IT1301807B1 - Formulazioni farmaceutiche iniettabili di derivati della partricina. - Google Patents
Formulazioni farmaceutiche iniettabili di derivati della partricina.Info
- Publication number
- IT1301807B1 IT1301807B1 IT1998MI001457A ITMI981457A IT1301807B1 IT 1301807 B1 IT1301807 B1 IT 1301807B1 IT 1998MI001457 A IT1998MI001457 A IT 1998MI001457A IT MI981457 A ITMI981457 A IT MI981457A IT 1301807 B1 IT1301807 B1 IT 1301807B1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- pharmaceutical formulations
- injectable pharmaceutical
- partricine
- partricin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NVJUPMZQNWDHTL-BGZDCYLNSA-N 3-[(2s,3r,4r,5r,6s)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-23,27,29,31,33,35,37-heptahydroxy-18-methyl-21,25-dioxo-20,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylic acid Chemical class O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)C=CC=CC=CC=CC=CC=CC=CC(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-BGZDCYLNSA-N 0.000 title 1
- NVJUPMZQNWDHTL-MJODAWFJSA-N partricin Chemical class O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-MJODAWFJSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/905—Specially adapted for travel through blood circulatory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001457A IT1301807B1 (it) | 1998-06-25 | 1998-06-25 | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
| AT99914507T ATE301453T1 (de) | 1998-06-25 | 1999-03-11 | Injizierbare arzneiformulierungen von partricin derivaten |
| DK99914507T DK1089710T3 (da) | 1998-06-25 | 1999-03-11 | Injicerbare farmaceutiske formuleringer af partricinderivater |
| PCT/EP1999/001571 WO1999066902A1 (en) | 1998-06-25 | 1999-03-11 | Injectable pharmaceutical formulations of partricin derivatives |
| PT99914507T PT1089710E (pt) | 1998-06-25 | 1999-03-11 | Formulas farmaceuticas injectaveis de derivados da partricina |
| DE69926633T DE69926633T2 (de) | 1998-06-25 | 1999-03-11 | Injizierbare arzneiformulierungen von partricin derivaten |
| KR1020007014665A KR100622290B1 (ko) | 1998-06-25 | 1999-03-11 | 파르트리신 유도체의 주사가능한 약제학적 제형 |
| EP99914507A EP1089710B1 (en) | 1998-06-25 | 1999-03-11 | Injectable pharmaceutical formulations of partricin derivatives |
| JP2000555588A JP4719355B2 (ja) | 1998-06-25 | 1999-03-11 | パルトリシン誘導体の注射可能な薬学的処方物 |
| US09/720,236 US6586407B1 (en) | 1998-06-25 | 1999-03-11 | Injectable pharmaceutical formulations for partricin derivatives |
| ES99914507T ES2245096T3 (es) | 1998-06-25 | 1999-03-11 | Formulaciones farmaceuticas inyectables de derivados de partricina. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001457A IT1301807B1 (it) | 1998-06-25 | 1998-06-25 | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI981457A1 ITMI981457A1 (it) | 1999-12-25 |
| IT1301807B1 true IT1301807B1 (it) | 2000-07-07 |
Family
ID=11380320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1998MI001457A IT1301807B1 (it) | 1998-06-25 | 1998-06-25 | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6586407B1 (enExample) |
| EP (1) | EP1089710B1 (enExample) |
| JP (1) | JP4719355B2 (enExample) |
| KR (1) | KR100622290B1 (enExample) |
| AT (1) | ATE301453T1 (enExample) |
| DE (1) | DE69926633T2 (enExample) |
| DK (1) | DK1089710T3 (enExample) |
| ES (1) | ES2245096T3 (enExample) |
| IT (1) | IT1301807B1 (enExample) |
| PT (1) | PT1089710E (enExample) |
| WO (1) | WO1999066902A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| WO2012051116A1 (en) * | 2010-10-12 | 2012-04-19 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| AU2019231699B2 (en) * | 2018-03-07 | 2023-03-09 | Andrew Xian Chen | Aqueous formulations for insoluble drugs |
| JP2024524636A (ja) * | 2021-07-12 | 2024-07-05 | バイオセウティカ・べー・フェー | ジアスコルビン酸アムシパトリシン（ａｍｃｉｐａｔｒｉｃｉｎ）の製造方法、及び従来の抗真菌剤に耐性のある侵襲性真菌感染症の処置のためのその使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1359473A (en) * | 1970-11-03 | 1974-07-10 | Prodotti Antibiotici Spa | Polyenic antibiotic |
| GB1406774A (en) * | 1973-02-15 | 1975-09-17 | Prodotti Antibiotici Spa | Esters of patricin and of partricin derivatives |
| GB1413256A (en) * | 1973-05-14 | 1975-11-12 | Prodotti Antibiotici Spa | Water-solubilised antibiotics |
| GB1463348A (en) * | 1974-09-03 | 1977-02-02 | Prodotti Antibiotici Spa | Water-solubilised compositions |
| IE60901B1 (en) * | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| EP0598116B1 (en) * | 1989-11-27 | 1996-07-24 | Nippon Shinyaku Company, Limited | Fat emulsion |
| JP2830243B2 (ja) * | 1989-12-21 | 1998-12-02 | 味の素株式会社 | ポリエン含有組成物 |
| IT1243404B (it) * | 1990-12-03 | 1994-06-10 | Prodotti Antibiotici Spa | Derivati della partricina |
| IT1283149B1 (it) * | 1996-07-12 | 1998-04-07 | Prodotti Antibiotici Spa | Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato |
-
1998
- 1998-06-25 IT IT1998MI001457A patent/IT1301807B1/it active IP Right Grant
-
1999
- 1999-03-11 JP JP2000555588A patent/JP4719355B2/ja not_active Expired - Fee Related
- 1999-03-11 US US09/720,236 patent/US6586407B1/en not_active Expired - Lifetime
- 1999-03-11 WO PCT/EP1999/001571 patent/WO1999066902A1/en not_active Ceased
- 1999-03-11 AT AT99914507T patent/ATE301453T1/de active
- 1999-03-11 ES ES99914507T patent/ES2245096T3/es not_active Expired - Lifetime
- 1999-03-11 DE DE69926633T patent/DE69926633T2/de not_active Expired - Lifetime
- 1999-03-11 EP EP99914507A patent/EP1089710B1/en not_active Expired - Lifetime
- 1999-03-11 PT PT99914507T patent/PT1089710E/pt unknown
- 1999-03-11 KR KR1020007014665A patent/KR100622290B1/ko not_active Expired - Fee Related
- 1999-03-11 DK DK99914507T patent/DK1089710T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999066902A8 (en) | 2001-02-15 |
| DE69926633T2 (de) | 2006-05-18 |
| PT1089710E (pt) | 2005-11-30 |
| ES2245096T3 (es) | 2005-12-16 |
| EP1089710B1 (en) | 2005-08-10 |
| JP4719355B2 (ja) | 2011-07-06 |
| US6586407B1 (en) | 2003-07-01 |
| ATE301453T1 (de) | 2005-08-15 |
| ITMI981457A1 (it) | 1999-12-25 |
| KR20010071581A (enExample) | 2001-07-28 |
| KR100622290B1 (ko) | 2006-09-11 |
| WO1999066902A1 (en) | 1999-12-29 |
| DE69926633D1 (de) | 2005-09-15 |
| JP2002518431A (ja) | 2002-06-25 |
| EP1089710A1 (en) | 2001-04-11 |
| DK1089710T3 (da) | 2005-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |