizzazione preferita sono descritti nelle rivendicazioni dipendenti. The technical task and the specified purposes are achieved by a cosmetic product as claimed in the attached claim 1. Examples of preferred embodiment are described in the dependent claims.
Nel presente documento, le misure, i valori, le forme e i riferimenti geometrici 5 (come perpendicolarità e parallelismo), quando associati a parole come "circa" o altri simili termini quali "pressoché" o "sostanzialmente", sono da intendersi come a meno di errori di misura o imprecisioni dovute a errori di produzione e/o fabbricazione e, soprattutto, a meno di una lieve divergenza dal valore, dalla misura, dalla forma o riferimento geometrico cui è associato. Ad esempio, tali 10 termini, se associati a un valore, indicano preferibilmente una divergenza non superiore al 10% del valore stesso. In this document, measurements, values, shapes and geometric references 5 (such as perpendicularity and parallelism), when associated with words such as "about" or other similar terms such as "almost" or "substantially", are to be understood as unless of measurement errors or inaccuracies due to production and / or manufacturing errors and, above all, unless there is a slight divergence from the value, measurement, shape or geometric reference to which it is associated. For example, these 10 terms, if associated with a value, preferably indicate a divergence of no more than 10% of the value itself.
Le misurazioni e i dati riportati nel presente testo sono da considerarsi, salvo diversamente indicato, come effettuati in Atmosfera Standard Internazionale ICAO (ISO 2533). The measurements and data reported in this text are to be considered, unless otherwise indicated, as carried out in the ICAO International Standard Atmosphere (ISO 2533).
15 Il prodotto cosmetico secondo l'invenzione è identificabile in una crema, una lozione, un gel o altro prodotto ad azione cosmetica preferibilmente per la cura del corpo, del viso e in particolare della pelle. 15 The cosmetic product according to the invention can be identified as a cream, a lotion, a gel or other product with a cosmetic action, preferably for the care of the body, face and in particular the skin.
Il prodotto cosmetico comprende pterostilbene (4-idrossi-3,5-dimetossistilbene). Lo pterostilbene è chimicamente affine al resveratrolo. Esso è un polifenolo con 20 derivazione dalla forma metilata del resveratrolo. The cosmetic product includes pterostilbene (4-hydroxy-3,5-dimethoxystilbene). Pterostilbene is chemically related to resveratrol. It is a polyphenol with 20 derivation from the methylated form of resveratrol.
Preferibilmente il prodotto cosmetico comprende estratti di Vitis vinifera (Vitis vinifera L.) comprendenti lo pterostilbene. Preferably the cosmetic product comprises extracts of Vitis vinifera (Vitis vinifera L.) comprising pterostilbene.
Più preferibilmente il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Vitis vinifera sostanzialmente compreso tra 25 0,1 g e 2 g in dettaglio tra 0,2 g e 1,5 g e più in dettaglio tra 0,4 g e 0,8 g. More preferably, the cosmetic product comprises, on 100 g of cosmetic product, a content of extracts of Vitis vinifera substantially comprised between 25 0.1 g and 2 g in detail between 0.2 g and 1.5 g and more in detail between 0.4 g and 0.8 g.
Essi possono essere derivati dalla lavorazione di bucce degli acini di Vitis vinifera e/o dagli stessi tralci di Vitis vinifera. They can be derived from the processing of grape skins of Vitis vinifera and / or from the same shoots of Vitis vinifera.
Gli estratti di Vitis vinifera sono ottenibili per estrazione a riflusso del tipo soxhlet, con ultrasuoni o con gas supercritici, e l’aggiunta di anidride solforosa come 5 solvente. Preferibilmente, tali estratti sono ottenuti con il metodo soxhlet a riflusso con metanolo. Questo metodo prevede fermentazione e idrolisi dell’uva di Vitis vinifera con aggiunta di lievito opportunamente Saccharomycetaceae (quale Saccharomyces cerevisiae) e preferibilmente operando a pH 7 per circa 4 giorni; evaporazione e centrifuga per eliminare il solvente dalla soluzione sopra ottenuta; 10 estrazione soxhlet; eliminazione per riscaldamento a punto di ebollizione del metanolo e quindi sua estrazione per evaporazione. Vitis vinifera extracts can be obtained by reflux extraction of the soxhlet type, with ultrasound or with supercritical gases, and the addition of sulfur dioxide as 5 solvent. Preferably, these extracts are obtained by the soxhlet reflux method with methanol. This method involves fermentation and hydrolysis of Vitis vinifera grapes with the addition of Saccharomycetaceae yeast (such as Saccharomyces cerevisiae) and preferably operating at pH 7 for about 4 days; evaporation and centrifuge to remove the solvent from the solution obtained above; 10 soxhlet extraction; elimination by heating to boiling point of methanol and then its extraction by evaporation.
In alternativa o aggiunta agli estratti di Vitis vinifera il prodotto cosmetico comprende estratti di Polygonum Cuspidatum comprendenti pterostilbene. Alternatively or in addition to the extracts of Vitis vinifera, the cosmetic product comprises extracts of Polygonum Cuspidatum including pterostilbene.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di 15 estratti di Polygonum Cuspidatum sostanzialmente compreso tra 0,1 g e 2 g in dettaglio tra 0,1 g e 1,5 g e più in dettaglio tra 0,2 g e 0,8 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of 15 extracts of Polygonum Cuspidatum substantially between 0.1 g and 2 g in detail between 0.1 g and 1.5 g and more in detail between 0.2 g and 0, 8 g.
Gli estratti di Polygonum Cuspidatum sono ottenibili attraverso un procedimento di essiccazione e titolazione delle polveri o con estrazione con solvente. Polygonum Cuspidatum extracts can be obtained through a drying and titration process of the powders or with solvent extraction.
Il prodotto cosmetico comprende resveratrolo. The cosmetic product includes resveratrol.
20 In dettaglio il prodotto cosmetico comprende estratti di Vitis vinifera comprendenti resveratrolo. 20 In detail, the cosmetic product comprises extracts of Vitis vinifera including resveratrol.
In alternativa o aggiunta il prodotto cosmetico comprende estratti di Polygonum Cuspidatum comprendenti resveratrolo. Alternatively or in addition, the cosmetic product comprises Polygonum Cuspidatum extracts comprising resveratrol.
Il prodotto cosmetico comprende betaina. The cosmetic product includes betaine.
25 La betaina è un composto naturale neutro dotato di un gruppo funzionale cationico con carica positiva o un catione fosfonico PR1R2R3R4. Per la precisione essa è una N,N,N-trimetilglicina o più precisamente un aminoacido N-trimetilato in forma zwitteronica a pH neutro. La betaina è spesso denominata trimetilglicina. 25 Betaine is a neutral natural compound with a positively charged cationic functional group or a phosphonic cation PR1R2R3R4. To be precise, it is an N, N, N-trimethylglycine or more precisely an N-trimethylated amino acid in the zwitteronic form at neutral pH. Betaine is often referred to as trimethylglycine.
Preferibilmente il prodotto cosmetico comprende estratti di Beta vulgaris 5 comprendenti betaina. Preferably the cosmetic product comprises extracts of Beta vulgaris 5 comprising betaine.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Beta vulgaris sostanzialmente compreso tra 1 g e 20 g in dettaglio tra 2 g e 10 g e più in dettaglio tra 4 g e 8 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of Beta vulgaris extracts substantially between 1 g and 20 g in detail between 2 g and 10 g and more in detail between 4 g and 8 g.
Gli estratti di Beta vulgaris sono ottenibili per essiccazione, estrazione e titolazione 10 delle polveri di Beta vulgaris o con estrazione con solvente. Beta vulgaris extracts can be obtained by drying, extraction and titration 10 of Beta vulgaris powders or by solvent extraction.
Il prodotto cosmetico comprende acido folico e per la precisione estratti di Medicago sativa comprendente acido folico preferibilmente nella forma 5- metiltetraidrofolato. The cosmetic product comprises folic acid and specifically Medicago sativa extracts comprising folic acid preferably in the 5-methyltetrahydrofolate form.
Gli estratti di Medicago sativa possono essere ottenuti tramite un processo che 15 prevedente: essiccazione della Medicago sativa, macinazione, vagliatura e titolazione dei singoli fitocomplessi o con estrazione con solventi. Medicago sativa extracts can be obtained through a process that includes: drying of Medicago sativa, grinding, screening and titration of the individual phytocomplexes or by extraction with solvents.
Il prodotto cosmetico comprende oligosaccaridi e per la precisione estratti di Medicago sativa comprendenti oligosaccaridi. The cosmetic product comprises oligosaccharides and to be more precise extracts of Medicago sativa comprising oligosaccharides.
