IT1299198B1 - Sali nitrati di farmaci antiulcera - Google Patents
Sali nitrati di farmaci antiulceraInfo
- Publication number
- IT1299198B1 IT1299198B1 IT98MI000442A ITMI980442A IT1299198B1 IT 1299198 B1 IT1299198 B1 IT 1299198B1 IT 98MI000442 A IT98MI000442 A IT 98MI000442A IT MI980442 A ITMI980442 A IT MI980442A IT 1299198 B1 IT1299198 B1 IT 1299198B1
- Authority
- IT
- Italy
- Prior art keywords
- salts
- nitrated
- och3
- ulcer drugs
- formula
- Prior art date
Links
- 239000003699 antiulcer agent Substances 0.000 title 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI000442A IT1299198B1 (it) | 1998-03-05 | 1998-03-05 | Sali nitrati di farmaci antiulcera |
| JP2000534547A JP2002505328A (ja) | 1998-03-05 | 1999-02-25 | 抗潰瘍医薬の硝酸塩 |
| CNB998035343A CN1249053C (zh) | 1998-03-05 | 1999-02-25 | 抗溃疡药物硝酸盐 |
| KR1020007009693A KR20010041522A (ko) | 1998-03-05 | 1999-02-25 | 항-궤양의 질산염 약제 |
| PT99911708T PT1068196E (pt) | 1998-03-05 | 1999-02-25 | Sais nitratos de medixamentos anti-ulceras |
| EP99911708A EP1068196B1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| PCT/EP1999/001226 WO1999045004A1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| BR9908428-7A BR9908428A (pt) | 1998-03-05 | 1999-02-25 | Sais de nitrato, composições, uso de sal e composição, e, processo para preparação de sais de nitrato |
| CA002322493A CA2322493A1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| SI9930655T SI1068196T1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| AU30303/99A AU752919B2 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| ES99911708T ES2226357T3 (es) | 1998-03-05 | 1999-02-25 | Nitratos que forman parte de un medicamento antiulceroso. |
| RU2000122968/04A RU2228331C2 (ru) | 1998-03-05 | 1999-02-25 | Нитратные соли гетероциклических соединений, способ их получения и фармацевтические композиции на их основе |
| HU0100853A HUP0100853A3 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine and pharmaceutical compositions containing the same compounds |
| IL13772199A IL137721A0 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| DK99911708T DK1068196T3 (da) | 1998-03-05 | 1999-02-25 | Salpetersyresalt af antiulcuslægemidler |
| AT99911708T ATE273297T1 (de) | 1998-03-05 | 1999-02-25 | Salpetersäuresalz von antiulcus arzneimitteln |
| US09/622,068 US6503929B1 (en) | 1998-03-05 | 1999-02-25 | Nitrate salt of anti-ulcer medicine |
| DE69919341T DE69919341T2 (de) | 1998-03-05 | 1999-02-25 | Salpetersäuresalz von antiulcus arzneimitteln |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI000442A IT1299198B1 (it) | 1998-03-05 | 1998-03-05 | Sali nitrati di farmaci antiulcera |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI980442A1 ITMI980442A1 (it) | 1999-09-05 |
| IT1299198B1 true IT1299198B1 (it) | 2000-02-29 |
Family
ID=11379185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT98MI000442A IT1299198B1 (it) | 1998-03-05 | 1998-03-05 | Sali nitrati di farmaci antiulcera |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6503929B1 (https=) |
| EP (1) | EP1068196B1 (https=) |
| JP (1) | JP2002505328A (https=) |
| KR (1) | KR20010041522A (https=) |
| CN (1) | CN1249053C (https=) |
| AT (1) | ATE273297T1 (https=) |
| AU (1) | AU752919B2 (https=) |
| BR (1) | BR9908428A (https=) |
| CA (1) | CA2322493A1 (https=) |
| DE (1) | DE69919341T2 (https=) |
| DK (1) | DK1068196T3 (https=) |
| ES (1) | ES2226357T3 (https=) |
| HU (1) | HUP0100853A3 (https=) |
| IL (1) | IL137721A0 (https=) |
| IT (1) | IT1299198B1 (https=) |
| PT (1) | PT1068196E (https=) |
| RU (1) | RU2228331C2 (https=) |
| SI (1) | SI1068196T1 (https=) |
| WO (1) | WO1999045004A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| AU772188B2 (en) | 1998-11-17 | 2004-04-08 | Nitromed, Inc. | Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| CA2393724A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
| SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
| JP4092203B2 (ja) | 2000-12-21 | 2008-05-28 | ニトロメッド，インク． | 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法 |
| US7129161B2 (en) * | 2001-07-19 | 2006-10-31 | Trikon Holdings Limited | Depositing a tantalum film |
| WO2003103602A2 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| AU2003279622A1 (en) | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| WO2004012659A2 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| RU2304967C2 (ru) * | 2005-05-26 | 2007-08-27 | Государственное общеобразовательное учреждение высшего профессионального образования Казанский государственный медицинский университет | Способ лечения язвенной болезни желудка и двенадцатиперстной кишки |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4375547A (en) * | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
| EP0224612A1 (de) | 1985-12-05 | 1987-06-10 | HEUMANN PHARMA GMBH & CO | Verfahren zur Herstellung von N-Cyano-N'-methyl-N"[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidin |
| ES2053462T3 (es) * | 1987-04-06 | 1994-08-01 | Heumann Pharma Gmbh & Co | Procedimiento para la produccion de derivados de nitroetano. |
| TW205041B (https=) * | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co |
-
1998
- 1998-03-05 IT IT98MI000442A patent/IT1299198B1/it active IP Right Grant
-
1999
- 1999-02-25 IL IL13772199A patent/IL137721A0/xx unknown
- 1999-02-25 US US09/622,068 patent/US6503929B1/en not_active Expired - Fee Related
- 1999-02-25 JP JP2000534547A patent/JP2002505328A/ja not_active Withdrawn
- 1999-02-25 CN CNB998035343A patent/CN1249053C/zh not_active Expired - Fee Related
- 1999-02-25 EP EP99911708A patent/EP1068196B1/en not_active Expired - Lifetime
- 1999-02-25 ES ES99911708T patent/ES2226357T3/es not_active Expired - Lifetime
- 1999-02-25 AU AU30303/99A patent/AU752919B2/en not_active Ceased
- 1999-02-25 DE DE69919341T patent/DE69919341T2/de not_active Expired - Fee Related
- 1999-02-25 KR KR1020007009693A patent/KR20010041522A/ko not_active Abandoned
- 1999-02-25 BR BR9908428-7A patent/BR9908428A/pt not_active Application Discontinuation
- 1999-02-25 RU RU2000122968/04A patent/RU2228331C2/ru not_active IP Right Cessation
- 1999-02-25 CA CA002322493A patent/CA2322493A1/en not_active Abandoned
- 1999-02-25 PT PT99911708T patent/PT1068196E/pt unknown
- 1999-02-25 WO PCT/EP1999/001226 patent/WO1999045004A1/en not_active Ceased
- 1999-02-25 DK DK99911708T patent/DK1068196T3/da active
- 1999-02-25 SI SI9930655T patent/SI1068196T1/xx unknown
- 1999-02-25 HU HU0100853A patent/HUP0100853A3/hu unknown
- 1999-02-25 AT AT99911708T patent/ATE273297T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100853A3 (en) | 2003-01-28 |
| JP2002505328A (ja) | 2002-02-19 |
| DE69919341T2 (de) | 2005-09-08 |
| HUP0100853A2 (hu) | 2001-10-28 |
| CN1291982A (zh) | 2001-04-18 |
| CN1249053C (zh) | 2006-04-05 |
| RU2228331C2 (ru) | 2004-05-10 |
| IL137721A0 (en) | 2001-10-31 |
| DK1068196T3 (da) | 2004-11-29 |
| AU752919B2 (en) | 2002-10-03 |
| CA2322493A1 (en) | 1999-09-10 |
| PT1068196E (pt) | 2004-10-29 |
| ATE273297T1 (de) | 2004-08-15 |
| EP1068196A1 (en) | 2001-01-17 |
| WO1999045004A1 (en) | 1999-09-10 |
| SI1068196T1 (en) | 2004-12-31 |
| US6503929B1 (en) | 2003-01-07 |
| DE69919341D1 (de) | 2004-09-16 |
| ES2226357T3 (es) | 2005-03-16 |
| EP1068196B1 (en) | 2004-08-11 |
| BR9908428A (pt) | 2000-10-31 |
| AU3030399A (en) | 1999-09-20 |
| ITMI980442A1 (it) | 1999-09-05 |
| KR20010041522A (ko) | 2001-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |