IT1400119B1 - Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali. - Google Patents

Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali.

Info

Publication number
IT1400119B1
IT1400119B1 ITMI2010A000929A ITMI20100929A IT1400119B1 IT 1400119 B1 IT1400119 B1 IT 1400119B1 IT MI2010A000929 A ITMI2010A000929 A IT MI2010A000929A IT MI20100929 A ITMI20100929 A IT MI20100929A IT 1400119 B1 IT1400119 B1 IT 1400119B1
Authority
IT
Italy
Prior art keywords
mesalazine
derivatives
treatment
new
inflammatory diseases
Prior art date
Application number
ITMI2010A000929A
Other languages
English (en)
Inventor
Carla Labruzzo
Original Assignee
Sofar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sofar Spa filed Critical Sofar Spa
Priority to ITMI2010A000929A priority Critical patent/IT1400119B1/it
Priority to CA2799893A priority patent/CA2799893C/en
Priority to LTEP11729709.3T priority patent/LT2576495T/lt
Priority to PCT/IB2011/052175 priority patent/WO2011148297A1/en
Priority to ES11729709.3T priority patent/ES2653337T3/es
Priority to EP11729709.3A priority patent/EP2576495B1/en
Publication of ITMI20100929A1 publication Critical patent/ITMI20100929A1/it
Priority to US13/683,101 priority patent/US9193673B2/en
Application granted granted Critical
Publication of IT1400119B1 publication Critical patent/IT1400119B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ITMI2010A000929A 2010-05-24 2010-05-24 Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali. IT1400119B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI2010A000929A IT1400119B1 (it) 2010-05-24 2010-05-24 Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali.
CA2799893A CA2799893C (en) 2010-05-24 2011-05-18 Novel derivatives of mesalazine, process for their preparation and their use in the treatment of intestinal inflammatory diseases
LTEP11729709.3T LT2576495T (lt) 2010-05-24 2011-05-18 Nauji mesalazino dariniai, jų gavimo būdas ir naudojimas uždegiminių žarnyno ligų gydymui
PCT/IB2011/052175 WO2011148297A1 (en) 2010-05-24 2011-05-18 Novel derivatives of mesalazine, process of their preparation and their use in the treatment of intestinal inflammatory diseases
ES11729709.3T ES2653337T3 (es) 2010-05-24 2011-05-18 Nuevos derivados de mesalazina, procedimiento para su preparación, y su utilización en el tratamiento de enfermedades inflamatorias intestinales
EP11729709.3A EP2576495B1 (en) 2010-05-24 2011-05-18 Novel derivatives of mesalazine, process for their preparation and their use in the treatment of intestinal inflammatory diseases
US13/683,101 US9193673B2 (en) 2010-05-24 2012-11-21 Derivatives of mesalazine, process of their preparation and their use in the treatment of intestinal inflammatory diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A000929A IT1400119B1 (it) 2010-05-24 2010-05-24 Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali.

Publications (2)

Publication Number Publication Date
ITMI20100929A1 ITMI20100929A1 (it) 2011-11-25
IT1400119B1 true IT1400119B1 (it) 2013-05-17

Family

ID=43332532

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A000929A IT1400119B1 (it) 2010-05-24 2010-05-24 Nuovi derivati della mesalazina, processo di sintesi ed uso nel trattamento di malattie infiammatorie intestinali.

Country Status (7)

Country Link
US (1) US9193673B2 (it)
EP (1) EP2576495B1 (it)
CA (1) CA2799893C (it)
ES (1) ES2653337T3 (it)
IT (1) IT1400119B1 (it)
LT (1) LT2576495T (it)
WO (1) WO2011148297A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20111288A1 (it) * 2011-07-11 2013-01-12 Chemi Spa Precursore farmaceutico di un principio attivo antiinfiammatorio
CN103351307A (zh) * 2013-06-09 2013-10-16 西安交通大学 2-(丁酰氧基)-5-氨基苯甲酸及其制备方法和应用
SG10202101247QA (en) * 2016-08-11 2021-03-30 Cellix Bio Private Ltd Compositions and methods for the treatment of irritable bowel syndrome

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060270635A1 (en) * 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid

Also Published As

Publication number Publication date
ITMI20100929A1 (it) 2011-11-25
EP2576495B1 (en) 2017-10-25
US9193673B2 (en) 2015-11-24
EP2576495A1 (en) 2013-04-10
US20130079399A1 (en) 2013-03-28
CA2799893A1 (en) 2011-12-01
LT2576495T (lt) 2018-02-12
WO2011148297A1 (en) 2011-12-01
CA2799893C (en) 2018-08-21
ES2653337T3 (es) 2018-02-06

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