Il prodotto cosmetico comprende acido pantotenico o vitamina B5 e per la 20 precisione estratti di Medicago sativa comprendenti vitamina B5. The cosmetic product includes pantothenic acid or vitamin B5 and more specifically Medicago sativa extracts including vitamin B5.
Il prodotto cosmetico comprende pantotenico, vitamine A, B1, B6, B12, C, E, K1, biotina, saponine triterpeniche, isoflavoni – policosanoli. Detti elementi possono essere compresi negli estratti di Medicago sativa. The cosmetic product includes pantothenic, vitamins A, B1, B6, B12, C, E, K1, biotin, triterpene saponins, isoflavones - policosanols. These elements can be included in Medicago sativa extracts.
L’integratore alimentare può comprendere coenzima Q10 (detto anche ubichinone 25 o vitamina Q). The food supplement may include coenzyme Q10 (also called ubiquinone 25 or vitamin Q).
Preferibilmente esso comprende estratti di Medicago sativa comprendenti coenzima Q10. Preferably it comprises Medicago sativa extracts comprising coenzyme Q10.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Medicago sativa sostanzialmente compreso tra 0,5 g e 20 g in dettaglio 5 tra 2 g e 10 g e più in dettaglio tra 4 g e 8 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of Medicago sativa extracts substantially comprised between 0.5 g and 20 g in detail 5 between 2 g and 10 g and more in detail between 4 g and 8 g.
Il prodotto cosmetico comprende se-metil-selenocisteina e in dettaglio estratti di Astragalus membranaceus comprendente se-metil-selenocisteina. The cosmetic product comprises se-methyl-selenocysteine and in detail extracts of Astragalus membranaceus comprising se-methyl-selenocysteine.
Il prodotto cosmetico comprende TA-65 (complesso enzimatico) e per la precisione estratti di Astragalus membranaceus comprendente TA-65. The cosmetic product includes TA-65 (enzyme complex) and to be precise extracts of Astragalus membranaceus including TA-65.
10 Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Astragalus membranaceus sostanzialmente compreso tra 0,1 g e 5 g in dettaglio tra 0,1 g e 2 g e più in dettaglio tra 0,2 g e 1 g. 10 The cosmetic product comprises, on 100 g of cosmetic product, a content of Astragalus membranaceus extracts substantially between 0.1 g and 5 g in detail between 0.1 g and 2 g and more in detail between 0.2 g and 1 g.
Detti estratti di Astragalus membranaceus sono derivanti dall’apparato radicale. Gli estratti di Astragalus possono essere ottenuti tramite un processo di estrazione 15 prevedente nell’ordine: essiccazione dell’Astragalus, macinazione, vagliatura e titolazione dei singoli fitocomplessi. These extracts of Astragalus membranaceus are derived from the root system. Astragalus extracts can be obtained through an extraction process 15 foreseeing in the order: drying of Astragalus, grinding, screening and titration of the individual phytocomplexes.
Il prodotto cosmetico comprende uno o più e preferibilmente la totalità di saponine triterpeniche (Astragalosidi I-VIII, acetil-astragaloside I, soyasaponina I, Acetil, astragalosidi I-VI, astragalo side VII neutro), isoflavoni (calicosina, formononetina), 20 isoflavani (isomucronulatol), Pterocarpani (9-methoxyl-nissolin), Polisaccaridi (Astragalani I, II, III,alfa-1-4-gluc.:MW36.300, Astraglucani 1,2,3 alfa-1-4-, alfa-1-6-gluc. Astraeterosaccaridi 1,2 galacturon./ Glucuron. Acid, rha, gluc, ara AMem-P (galacturon.acid, ara, gala, rha, Amine biogene, Betaina, colina, acido y- amino -butirrico GABA), Amine piogene: Betaina, colina, acido gamma-amino-butirrico 25 (GABA). Tali fitocomplessi sono compresi negli estratti di Astragalus membranaceus. The cosmetic product comprises one or more and preferably the totality of triterpene saponins (Astragalosides I-VIII, acetyl-astragaloside I, soyasaponin I, Acetyl, astragalosides I-VI, astragalus side VII neutral), isoflavones (calicosine, formononetin), 20 isoflavans (isomucronulatol), Pterocarpani (9-methoxyl-nissolin), Polysaccharides (Astragalans I, II, III, alpha-1-4-gluc.: MW36.300, Astraglucans 1,2,3 alpha-1-4-, alpha- 1-6-gluc. Astraeterosaccharides 1,2 galacturon./ Glucuron. Acid, rha, gluc, ara AMem-P (galacturon.acid, ara, gala, rha, Amine biogen, Betaine, choline, y-amino-butyric acid GABA ), Pyogenic amines: Betaine, choline, gamma-amino-butyric acid 25 (GABA) These phytocomplexes are included in the extracts of Astragalus membranaceus.
Il prodotto cosmetico comprende mucopolisaccaridi e in dettaglio estratti di Fucus vesicolosus comprendenti mucopolisaccaridi. The cosmetic product includes mucopolysaccharides and in detail Fucus vesicolosus extracts including mucopolysaccharides.
Gli estratti di Fucus vesicolosus possono essere ottenuti attraverso essiccazione, 5 polverizzazione e frammentazione del tallo intero del Fucus. Fucus vesicolosus extracts can be obtained by drying, 5 pulverizing and fragmentation of the whole Fucus thallus.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Fucus vesicolosus sostanzialmente compreso tra 0,1 g e 3 g in dettaglio tra 0,1 g e 1,5 g e più in dettaglio tra 0,2 g e 0,6 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of Fucus vesicolosus extracts substantially between 0.1 g and 3 g in detail between 0.1 g and 1.5 g and more in detail between 0.2 g and 0.6 g.
I mucopolisaccaridi comprendono uno o più e preferibilmente la totalità di acido 10 alginico, fucoidano e laminarina; composti polifenolici (come floroglucinolo, fenilfloroglucinolo, fucoli, florotannini, floroglucinolici); steroli (tra cui fucosterolo, il tetraterpene fucoxantina; lipidi polari quali galattolipidi, digliceridi solfati, mono-e poliesteri glicosilsolfati; pirenoidi, sali minerali ed oligoelementi. The mucopolysaccharides comprise one or more and preferably all of alginic acid 10, fucoidan and laminarine; polyphenolic compounds (such as phloroglucinol, phenylfloroglucinol, fucoli, phlorotannins, phloroglucinolics); sterols (including fucosterol, fucoxanthin tetraterpene; polar lipids such as galactolipids, diglycerides sulphates, mono- and polyesters glycosyl sulphates; pyrenoids, mineral salts and trace elements.
Il prodotto cosmetico comprende vitamina C e preferibilmente le vitamine A, B1, 15 B2, B5, B6, B12, D ed E e in dettaglio estratti di Fucus vesicolosus comprendenti vitamina C e preferibilmente dette vitamine. The cosmetic product comprises vitamin C and preferably vitamins A, B1, 15 B2, B5, B6, B12, D and E and in detail extracts of Fucus vesicolosus comprising vitamin C and preferably said vitamins.
Riassumendo gli estratti di Fucus vesicolosus comprendono principalmente acido alginico, fucoidano, laminaria, composti polifenolici, fuco xantina, vitamina C. Summarizing, the extracts of Fucus vesicolosus mainly include alginic acid, fucoidan, laminaria, polyphenolic compounds, kelp xanthine, vitamin C.
Per la precisione gli estratti di Fucus vesicolosus possano comprendere enzimi 20 catalizzanti dei processi metabolici e sali minerali di, ad esempio, sodio, potassio, fosforo, calcio, magnesio, zolfo, cloro, manganese, iodio, silicio, ferro, rame, zinco, stronzio, cobalto, nichel, molibdeno, piombo, stagno, bromo, argento, cromo, litio. Il prodotto cosmetico comprende arthrospira e per la precisione estratti di Alga arthrospira fusiformis comprendenti arthrospira. To be precise, the extracts of Fucus vesicolosus may include enzymes 20 catalysing the metabolic processes and mineral salts of, for example, sodium, potassium, phosphorus, calcium, magnesium, sulfur, chlorine, manganese, iodine, silicon, iron, copper, zinc, strontium, cobalt, nickel, molybdenum, lead, tin, bromine, silver, chromium, lithium. The cosmetic product includes arthrospira and specifically extracts of Alga arthrospira fusiformis including arthrospira.
25 Gli estratti di Alga arthrospira fusiformis possono essere ottenuti per essiccazione, polverizzazione e frammentazione del tallo intero. 25 Alga arthrospira fusiformis extracts can be obtained by drying, pulverizing and fragmentation of the whole thallus.
