IT1270995B - Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporine - Google Patents
Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporineInfo
- Publication number
- IT1270995B IT1270995B ITMI941554A ITMI941554A IT1270995B IT 1270995 B IT1270995 B IT 1270995B IT MI941554 A ITMI941554 A IT MI941554A IT MI941554 A ITMI941554 A IT MI941554A IT 1270995 B IT1270995 B IT 1270995B
- Authority
- IT
- Italy
- Prior art keywords
- group
- azetidinon
- butenoic acid
- cephalosporins
- synthesis
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 2- (2-azetidinon-N-yl) -3-butenoic acid esters Chemical class 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004119 disulfanediyl group Chemical class *SS* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Si descrivono esteri di acido 2-(2-azetidinon-N-il)-3-butenoico di formula (I) (FORMULA I) In cui X è un gruppo acilamino Y è un gruppo ditio S-sostituito o un gruppo sulfoniltio oppure X ed Y sono uniti per formare un gruppo (a) (FORMULA II) In cui R1 è il residuo alifatico, aromatico o arilalifatico legato al carbonile del suddetto gruppo acilamino e R2 rappresenta un gruppo protettivo del carbossile. I composti (I) sono intermedi per la preparazione di derivati cefem non sostituiti in posizione 3.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941554A IT1270995B (it) | 1994-07-22 | 1994-07-22 | Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporine |
AU31648/95A AU3164895A (en) | 1994-07-22 | 1995-07-21 | 2-(2-azetidinon-n-yl)-2- and 3-butenoic acids derivatives and their use in the cephalosporine synthesis |
PCT/EP1995/002911 WO1996003373A1 (en) | 1994-07-22 | 1995-07-21 | 2-(2-azetidinon-n-yl)-2- and 3-butenoic acids derivatives and their use in the cephalosporine synthesis |
JP8505466A JPH10503190A (ja) | 1994-07-22 | 1995-07-21 | 2−(2−アゼチジノン−n−イル)−2−および3−ブテノン酸誘導体およびセファロスポリン合成におけるそれらの用途 |
EP95927711A EP0773928A1 (en) | 1994-07-22 | 1995-07-21 | 2-(2-azetidinon-n-yl)-2- and 3-butenoic acids derivatives and their use in the cephalosporine synthesis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941554A IT1270995B (it) | 1994-07-22 | 1994-07-22 | Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporine |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941554A0 ITMI941554A0 (it) | 1994-07-22 |
ITMI941554A1 ITMI941554A1 (it) | 1996-01-22 |
IT1270995B true IT1270995B (it) | 1997-05-26 |
Family
ID=11369339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941554A IT1270995B (it) | 1994-07-22 | 1994-07-22 | Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0773928A1 (it) |
JP (1) | JPH10503190A (it) |
AU (1) | AU3164895A (it) |
IT (1) | IT1270995B (it) |
WO (1) | WO1996003373A1 (it) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206361A (en) * | 1990-03-08 | 1993-04-27 | Otsuka Kagaku Kabushiki Kaisha | Thiazolinoazetidinone derivative |
JP2993576B2 (ja) * | 1991-03-11 | 1999-12-20 | 大塚化学株式会社 | アレニルβ−ラクタム化合物及びその製造法 |
-
1994
- 1994-07-22 IT ITMI941554A patent/IT1270995B/it active IP Right Grant
-
1995
- 1995-07-21 EP EP95927711A patent/EP0773928A1/en not_active Withdrawn
- 1995-07-21 AU AU31648/95A patent/AU3164895A/en not_active Abandoned
- 1995-07-21 JP JP8505466A patent/JPH10503190A/ja active Pending
- 1995-07-21 WO PCT/EP1995/002911 patent/WO1996003373A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ITMI941554A1 (it) | 1996-01-22 |
EP0773928A1 (en) | 1997-05-21 |
JPH10503190A (ja) | 1998-03-24 |
WO1996003373A1 (en) | 1996-02-08 |
AU3164895A (en) | 1996-02-22 |
ITMI941554A0 (it) | 1994-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |