IT1261646B - Derivati peptidici ad attivita' citostimolante e citoprotettiva - Google Patents
Derivati peptidici ad attivita' citostimolante e citoprotettivaInfo
- Publication number
- IT1261646B IT1261646B ITMI921914A ITMI921914A IT1261646B IT 1261646 B IT1261646 B IT 1261646B IT MI921914 A ITMI921914 A IT MI921914A IT MI921914 A ITMI921914 A IT MI921914A IT 1261646 B IT1261646 B IT 1261646B
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- activities
- citostimulating
- citoprotective
- peptidal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invenzione ha per oggetto derivati del peptide Gly-HisLys (GHL), ad attività citostimolante e citoprotettiva, al loro uso terapeutico e a composizioni farmaceutiche che li contengono. I derivati dell'invenzione sono dotati, oltre a migliorate attività terapeutiche, di sorprendente resistenza agli enzimi idrolitici.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921914A IT1261646B (it) | 1992-08-04 | 1992-08-04 | Derivati peptidici ad attivita' citostimolante e citoprotettiva |
JP6504972A JPH07509704A (ja) | 1992-08-04 | 1993-07-28 | グリシルーヒスチジルーリシン(ghl)誘導体 |
EP93917672A EP0656009A1 (en) | 1992-08-04 | 1993-07-28 | Glycyl-hystidyle-lysine (ghl) derivatives |
AU47033/93A AU4703393A (en) | 1992-08-04 | 1993-07-28 | Glycyl-hystidyle-lysine (ghl) derivatives |
PCT/EP1993/002004 WO1994003482A1 (en) | 1992-08-04 | 1993-07-28 | Glycyl-hystidyle-lysine (ghl) derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921914A IT1261646B (it) | 1992-08-04 | 1992-08-04 | Derivati peptidici ad attivita' citostimolante e citoprotettiva |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI921914A0 ITMI921914A0 (it) | 1992-08-04 |
ITMI921914A1 ITMI921914A1 (it) | 1994-02-05 |
IT1261646B true IT1261646B (it) | 1996-05-28 |
Family
ID=11363826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI921914A IT1261646B (it) | 1992-08-04 | 1992-08-04 | Derivati peptidici ad attivita' citostimolante e citoprotettiva |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0656009A1 (it) |
JP (1) | JPH07509704A (it) |
AU (1) | AU4703393A (it) |
IT (1) | IT1261646B (it) |
WO (1) | WO1994003482A1 (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5538945A (en) * | 1994-06-17 | 1996-07-23 | Procyte Corporation | Stimulation of hair growth by peptide copper complexes |
FR2791684B1 (fr) * | 1999-03-30 | 2001-05-11 | Sederma Sa | Composition cosmetiques ou dermopharmaceutiques contenant le tripeptide n-n-biotinyl-gly-his-lys pour prevenir, reduire ou supprimer la chute des cheveux ainsi que pour favoriser leur repousse |
FR2802413B1 (fr) * | 1999-12-17 | 2003-10-31 | Sederma Sa | Compositions cosmetiques ou dermopharmaceutiques contenant le tripeptide n-palmytoyl-gly-hys-lys, pour eliminer, reduire ou prevenir l'apparition de rides quelles qu'en soient la localisation et la cause |
US20030148927A1 (en) * | 2001-10-05 | 2003-08-07 | Procyte Corporation | Stable solutions of peptide copper complexes and cosmetic and pharmaceutical formulations produced therefrom |
JP2006504448A (ja) * | 2002-07-02 | 2006-02-09 | プロサイト コーポレイション | ペプチド銅錯体および軟組織充填物を含有する組成物 |
US6927206B2 (en) | 2003-06-06 | 2005-08-09 | Procyte Corporation | Compositions and methods for treatment of rosacea |
US7384916B2 (en) | 2005-03-16 | 2008-06-10 | Procyte Corporation | Methods and compositions for preventing and treating aging or photodamaged skin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1184164B (it) * | 1985-03-19 | 1987-10-22 | Eniricerche Spa | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
DE3888718T2 (de) * | 1987-04-20 | 1994-07-14 | Procyte Corp | Chemische Derivate von GHL-Cu. |
-
1992
- 1992-08-04 IT ITMI921914A patent/IT1261646B/it active IP Right Grant
-
1993
- 1993-07-28 JP JP6504972A patent/JPH07509704A/ja active Pending
- 1993-07-28 WO PCT/EP1993/002004 patent/WO1994003482A1/en not_active Application Discontinuation
- 1993-07-28 EP EP93917672A patent/EP0656009A1/en not_active Withdrawn
- 1993-07-28 AU AU47033/93A patent/AU4703393A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU4703393A (en) | 1994-03-03 |
EP0656009A1 (en) | 1995-06-07 |
ITMI921914A0 (it) | 1992-08-04 |
JPH07509704A (ja) | 1995-10-26 |
WO1994003482A1 (en) | 1994-02-17 |
ITMI921914A1 (it) | 1994-02-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950830 |