IL107903A0 - Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them - Google Patents

Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them

Info

Publication number
IL107903A0
IL107903A0 IL10790393A IL10790393A IL107903A0 IL 107903 A0 IL107903 A0 IL 107903A0 IL 10790393 A IL10790393 A IL 10790393A IL 10790393 A IL10790393 A IL 10790393A IL 107903 A0 IL107903 A0 IL 107903A0
Authority
IL
Israel
Prior art keywords
azasteroids
antiandrogens
thio
oxo
processes
Prior art date
Application number
IL10790393A
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT002801 external-priority patent/IT1256635B/en
Priority claimed from IT93MI001730A external-priority patent/IT1264535B1/en
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Publication of IL107903A0 publication Critical patent/IL107903A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
IL10790393A 1992-12-10 1993-12-06 Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them IL107903A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002801 IT1256635B (en) 1992-12-10 1992-12-10 New 3-(thi)-oxo-4-aza-androstane derivs - used as testosterone 5-alpha-reductase inhibitors for treating super-androgenic conditions e.g. acne or prostate carcinoma.
IT93MI001730A IT1264535B1 (en) 1993-07-30 1993-07-30 Thioazasteroids, their use as antiandrogens and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
IL107903A0 true IL107903A0 (en) 1994-04-12

Family

ID=26330938

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10790393A IL107903A0 (en) 1992-12-10 1993-12-06 Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them

Country Status (4)

Country Link
AU (1) AU5695594A (en)
IL (1) IL107903A0 (en)
MX (1) MX9307794A (en)
WO (1) WO1994013691A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU675225B2 (en) * 1992-05-20 1997-01-30 Merck & Co., Inc. 17-amino substituted 4-azasteroid 5alpha-reductase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones

Also Published As

Publication number Publication date
AU5695594A (en) 1994-07-04
MX9307794A (en) 1994-07-29
WO1994013691A1 (en) 1994-06-23

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IL107903A0 (en) Thio- and oxo-azasteroids, processes for the preparation thereof, use thereof as antiandrogens and pharmaceutical compositions containing them