IT1398773B1 - Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico. - Google Patents

Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico.

Info

Publication number
IT1398773B1
IT1398773B1 ITRM2009A000489A ITRM20090489A IT1398773B1 IT 1398773 B1 IT1398773 B1 IT 1398773B1 IT RM2009A000489 A ITRM2009A000489 A IT RM2009A000489A IT RM20090489 A ITRM20090489 A IT RM20090489A IT 1398773 B1 IT1398773 B1 IT 1398773B1
Authority
IT
Italy
Prior art keywords
inhibitric
oligonucleotid
cycline
sequences
expression
Prior art date
Application number
ITRM2009A000489A
Other languages
English (en)
Inventor
Emanuela Guerra
Saverio Alberti
Original Assignee
Alberti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alberti filed Critical Alberti
Priority to ITRM2009A000489A priority Critical patent/IT1398773B1/it
Publication of ITRM20090489A1 publication Critical patent/ITRM20090489A1/it
Application granted granted Critical
Publication of IT1398773B1 publication Critical patent/IT1398773B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ITRM2009A000489A 2008-09-25 2009-09-25 Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico. IT1398773B1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ITRM2009A000489A IT1398773B1 (it) 2008-09-25 2009-09-25 Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000021A ITCH20080021A1 (it) 2008-09-25 2008-09-25 Usi in diagnosi e terapia dei tumori di un rna di fusione tra ciclina d1 e trop2
ITRM2009A000489A IT1398773B1 (it) 2008-09-25 2009-09-25 Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico.

Publications (2)

Publication Number Publication Date
ITRM20090489A1 ITRM20090489A1 (it) 2010-03-26
IT1398773B1 true IT1398773B1 (it) 2013-03-18

Family

ID=40584776

Family Applications (2)

Application Number Title Priority Date Filing Date
IT000021A ITCH20080021A1 (it) 2008-09-25 2008-09-25 Usi in diagnosi e terapia dei tumori di un rna di fusione tra ciclina d1 e trop2
ITRM2009A000489A IT1398773B1 (it) 2008-09-25 2009-09-25 Sequenze oligonucleotidiche inibitrici dell'espressione della chimera ciclina d1/trop2 e loro uso in campo medico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IT000021A ITCH20080021A1 (it) 2008-09-25 2008-09-25 Usi in diagnosi e terapia dei tumori di un rna di fusione tra ciclina d1 e trop2

Country Status (7)

Country Link
US (1) US8507664B2 (it)
EP (1) EP2342342B1 (it)
JP (1) JP2012503483A (it)
AU (1) AU2009297961B2 (it)
CA (1) CA2743354C (it)
IT (2) ITCH20080021A1 (it)
WO (1) WO2010035304A2 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073522A1 (es) 2008-09-30 2010-11-10 Biolab Sanus Farmaceutica Ltda Compuestos derivados de 2-(3-metilenodioxi) - benzoil indol
ITCH20120016A1 (it) * 2012-11-12 2014-05-13 Saverio Alberti Sequenze oligonucleotidiche che inibiscono l¿espressione di mrna chimerici che controllano la crescita di cellule tumorali e loro uso in campo medico
KR101620623B1 (ko) 2013-10-25 2016-05-24 건국대학교 산학협력단 Cyclin D1 발현을 억제하는 shRNA
JP6746845B2 (ja) * 2015-04-22 2020-08-26 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． 循環ｔｒｏｐ−２陽性癌細胞の単離、検出、診断及び／または特徴付け
WO2017120504A1 (en) 2016-01-08 2017-07-13 Durfee Paul N Osteotropic nanoparticles for prevention or treatment of bone metastases
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050164224A1 (en) * 2001-05-18 2005-07-28 Sirna Therapeutics, Inc. RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
ES2766549T3 (es) * 2005-02-03 2020-06-12 Coda Therapeutics Ltd Compuestos anticonexina 43 para el tratamiento de heridas crónicas

Also Published As

Publication number Publication date
EP2342342A2 (en) 2011-07-13
CA2743354C (en) 2017-11-21
ITCH20080021A1 (it) 2010-03-26
US8507664B2 (en) 2013-08-13
CA2743354A1 (en) 2010-04-01
US20110213015A1 (en) 2011-09-01
AU2009297961A1 (en) 2010-04-01
AU2009297961A8 (en) 2011-04-28
JP2012503483A (ja) 2012-02-09
WO2010035304A2 (en) 2010-04-01
AU2009297961B2 (en) 2014-10-30
WO2010035304A3 (en) 2010-07-29
ITRM20090489A1 (it) 2010-03-26
EP2342342B1 (en) 2016-04-20

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