IT1251716B - Complessi del platino(ii)anti-tumorali e procedimento per la loro preparazione - Google Patents

Complessi del platino(ii)anti-tumorali e procedimento per la loro preparazione

Info

Publication number
IT1251716B
IT1251716B ITMI912938A ITMI912938A IT1251716B IT 1251716 B IT1251716 B IT 1251716B IT MI912938 A ITMI912938 A IT MI912938A IT MI912938 A ITMI912938 A IT MI912938A IT 1251716 B IT1251716 B IT 1251716B
Authority
IT
Italy
Prior art keywords
complexes
procedure
preparation
linked
methyl
Prior art date
Application number
ITMI912938A
Other languages
English (en)
Inventor
Youn Soo Sohn
Kwan Mook Kim
Original Assignee
Korea Inst Sci & Tech
Korea Inst Of Scienze And Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Inst Sci & Tech, Korea Inst Of Scienze And Tech filed Critical Korea Inst Sci & Tech
Publication of ITMI912938A0 publication Critical patent/ITMI912938A0/it
Publication of ITMI912938A1 publication Critical patent/ITMI912938A1/it
Application granted granted Critical
Publication of IT1251716B publication Critical patent/IT1251716B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invenzione riguarda complessi del platino anti-tumorali rappresentati dalla formula generale I: (FORMULA I) in cui A è scelto da un'ammina e da alchil- e cicloalchilammine primarie monodentate con 1-3 atomi di carbonio come metil-, etil-, n-propil-, isopropil- e ciclopropilammine, o i due gruppi amminici possono essere combinati in modo da dare una diammina bidentata di forma chelante (SIMBOLO) come etilendiammina, 1,2-diamminocicloesano, e 2-idrossi-1,3-diamminopropano, e X è o vinilene (-CH-CH-) o etilene (-CH2-CH2) quando è legato a due atomi di zolfo in una forma ciclica o rappresenta due gruppi metile separatamente legati a ciascun atomo di zolfo.
ITMI912938A 1991-07-05 1991-11-06 Complessi del platino(ii)anti-tumorali e procedimento per la loro preparazione IT1251716B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910011401A KR940010295B1 (ko) 1991-07-05 1991-07-05 신규 항암성 백금 착화합물 유도체 및 그 제조방법

Publications (3)

Publication Number Publication Date
ITMI912938A0 ITMI912938A0 (it) 1991-11-06
ITMI912938A1 ITMI912938A1 (it) 1993-05-06
IT1251716B true IT1251716B (it) 1995-05-20

Family

ID=19316809

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912938A IT1251716B (it) 1991-07-05 1991-11-06 Complessi del platino(ii)anti-tumorali e procedimento per la loro preparazione

Country Status (7)

Country Link
US (1) US5142075A (it)
JP (1) JPH0689011B2 (it)
KR (1) KR940010295B1 (it)
DE (1) DE4137930C2 (it)
FR (1) FR2678623B1 (it)
GB (1) GB2257138B (it)
IT (1) IT1251716B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970010594B1 (ko) * 1993-10-16 1997-06-28 한국과학기술연구원 말론산 유도체의 백금착화합물 및 그 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657927A (en) * 1978-05-04 1987-04-14 Research Corporation Malonato platinum compounds
US4560782A (en) * 1982-11-19 1985-12-24 Research Corporation Anti-tumor diplatinum coordination compounds
US4533502A (en) * 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
US4668799A (en) * 1985-05-30 1987-05-26 Banyu Pharmaceutical Co., Ltd. Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor
US4797393A (en) * 1986-07-25 1989-01-10 University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
ES2000614A6 (es) * 1986-08-04 1988-03-01 Ferrer Int Procedimiento de obtencion de nuevos complejos de platino (ii) derivados del 2,3-dimercapto-2-butene-dinitrilato (2-)-s,s'"
US4870070A (en) * 1987-08-10 1989-09-26 American Cyanamid Company Water soluble platinum complexes of novel malonate derivatives

Also Published As

Publication number Publication date
JPH0578378A (ja) 1993-03-30
DE4137930C2 (de) 1994-02-17
KR940010295B1 (ko) 1994-10-22
FR2678623B1 (fr) 1996-03-08
ITMI912938A0 (it) 1991-11-06
US5142075A (en) 1992-08-25
FR2678623A1 (fr) 1993-01-08
GB2257138B (en) 1995-02-22
ITMI912938A1 (it) 1993-05-06
GB9122559D0 (en) 1991-12-04
DE4137930A1 (de) 1993-01-14
GB2257138A (en) 1993-01-06
JPH0689011B2 (ja) 1994-11-09
KR930002367A (ko) 1993-02-23

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971129