IT1396528B1 - Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). - Google Patents

Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).

Info

Publication number
IT1396528B1
IT1396528B1 ITFI2009A000007A ITFI20090007A IT1396528B1 IT 1396528 B1 IT1396528 B1 IT 1396528B1 IT FI2009A000007 A ITFI2009A000007 A IT FI2009A000007A IT FI20090007 A ITFI20090007 A IT FI20090007A IT 1396528 B1 IT1396528 B1 IT 1396528B1
Authority
IT
Italy
Prior art keywords
vwf
fibronectin
purification process
highly selective
von willebrand
Prior art date
Application number
ITFI2009A000007A
Other languages
English (en)
Italian (it)
Inventor
Filippo Mori
Ilaria Nardini
Paola Rossi
Claudia Nardini
Original Assignee
Kedrion Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kedrion Spa filed Critical Kedrion Spa
Priority to ITFI2009A000007A priority Critical patent/IT1396528B1/it
Priority to PCT/IB2010/050230 priority patent/WO2010082184A1/fr
Priority to AU2010205403A priority patent/AU2010205403B2/en
Priority to CA2749902A priority patent/CA2749902C/fr
Priority to US13/145,038 priority patent/US9422361B2/en
Priority to ES10706368T priority patent/ES2420535T3/es
Priority to EP10706368.7A priority patent/EP2387582B1/fr
Publication of ITFI20090007A1 publication Critical patent/ITFI20090007A1/it
Application granted granted Critical
Publication of IT1396528B1 publication Critical patent/IT1396528B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ITFI2009A000007A 2009-01-19 2009-01-19 Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). IT1396528B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITFI2009A000007A IT1396528B1 (it) 2009-01-19 2009-01-19 Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).
PCT/IB2010/050230 WO2010082184A1 (fr) 2009-01-19 2010-01-19 Nouveau procédé de purification hautement sélective de deux protéines du plasma : le facteur willebrand (vwf) et la fibronectine (fn)
AU2010205403A AU2010205403B2 (en) 2009-01-19 2010-01-19 New process for highly selective purification of two plasma proteins: von Willebrand factor (vWF) and Fibronectin (Fn)
CA2749902A CA2749902C (fr) 2009-01-19 2010-01-19 Nouveau procede de purification hautement selective de deux proteines du plasma : le facteur willebrand (vwf) et la fibronectine (fn)
US13/145,038 US9422361B2 (en) 2009-01-19 2010-01-19 Process for highly selective purification of two plasma proteins: von willebrand factor (vWF) and fibronectin (Fn)
ES10706368T ES2420535T3 (es) 2009-01-19 2010-01-19 Nuevo proceso para la purificación altamente selectiva de dos proteínas plasmáticas: factor de von willebrand (vwf) y fibronectina (fn).
EP10706368.7A EP2387582B1 (fr) 2009-01-19 2010-01-19 Methode de purification du facteur von willebrand (vwf) et de la fibronectine (fn).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI2009A000007A IT1396528B1 (it) 2009-01-19 2009-01-19 Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).

Publications (2)

Publication Number Publication Date
ITFI20090007A1 ITFI20090007A1 (it) 2010-07-20
IT1396528B1 true IT1396528B1 (it) 2012-12-14

Family

ID=40941762

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI2009A000007A IT1396528B1 (it) 2009-01-19 2009-01-19 Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).

Country Status (7)

Country Link
US (1) US9422361B2 (fr)
EP (1) EP2387582B1 (fr)
AU (1) AU2010205403B2 (fr)
CA (1) CA2749902C (fr)
ES (1) ES2420535T3 (fr)
IT (1) IT1396528B1 (fr)
WO (1) WO2010082184A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103274954B (zh) * 2013-05-22 2016-01-06 厦门世达膜科技有限公司 一种甘氨酸生产工艺
CN105622747A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种vWF活性保护液
CN105541997A (zh) * 2016-02-04 2016-05-04 江西博雅生物制药股份有限公司 一种高纯度和高活性血管性血友病因子的制备工艺
CN105622746A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺
CA3079956C (fr) 2017-10-27 2023-06-27 Green Cross Holdings Corporation Procede de preparation d'une composition contenant un facteur 8 capable de controler la teneur en facteur von willebrand (facteur vw) et facteurvon willebrand

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632309B1 (fr) 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
FR2665449B1 (fr) 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.
FR2673632A1 (fr) 1991-03-08 1992-09-11 Lille Transfusion Sanguine Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.
AT406867B (de) 1997-02-27 2000-10-25 Immuno Ag Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex
EP1148063A1 (fr) * 2000-04-18 2001-10-24 Octapharma AG Composition contenant du vWF (facteur von Willebrand) hémostatique actif et procédé pour sa préparation
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
DE102004044429B4 (de) * 2004-09-14 2009-04-30 Biotest Ag Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor
ITLU20070007A1 (it) 2007-05-07 2008-11-08 Kedrion Spa Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand.

Also Published As

Publication number Publication date
EP2387582A1 (fr) 2011-11-23
EP2387582B1 (fr) 2013-04-17
US9422361B2 (en) 2016-08-23
US20110282032A1 (en) 2011-11-17
ITFI20090007A1 (it) 2010-07-20
CA2749902C (fr) 2019-09-17
CA2749902A1 (fr) 2010-07-22
WO2010082184A1 (fr) 2010-07-22
AU2010205403B2 (en) 2014-04-10
AU2010205403A1 (en) 2011-09-01
ES2420535T3 (es) 2013-08-23

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