Il prodotto cosmetico comprende fenilalanina, isoleucina, leucina, lisina, metionina, treonina, triptofano, valina, acidi grassi essenziali, carboidrati, vitamine A, D, K e vitamine del gruppo B, sali minerali. Detti principi attivi sono compresi negli estratti 5 di Alga arthrospira fusiformis. The cosmetic product includes phenylalanine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, valine, essential fatty acids, carbohydrates, vitamins A, D, K and B vitamins, mineral salts. Said active ingredients are included in the extracts 5 of Alga arthrospira fusiformis.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Alga arthrospira fusiformis sostanzialmente compreso tra 0,5 g e 10 g in dettaglio tra 1 g e 7 g e più in dettaglio tra 2 g e 4 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of extracts of Alga arthrospira fusiformis substantially between 0.5 g and 10 g in detail between 1 g and 7 g and more in detail between 2 g and 4 g.
Il prodotto cosmetico comprende acido glicuronico e per la precisione estratti di 10 Tremella fuciformis fusiformis comprendenti acido glicuronico. The cosmetic product includes glucuronic acid and to be precise extracts of 10 Tremella fuciformis fusiformis including glucuronic acid.
Il prodotto cosmetico comprende N-acetilglucosamina e per la precisione estratti di Tremella fuciformis fusiformis comprendenti N-acetilglucosamina. The cosmetic product includes N-acetylglucosamine and specifically extracts of Tremella fuciformis fusiformis including N-acetylglucosamine.
Il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Tremella fuciformis fusiformis sostanzialmente compreso tra 0,5 g e 10 g 15 in dettaglio tra 2 g e 8 g e più in dettaglio tra 4 g e 6 g. The cosmetic product comprises, on 100 g of cosmetic product, a content of extracts of Tremella fuciformis fusiformis substantially between 0.5 g and 10 g 15 in detail between 2 g and 8 g and more in detail between 4 g and 6 g.
Gli estratti di Tremella fuciformis fusiformis possono essere ottenuti tramite estrazione con solvente opportunamente dal carpoforo della Tremella. Tremella fuciformis fusiformis extracts can be obtained by solvent extraction from the Tremella carpophore.
Riassumendo il prodotto cosmetico comprende pterostilbene, betaina, acido folico opportunamente nella forma 5- metil-tetraidrofolato, trimetilglicina e preferibilmente 20 resveratrolo. In dettaglio oltre a tali principi attivi il prodotto cosmetico può comprendere uno o più tra TA-65, oligosaccaridi, vitamina B5, coenzima Q10, mucopolisaccaridi, arthrospira, acido ialuronico e N-acetilglucosamina. Più in dettaglio il prodotto cosmetico comprende pterostilbene, acido folico opportunamente nella forma 5-metil-tetraidrofolato, trimetilglicina, resveratrolo, TA-25 65, oligosaccaridi, vitamina B5, coenzima Q10, mucopolisaccaridi, arthrospira, acido ialuronico e preferibilmente N-acetilglucosamina. In summary, the cosmetic product comprises pterostilbene, betaine, folic acid suitably in the form 5-methyl-tetrahydrofolate, trimethylglycine and preferably 20 resveratrol. In detail, in addition to these active ingredients, the cosmetic product can comprise one or more of TA-65, oligosaccharides, vitamin B5, coenzyme Q10, mucopolysaccharides, arthrospira, hyaluronic acid and N-acetylglucosamine. More in detail, the cosmetic product comprises pterostilbene, folic acid suitably in the form 5-methyl-tetrahydrofolate, trimethylglycine, resveratrol, TA-25 65, oligosaccharides, vitamin B5, coenzyme Q10, mucopolysaccharides, arthrospira, hyaluronic acid and preferably N-acetylglucosamine.
