IT1301994B1 - HYALURONIC ACID DERIVATIVES. - Google Patents

HYALURONIC ACID DERIVATIVES.

Info

Publication number
IT1301994B1
IT1301994B1 IT1998MI001836A ITMI981836A IT1301994B1 IT 1301994 B1 IT1301994 B1 IT 1301994B1 IT 1998MI001836 A IT1998MI001836 A IT 1998MI001836A IT MI981836 A ITMI981836 A IT MI981836A IT 1301994 B1 IT1301994 B1 IT 1301994B1
Authority
IT
Italy
Prior art keywords
hyaluronic acid
salts
acid derivatives
molecular weight
high molecular
Prior art date
Application number
IT1998MI001836A
Other languages
Italian (it)
Inventor
Giuliana Abbiati
Original Assignee
Jasper Ltd Liability Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jasper Ltd Liability Co filed Critical Jasper Ltd Liability Co
Publication of ITMI981836A0 publication Critical patent/ITMI981836A0/en
Priority to IT1998MI001836A priority Critical patent/IT1301994B1/en
Priority to ES99936979T priority patent/ES2190653T3/en
Priority to PCT/IT1999/000250 priority patent/WO2000008061A1/en
Priority to DE69906128T priority patent/DE69906128T2/en
Priority to AT99936979T priority patent/ATE234867T1/en
Priority to CA002339290A priority patent/CA2339290C/en
Priority to EP99936979A priority patent/EP1137671B1/en
Priority to JP2000563692A priority patent/JP2002522570A/en
Priority to US09/744,685 priority patent/US6495148B1/en
Publication of ITMI981836A1 publication Critical patent/ITMI981836A1/en
Application granted granted Critical
Publication of IT1301994B1 publication Critical patent/IT1301994B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

New high molecular weight salts of hyaluronic acid, especially salts having as a counterion a natural amino acid are described. They are prepared starting from high molecular weight hyaluronic acid or its salts. These high molecular weight salts of hyaluronic acid are advantageously employed in cosmetic and pharmaceutical uses.
IT1998MI001836A 1998-08-05 1998-08-05 HYALURONIC ACID DERIVATIVES. IT1301994B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT1998MI001836A IT1301994B1 (en) 1998-08-05 1998-08-05 HYALURONIC ACID DERIVATIVES.
AT99936979T ATE234867T1 (en) 1998-08-05 1999-07-29 REACTION PRODUCTS OF HYALURONIC ACID AND NATURAL AMINO ACIDS AND THEIR USE IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS
PCT/IT1999/000250 WO2000008061A1 (en) 1998-08-05 1999-07-29 Reaction products of hyaluronic acid and natural amino acids and their use in cosmetic and pharmaceutical compositions
DE69906128T DE69906128T2 (en) 1998-08-05 1999-07-29 REACTION PRODUCTS OF HYALURONIC ACID AND NATURAL AMINO ACIDS AND THEIR USE IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS
ES99936979T ES2190653T3 (en) 1998-08-05 1999-07-29 Reaction products of hyaluronic acid and amino NATURAL and their use in cosmetic and pharmaceutical compositions.
CA002339290A CA2339290C (en) 1998-08-05 1999-07-29 Reaction products of hyaluronic acid and natural amino acids and their use in cosmetic and pharmaceutical compositions
EP99936979A EP1137671B1 (en) 1998-08-05 1999-07-29 Reaction products of hyaluronic acid and natural amino acids and their use in cosmetic and pharmaceutical compositions
JP2000563692A JP2002522570A (en) 1998-08-05 1999-07-29 Reaction product of hyaluronic acid and natural amino acid, and use in cosmetic and pharmaceutical compositions
US09/744,685 US6495148B1 (en) 1998-08-05 1999-07-29 Reaction products of hyaluronic acid and natural amino acids and their use in cosmetic and pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI001836A IT1301994B1 (en) 1998-08-05 1998-08-05 HYALURONIC ACID DERIVATIVES.

Publications (3)

Publication Number Publication Date
ITMI981836A0 ITMI981836A0 (en) 1998-08-05
ITMI981836A1 ITMI981836A1 (en) 2000-02-05
IT1301994B1 true IT1301994B1 (en) 2000-07-20

Family

ID=11380614

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998MI001836A IT1301994B1 (en) 1998-08-05 1998-08-05 HYALURONIC ACID DERIVATIVES.

Country Status (9)

Country Link
US (1) US6495148B1 (en)
EP (1) EP1137671B1 (en)
JP (1) JP2002522570A (en)
AT (1) ATE234867T1 (en)
CA (1) CA2339290C (en)
DE (1) DE69906128T2 (en)
ES (1) ES2190653T3 (en)
IT (1) IT1301994B1 (en)
WO (1) WO2000008061A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ524076A (en) * 2000-07-31 2004-07-30 Dermal Res Lab Inc Preventing or treating diseases associated with allergies, autoimmunity and adhesion, metastatic and coronary cascades using complex carbohydrates, in particular hyaluronic acid
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
WO2002094256A1 (en) * 2001-05-23 2002-11-28 Debatosh Datta Lysine and/or analogues and/or polymers thereof for promoting wound healing and angiogenesis
US20050142208A1 (en) 2002-05-09 2005-06-30 Won Min Yoo Pharmceutical composition for treatment of wounds conntaining blood plasma or serum
CZ13928U1 (en) * 2003-10-08 2004-01-20 Cpn Spol. S R.O. Dietetic preparation for the prevention and treatment of osteoporosis
JP2007511213A (en) * 2003-11-14 2007-05-10 アクヴァノヴァ・ジャーマン・ソリュービリセイト・テクノロジーズ・（アーゲーテー）・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Oily composition containing fluid active ingredients
CZ297658B6 (en) * 2004-05-06 2007-02-28 Cpn Spol. S R. O. Process for preparing hyaluronate derivatives attached by carbamate bond
CZ297711B6 (en) * 2004-05-06 2007-03-07 Cpn Spol. S R. O. Process for preparing hyaluronate derivatives attached by ether or amine bond
US7956180B2 (en) * 2004-05-27 2011-06-07 Novozymes A/S Dried and agglomerated hyaluronic acid product
DE102004057417A1 (en) * 2004-11-26 2006-06-01 Aquanova German Solubilisate Technologies (Agt) Gmbh Method for defoaming a composition used during the production of foodstuff comprises adding wax to the composition heated to the melting temperature of the wax
WO2007010924A1 (en) * 2005-07-21 2007-01-25 National University Corporation University Of Toyama Gelatinized product of cell, and preparation system for high density cell or tissue array
US7323184B2 (en) 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
KR100939983B1 (en) 2006-10-31 2010-02-03 주식회사 엘지생명과학 Hyaluronic Acid and Hydrophobic Poly Amino Acid Copolymer
US7691419B2 (en) * 2007-12-20 2010-04-06 Dileva Rose Marie Compositions and methods for treating skin conditions in mammals
EP2249640A1 (en) * 2008-02-05 2010-11-17 Mario Antonello Principato Pupicidal and larvicidal composition
KR101449687B1 (en) * 2008-03-13 2014-10-14 주식회사 바이오랜드 Anti-aging Composition for external Use comprising low and high molecular weight hyaluronic acids and the polysaccharides extracted from roots of Ulmus davidiana var. japonica
JP5722217B2 (en) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． Yarn of hyaluronic acid and / or its derivative, method for its preparation and use thereof
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
EP3520827B1 (en) 2010-03-22 2022-05-25 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102015676B1 (en) 2011-06-03 2019-10-21 알러간, 인코포레이티드 Dermal filler compositions including antioxidants
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
WO2014041528A2 (en) * 2012-09-14 2014-03-20 Martin Roslain Margaret A composition
GR1008308B (en) * 2013-05-31 2014-10-02 UNI-PHARMA ΚΛΕΩΝ ΤΣΕΤΗΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΕΡΓΑΣΤΗΡΙΑ ΑΒΕΕ με δ.τ. "UNI-PHARMA ABEE", Local pharmaceutical and medi-tech compositions containing combinations of sucralfat, hyaluronic acid, arginine and one natural moistening factor
EP3620184A1 (en) 2014-09-30 2020-03-11 Allergan Industrie, SAS Stable hydrogel compositions including additives
IT201700048653A1 (en) 2017-05-05 2018-11-05 Mattei Gianmario SUPRAMOLECULAR COMPOUNDS CONSISTING OF HYALURONIC ACID, SODIUM, ESSENTIAL (OR NON-ESSENTIAL) AMINO ACIDS, LINOLEIC ACID, LYCOPENE AND REVESTRADIOL.
WO2019131892A1 (en) * 2017-12-27 2019-07-04 ロート製薬株式会社 External composition containing ascorbic acid and/or salt thereof
WO2019202015A1 (en) * 2018-04-18 2019-10-24 i.com medical GmbH High molecular weight hyaluronic acid for enhancing epithelial survival and reconstitution of body surfaces
CN114364366B (en) * 2019-09-03 2024-10-15 株式会社Lg生活健康 Cosmetic composition comprising a polymer with improved solubility in the solid phase
KR102444133B1 (en) * 2019-09-03 2022-09-19 주식회사 엘지생활건강 Cosmetic composition comprising solid polymer components having improved solubility
US11684586B1 (en) 2022-02-28 2023-06-27 Peace Out, Llc Anhydrous hydrocolloid matrix comprising homogeneously distributed encapsulated therapeutic agents

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JPS59219209A (en) * 1983-05-28 1984-12-10 Kanebo Ltd Skin cosmetic
US5702688A (en) * 1986-12-23 1997-12-30 Tristrata Technology, Inc. Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
US5527893A (en) 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
IT1268955B1 (en) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl ACTIVE ESTERS OF CARBOXYL POLYSACCHARIDES
JPH08283138A (en) * 1995-04-12 1996-10-29 Toyo Beauty Kk Skin cosmetic
JPH09227385A (en) * 1996-02-29 1997-09-02 Ofutekusu:Kk Adjuvant for ophthalmic operation
JPH10194949A (en) * 1997-01-06 1998-07-28 Pola Chem Ind Inc Lotion for improving skin condition

Also Published As

Publication number Publication date
US6495148B1 (en) 2002-12-17
ES2190653T3 (en) 2003-08-01
EP1137671A1 (en) 2001-10-04
CA2339290C (en) 2008-09-16
JP2002522570A (en) 2002-07-23
ATE234867T1 (en) 2003-04-15
DE69906128T2 (en) 2003-10-30
ITMI981836A1 (en) 2000-02-05
CA2339290A1 (en) 2000-02-17
EP1137671B1 (en) 2003-03-19
DE69906128D1 (en) 2003-04-24
ITMI981836A0 (en) 1998-08-05
WO2000008061A1 (en) 2000-02-17

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