IT1261646B - Derivati peptidici ad attivita' citostimolante e citoprotettiva - Google Patents

Derivati peptidici ad attivita' citostimolante e citoprotettiva

Info

Publication number
IT1261646B
IT1261646B ITMI921914A ITMI921914A IT1261646B IT 1261646 B IT1261646 B IT 1261646B IT MI921914 A ITMI921914 A IT MI921914A IT MI921914 A ITMI921914 A IT MI921914A IT 1261646 B IT1261646 B IT 1261646B
Authority
IT
Italy
Prior art keywords
derivatives
activities
citostimulating
citoprotective
peptidal
Prior art date
Application number
ITMI921914A
Other languages
English (en)
Original Assignee
Ellem Ind Farmaceutica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ellem Ind Farmaceutica filed Critical Ellem Ind Farmaceutica
Priority to ITMI921914A priority Critical patent/IT1261646B/it
Publication of ITMI921914A0 publication Critical patent/ITMI921914A0/it
Priority to AU47033/93A priority patent/AU4703393A/en
Priority to EP93917672A priority patent/EP0656009A1/en
Priority to JP6504972A priority patent/JPH07509704A/ja
Priority to PCT/EP1993/002004 priority patent/WO1994003482A1/en
Publication of ITMI921914A1 publication Critical patent/ITMI921914A1/it
Application granted granted Critical
Publication of IT1261646B publication Critical patent/IT1261646B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invenzione ha per oggetto derivati del peptide Gly-HisLys (GHL), ad attività citostimolante e citoprotettiva, al loro uso terapeutico e a composizioni farmaceutiche che li contengono. I derivati dell'invenzione sono dotati, oltre a migliorate attività terapeutiche, di sorprendente resistenza agli enzimi idrolitici.
ITMI921914A 1992-08-04 1992-08-04 Derivati peptidici ad attivita' citostimolante e citoprotettiva IT1261646B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI921914A IT1261646B (it) 1992-08-04 1992-08-04 Derivati peptidici ad attivita' citostimolante e citoprotettiva
AU47033/93A AU4703393A (en) 1992-08-04 1993-07-28 Glycyl-hystidyle-lysine (ghl) derivatives
EP93917672A EP0656009A1 (en) 1992-08-04 1993-07-28 Glycyl-hystidyle-lysine (ghl) derivatives
JP6504972A JPH07509704A (ja) 1992-08-04 1993-07-28 グリシルーヒスチジルーリシン（ｇｈｌ）誘導体
PCT/EP1993/002004 WO1994003482A1 (en) 1992-08-04 1993-07-28 Glycyl-hystidyle-lysine (ghl) derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921914A IT1261646B (it) 1992-08-04 1992-08-04 Derivati peptidici ad attivita' citostimolante e citoprotettiva

Publications (3)

Publication Number Publication Date
ITMI921914A0 ITMI921914A0 (it) 1992-08-04
ITMI921914A1 ITMI921914A1 (it) 1994-02-05
IT1261646B true IT1261646B (it) 1996-05-28

Family

ID=11363826

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921914A IT1261646B (it) 1992-08-04 1992-08-04 Derivati peptidici ad attivita' citostimolante e citoprotettiva

Country Status (5)

Country Link
EP (1) EP0656009A1 (it)
JP (1) JPH07509704A (it)
AU (1) AU4703393A (it)
IT (1) IT1261646B (it)
WO (1) WO1994003482A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538945A (en) * 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes
FR2791684B1 (fr) * 1999-03-30 2001-05-11 Sederma Sa Composition cosmetiques ou dermopharmaceutiques contenant le tripeptide n-n-biotinyl-gly-his-lys pour prevenir, reduire ou supprimer la chute des cheveux ainsi que pour favoriser leur repousse
FR2802413B1 (fr) * 1999-12-17 2003-10-31 Sederma Sa Compositions cosmetiques ou dermopharmaceutiques contenant le tripeptide n-palmytoyl-gly-hys-lys, pour eliminer, reduire ou prevenir l'apparition de rides quelles qu'en soient la localisation et la cause
WO2003030926A1 (en) * 2001-10-05 2003-04-17 Procyte Corporation Stable solutions of peptide copper complexes and cosmetic and pharmaceutical formulations produced therefrom
WO2004004671A1 (en) * 2002-07-02 2004-01-15 Procyte Corporation Compositions containing peptide copper complexes and soft tissue fillers
US6927206B2 (en) 2003-06-06 2005-08-09 Procyte Corporation Compositions and methods for treatment of rosacea
US7384916B2 (en) 2005-03-16 2008-06-10 Procyte Corporation Methods and compositions for preventing and treating aging or photodamaged skin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1184164B (it) * 1985-03-19 1987-10-22 Eniricerche Spa Triptidi ad azione ipotensiva e procedimento per la loro sintesi
ATE103608T1 (de) * 1987-04-20 1994-04-15 Procyte Corp Chemische derivate von ghl-cu.

Also Published As

Publication number Publication date
ITMI921914A0 (it) 1992-08-04
WO1994003482A1 (en) 1994-02-17
JPH07509704A (ja) 1995-10-26
EP0656009A1 (en) 1995-06-07
ITMI921914A1 (it) 1994-02-05
AU4703393A (en) 1994-03-03

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950830