IT1256635B - Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazione - Google Patents
Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazioneInfo
- Publication number
- IT1256635B IT1256635B ITMI922801A IT1256635B IT 1256635 B IT1256635 B IT 1256635B IT MI922801 A ITMI922801 A IT MI922801A IT 1256635 B IT1256635 B IT 1256635B
- Authority
- IT
- Italy
- Prior art keywords
- beta
- alpha
- thi
- aza
- oxo
- Prior art date
Links
- 239000002677 5-alpha reductase inhibitor Substances 0.000 title 1
- 208000002874 Acne Vulgaris Diseases 0.000 title 1
- 206010060862 Prostate cancer Diseases 0.000 title 1
- 206010000496 acne Diseases 0.000 title 1
- 201000001514 prostate carcinoma Diseases 0.000 title 1
- 229940095585 testosterone-5-alpha reductase inhibitors for benign prostatic hypertrophy Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HFVMLYAGWXSTQI-QYXZOKGRSA-N 5alpha-androst-16-en-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CC[C@H]21 HFVMLYAGWXSTQI-QYXZOKGRSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 125000006533 methyl amino methyl group Chemical group [H]N(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
Abstract
Sono descritti composti di formula generale (FORMULA) nella quale il legame carbonio-carbonio nelle posizioni 1-2 può essere semplice o doppio, RI, RII e RIII hanno i significati descritti di seguito. Tali composti sono dotati di attività inibitrice della 5-?-riduttasi del testosterone.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002801 IT1256635B (it) | 1992-12-10 | 1992-12-10 | Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazione |
| AU56955/94A AU5695594A (en) | 1992-12-10 | 1993-12-03 | Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them |
| PCT/EP1993/003400 WO1994013691A1 (en) | 1992-12-10 | 1993-12-03 | Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them |
| IL10790393A IL107903A0 (en) | 1992-12-10 | 1993-12-06 | Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them |
| MX9307794A MX9307794A (es) | 1992-12-10 | 1993-12-09 | Tio-y oxo-azasteroides, proceso para su preparacion y composicion farmaceutica que los contiene. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002801 IT1256635B (it) | 1992-12-10 | 1992-12-10 | Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazione |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI922801A0 ITMI922801A0 (it) | 1992-12-10 |
| ITMI922801A1 ITMI922801A1 (it) | 1994-06-10 |
| IT1256635B true IT1256635B (it) | 1995-12-12 |
Family
ID=11364425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT002801 IT1256635B (it) | 1992-12-10 | 1992-12-10 | Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazione |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1256635B (it) |
-
1992
- 1992-12-10 IT IT002801 patent/IT1256635B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI922801A0 (it) | 1992-12-10 |
| ITMI922801A1 (it) | 1994-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8704161A1 (es) | Un procedimiento para preparar dihidroquinoleinas antibacterianas. | |
| DE69303032D1 (de) | Als süsstoffe brauchbare verbindungen und hir herstellungsverfahren | |
| MY127751A (en) | Process for the preparation of dihydroxy esters and derivatives thereof | |
| HK1006412A1 (en) | Medicament for treating prostatic adenocarcinoma | |
| ZA906710B (en) | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase | |
| RU93005334A (ru) | Производные стероидов для лечения гипертрофии предстательной железы, способ их получения, использование, фармкомпозиция | |
| MA23216A1 (fr) | Procede de preparation et de production de lipopeptides d'actinoplanes sp . | |
| FR2691968B1 (fr) | Nouveau procede de preparation d'un derive sterouide 11-ceto. | |
| DE69410081T2 (de) | Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten | |
| AU4700389A (en) | Phosphonic acid substituted steroids as steroid 5alpha- reductase inhibitors | |
| IT1256635B (it) | Antiandrogeni per la terapia dell'ipertrofia prostatica, dell'irsutismo, dell'acne e della seborrea e relativi procedimenti di preparazione | |
| EA199800468A1 (ru) | 25-гидрокси-16-ен-26,27-бисгомохолекальциферолы | |
| TW427997B (en) | New preparation process for a 16 β-methyl steroid and new intermediates | |
| AU567877B2 (en) | Carbacyclin esters | |
| DE3160599D1 (en) | Process for the preparation of 17-alpha-hydroxy and 17a-alpha-hydroxy-d-homo-etio-carboxylic acids | |
| EP1067195A3 (de) | Verfahren zur Reduktion von Ketogruppen enthaltende Verbindungen | |
| NO942531L (no) | Fremgangsmåte for fremstilling av 3-acylöstratriener og acylbenzener | |
| MY110167A (en) | Improved process and intermediates for certain bis-aza- bicyclic anxiolytic agents. | |
| DE3262771D1 (en) | Process for the preparation of tetronic acid | |
| GB1130190A (en) | Improvements in or relating to steroid intermediates and the production thereof | |
| GR850486B (it) | ||
| TW427998B (en) | Steroid esters, process for their production and their pharmaceutical use | |
| AU547375B2 (en) | 3-hydroxy dodecahydro benz(e) indene-7-one anti-androgenic use | |
| FR2694007B1 (fr) | Nouveau procédé de préparation de composés stéroïdes 20-céto 21 (S) hydroxy et des intermédiaires. | |
| ATE33829T1 (de) | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971223 |