Quindi il prodotto cosmetico comprende, nei contenuti sopra indicati, estratti di: x Beta vulagris opprtunamente comprendenti trimetilglicina; Therefore, the cosmetic product includes, in the contents indicated above, extracts of: x Beta vulagris suitably comprising trimethylglycine;
x Medicago sativa opprtunamente comprendenti acido folico (preferibilmente 5 nella forma 5- metil-tetraidrofolato) e opzionalmente uno o più tra o più precisamente la totalità di oligosaccaridi, vitamina B5 e coenzima Q10; e almeno uno tra gli estratti di x Medicago sativa suitably comprising folic acid (preferably 5 in the 5-methyl-tetrahydrofolate form) and optionally one or more among or more precisely the totality of oligosaccharides, vitamin B5 and coenzyme Q10; and at least one of the extracts from
x Vitis vinifera L opprtunamente comprendenti pterostilbene e in dettaglio resveratrolo; e x Vitis vinifera L suitably including pterostilbene and in detail resveratrol; And
10 x Polygonum cuspidatum opprtunamente comprendenti pterostilbene e in dettaglio resveratrolo. 10 x Polygonum cuspidatum suitably including pterostilbene and resveratrol in detail.
Preferibilmente il prodotto cosmetico comprende estratti di Beta vulagris, Medicago sativa, Vitis vinifera e Polygonum cuspidatum. Preferably the cosmetic product comprises extracts of Beta vulagris, Medicago sativa, Vitis vinifera and Polygonum cuspidatum.
Oltre a detti estratti il prodotto cosmetico può comprendere uno o più tra estratti di: 15 x Astragalus membranaceus opprtunamente comprendenti TA-65; In addition to said extracts, the cosmetic product can comprise one or more of extracts of: 15 x Astragalus membranaceus suitably comprising TA-65;
x Fucus vesicolosus opportunamente comprendenti mucopolisaccaridi e preferibilmente vitamina C; x Fucus vesicolosus suitably comprising mucopolysaccharides and preferably vitamin C;
x Alga arthrospira fusiformis opportunamente comprendenti arthrospira; e x Tremella fuciformis opportunamente comprendenti acido ialuronico e 20 preferibilmente N-acetilglucosamina. x Alga arthrospira fusiformis suitably including arthrospira; and x Tremella fuciformis suitably comprising hyaluronic acid and 20 preferably N-acetylglucosamine.
Il prodotto cosmetico comprende, nei contenuti sopra indicati, estratti di Beta vulagris, Medicago sativa. Vitis vinifera L. Polygonum cuspidatum, Astragalus membranaceus, Fucus vesicolosus, Alga arthrospira fusiformis, Tremella fuciformis. The cosmetic product includes, in the contents indicated above, extracts of Beta vulagris, Medicago sativa. Vitis vinifera L. Polygonum cuspidatum, Astragalus membranaceus, Fucus vesicolosus, Alga arthrospira fusiformis, Tremella fuciformis.
25 In un esempio di formulazione non limitante il prodotto cosmetico comprende, su 100 g di prodotto cosmetico, un contenuto di estratti di Vitis vinifera sostanzialmente compreso tra 0,4 g e 0,8 g, un contenuto di estratti di Polygonum Cuspidatum sostanzialmente compreso tra 0,2 g e 0,8 g, un contenuto di estratti di Beta vulgaris sostanzialmente compreso tra 4 g e 8 g, un contenuto di estratti di 5 Medicago sativa sostanzialmente compreso tra 4 g e 8 g, un contenuto di estratti di Astragalus membranaceus sostanzialmente compreso tra 0,2 g e 1 g, un contenuto di estratti di Fucus vesicolosus sostanzialmente compreso tra 0,2 g e 0,6 g, un contenuto di estratti di Alga arthrospira fusiformis sostanzialmente compreso tra 2 g e 4 g, un contenuto di estratti di Tremella fuciformis fusiformis 10 sostanzialmente compreso tra 4 g e 6 g. 25 In an example of a non-limiting formulation, the cosmetic product comprises, on 100 g of cosmetic product, a content of extracts of Vitis vinifera substantially between 0.4 g and 0.8 g, a content of extracts of Polygonum Cuspidatum substantially between 0 , 2 g and 0.8 g, an extract content of Beta vulgaris substantially between 4 g and 8 g, an extract content of 5 Medicago sativa substantially between 4 g and 8 g, an extract content of Astragalus membranaceus substantially between 0 , 2 g and 1 g, a content of Fucus vesicolosus extracts substantially between 0.2 g and 0.6 g, a content of Alga arthrospira fusiformis extracts substantially between 2 g and 4 g, a content of Tremella fuciformis fusiformis 10 extracts substantially comprised between 4 g and 6 g.
Il funzionamento del prodotto cosmetico 1 precedentemente descritto in termini strutturali è il seguente. The operation of the cosmetic product 1 previously described in structural terms is as follows.
Il prodotto cosmetico è atto a essere applicato, per esempio sotto forma di crema, gel o lozione sulla pelle. The cosmetic product is adapted to be applied, for example in the form of a cream, gel or lotion, to the skin.
15 Il prodotto cosmetico secondo l’invenzione consegue importanti vantaggi. 15 The cosmetic product according to the invention achieves important advantages.
Infatti, la particolare selezione di principi attivi e quindi di fitocomplessi vegetali permette al prodotto cosmetico di essere dotato di forti attività scavenger, compattante, anti-infiammatoria, idratante, tonificante; caratterizzato da una forte azione anti-tumori cutanei ed una elevata capacità di sintesi di prodotti quali 20 collagene, elastina, acido ialuronico, carboidrati, e proteine. In fact, the particular selection of active ingredients and therefore of plant phytocomplexes allows the cosmetic product to be endowed with strong scavenger, compacting, anti-inflammatory, moisturizing, toning activity; characterized by a strong anti-skin cancer action and a high synthesis capacity of products such as 20 collagen, elastin, hyaluronic acid, carbohydrates, and proteins.
Tali effetti sono determinati dalle dinamiche sinergiche svolte di trimetilglicina, pterostilbene e di metilazione del resveratrolo indotta da agenti metilanti da cui deriva una maggiore formazione di pterostilbene nella sua forma più bioattiva in grado di apportare un’importante azione scavenger realizzando così il primo 25 prodotto cosmetico nutraceutico con titolo in pterostilbene (un fitocomplesso avente un’azione bioattiva calcolata in circa 150-200 volte superiore a quella del resveratrolo). These effects are determined by the synergistic dynamics of trimethylglycine, pterostilbene and methylation of resveratrol induced by methylating agents from which a greater formation of pterostilbene in its most bioactive form derives, capable of providing an important scavenger action, thus creating the first 25 cosmetic product nutraceutical with title in pterostilbene (a phytocomplex having a bioactive action calculated in about 150-200 times higher than that of resveratrol).
Le azioni benefiche dello pterostilbene (scavenger, anti-age, anti-infiammatoria, antiossidante sono coadiuvate dalla presenza della trimetilglicina che, svolgendo 5 azione metilante rivolta al resveratrolo, induce a sua volta la formazione dello pterostilbene. The beneficial actions of pterostilbene (scavenger, anti-aging, anti-inflammatory, antioxidant are assisted by the presence of trimethylglycine which, carrying out a methylating action aimed at resveratrol, in turn induces the formation of pterostilbene.
Tale aspetto è ulteriormente accentuato dal fatto che la trimetilglicina, associata acido folico e/o vitamina B12, rimetila il resveratrolo e riduce il 5- metiltetraidrofolato (MTHF) a metiltetraidrofolato che, a sua volta, fornisce il gruppo 10 metilico necessario alla formazione, da parte del resveratrolo, dello pterostilbene. This aspect is further accentuated by the fact that trimethylglycine, associated with folic acid and / or vitamin B12, replenishes resveratrol and reduces 5-methyltetrahydrofolate (MTHF) to methyltetrahydrofolate which, in turn, provides the methyl group 10 necessary for formation, from part of resveratrol, pterostilbene.
Si evidenzia come la sinergia pterostilbene-trimetilglicina è accentuata dalla presenza dell’acido folico che, soprattutto nella forma 5- metil-tetraidrofolato, risulta indispensabile nella reazione biochimica sopra descritta. It should be noted that the pterostilbene-trimethylglycine synergy is accentuated by the presence of folic acid which, especially in the 5-methyl-tetrahydrofolate form, is indispensable in the biochemical reaction described above.
Un altro vantaggio del prodotto cosmetico è che lo pterostilbene e, quindi, il 15 resveratrolo sono attivatori di SIRT1 stimolando così importanti azioni biologiche come l’incremento della longevità cellulare. Another advantage of the cosmetic product is that pterostilbene and, therefore, resveratrol 15 are activators of SIRT1 thus stimulating important biological actions such as increasing cellular longevity.
Un ulteriore vantaggio è dato dal fatto che la trimetilglicina, oltre all’azione metilante, è in grado di svolgere azione di conversione in S-adenosilmetionina (SAM) e quindi di estendere l’azione ad altre molecole attraverso reazioni di trans-20 metilazione. A further advantage is given by the fact that trimethylglycine, in addition to the methylating action, is able to convert into S-adenosylmethionine (SAM) and therefore to extend the action to other molecules through trans-20 methylation reactions.
La presenza dei sopra descritti vantaggi è accentuata dal TA-65 che, riattivando l’enzima telomerasi (enzima operante il riallungamento dei telomeri) e aiutando la rigenerazione del DNA, amplifica gli etffetti anti-age dello pterostilbene. The presence of the advantages described above is accentuated by TA-65 which, by reactivating the telomerase enzyme (enzyme operating the telomere re-elongation) and helping DNA regeneration, amplifies the anti-aging effects of pterostilbene.
L’azione anti-age dello pterostilbene e quindi del prodotto cosmetico è coadiuvata 25 dagli oligosaccaridi che migliorano l'aspetto generale della pelle matura e in dettaglio favoriscono la protezione della matrice extracellulare, stimolando la sintesi del collagene e limitando la degradazione della stessa grazie alla diminuzione dell'attività della metalloproteinasi-1 indotta da radiazioni UV. The anti-aging action of pterostilbene and therefore of the cosmetic product is supported 25 by oligosaccharides which improve the general appearance of mature skin and in detail favor the protection of the extracellular matrix, stimulating the synthesis of collagen and limiting its degradation thanks to the decrease in the activity of metalloproteinase-1 induced by UV radiation.
Le sopradescritte azioni di scavenger e anti-age sono sinergicamente 5 incrementate dall’acido ialuronico e dal coenzima Q10 che protegge le strutture cellulari dai radicali liberi sinergicamente alla vitamina E. The aforementioned scavenger and anti-aging actions are synergistically 5 increased by hyaluronic acid and coenzyme Q10 which protects cell structures from free radicals synergistically with vitamin E.
Altri vantaggi sono dati dalla vitamina B5 che agisce come precursore della produzione dei grassi, dei corticosteroidi, degli ormoni sessuali definendo una significativa azione idratante, emolliente, ammorbidente e protettiva della pelle. 10 Tale effetto è coadiuvato e quindi accentuato dalla presenza di estratti di Fucus vesicolosus grazie al proprio contenuto di alginati, polisaccaridi capaci di legare grandi quantità di acqua. Other advantages are given by vitamin B5 which acts as a precursor for the production of fats, corticosteroids, sex hormones, defining a significant moisturizing, emollient, softening and protective action on the skin. 10 This effect is supported and therefore accentuated by the presence of Fucus vesicolosus extracts thanks to its content of alginates, polysaccharides capable of binding large quantities of water.
Dette azioni anti-age e idratante proprie del prodotto cosmetico sono accentuate dall’acido ialuronico e dagli estratti di Alga arthrospira fusiformis che, avendo un 15 elevato contenuto proteico e una particolare composizione aminoacidica, forniscono un’ottima base nutritiva per la produzione endogena di collagene e di tutte le proteine alla base della regolazione del processo di idratazione della cute. Un altro vantaggio è dato dalla presenza di Arthrospira consente di somministrare dall'esterno sostanze azotate di elevato valore biologico, favorendo così l’azione 20 dei principi attivi del prodotto cosmetico qui descritto. These anti-aging and moisturizing actions of the cosmetic product are accentuated by the hyaluronic acid and the extracts of Alga arthrospira fusiformis which, having a high protein content and a particular amino acid composition, provide an excellent nutritional base for the endogenous production of collagen and of all the proteins at the base of the regulation of the skin's hydration process. Another advantage is given by the presence of Arthrospira, which allows you to administer nitrogenous substances of high biological value from the outside, thus favoring the action 20 of the active ingredients of the cosmetic product described here.
L’invenzione è suscettibile di varianti rientranti nell'ambito del concetto inventivo definito dalle rivendicazioni. In tale ambito tutti i dettagli sono sostituibili da elementi equivalenti e i materiali, le forme e le dimensioni possono essere qualsiasi. The invention is susceptible of variants falling within the scope of the inventive concept defined by the claims. In this context, all the details can be replaced by equivalent elements and the materials, shapes and dimensions can be any.
25 25
Claims (10)
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| EP2005941A2 (en) * | 2007-06-01 | 2008-12-24 | Henkel AG & Co. KGaA | Cellular rejuvenation compounds |
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